Detailed information for compound 435148

Basic information

Technical information
  • TDR Targets ID: 435148
  • Name: 3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin e-4,8-dicarboxylic acid
  • MW: 259.257 | Formula: C14H13NO4
  • H donors: 3 H acceptors: 4 LogP: 2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1Nc2ccc(cc2C2C1CC=C2)C(=O)O
  • InChi: 1S/C14H13NO4/c16-13(17)7-4-5-11-10(6-7)8-2-1-3-9(8)12(15-11)14(18)19/h1-2,4-6,8-9,12,15H,3H2,(H,16,17)(H,18,19)
  • InChiKey: RKSORIGFRQYENG-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • UNM000000520501
  • EU-0002578
  • STK027229
  • Oprea1_035916
  • NCGC00162004-01
  • MLS-0092010
  • MLS-0092010.0001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens heat shock 70kDa protein 1B Starlite/ChEMBL No references
Homo sapiens protein tyrosine phosphatase, non-receptor type 7 Starlite/ChEMBL No references
Rattus norvegicus Dual specificity protein phosphatase 6 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 1B 641 aa 613 aa 49.6 %
Echinococcus granulosus receptor type tyrosine protein phosphatase protein tyrosine phosphatase, non-receptor type 7 434 aa 400 aa 24.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Echinococcus granulosus 5'partial|tRNA 2 selenouridine synthase 0.0005 0.3625 0.3625
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0011 1 1
Onchocerca volvulus 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Trichomonas vaginalis cdc25b, putative 0.0005 0.3625 0.3625
Leishmania major hypothetical protein, unknown function 0.0005 0.3625 0.3625
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Toxoplasma gondii rhodanese family domain-containing protein 0.0005 0.3625 1
Onchocerca volvulus 0.0011 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0011 1 1
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0005 0.3625 0.3625
Trypanosoma brucei protein tyrosine phosphatase 1 0.0011 1 1
Giardia lamblia Thiosulfate sulfurtransferase 0.0005 0.3625 0.3625
Onchocerca volvulus 0.0005 0.3625 0.3625
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Schistosoma mansoni ubiquitin-activating enzyme E1 0.0005 0.3625 0.3625
Loa Loa (eye worm) hypothetical protein 0.0005 0.3625 0.3625
Brugia malayi RIKEN cDNA 4930451A13 0.0005 0.3625 0.3625
Schistosoma mansoni protein tyrosine phosphatase 0.0011 1 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0011 1 1
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0011 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0011 1 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 1 1
Chlamydia trachomatis hypothetical protein 0.0005 0.3625 0.5
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0005 0.3625 0.3625
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0005 0.3625 0.3625
Trypanosoma cruzi As/Sb Reductase, putative 0.0005 0.3625 0.3625
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0011 1 1
Plasmodium falciparum mitogen-activated protein kinase phosphatase 1, putative 0.0005 0.3625 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Onchocerca volvulus 0.0011 1 1
Entamoeba histolytica rodhanase-like domain containing protein 0.0005 0.3625 0.3625
Giardia lamblia Hypothetical protein 0.0005 0.3625 0.3625
Loa Loa (eye worm) protein tyrosine phosphatase 0.0011 1 1
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0011 1 1
Onchocerca volvulus 0.0011 1 1
Echinococcus multilocularis centrosomal protein of 41 kDa 0.0005 0.3625 0.3625
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 1 1
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0011 1 1
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.0005 0.3625 0.3625
Onchocerca volvulus 0.0011 1 1
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0011 1 1
Entamoeba histolytica hypothetical protein 0.0005 0.3625 0.3625
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0005 0.3625 0.3625
Trypanosoma cruzi mercaptopyruvate sulfurtransferase, putative 0.0005 0.3625 0.3625
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0005 0.3625 0.3625
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0011 1 1
Trichomonas vaginalis thiosulfate sulfertansferase, putative 0.0005 0.3625 0.3625
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0011 1 1
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0005 0.3625 0.3625
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Entamoeba histolytica hypothetical protein 0.0005 0.3625 0.3625
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 1 1
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase CysA3 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotran 0.0005 0.3625 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0011 1 1
Brugia malayi Rhodanese-like domain containing protein 0.0005 0.3625 0.3625
Loa Loa (eye worm) hypothetical protein 0.0005 0.3625 0.3625
