TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 326.582 | Formula: C10H14ClINO-
H donors: 2 H acceptors: 1 LogP: 3.55 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: NCc1cc(cc(c1O)I)C(C)C.[Cl-]
InChi: 1S/C10H14INO.ClH/c1-6(2)7-3-8(5-12)10(13)9(11)4-7;/h3-4,6,13H,5,12H2,1-2H3;1H/p-1
InChiKey: NJHNZTNGGPVCPM-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0082	0.0123	0.0123
Echinococcus multilocularis	Tubulin beta 2C chain	0.023	0.9432	0.9432
Loa Loa (eye worm)	ACC-1 protein	0.0082	0.0123	0.0123
Echinococcus multilocularis	caspase 2	0.0115	0.2174	0.2174
Echinococcus granulosus	gamma secretase subunit aph 1	0.0239	1	1
Leishmania major	alpha tubulin	0.0174	0.59	0.4682
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0082	0.0123	0.0123
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0082	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Leishmania major	alpha tubulin	0.0174	0.59	0.4682
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Trypanosoma brucei	alpha tubulin	0.0174	0.59	0.5905
Echinococcus granulosus	tubulin alpha	0.0124	0.2791	0.2791
Trichomonas vaginalis	tubulin beta chain, putative	0.0174	0.59	0.5571
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0082	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0082	0.0123	0.0123
Brugia malayi	Tubulin gamma chain	0.0124	0.2791	0.2791
Trichomonas vaginalis	tubulin epsilon chain, putative	0.023	0.9432	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Trypanosoma brucei	alpha tubulin	0.0174	0.59	0.5905
Loa Loa (eye worm)	BEN-1 protein	0.023	0.9432	0.9432
Echinococcus granulosus	Tubulin alpha 1 chain	0.0174	0.59	0.59
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0174	0.59	0.59
Leishmania major	beta tubulin	0.023	0.9432	1
Trypanosoma brucei	beta tubulin	0.023	0.9432	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Leishmania major	alpha tubulin	0.0174	0.59	0.4682
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Loa Loa (eye worm)	cytochrome P450 family protein	0.0138	0.367	0.367
Echinococcus granulosus	glycine receptor subunit beta	0.0082	0.0123	0.0123
Echinococcus granulosus	tubulin alpha 3 chain	0.0174	0.59	0.59
Echinococcus multilocularis	tubulin epsilon chain	0.0124	0.2791	0.2791
Loa Loa (eye worm)	BEN-1 protein	0.023	0.9432	0.9432
Plasmodium falciparum	alpha tubulin 2	0.0174	0.59	0.4682
Trypanosoma brucei	tubulin gamma chain	0.0124	0.2791	0.23
Loa Loa (eye worm)	beta-tubulin	0.023	0.9432	0.9432
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0082	0.0123	0.0123
Trichomonas vaginalis	tubulin gamma chain, putative	0.0124	0.2791	0.1672
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0082	0.0123	0.0123
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0082	0.0123	0.0123
Trypanosoma brucei	alpha tubulin	0.0174	0.59	0.5905
Brugia malayi	Cytochrome P450 family protein	0.0138	0.367	0.367
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0239	1	1
Brugia malayi	Cytochrome P450 family protein	0.0138	0.367	0.367
Plasmodium falciparum	tubulin beta chain	0.023	0.9432	1
Echinococcus multilocularis	tubulin alpha	0.0124	0.2791	0.2791
Trichomonas vaginalis	tubulin beta chain, putative	0.0174	0.59	0.5571
Trichomonas vaginalis	tubulin alpha chain, putative	0.0124	0.2791	0.1672
Echinococcus multilocularis	tubulin gamma 1 chain	0.0124	0.2791	0.2791
Loa Loa (eye worm)	cytochrome P450 family protein	0.0138	0.367	0.367
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Trypanosoma cruzi	tubulin gamma chain	0.0124	0.2791	0.23
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0174	0.59	0.59
Plasmodium falciparum	alpha tubulin 1	0.0174	0.59	0.4682
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0082	0.0123	0.0123
Loa Loa (eye worm)	tubulin beta-1 chain	0.023	0.9432	0.9432
Schistosoma mansoni	alpha tubulin	0.0174	0.59	0.59
Leishmania major	beta tubulin	0.023	0.9432	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0082	0.0123	0.0123
