Detailed information for compound 435735

Basic information

Technical information
  • TDR Targets ID: 435735
  • Name: 11-chloro-7-methyl-3H-diazepino[5,4-b]quinoli ne
  • MW: 243.692 | Formula: C13H10ClN3
  • H donors: 1 H acceptors: 2 LogP: 3.45 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc2c1nc1C=CNN=Cc1c2Cl
  • InChi: 1S/C13H10ClN3/c1-8-3-2-4-9-12(14)10-7-16-15-6-5-11(10)17-13(8)9/h2-7,15H,1H3
  • InChiKey: DSVADFATWBPPFM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 11-chloro-7-methyl-3H-[1,2]diazepino[5,4-b]quinoline

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0074 0.081 1
Echinococcus multilocularis geminin 0.0165 0.1961 0.1961
Trypanosoma cruzi NADH dehydrogenase, putative 0.0074 0.081 0.081
Plasmodium falciparum ferrodoxin reductase-like protein 0.0074 0.081 0.081
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0097
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0097 0.0097
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0074 0.081 0.0731
Schistosoma mansoni sulfide quinone reductase 0.0074 0.081 0.081
Brugia malayi AMP-binding enzyme family protein 0.0023 0.017 0.017
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.0179
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0803 1 1
Entamoeba histolytica thioredoxin reductase, putative 0.0074 0.081 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0074 0.081 0.2392
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0074 0.081 0.081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0441 0.0441
Treponema pallidum oxidoreductase 0.0074 0.081 0.2392
Plasmodium vivax ferrodoxin reductase, putative 0.0074 0.081 0.081
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.0179
Brugia malayi Immunoglobulin I-set domain containing protein 0.0026 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0074 0.081 0.081
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0074 0.081 0.2392
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.081 0.081
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0074 0.081 0.2392
Echinococcus multilocularis glutamate synthase 0.0074 0.081 0.081
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0097 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0441 0.0441
Echinococcus multilocularis Immunoglobulin 0.0024 0.0179 0.0179
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0074 0.081 0.081
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0074 0.081 1
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0074 0.081 0.081
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.0179
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0278 0.3386 0.333
Schistosoma mansoni disulfide oxidoreductase 0.0074 0.081 0.081
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0278 0.3386 0.3386
Echinococcus multilocularis neuroglian 0.003 0.0255 0.0255
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0278 0.3386 1
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0074 0.081 0.2392
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0074 0.081 0.0731
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0278 0.3386 0.3386
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.017 0.0503
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.003 0.0255 0.0255
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.081 0.081
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0278 0.3386 0.3386
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0074 0.081 0.0731
Loa Loa (eye worm) TK protein kinase 0.021 0.2524 0.2524
Schistosoma mansoni glutamate synthase 0.0074 0.081 0.081
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0278 0.3386 0.3272
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0441 0.0441
Echinococcus granulosus glutamate synthase 0.0074 0.081 0.081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0441 0.0441
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0074 0.081 0.0731
Plasmodium falciparum thioredoxin reductase 0.0803 1 1
Plasmodium falciparum thioredoxin reductase 0.0278 0.3386 0.3386
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0074 0.081 0.2392
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0204 0.2455 0.2455
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0097 0.0286
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.017 0.0503
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0278 0.3386 0.3386
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.017 0.0503
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0074 0.081 0.081
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.017 0.0503
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0074 0.081 0.081
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0278 0.3386 0.333
Echinococcus granulosus microtubule associated protein 2 0.0672 0.8358 0.8358
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0278 0.3386 0.3386
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0074 0.081 0.2392
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.017 0.0503
Giardia lamblia NADH oxidase lateral transfer candidate 0.0278 0.3386 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.017 0.0086
Schistosoma mansoni nephrin 0.003 0.0255 0.0255
Trichomonas vaginalis apoptosis inducing factor, putative 0.0074 0.081 0.2392
Trichomonas vaginalis glutamate synthase, putative 0.0074 0.081 0.2392
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.081 0.081
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0278 0.3386 1
