TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 387.446 | Formula: C20H19F2N3OS
H donors: 2 H acceptors: 3 LogP: 5.63 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)F)c1ccc(c(c1)c1nnc(s1)NC1CCCCC1)O
InChi: 1S/C20H19F2N3OS/c21-13-7-8-15(17(22)11-13)12-6-9-18(26)16(10-12)19-24-25-20(27-19)23-14-4-2-1-3-5-14/h6-11,14,26H,1-5H2,(H,23,25)
InChiKey: XOOKCHFMPMOBDT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0033	0.014	0.014
Leishmania major	DNA polymerase eta, putative	0.0045	0.0269	0.0444
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0465	0.0465
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0465	0.0465
Brugia malayi	Steroid receptor seven-up type 2	0.007	0.0525	0.0866
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0033	0.014	0.0231
Echinococcus granulosus	nuclear receptor nhr 48	0.0033	0.014	0.014
Brugia malayi	hypothetical protein	0.0033	0.014	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0231
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0602	0.606	0.606
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.007	0.0525	0.0525
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.007	0.0525	0.0546
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0032	0.0128	1
Brugia malayi	tailless protein	0.0033	0.014	0.0231
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0279	0.0279
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0071	0.0117
Loa Loa (eye worm)	hypothetical protein	0.007	0.0525	0.0866
Echinococcus granulosus	ecdysone induced protein 78C	0.007	0.0525	0.0525
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0033	0.014	0.0146
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.007	0.0525	0.0866
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0026	0.0071	0.0117
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.007	0.0525	0.0866
Schistosoma mansoni	flap endonuclease-1	0.0024	0.0045	0.0045
Brugia malayi	hypothetical protein	0.0033	0.014	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0181	0.0299
Loa Loa (eye worm)	hypothetical protein	0.007	0.0525	0.0866
Onchocerca volvulus	Bile acid receptor homolog	0.007	0.0525	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0602	0.606	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0231
Echinococcus granulosus	transcription factor Dp 1	0.0349	0.3422	0.3422
Brugia malayi	nuclear hormone receptor	0.0033	0.014	0.0231
Brugia malayi	orphan nuclear receptor NR2E1	0.0033	0.014	0.0231
Echinococcus multilocularis	geminin	0.0339	0.3321	0.3454
Schistosoma mansoni	nuclear receptor nhr-48	0.0033	0.014	0.014
Schistosoma mansoni	nuclear hormone receptor	0.0033	0.014	0.014
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.007	0.0525	0.0866
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0231
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0602	0.606	0.606
Brugia malayi	hypothetical protein	0.0037	0.0181	0.0299
Brugia malayi	nuclear receptor NHR-67	0.0033	0.014	0.0231
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.007	0.0525	0.0866
Brugia malayi	Nuclear hormone receptor E75	0.0033	0.014	0.0231
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.007	0.0525	0.0866
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0033	0.014	0.0146
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0033	0.014	0.0231
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.007	0.0525	0.0866
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0465	0.0484
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0279	0.029
Mycobacterium ulcerans	DNA polymerase IV	0.002	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.007	0.0525	0.0866
Leishmania major	hypothetical protein, conserved	0.0026	0.0062	0.0103
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0279	0.0279
Brugia malayi	Nuclear hormone receptor E75	0.0033	0.014	0.0231
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.007	0.0525	0.0525
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0602	0.606	0.6302
Schistosoma mansoni	thyroid hormone receptor	0.007	0.0525	0.0525
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0037	0.0181	0.0299
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0026	0.0071	0.0117
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.007	0.0525	0.0525
Echinococcus granulosus	geminin	0.0339	0.3321	0.3321
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0602	0.606	1
Brugia malayi	hypothetical protein	0.0037	0.0176	0.0291
Brugia malayi	hypothetical protein	0.0037	0.0181	0.0299
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.014	0.0146
Brugia malayi	Nuclear hormone receptor-like 1	0.0037	0.0181	0.0299
Brugia malayi	Nuclear hormone receptor-like 1	0.007	0.0525	0.0866
Brugia malayi	nuclear receptor NHR-88	0.007	0.0525	0.0866
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.007	0.0525	0.0866
Loa Loa (eye worm)	hypothetical protein	0.007	0.0525	0.0866
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.007	0.0525	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0181	0.0299
