Detailed information for compound 43574

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 440.453 | Formula: C23H27F3O5
  • H donors: 0 H acceptors: 0 LogP: 4.31 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H]1CCC2C34C1CC[C@@](OO3)(O[C@H]4OC(=C2COCc1ccccc1)C(F)(F)F)C
  • InChi: 1S/C23H27F3O5/c1-14-8-9-18-16(13-27-12-15-6-4-3-5-7-15)19(23(24,25)26)28-20-22(18)17(14)10-11-21(2,29-20)30-31-22/h3-7,14,17-18,20H,8-13H2,1-2H3/t14-,17?,18?,20-,21-,22?/m1/s1
  • InChiKey: KJFLXSMMBMBJOK-NIQBTHBBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Regulator of G protein signaling domain containing protein 0.0059 0.0098 0.0068
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.0056 0.0016
Schistosoma mansoni glutamate receptor kainate 0.124 0.3155 0.3558
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.0273 0.0274
Echinococcus granulosus lamin 0.0083 0.0159 0.0116
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.0572 0.0531
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0509 0.1263 0.1402
Entamoeba histolytica hypothetical protein 0.0059 0.0098 0.0834
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0099 0.0312
Brugia malayi Zona pellucida-like domain containing protein 0.0043 0.0056 0.0016
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0043 0.0128
Schistosoma mansoni glutamate receptor kainate 0.0712 0.1788 0.2
Echinococcus granulosus axis inhibition protein axin 0.0059 0.0098 0.0056
Echinococcus multilocularis metabotropic glutamate receptor 5 0.3884 1 1
Echinococcus multilocularis glutamate receptor 2 0.0875 0.221 0.2176
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0142 1
Echinococcus granulosus neutral amino acid transporter A 0.1242 0.3159 0.313
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0047 0.0905
Trichomonas vaginalis phosphofructokinase, putative 0.0221 0.0516 0.1675
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0098 0.0075
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0047 0.0859
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0099 0.0312
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0047 0.0141
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0059 0.0098 0.0075
Brugia malayi von Willebrand Factor 0.0043 0.0056 0.0016
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0047 0.0004
Echinococcus granulosus nmda type glutamate receptor 0.0727 0.1827 0.1792
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0023
Loa Loa (eye worm) CUTiclin family member 0.0043 0.0056 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0047 0.038
Schistosoma mansoni regulator of G protein signaling 0.0059 0.0098 0.0075
Schistosoma mansoni hypothetical protein 0.0049 0.0073 0.0046
Brugia malayi hypothetical protein 0.0242 0.0572 0.0649
Trypanosoma cruzi extracellular receptor, putative 0.046 0.1135 1
Loa Loa (eye worm) hypothetical protein 0.046 0.1135 0.1106
Loa Loa (eye worm) hypothetical protein 0.046 0.1135 0.1106
Schistosoma mansoni hypothetical protein 0.0345 0.0837 0.0918
Echinococcus granulosus geminin 0.0171 0.0386 0.0345
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2315 0.5938 0.5921
Loa Loa (eye worm) RGS-3 protein 0.0059 0.0098 0.0066
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0099 0.5716
Echinococcus granulosus atrial natriuretic peptide receptor 0.046 0.1135 0.1097
Echinococcus multilocularis axis inhibition protein axin 0.0059 0.0098 0.0056
Echinococcus granulosus intermediate filament protein 0.0083 0.0159 0.0116
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.0056 0.0016
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0043 0.0056 0.0013
Loa Loa (eye worm) phosphofructokinase 0.0221 0.0516 0.0485
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0127 0.0273 0.0231
Brugia malayi regulator of G-protein signaling egl-10 0.0059 0.0098 0.0068
Schistosoma mansoni intermediate filament proteins 0.0083 0.0159 0.0144
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0032 0.0414
Loa Loa (eye worm) cytochrome P450 family protein 0.0073 0.0133 0.0101
Echinococcus multilocularis excitatory amino acid transporter 2 0.1242 0.3159 0.313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0008 0.0014
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0489 0.121 0.3719
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.006 0.0099 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0004 0.0071
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1242 0.3159 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0043 0.0345
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0099 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0015 0.0036
Leishmania major ATP-dependent phosphofructokinase 0.0221 0.0516 0.4528
Schistosoma mansoni ap endonuclease 0.0039 0.0047 0.0017
Echinococcus granulosus axis inhibition protein axin 0.0059 0.0098 0.0056
Schistosoma mansoni 6-phosphofructokinase 0.0221 0.0516 0.0552