Schistosoma mansoni glutamate synthase 0.0074 0.081 0.081
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0074 0.081 0.0651
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0074 0.081 0.2392
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0278 0.3386 0.3386
Echinococcus granulosus fibroblast growth factor receptor 4 0.0204 0.2447 0.2447
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.017 0.2103
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0204 0.2455 0.2455
Onchocerca volvulus 0.0023 0.017 0.2103
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.081 0.081
Plasmodium vivax glutathione reductase, putative 0.0803 1 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0074 0.081 0.2392
Schistosoma mansoni cell adhesion molecule 0.0024 0.0179 0.0179
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0074 0.081 0.081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3386 0.3386
Brugia malayi hypothetical protein 0.0024 0.0179 0.0179
Treponema pallidum NADH oxidase 0.0278 0.3386 1
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0074 0.081 0.0731
Brugia malayi AMP-binding enzyme family protein 0.0023 0.017 0.017
Echinococcus granulosus twitchin 0.003 0.0255 0.0255
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0074 0.081 0.2392
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0441 0.0441
Trichomonas vaginalis mercuric reductase, putative 0.0278 0.3386 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.017 0.017
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0074 0.081 0.081
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.081 0.2392
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.081 0.081
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0074 0.081 0.081
Mycobacterium ulcerans NADH dehydrogenase 0.0074 0.081 0.2392
Schistosoma mansoni microtubule-associated protein tau 0.0672 0.8358 0.8358
Schistosoma mansoni hypothetical protein 0.0165 0.1961 0.1961
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0441 0.0441
Schistosoma mansoni sulfide quinone reductase 0.0074 0.081 0.081
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.081 0.081
Loa Loa (eye worm) glutathione reductase 0.0803 1 1
Echinococcus multilocularis roundabout 2 0.003 0.0255 0.0255
Leishmania major trypanothione reductase 0.0803 1 1
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0074 0.081 0.2392
Leishmania major hypothetical protein, conserved 0.0074 0.081 0.0651
Toxoplasma gondii NADPH-glutathione reductase 0.0278 0.3386 0.3386
Loa Loa (eye worm) thioredoxin reductase 0.0803 1 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0024 0.0179 0.0179
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0204 0.2447 0.2447
Loa Loa (eye worm) hypothetical protein 0.003 0.0255 0.0255
Plasmodium vivax thioredoxin reductase, putative 0.0803 1 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.017 0.0503
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0074 0.081 0.2392
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0278 0.3386 0.3386
Toxoplasma gondii thioredoxin reductase 0.0803 1 1
Leishmania major NADH dehydrogenase, putative 0.0074 0.081 0.0651
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0278 0.3386 0.3272
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0074 0.081 0.081
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.0179
Schistosoma mansoni hypothetical protein 0.0165 0.1961 0.1961
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0074 0.081 0.081
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0204 0.2447 0.2447
Leishmania major hypothetical protein, conserved 0.0074 0.081 0.0651
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0074 0.081 1
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0074 0.081 0.081
Brugia malayi Fibronectin type III domain containing protein 0.0024 0.0179 0.0179
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0074 0.081 0.081
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0074 0.081 0.0731
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0278 0.3386 0.3386
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3386 0.3386
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0097
Plasmodium falciparum glutathione reductase 0.0278 0.3386 0.3386
Schistosoma mansoni glutamate synthase 0.0074 0.081 0.081
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.081 0.2392
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0074 0.081 0.2392
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0074 0.081 0.081
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0278 0.3386 0.3386
Echinococcus multilocularis microtubule associated protein 2 0.0672 0.8358 0.8358
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0074 0.081 0.081
Plasmodium falciparum glutathione reductase 0.0803 1 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0097 0.0286
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0074 0.081 0.2392
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0278 0.3386 0.333
Echinococcus granulosus defective proboscis extension response 0.0024 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0023 0.017 0.017
Mycobacterium tuberculosis Probable dehydrogenase 0.0074 0.081 0.0731
Echinococcus multilocularis Immunoglobulin 0.0024 0.0179 0.0179
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.017 0.0503
Trichomonas vaginalis glutamate synthase, putative 0.0074 0.081 0.2392
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0278 0.3386 0.3386
