Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ATP binding cassette sub family G | 0.001 | 0.1931 | 0.1931 |
Trichomonas vaginalis | taga, putative | 0.001 | 0.2137 | 1 |
Leishmania major | ATP-binding cassette protein subfamily B, member 2, putative | 0.001 | 0.2137 | 1 |
Brugia malayi | ABC transporter family protein | 0.0008 | 0.1489 | 0.1489 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.001 | 0.2137 | 0.2137 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.001 | 0.2137 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0007 | 0.1198 | 0.5606 |
Entamoeba histolytica | P-glycoprotein 5, putative | 0.001 | 0.2137 | 0.2137 |
Toxoplasma gondii | ATP-binding cassette G family transporter ABCG84 | 0.001 | 0.1931 | 0.9034 |
Mycobacterium leprae | PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER | 0.0003 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.001 | 0.2137 | 0.2137 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.001 | 0.1931 | 0.1931 |
Trypanosoma cruzi | ATP-binding cassette protein, putative | 0.001 | 0.1931 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.1422 | 0.1422 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.001 | 0.2137 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.001 | 0.207 | 0.207 |
Loa Loa (eye worm) | ATP-binding cassette sub-family B member 2 | 0.001 | 0.2137 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.001 | 0.2137 | 0.2137 |
Trichomonas vaginalis | abcb9, putative | 0.001 | 0.2137 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.001 | 0.2137 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.001 | 0.2137 | 0.2137 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.001 | 0.2137 | 0.2137 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 1 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.001 | 0.2137 | 1 |
Plasmodium vivax | ABC transporter G family member 2, putative | 0.001 | 0.1931 | 0.9034 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.001 | 0.1931 | 0.1931 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.001 | 0.2137 | 0.2137 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.001 | 0.2137 | 0.2137 |
Entamoeba histolytica | P-glycoprotein-5 | 0.001 | 0.2137 | 0.2137 |
Brugia malayi | multidrug resistance protein 3 | 0.001 | 0.2137 | 0.2137 |
Schistosoma mansoni | ATP-binding cassette sub-family g2 (white protein) (abcg2) | 0.001 | 0.1931 | 0.1931 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.001 | 0.2137 | 0.2137 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.001 | 0.2137 | 0.2137 |
Leishmania major | ATP-binding cassette protein subfamily G, member 4, putative | 0.001 | 0.1931 | 0.9034 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.001 | 0.2137 | 0.2137 |
Entamoeba histolytica | ABC transporter, putative | 0.001 | 0.1931 | 0.1931 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.001 | 0.2137 | 0.2137 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.001 | 0.1931 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.001 | 0.2137 | 1 |
Wolbachia endosymbiont of Brugia malayi | ABC-type multidrug transport system, ATPase and permease component | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.001 | 0.2137 | 1 |
Wolbachia endosymbiont of Brugia malayi | ABC-type protease secretion system, ATPase and permease component, AprD | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.001 | 0.2137 | 1 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0007 | 0.1198 | 0.1198 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 1 | 1 |
Entamoeba histolytica | P-glyco protein 6, putative | 0.001 | 0.2137 | 0.2137 |
Trypanosoma brucei | ABC transporter, putative | 0.001 | 0.1931 | 1 |
Toxoplasma gondii | ATP-binding cassette transporter ABC.B1 | 0.001 | 0.2137 | 1 |
Plasmodium vivax | multidrug resistance protein 1, putative | 0.001 | 0.2137 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.001 | 0.2137 | 1 |
Plasmodium falciparum | multidrug resistance protein 1 | 0.001 | 0.2137 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.001 | 0.2137 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0007 | 0.1198 | 0.1198 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.001 | 0.1931 | 0.1931 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.001 | 0.2137 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.001 | 0.1931 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.001 | 0.2137 | 0.2137 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.001 | 0.2137 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.001 | 0.2137 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.001 | 0.1931 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.001 | 0.2137 | 0.2137 |
Schistosoma mansoni | multidrug resistance protein | 0.001 | 0.2137 | 0.2137 |
Toxoplasma gondii | ABC transporter transmembrane region domain-containing protein | 0.001 | 0.2137 | 1 |
Onchocerca volvulus | 0.001 | 0.2137 | 0.5 | |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.001 | 0.2137 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.001 | 0.2137 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.001 | 0.2137 | 1 |