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0033	0.014	0.0231
Brugia malayi	ImpB/MucB/SamB family protein	0.0045	0.0269	0.0444
Brugia malayi	nuclear hormone receptor family member odr-7	0.0033	0.014	0.0231
Trypanosoma cruzi	DNA polymerase eta, putative	0.0032	0.0128	0.0212
Trypanosoma brucei	DNA polymerase eta, putative	0.0045	0.0269	0.0444
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.007	0.0525	0.0866
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.007	0.0525	0.0546
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.007	0.0525	0.0866
Giardia lamblia	Flap structure-specific endonuclease	0.0026	0.0071	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0176	0.0176
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0176	0.0176
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0037	0.0181	0.0181
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.007	0.0525	0.0866
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0033	0.014	0.014
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0033	0.014	0.014
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0465	0.0465
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0465	0.0465
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.007	0.0525	0.0866
Brugia malayi	conserved hypotetical protein	0.0033	0.014	0.0231
Schistosoma mansoni	RAR-like nuclear receptor	0.007	0.0525	0.0525
Echinococcus multilocularis	dna polymerase eta	0.0045	0.0269	0.028
Echinococcus granulosus	dna polymerase eta	0.0045	0.0269	0.0269
Entamoeba histolytica	hypothetical protein	0.0037	0.0176	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0181	0.0299
Entamoeba histolytica	hypothetical protein	0.0037	0.0176	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0231
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.007	0.0525	0.0866
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.007	0.0525	0.0525
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.007	0.0525	0.0866
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0062	0.0103
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0176	0.0183
Schistosoma mansoni	retinoic acid receptor RXR	0.0981	1	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0269	0.0444
Leishmania major	DNA polymerase eta, putative	0.0032	0.0128	0.0212
Loa Loa (eye worm)	hypothetical protein	0.007	0.0525	0.0866
Schistosoma mansoni	zinc finger protein	0.0033	0.014	0.014
Echinococcus granulosus	FTZ F1 alpha	0.007	0.0525	0.0525
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.007	0.0525	0.0525
Echinococcus multilocularis	nuclear receptor nhr 48	0.0033	0.014	0.0146
Entamoeba histolytica	hypothetical protein	0.0037	0.0176	0.0291
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0279	0.0461
Entamoeba histolytica	hypothetical protein	0.0037	0.0176	0.0291
Entamoeba histolytica	Flap nuclease, putative	0.0026	0.0071	0.0117
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0037	0.0181	0.0181
Schistosoma mansoni	hypothetical protein	0.0339	0.3321	0.3321
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0033	0.014	0.014
Brugia malayi	TAR-binding protein	0.0064	0.0465	0.0767
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0231
Brugia malayi	hypothetical protein	0.0026	0.0062	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0231
Onchocerca volvulus	Protein ultraspiracle homolog	0.007	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0231
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.007	0.0525	0.0525
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.007	0.0525	0.0866
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0465	0.0465
Schistosoma mansoni	nuclear receptor	0.0033	0.014	0.014
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0071	1
Schistosoma mansoni	hypothetical protein	0.0339	0.3321	0.3321
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0602	0.606	1
Brugia malayi	steroid hormone receptor	0.007	0.0525	0.0866
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.007	0.0525	0.0546
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0033	0.014	0.0231
Loa Loa (eye worm)	nuclear hormone receptor	0.0033	0.014	0.0231
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0465	0.0767
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0071	0.0117
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.007	0.0525	0.0546
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.007	0.0525	0.0866
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0944	0.9615	1
Loa Loa (eye worm)	DR-78	0.0033	0.014	0.0231
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0176	0.0176
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0062	0.0103
Echinococcus multilocularis	transcription factor Dp 1	0.0349	0.3422	0.3559
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0279	0.0461
Brugia malayi	nuclear receptor RXR	0.0037	0.0181	0.0299
Brugia malayi	nuclear hormone receptor	0.007	0.0525	0.0866
Echinococcus multilocularis	ecdysone induced protein 78C	0.007	0.0525	0.0546