Echinococcus granulosus	tubulin alpha 3 chain	0.0174	0.59	0.59
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Leishmania major	alpha tubulin	0.0174	0.59	0.4682
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0082	0.0123	0.0123
Loa Loa (eye worm)	alpha-tubulin	0.0174	0.59	0.59
Echinococcus multilocularis	glycine receptor subunit beta	0.0082	0.0123	0.0123
Loa Loa (eye worm)	tubulin alpha chain	0.0174	0.59	0.59
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0082	0.0123	0.0123
Schistosoma mansoni	tubulin subunit beta	0.023	0.9432	0.9432
Brugia malayi	tubulin alpha-2 chain	0.0174	0.59	0.59
Echinococcus multilocularis	beta tubulin	0.023	0.9432	0.9432
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0082	0.0123	0.0123
Echinococcus multilocularis	tubulin alpha 1C chain	0.0174	0.59	0.59
Schistosoma mansoni	tubulin subunit alpha	0.0174	0.59	0.59
Schistosoma mansoni	nAChR subunit	0.0082	0.0123	0.0123
Echinococcus granulosus	tubulin alpha chain	0.0174	0.59	0.59
Echinococcus granulosus	tubulin alpha 1C chain	0.0174	0.59	0.59
Echinococcus granulosus	tubulin alpha chain	0.0174	0.59	0.59
Loa Loa (eye worm)	hypothetical protein	0.0115	0.2174	0.2174
Entamoeba histolytica	tubulin family protein	0.023	0.9432	1
Echinococcus granulosus	tubulin gamma 1 chain	0.0124	0.2791	0.2791
Leishmania major	alpha tubulin	0.0174	0.59	0.4682
Trichomonas vaginalis	tubulin alpha chain, putative	0.023	0.9432	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.023	0.9432	0.9432
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0082	0.0123	0.0123
Echinococcus granulosus	tubulin epsilon chain	0.0124	0.2791	0.2791
Trichomonas vaginalis	tubulin epsilon chain, putative	0.023	0.9432	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.023	0.9432	1
Schistosoma mansoni	tubulin subunit beta	0.023	0.9432	0.9432
Echinococcus multilocularis	Tubulin beta 2C chain	0.023	0.9432	0.9432
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.012	0.2491	0.2491
Brugia malayi	Tubulin alpha-2 chain	0.0174	0.59	0.59
Echinococcus multilocularis	tubulin subunit TubB	0.0174	0.59	0.59
Echinococcus granulosus	Tubulin beta 2C chain	0.023	0.9432	0.9432
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0082	0.0123	0.0123
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0082	0.0123	0.0123
Loa Loa (eye worm)	tubulin alpha 2	0.012	0.2491	0.2491
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0174	0.59	0.59
Entamoeba histolytica	tubulin alpha-1 chain	0.0174	0.59	0.4682
Schistosoma mansoni	tubulin subunit alpha	0.0174	0.59	0.59
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0082	0.0123	0.0123
Echinococcus multilocularis	tubulin subunit beta	0.023	0.9432	0.9432
Echinococcus granulosus	tubulin alpha 1C chain	0.0174	0.59	0.59
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Toxoplasma gondii	beta tubulin	0.023	0.9432	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0082	0.0123	0.0123
Echinococcus multilocularis	tubulin alpha 3 chain	0.0174	0.59	0.59
Trypanosoma cruzi	cytochrome P450, putative	0.0138	0.367	0.3319
Trypanosoma brucei	beta tubulin	0.023	0.9432	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Schistosoma mansoni	nAChR subunit	0.0082	0.0123	0.0123
Loa Loa (eye worm)	CYP4Cod1	0.0138	0.367	0.367
Leishmania major	beta tubulin	0.023	0.9432	1
Brugia malayi	Tubulin alpha chain	0.0174	0.59	0.59
Trichomonas vaginalis	tubulin gamma chain, putative	0.0124	0.2791	0.1672
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Trypanosoma brucei	beta tubulin	0.023	0.9432	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Schistosoma mansoni	tubulin subunit beta	0.023	0.9432	0.9432
Leishmania major	alpha tubulin	0.0174	0.59	0.4682
Schistosoma mansoni	tubulin subunit alpha	0.0174	0.59	0.59
Onchocerca volvulus		0.0082	0.0123	0.0564
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0239	1	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0082	0.0123	0.0123