Treponema pallidum thioredoxin reductase (trxB) 0.0074 0.081 0.2392
Mycobacterium tuberculosis Probable reductase 0.0074 0.081 0.0731
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0074 0.081 0.2392
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0074 0.081 0.081
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.081 0.081
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0026 0.0206 0.0206
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0278 0.3386 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0278 0.3386 0.3272
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0074 0.081 0.2392
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3386 0.3386
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0074 0.081 0.0731
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0074 0.081 0.081
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0074 0.081 0.081
Trypanosoma cruzi trypanothione reductase, putative 0.0278 0.3386 0.3386
Brugia malayi Immunoglobulin I-set domain containing protein 0.021 0.2524 0.2524
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0074 0.081 0.2392
Giardia lamblia Glutamate synthase 0.0074 0.081 0.2392
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3386 0.3386
Loa Loa (eye worm) programmed cell death 8 0.0074 0.081 0.081
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.017 0.2103
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0074 0.081 0.0731
Brugia malayi Thioredoxin reductase 0.0803 1 1
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0074 0.081 0.081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3386 0.3386
Mycobacterium ulcerans glutamate synthase subunit beta 0.0074 0.081 0.2392
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0024 0.0179 0.0179
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0278 0.3386 0.3386
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0278 0.3386 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0278 0.3386 0.3386
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0074 0.081 1
Schistosoma mansoni vesicular amine transporter 0.0024 0.0179 0.0179
Mycobacterium ulcerans dehydrogenase 0.0074 0.081 0.2392
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0074 0.081 0.2392
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0074 0.081 0.2392
Trypanosoma cruzi trypanothione reductase, putative 0.0803 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0441 0.0441
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0074 0.081 0.2392
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.017 0.0503
Echinococcus granulosus neuroglian 0.003 0.0255 0.0255
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.081 0.2392
Echinococcus granulosus roundabout 2 0.003 0.0255 0.0255
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0278 0.3386 0.3272
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0074 0.081 0.0651
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0074 0.081 0.081
Echinococcus granulosus Immunoglobulin 0.0024 0.0179 0.0179
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0074 0.081 0.081
Echinococcus multilocularis thioredoxin glutathione reductase 0.0803 1 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.081 0.081
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0278 0.3386 0.3386
Trypanosoma cruzi NADH dehydrogenase, putative 0.0074 0.081 0.081
Mycobacterium ulcerans monoxygenase 0.0074 0.081 0.2392
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.017 0.2103
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0204 0.2447 0.2447
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.3386 0.3386
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0074 0.081 0.081
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.017 0.0503
Mycobacterium ulcerans hypothetical protein 0.0074 0.081 0.2392
Brugia malayi glutamate synthase 0.0074 0.081 0.081
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.081 0.2392
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0074 0.081 0.081
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.081 0.081
Onchocerca volvulus 0.0074 0.081 1
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0074 0.081 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.017 0.017
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0278 0.3386 0.3386
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0278 0.3386 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.0179
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0074 0.081 0.081
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0097
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0074 0.081 0.081
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0024 0.0179 0.0179
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0024 0.0179 0.0179
Trichomonas vaginalis glutathione reductase, putative 0.0278 0.3386 1
Echinococcus granulosus geminin 0.0165 0.1961 0.1961
Mycobacterium ulcerans hypothetical protein 0.0023 0.017 0.0503
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0074 0.081 0.081
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.0179
Echinococcus granulosus thioredoxin glutathione reductase 0.0803 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0441 0.0441
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.081 0.2392
Brugia malayi AMP-binding enzyme family protein 0.0023 0.017 0.017
Entamoeba histolytica disulphide oxidoreductase, putative 0.0074 0.081 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.0179
