Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | NA 0 mg kg-1 | Dose required to produce an acute inflammatory response of the algal poly saccharide carrageenan into the pleural cavity of rat; IA is Inactive at 9 mg/kg | ChEMBL. | 3941408 |
Inhibition (functional) | < 5 % | Inhibition of lymphocyte-mediated cytolysis at a concentratioon of 100 uM in [51Cr]- labelled EL4 leukemia cells | ChEMBL. | 3941408 |
Inhibition (functional) | = 8 % | Compound was tested for inhibition of mouse connective tissue cell (L) growth at a concentration of 100 uM | ChEMBL. | 3941408 |
Inhibition (functional) | = 10 % | Compound was tested for inhibition of human sternal marrow cell (D98) growth at a concentration of 100 uM | ChEMBL. | 3941408 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.