Leishmania major	beta tubulin	0.023	0.9432	1
Plasmodium vivax	tubulin beta chain, putative	0.023	0.9432	1
Loa Loa (eye worm)	LGC-31 protein	0.0082	0.0123	0.0123
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0174	0.59	0.5571
Trichomonas vaginalis	tubulin beta chain, putative	0.0174	0.59	0.5571
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0082	0.0123	0.0123
Echinococcus granulosus	Tubulin beta 2C chain	0.023	0.9432	0.9432
Echinococcus multilocularis	tubulin beta 1 chain	0.023	0.9432	0.9432
Trypanosoma brucei	epsilon tubulin	0.0124	0.2791	0.23
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0082	0.0123	0.0123
Leishmania major	beta tubulin	0.023	0.9432	1
Schistosoma mansoni	alpha tubulin	0.0174	0.59	0.59
Brugia malayi	Cation transporter family protein	0.0082	0.0123	0.0123
Loa Loa (eye worm)	alpha-tubulin	0.0174	0.59	0.59
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1158	0.1158
Echinococcus multilocularis	tubulin alpha 1C chain	0.0174	0.59	0.59
Leishmania major	beta tubulin	0.023	0.9432	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0082	0.0123	0.0123
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0082	0.0123	0.0123
Trypanosoma brucei	beta tubulin	0.023	0.9432	1
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0082	0.0123	0.0123
Schistosoma mansoni	tubulin subunit beta	0.023	0.9432	0.9432
Trypanosoma cruzi	cytochrome P450, putative	0.0138	0.367	0.3319
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0082	0.0123	0.0123
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0174	0.59	0.5571
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0138	0.367	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0082	0.0123	0.0123
Leishmania major	alpha tubulin	0.0174	0.59	0.4682
Trypanosoma brucei	epsilon tubulin	0.0124	0.2791	0.23
Trypanosoma cruzi	beta tubulin, putative	0.023	0.9432	1
Echinococcus granulosus	tubulin alpha chain	0.0174	0.59	0.59
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0082	0.0123	0.0123
Toxoplasma gondii	alpha tubulin TUBA1	0.0174	0.59	0.4682
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Echinococcus multilocularis	tubulin alpha 3 chain	0.0174	0.59	0.59
Plasmodium vivax	tubulin alpha chain, putative	0.0174	0.59	0.4682
Leishmania major	beta tubulin	0.023	0.9432	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1458	0.1458
Brugia malayi	Tubulin beta-1 chain	0.023	0.9432	0.9432
Echinococcus multilocularis	beta tubulin	0.023	0.9432	0.9432
Entamoeba histolytica	tubulin family protein	0.023	0.9432	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0082	0.0123	0.0123
Echinococcus granulosus	tubulin beta 4A class IVa	0.023	0.9432	0.9432
Onchocerca volvulus		0.0082	0.0123	0.0564
Echinococcus multilocularis	tubulin alpha chain	0.0174	0.59	0.59
Echinococcus granulosus	peroxisome assembly protein 26	0.0174	0.59	0.59
Echinococcus multilocularis	tubulin alpha chain	0.0174	0.59	0.59
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0082	0.0123	0.0123
Leishmania major	beta tubulin	0.023	0.9432	1
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0082	0.0123	0.0123
Echinococcus granulosus	beta tubulin	0.023	0.9432	0.9432
Trypanosoma brucei	beta tubulin	0.0124	0.2791	0.23
Brugia malayi	alpha-tubulin	0.0174	0.59	0.59
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0082	0.0123	0.0123
Giardia lamblia	Beta tubulin	0.023	0.9432	1
Brugia malayi	Cation transporter family protein	0.0082	0.0123	0.0123
Trypanosoma brucei	alpha tubulin	0.0174	0.59	0.5905
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0082	0.0123	0.0123
Leishmania major	alpha tubulin	0.0174	0.59	0.4682
Plasmodium vivax	tubulin alpha chain, putative	0.0174	0.59	0.4682
Leishmania major	alpha tubulin	0.0174	0.59	0.4682
Loa Loa (eye worm)	hypothetical protein	0.012	0.2491	0.2491
Onchocerca volvulus		0.0082	0.0123	0.0564
Schistosoma mansoni	nAChR subunit	0.0082	0.0123	0.0123
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0082	0.0123	0.0123