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.017 0.0086
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0074 0.081 0.081
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0074 0.081 0.2392
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0074 0.081 0.081
Trypanosoma brucei NADH dehydrogenase 0.0074 0.081 0.081
Chlamydia trachomatis thioredoxin reductase 0.0074 0.081 0.2392
Giardia lamblia Thioredoxin reductase 0.0074 0.081 0.2392
Toxoplasma gondii selenide, water dikinase 0.0074 0.081 0.081
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.081 0.081
Schistosoma mansoni tyrosine kinase 0.0204 0.2447 0.2447
Leishmania major hypothetical protein, conserved 0.0074 0.081 0.0651
Trypanosoma brucei trypanothione reductase 0.0803 1 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0074 0.081 0.081
Mycobacterium tuberculosis Probable oxidoreductase 0.0278 0.3386 0.333
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0074 0.081 0.0731
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0278 0.3386 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0097
Mycobacterium ulcerans ferredoxin reductase 0.0074 0.081 0.2392
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0278 0.3386 0.3386
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0074 0.081 0.0731
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0441 0.0441
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.081 0.2392
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0278 0.3386 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Antibacterial activity against Escherichia coli at 0.125% (w/v) concentration after 24 hrs by disc diffusion method ChEMBL. 17331623
Activity (functional) 0 Antifungal activity against Penicillium funiculosum at 0.5% (w/v) concentration by disc diffusion method ChEMBL. 17331623
Activity (functional) = 0.3 % Induction of chromosomal aberration in human peripheral blood leukocytes assessed as number of chromatid breaks at 20 ug/mL after 24 hrs ChEMBL. 17331623
Activity (functional) = 0.6 % Induction of chromosomal aberration in human peripheral blood leukocytes assessed as number of chromatid gaps at 20 ug/mL after 24 hrs ChEMBL. 17331623
IZ (functional) = 2 mm Antibacterial activity against Escherichia coli at 0.25% (w/v) concentration after 24 hrs by disc diffusion method ChEMBL. 17331623
IZ (functional) = 2 mm Antifungal activity against Aspergillus flavus at 0.5% (w/v) concentration by disc diffusion method ChEMBL. 17331623
IZ (functional) = 2 mm Antifungal activity against Fusarium oxysporum at 0.5% (w/v) concentration by disc diffusion method ChEMBL. 17331623
IZ (functional) = 2 mm Antibacterial activity against Escherichia coli at 0.25% (w/v) concentration after 24 hrs by disc diffusion method ChEMBL. 17331623
IZ (functional) = 3 mm Antifungal activity against Penicillium funiculosum at 1% (w/v) concentration by disc diffusion method ChEMBL. 17331623
IZ (functional) = 3 mm Antifungal activity against Alternaria macrospora at 0.5% (w/v) concentration by disc diffusion method ChEMBL. 17331623
IZ (functional) = 4 mm Antibacterial activity against Aeromonas hydrophila at 0.125% (w/v) concentration after 24 hrs by disc diffusion method ChEMBL. 17331623
IZ (functional) = 4 mm Antifungal activity against Aspergillus flavus at 1% (w/v) concentration by disc diffusion method ChEMBL. 17331623
IZ (functional) = 5 mm Antibacterial activity against Salmonella typhi at 0.125% (w/v) concentration after 24 hrs by disc diffusion method ChEMBL. 17331623
IZ (functional) = 6 mm Antibacterial activity against Escherichia coli at 0.5% (w/v) concentration by after 24 hrs by disc diffusion method ChEMBL. 17331623
IZ (functional) = 6 mm Antifungal activity against Alternaria macrospora at 1% (w/v) concentration by disc diffusion method ChEMBL. 17331623
IZ (functional) = 6 mm Antifungal activity against Fusarium oxysporum at 1% (w/v) concentration by disc diffusion method ChEMBL. 17331623
IZ (functional) = 6 mm Antibacterial activity against Escherichia coli at 0.5% (w/v) concentration by after 24 hrs by disc diffusion method ChEMBL. 17331623
IZ (functional) = 7 mm Antibacterial activity against Aeromonas hydrophila at 0.25% (w/v) concentration after 24 hrs by disc diffusion method ChEMBL. 17331623
IZ (functional) = 7 mm Antibacterial activity against Salmonella typhi at 0.25% (w/v) concentration after 24 hrs by disc diffusion method ChEMBL. 17331623
IZ (functional) = 8 mm Antifungal activity against Aspergillus flavus at 2% (w/v) concentration by disc diffusion method ChEMBL. 17331623
IZ (functional) = 10 mm Antifungal activity against Penicillium funiculosum at 2% (w/v) concentration by disc diffusion method ChEMBL. 17331623
IZ (functional) = 10 mm Antifungal activity against Alternaria macrospora at 2% (w/v) concentration by disc diffusion method ChEMBL. 17331623
IZ (functional) = 10 mm Antifungal activity against Fusarium oxysporum at 2% (w/v) concentration by disc diffusion method ChEMBL. 17331623
IZ (functional) = 11 mm Antibacterial activity against Aeromonas hydrophila at 0.5% (w/v) concentration after 24 hrs by disc diffusion method ChEMBL. 17331623
IZ (functional) = 12 mm Antibacterial activity against Salmonella typhi at 0.5% (w/v) concentration after 24 hrs by disc diffusion method ChEMBL. 17331623

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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