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0011 1 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Wolbachia endosymbiont of Brugia malayi sulfurtransferase 0.0005 0.3625 0.5
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 1 1
Mycobacterium leprae Conserved hypothetical protein 0.0005 0.3625 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 1 1
Trypanosoma brucei mercaptopyruvate sulfurtransferase, putative 0.0005 0.3625 0.3625
Schistosoma mansoni hypothetical protein 0.0005 0.3625 0.3625
Onchocerca volvulus 0.0011 1 1
Brugia malayi Protein-tyrosine phosphatase 1 0.0011 1 1
Onchocerca volvulus 0.0011 1 1
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0005 0.3625 0.3625
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0005 0.3625 0.3625
Onchocerca volvulus 0.0005 0.3625 0.3625
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0011 1 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0011 1 1
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0005 0.3625 0.3625
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Trypanosoma cruzi As/Sb Reductase, putative 0.0005 0.3625 0.3625
Onchocerca volvulus 0.0011 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.3625 0.3625
Onchocerca volvulus 0.0011 1 1
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0011 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.3625 0.3625
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0005 0.3625 0.3625
Entamoeba histolytica hypothetical protein, conserved 0.0005 0.3625 0.3625
Schistosoma mansoni hypothetical protein 0.0005 0.3625 0.3625
Mycobacterium tuberculosis Probable transcriptional regulatory protein 0.0005 0.3625 0.5
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0011 1 1
Trichomonas vaginalis pten, drome, putative 0.0011 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Giardia lamblia Dual specificity phosphatase Cdc25, putative 0.0005 0.3625 0.3625
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0005 0.3625 0.3625
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0011 1 1
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0011 1 1
Onchocerca volvulus 0.0011 1 1
Trichomonas vaginalis Phage shock protein E precursor, putative 0.0005 0.3625 0.3625
Brugia malayi hypothetical protein 0.0011 1 1
Echinococcus multilocularis hypothetical protein 0.0011 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.3625 0.3625
Schistosoma mansoni protein tyrosine phosphatase 0.0011 1 1
Onchocerca volvulus 0.0011 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0005 0.3625 0.3625
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Plasmodium vivax mitogen-activated protein kinase phosphatase 1, putative 0.0005 0.3625 1
Entamoeba histolytica rodhanase-like domain containing protein 0.0005 0.3625 0.3625
Brugia malayi Rhodanese-like domain containing protein 0.0005 0.3625 0.3625
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0011 1 1
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0005 0.3625 0.3625
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0011 1 1
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0011 1 1
Echinococcus granulosus protein tyrosine phosphatase n9 0.0011 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0011 1 1
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0011 1 1
Echinococcus multilocularis Rhodanese 0.0005 0.3625 0.3625
Echinococcus multilocularis heat shock protein 67b2 0.0005 0.3625 0.3625
Trichomonas vaginalis Phage shock protein E precursor, putative 0.0005 0.3625 0.3625
Trichomonas vaginalis cdc25c, putative 0.0005 0.3625 0.3625
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Schistosoma mansoni hypothetical protein 0.0005 0.3625 0.3625
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Schistosoma mansoni hypothetical protein 0.0005 0.3625 0.3625
Leishmania major hypothetical protein, conserved 0.0005 0.3625 0.3625
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Entamoeba histolytica rodhanase-like domain containing protein 0.0005 0.3625 0.3625
Brugia malayi hypothetical protein 0.0011 1 1
Mycobacterium tuberculosis Possible transcriptional regulatory protein (possibly ArsR-family) 0.0005 0.3625 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0011 1 1
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase SseB 0.0005 0.3625 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0011 1 1
Leishmania major As/Sb Reductase 0.0005 0.3625 0.3625
Loa Loa (eye worm) hypothetical protein 0.0005 0.3625 0.3625
Onchocerca volvulus 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 1 1
Mycobacterium leprae PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA2 (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRAN 0.0005 0.3625 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0011 1 1
Giardia lamblia Hypothetical protein 0.0005 0.3625 0.3625