Onchocerca volvulus		0.0082	0.0123	0.0564
Echinococcus granulosus	Tubulin alpha 1 chain	0.0174	0.59	0.59
Giardia lamblia	Alpha-tubulin	0.0174	0.59	0.4682
Leishmania major	beta tubulin	0.023	0.9432	1
Leishmania major	beta tubulin	0.023	0.9432	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0082	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0174	0.59	0.59
Giardia lamblia	Beta tubulin	0.023	0.9432	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0174	0.59	0.4682
Loa Loa (eye worm)	ACC-1 protein	0.0082	0.0123	0.0123
Trypanosoma brucei	cytochrome P450, putative	0.0138	0.367	0.3319
Trichomonas vaginalis	tubulin beta chain, putative	0.023	0.9432	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0082	0.0123	0.0123
Toxoplasma gondii	beta-tubulin, putative	0.023	0.9432	1
Toxoplasma gondii	alpha-tubulin I, putative	0.0174	0.59	0.4682
Leishmania major	alpha tubulin	0.0174	0.59	0.4682
Leishmania major	beta tubulin	0.023	0.9432	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0082	0.0123	0.0123
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0082	0.0123	0.0123
Onchocerca volvulus	Cell death protein 3 homolog	0.0115	0.2174	1
Echinococcus granulosus	tubulin beta 1 chain	0.023	0.9432	0.9432
Loa Loa (eye worm)	tubulin beta-2A chain	0.023	0.9432	0.9432
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.012	0.2491	0.1296
Echinococcus multilocularis	peroxisome assembly protein 26	0.0174	0.59	0.59
Echinococcus multilocularis	Tubulin beta 2C chain	0.023	0.9432	0.9432
Echinococcus granulosus	Tubulin beta 2C chain	0.023	0.9432	0.9432
Schistosoma mansoni	tubulin subunit beta	0.023	0.9432	0.9432
Schistosoma mansoni	tubulin subunit epsilon	0.0124	0.2791	0.2791
Schistosoma mansoni	tubulin subunit gamma	0.0124	0.2791	0.2791
Echinococcus granulosus	glycine receptor subunit beta	0.0082	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Leishmania major	cytochrome p450-like protein	0.0138	0.367	0.1323
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0082	0.0123	0.0123
Leishmania major	beta tubulin	0.023	0.9432	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0082	0.0123	0.0123
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0174	0.59	0.5571
Onchocerca volvulus		0.0082	0.0123	0.0564
Schistosoma mansoni	alpha tubulin	0.0174	0.59	0.59
Echinococcus granulosus	tubulin alpha chain	0.0174	0.59	0.59
Echinococcus multilocularis	nAChR subunit	0.0082	0.0123	0.0123
Loa Loa (eye worm)	tubulin alpha 2	0.012	0.2491	0.2491
Loa Loa (eye worm)	tubulin beta chain	0.023	0.9432	0.9432
Loa Loa (eye worm)	tubulin gamma chain	0.0124	0.2791	0.2791
Leishmania major	beta tubulin	0.023	0.9432	1
Leishmania major	beta tubulin	0.023	0.9432	1
Trichomonas vaginalis	tubulin, putative	0.023	0.9432	1
Schistosoma mansoni	nAChR subunit	0.0082	0.0123	0.0123
Echinococcus multilocularis	tubulin alpha chain	0.0174	0.59	0.59
Trichomonas vaginalis	tubulin beta chain, putative	0.0174	0.59	0.5571
Schistosoma mansoni	nAChR subunit	0.0082	0.0123	0.0123
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0082	0.0123	0.0123
Echinococcus multilocularis	tubulin alpha chain	0.0174	0.59	0.59
Trichomonas vaginalis	tubulin beta chain, putative	0.0174	0.59	0.5571
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0082	0.0123	0.0123
Leishmania major	alpha tubulin	0.0174	0.59	0.4682
Giardia lamblia	Alpha-tubulin	0.0174	0.59	0.4682
Brugia malayi	Cation transporter family protein	0.0082	0.0123	0.0123
Echinococcus multilocularis	tubulin alpha chain	0.0174	0.59	0.59
Trypanosoma cruzi	epsilon tubulin, putative	0.0124	0.2791	0.23
Schistosoma mansoni	nAChR subunit	0.0082	0.0123	0.0123
Echinococcus multilocularis	hypothetical protein	0.0174	0.59	0.59
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Trypanosoma brucei	epsilon tubulin	0.0124	0.2791	0.23
Echinococcus granulosus	caspase 2	0.0115	0.2174	0.2174
Loa Loa (eye worm)	tubulin alpha chain	0.0174	0.59	0.59