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0602	0.606	1
Onchocerca volvulus		0.007	0.0525	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0033	0.014	0.014
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0026	0.0071	0.1335
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.007	0.0525	0.0525
Echinococcus multilocularis	FTZ F1 alpha	0.007	0.0525	0.0546
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.007	0.0525	0.0525
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.007	0.0525	0.0866
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.007	0.0525	0.0866
Schistosoma mansoni	nuclear receptor	0.0033	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0062	0.0103
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.007	0.0525	0.0525
Schistosoma mansoni	DNA polymerase eta	0.0045	0.0269	0.0269
Brugia malayi	Flap endonuclease-1	0.0026	0.0071	0.0117
Mycobacterium ulcerans	DNA polymerase IV	0.002	0	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.007	0.0525	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0231
Schistosoma mansoni	thyroid hormone receptor	0.007	0.0525	0.0525
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0071	0.0074
Schistosoma mansoni	coup transcription factor	0.007	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0231
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0033	0.014	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0181	0.0299
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0602	0.606	1
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0465	0.0767
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0231
Echinococcus granulosus	thyroid hormone receptor alpha	0.0033	0.014	0.014
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.007	0.0525	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.007	0.0525	0.0525
Brugia malayi	RNA binding protein	0.0064	0.0465	0.0767
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.007	0.0525	0.0866
Schistosoma mansoni	steroid hormone receptor ad4bp	0.007	0.0525	0.0525
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.007	0.0525	0.0866
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.007	0.0525	0.0866
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0465	0.0465
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0465	0.0767
Schistosoma mansoni	nuclear hormone receptor	0.007	0.0525	0.0525
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0602	0.606	1
Trichomonas vaginalis	flap endonuclease-1, putative	0.0026	0.0071	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0602	0.606	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0525	0.0866
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0465	0.0767
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.007	0.0525	0.0546
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0037	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0181	0.0299
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.007	0.0525	0.0525
Brugia malayi	ecdysone receptor	0.0033	0.014	0.0231
Brugia malayi	ecdysteroid receptor	0.007	0.0525	0.0866
Loa Loa (eye worm)	hypothetical protein	0.007	0.0525	0.0866
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0062	0.0103
Brugia malayi	photoreceptor-specific nuclear receptor	0.007	0.0525	0.0866
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0231
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0279	0.0279
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.007	0.0525	0.0525
Brugia malayi	Nuclear hormone receptor-like 1	0.0037	0.0181	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0033	0.014	0.0231
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0279	0.029
Plasmodium falciparum	flap endonuclease 1	0.0026	0.0071	1
Brugia malayi	nuclear receptor RXR	0.0033	0.014	0.0231
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0037	0.0181	0.0188
Brugia malayi	nuclear receptor NHR-88	0.0033	0.014	0.0231
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.007	0.0525	0.0866
Loa Loa (eye worm)	steroid hormone receptor	0.007	0.0525	0.0866
Schistosoma mansoni	nuclear hormone receptor	0.0033	0.014	0.014
Trypanosoma cruzi	DNA polymerase eta, putative	0.0045	0.0269	0.0444

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 12.5 s	Antinociceptive activity against mouse assessed as paw withdrawal latency at 50 mg/kg, po after 60 mins by hot plate test	ChEMBL.	17418454
Activity (functional)	= 12.5 s	Antinociceptive activity against mouse assessed as paw withdrawal latency at 50 mg/kg, po after 60 mins by hot plate test	ChEMBL.	17418454
Inhibition (functional)	= 41.4 %	Antiinflammatory activity against BALB/c mouse assessed as inhibition of carrageenen-induced paw edema at 50 mg/kg, po after 4 hrs	ChEMBL.	17418454
Inhibition (functional)	= 41.4 %	Antiinflammatory activity against BALB/c mouse assessed as inhibition of carrageenen-induced paw edema at 50 mg/kg, po after 4 hrs	ChEMBL.	17418454

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL244734

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 435478