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Brugia malayi Protein-tyrosine phosphatase 0.0011 1 1
Leishmania major 3-mercaptopyruvate sulfurtransferase 0.0005 0.3625 0.3625
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.3625 0.3625
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0005 0.3625 0.3625
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0011 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Trichomonas vaginalis cdc25a, putative 0.0005 0.3625 0.3625
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0005 0.3625 0.3625
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0011 1 1
Onchocerca volvulus 0.0011 1 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0011 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0005 0.3625 0.5
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0011 1 1
Brugia malayi Thiosulfate sulfurtransferase D2023.5 0.0005 0.3625 0.3625
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0011 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.3625 0.3625
Brugia malayi hypothetical protein 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.3625 0.3625
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0011 1 1
Onchocerca volvulus 0.0011 1 1
Echinococcus multilocularis tRNA 2 selenouridine synthase 0.0005 0.3625 0.3625
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0005 0.3625 0.3625
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0011 1 1
Leishmania major hypothetical protein, conserved 0.0005 0.3625 0.3625
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.3625 0.3625
Onchocerca volvulus 0.0011 1 1
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0011 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.3625 0.3625
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Plasmodium vivax rhodanese like protein, putative 0.0005 0.3625 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.3625 0.3625
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Trichomonas vaginalis cdc25b, putative 0.0005 0.3625 0.3625
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Brugia malayi hypothetical protein 0.0011 1 1
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0005 0.3625 0.3625
Onchocerca volvulus 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Onchocerca volvulus 0.0011 1 1
Onchocerca volvulus 0.0005 0.3625 0.3625
Leishmania major hypothetical protein, conserved 0.0005 0.3625 0.3625
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Echinococcus granulosus centrosomal protein of 41 kDa 0.0005 0.3625 0.3625
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0005 0.3625 0.3625
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0011 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0011 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.3625 0.3625
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0005 0.3625 0.3625
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0011 1 1
Onchocerca volvulus 0.0011 1 1
Schistosoma mansoni Centrosomal protein of 41 kDa (Cep41 protein) (Testis-specificprotein A14 protein) 0.0005 0.3625 0.3625
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Leishmania major hypothetical protein, conserved 0.0005 0.3625 0.3625
Leishmania major hypothetical protein, conserved 0.0005 0.3625 0.3625
Leishmania major hypothetical protein, conserved 0.0005 0.3625 0.3625
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0005 0.3625 0.3625
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0011 1 1
Onchocerca volvulus 4.1 G protein, putative homolog 0.0011 1 1
Echinococcus granulosus heat shock protein 67b2 0.0005 0.3625 0.3625
Onchocerca volvulus 0.0005 0.3625 0.3625
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 1 1
Entamoeba histolytica hypothetical protein 0.0005 0.3625 0.3625
Brugia malayi Rhodanese-like domain containing protein 0.0005 0.3625 0.3625
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase CysA2 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotran 0.0005 0.3625 0.5
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0005 0.3625 0.3625
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 1 1
Entamoeba histolytica rodhanase-like domain containing protein 0.0005 0.3625 0.3625
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0011 1 1
Onchocerca volvulus 0.0011 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Onchocerca volvulus 0.0011 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Entamoeba histolytica rodhanase-like domain containing protein 0.0005 0.3625 0.3625
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0011 1 1
Entamoeba histolytica rodhanase-like domain containing protein 0.0005 0.3625 0.3625
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Plasmodium falciparum rhodanese like protein, putative 0.0005 0.3625 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0011 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0011 1 1