Brugia malayi	Tubulin alpha-2 chain	0.0174	0.59	0.59
Echinococcus multilocularis	Tubulin beta 2C chain	0.023	0.9432	0.9432
Trichomonas vaginalis	tubulin beta chain, putative	0.0174	0.59	0.5571
Leishmania major	beta tubulin	0.023	0.9432	1
Brugia malayi	beta-tubulin, identical	0.023	0.9432	0.9432
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0082	0.0123	0.0123
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0082	0.0123	0.0123
Echinococcus multilocularis	glycine receptor subunit beta	0.0082	0.0123	0.0123
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0082	0.0123	0.0123
Echinococcus granulosus	Tubulin beta 2C chain	0.023	0.9432	0.9432
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0082	0.0123	0.0123
Schistosoma mansoni	tubulin subunit beta	0.023	0.9432	0.9432
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.023	0.9432	0.9432
Echinococcus granulosus	Tubulin alpha 1 chain	0.0174	0.59	0.59
Schistosoma mansoni	nAChR subunit	0.0082	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Leishmania major	beta tubulin	0.023	0.9432	1
Toxoplasma gondii	beta-1 tubulin, putative	0.023	0.9432	1
Leishmania major	alpha tubulin	0.0174	0.59	0.4682
Echinococcus granulosus	beta tubulin	0.023	0.9432	0.9432
Schistosoma mansoni	caspase-7 (C14 family)	0.0115	0.2174	0.2174
Echinococcus granulosus	alpha tubulin	0.0174	0.59	0.59
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0123	0.0123
Trypanosoma cruzi	alpha tubulin, putative	0.0174	0.59	0.5905
Echinococcus multilocularis	Tubulin beta 2C chain	0.023	0.9432	0.9432
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0082	0.0123	0.0123
Onchocerca volvulus		0.0082	0.0123	0.0564
Echinococcus granulosus	nAChR subunit	0.0082	0.0123	0.0123
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0082	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0174	0.59	0.59
Echinococcus granulosus	tubulin subunit beta	0.023	0.9432	0.9432
Onchocerca volvulus	Putative nachr subunit	0.0082	0.0123	0.0564
Echinococcus granulosus	tubulin subunit TubB	0.0174	0.59	0.59
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0082	0.0123	0.0123
Echinococcus granulosus	Tubulin beta 2C chain	0.023	0.9432	0.9432
Brugia malayi	excitatory GABA receptor EXP-1A	0.0082	0.0123	0.0123
Brugia malayi	Cell death protein 3 precursor	0.0115	0.2174	0.2174
Brugia malayi	tubulin alpha chain - mouse	0.0174	0.59	0.59
Trypanosoma cruzi	epsilon tubulin, putative	0.0124	0.2791	0.23
Giardia lamblia	Beta tubulin	0.023	0.9432	1
Leishmania major	beta tubulin	0.023	0.9432	1
Echinococcus granulosus	tubulin alpha chain	0.0174	0.59	0.59
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0103	0.1458	0.1458
Leishmania major	beta tubulin	0.023	0.9432	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0082	0.0123	0.0123
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0239	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Diuretic activity (ADMET)	= 0.7	Compound administered orally at a dose of 1 mg/kg was evaluated for salidiuretic activity measured as sodium ion excretion in Rat	ChEMBL.	7452697
Diuretic activity (binding)	= 2.6	Compound administered orally at a dose of 5 mg/kg was evaluated for salidiuretic activity measured as sodium ion excretion in Rat	ChEMBL.	7452697
Diuretic activity (binding)	= 3.3	Evaluated for salidiuretic activity measured as sodium ion excretion in Rat, administered orally at a dose of 16.5 mg/kg	ChEMBL.	7452697
Diuretic activity (functional)	= 3.6	Evaluated for salidiuretic activity measured as sodium ion excretion in Rat, administered orally at a dose of 50 mg/kg	ChEMBL.	7452697
Diuretic activity (ADMET)	= 600	Compound administered intravenously at a dose of 5 mg/kg was evaluated for salidiuretic activity measured as sodium ion excretion in Dog; Value ranges from 600-799	ChEMBL.	7452697

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 145283

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 43493