Schistosoma mansoni | ABC transporter | 0.0008 | 0.1489 | 0.1489 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.001 | 0.1931 | 0.1931 |
Echinococcus granulosus | 5'partial|ATP binding cassette sub family B | 0.001 | 0.207 | 0.207 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.001 | 0.2137 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 1 | 1 |
Trichomonas vaginalis | abcb9, putative | 0.001 | 0.2137 | 1 |
Leishmania major | p-glycoprotein | 0.001 | 0.2137 | 1 |
Plasmodium falciparum | ABC transporter G family member 2 | 0.001 | 0.1931 | 0.9034 |
Schistosoma mansoni | multidrug resistance protein | 0.001 | 0.2137 | 0.2137 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.207 | 0.9683 |
Brugia malayi | ABC transporter family protein | 0.001 | 0.2137 | 0.2137 |
Giardia lamblia | ABC transporter | 0.001 | 0.1863 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane ATP-binding protein ABC transporter | 0.0008 | 0.1422 | 0.6651 |
Mycobacterium tuberculosis | Probable transmembrane multidrug efflux pump | 0.001 | 0.2137 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.001 | 0.2137 | 0.2137 |
Trichomonas vaginalis | ABC transporter, half transporter, putative | 0.001 | 0.2137 | 1 |
Trichomonas vaginalis | ABC transporter, putative | 0.001 | 0.2137 | 1 |
Leishmania major | ATP-binding cassette protein subfamily G, member 6, putative | 0.001 | 0.1931 | 0.9034 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 1 | 1 |
Trichomonas vaginalis | abcb9, putative | 0.001 | 0.2137 | 1 |
Loa Loa (eye worm) | ABC transporter | 0.0008 | 0.1489 | 0.6969 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2137 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.001 | 0.2137 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.001 | 0.2137 | 1 |
Loa Loa (eye worm) | multidrug resistance protein 3 | 0.001 | 0.2137 | 1 |
Trichomonas vaginalis | lipid A export ATP-binding/permease protein msba, putative | 0.001 | 0.2137 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.001 | 0.2137 | 1 |
Trypanosoma brucei | ATP-binding cassette protein, putative | 0.001 | 0.1931 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Entamoeba histolytica | P-glycoprotein-2, putative | 0.001 | 0.2137 | 0.2137 |
Entamoeba histolytica | P-glycoprotein-2 | 0.001 | 0.2137 | 0.2137 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2137 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.001 | 0.2137 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.001 | 0.2137 | 1 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.001 | 0.2137 | 0.2137 |
Entamoeba histolytica | P-glycoprotein-1 | 0.001 | 0.2137 | 0.2137 |
Schistosoma mansoni | smdr2 | 0.001 | 0.2137 | 0.2137 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0007 | 0.1198 | 0.1198 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.001 | 0.1931 | 0.1931 |
Chlamydia trachomatis | ABC transporter ATP binding protein/permease | 0.001 | 0.2137 | 0.5 |
Trypanosoma cruzi | ABC transporter, putative | 0.001 | 0.1931 | 1 |
Trichomonas vaginalis | multidrug resistance protein 1, 2, putative | 0.001 | 0.2137 | 1 |
Entamoeba histolytica | P-glycoprotein-2 | 0.001 | 0.2137 | 0.2137 |
Trichomonas vaginalis | ABC transporter, putative | 0.001 | 0.2137 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 | Cytotoxicity against human HeLa S3 cells after 120 hrs by MTT assay | ChEMBL. | 17300856 |
IC50 (functional) | > 1000 ug ml-1 | Antifungal activity against Candida albicans ATCC 10261 after 48 hrs by serial dilution microtiter plate method | ChEMBL. | 17300856 |
IC50 (functional) | > 1000 ug ml-1 | Bacteriostatic activity against Micrococcus luteus after 24 hrs by serial dilution microtiter plate method | ChEMBL. | 17300856 |
IC50 (functional) | > 1000 ug ml-1 | Bacteriostatic activity against Staphylococcus aureus ATCC 9144 after 24 hrs by serial dilution microtiter plate method | ChEMBL. | 17300856 |
IC50 (functional) | > 1000 ug ml-1 | Bacteriostatic activity against Salmonella typhimurium PCM 2180 after 24 hrs by serial dilution microtiter plate method | ChEMBL. | 17300856 |
IC50 (functional) | > 1000 ug ml-1 | Bacteriostatic activity against Escherichia coli ATCC 11775 after 24 hrs by serial dilution microtiter plate method | ChEMBL. | 17300856 |
IC50 (functional) | > 1000 ug ml-1 | Bacteriostatic activity against Proteus vulgaris ATCC 6380 after 24 hrs by serial dilution microtiter plate method | ChEMBL. | 17300856 |
IC50 (functional) | > 1000 ug ml-1 | Antifungal activity against Candida albicans ATCC 10261 after 48 hrs by serial dilution microtiter plate method | ChEMBL. | 17300856 |
IC50 (functional) | > 1000 ug ml-1 | Bacteriostatic activity against Escherichia coli ATCC 11775 after 24 hrs by serial dilution microtiter plate method | ChEMBL. | 17300856 |
MIC (functional) | > 100 ug ml-1 | Tuberculostatic activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 17300856 |
MIC (functional) | > 100 ug ml-1 | Tuberculostatic activity against Mycobacterium kansasii | ChEMBL. | 17300856 |
MIC (functional) | > 100 ug ml-1 | Tuberculostatic activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 17300856 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.