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0005 0.3625 0.3625
Mycobacterium tuberculosis Conserved protein 0.0005 0.3625 0.5
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) 0.0005 0.3625 0.5
Trichomonas vaginalis cdc25c, putative 0.0005 0.3625 0.3625
Mycobacterium leprae Probable thiosulfate sulfurtransferase SseA (RHODANESE) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE) 0.0005 0.3625 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Leishmania major tyrosine specific protein phosphatase, putative 0.0011 1 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Schistosoma mansoni dual specificity protein phosphatase 0.0008 0.6315 0.6315
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Mycobacterium ulcerans thiosulfate sulfurtransferase, CysA2 0.0005 0.3625 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Echinococcus granulosus Rhodanese 0.0005 0.3625 0.3625
Mycobacterium ulcerans hypothetical protein 0.0005 0.3625 0.5
Mycobacterium ulcerans molybdopterin biosynthesis-like protein MoeZ 0.0005 0.3625 0.5
Onchocerca volvulus 0.0011 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Entamoeba histolytica hypothetical protein 0.0005 0.3625 0.3625
Schistosoma mansoni protein tyrosine phosphatase 0.0011 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.3625 0.3625
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.3625 0.3625
Onchocerca volvulus 0.0011 1 1
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0005 0.3625 0.3625
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Mycobacterium tuberculosis Probable molybdenum cofactor biosynthesis protein MoeB2 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase) 0.0005 0.3625 0.5
Brugia malayi hypothetical protein 0.0011 1 1
Mycobacterium leprae PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE) 0.0005 0.3625 0.5
Onchocerca volvulus 0.0011 1 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0011 1 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0011 1 1
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0005 0.3625 0.3625
Brugia malayi Protein-tyrosine phosphatase 0.0011 1 1
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0011 1 1
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0005 0.3625 0.3625
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0011 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 1 1
Echinococcus multilocularis 0.0011 1 1
Onchocerca volvulus 0.0005 0.3625 0.3625
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0011 1 1
Onchocerca volvulus 0.0005 0.3625 0.3625
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0011 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Brugia malayi MoeZ/MoeB domain containing protein 0.0005 0.3625 0.3625
Mycobacterium ulcerans thiosulfate sulfurtransferase SseA 0.0005 0.3625 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 1 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 1 1
Schistosoma mansoni pcd6 interacting protein-related 0.0011 1 1
Giardia lamblia Protein tyrosine phosphatase 0.0011 1 1
Loa Loa (eye worm) thiosulfate sulfurtransferase 0.0005 0.3625 0.3625
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0011 1 1
Brugia malayi Rhodanese-like domain containing protein 0.0005 0.3625 0.3625
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0011 1 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0011 1 1

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells ChEMBL. 17367895
Activity (binding) 0 Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells ChEMBL. 17367895
IC50 (binding) = 2.42 um PUBCHEM_BIOASSAY: In Vitro Hsp70 Dose Response Fluorescence Polarization Assay for SAR Study. (Class of assay: confirmatory) [Related pubchem assays: 786, 583 ] ChEMBL. No reference
IC50 (functional) = 2.51 um PUBCHEM_BIOASSAY: In Vitro HePTP Dose Response Colorimetric Assay for SAR Study. (Class of assay: confirmatory) [Related pubchem assays: 521 ] ChEMBL. No reference
IC50 (functional) = 15.523 uM PUBCHEM_BIOASSAY: In Vitro MKP-3 Dose Response Assay for SAR Study. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1052, AID1661, AID2085, AID2679, AID425, AID553, AID566] ChEMBL. No reference
IC50 (binding) = 17.8 uM PUBCHEM_BIOASSAY: MKP-3 in vitro secondary assay for identification of irreversible and slow-binding inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1054, AID1055, AID425, AID553, AID566] ChEMBL. No reference
IC50 (binding) > 100 um PUBCHEM_BIOASSAY: GAPDH Dose Response Colorimetric Assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 100 um PUBCHEM_BIOASSAY: In Vitro Hsc70 Dose Response Fluorescence Polarization Assay. (Class of assay: confirmatory) [Related pubchem assays: 1072 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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