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0047 0.0004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0127 0.0273 0.0725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0038 0.0111
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0152 0.0338 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.019
Loa Loa (eye worm) PXA domain-containing protein 0.0059 0.0098 0.0066
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0047 0.0005
Schistosoma mansoni regulator of G protein signaling 0.0059 0.0098 0.0075
Echinococcus granulosus glutamate receptor subunit protein glur 0.0393 0.0962 0.0923
Brugia malayi 6-phosphofructokinase 0.0221 0.0516 0.058
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0345 0.0837 0.0798
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0221 0.0516 0.4528
Brugia malayi A-kinase anchor protein 10, precursor 0.0059 0.0098 0.0068
Toxoplasma gondii microneme protein MIC2 0.0043 0.0056 0.1174
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0152 0.0338 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0023 0.0064
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0221 0.0516 0.1508
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0062 0.0019
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0059 0.0027
Echinococcus multilocularis GPCR, family 3, C terminal 0.0489 0.121 0.1172
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0056 0.1149
Brugia malayi hypothetical protein 0.0105 0.0216 0.0212
Echinococcus granulosus glutamate receptor 2 0.0875 0.221 0.2176
Trichomonas vaginalis phosphofructokinase, putative 0.0221 0.0516 0.1675
Loa Loa (eye worm) RGC/RGC protein kinase 0.046 0.1135 0.1106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0008 0.0013
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1242 0.3159 1
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0043 0.0056 0.1149
Echinococcus granulosus neutral amino acid transporter A 0.1242 0.3159 0.313
Onchocerca volvulus 0.0049 0.0073 0.0054
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0062 0.0513
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0043 0.0012
Brugia malayi Cytochrome P450 family protein 0.0073 0.0133 0.0111
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0062 0.0513
Loa Loa (eye worm) glutamate receptor 0.3188 0.8198 0.8193
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.3424 0.8809 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0221 0.0516 0.0485
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0062 0.1196
Onchocerca volvulus 0.1205 0.3063 0.9689
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0093 0.0185 0.0175
Echinococcus granulosus GPCR family 3 C terminal 0.0489 0.121 0.1172
Chlamydia trachomatis glutamine binding protein 0.0382 0.0934 0.2728
Brugia malayi Receptor family ligand binding region containing protein 0.0949 0.2401 0.2891
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0047 0.0141
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0043 0.0056 0.1417
Brugia malayi M-phase phosphoprotein, mpp8 0.0105 0.0216 0.0212
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0047 0.0705
Onchocerca volvulus 0.0105 0.0216 0.0516
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0159 0.0142
Echinococcus granulosus collagen alpha 1VII chain 0.0043 0.0056 0.0013
Echinococcus multilocularis neutral amino acid transporter A 0.1242 0.3159 0.313
Loa Loa (eye worm) glutamate receptor 1 0.076 0.1912 0.1885
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.17 0.4346 0.4322
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0098 0.0075
Mycobacterium ulcerans endonuclease IV 0.0076 0.0142 0.1074
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0099 0.0312
Echinococcus multilocularis neutral amino acid transporter A 0.1242 0.3159 0.313
Schistosoma mansoni regulator of G protein signaling 0.0059 0.0098 0.0075
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.046 0.1135 0.1106
Loa Loa (eye worm) hypothetical protein 0.0059 0.0098 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0008 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0032 0.0092
Trichomonas vaginalis 6-phosphofructokinase, putative 0.006 0.0099 0.0312
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0073 0.0037
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0059 0.0098 0.0066
Trichomonas vaginalis set domain proteins, putative 0.1205 0.3063 1
Brugia malayi hypothetical protein 0.0059 0.0098 0.0068
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.122 0.3103 0.3073
Entamoeba histolytica hypothetical protein 0.0043 0.0056 0.0462
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0382 0.0934 0.3236
Schistosoma mansoni serine-rich repeat protein 0.0544 0.1352 0.1505
Treponema pallidum glutamate/aspartate transporter 0.055 0.137 0.4824
Entamoeba histolytica hypothetical protein, conserved 0.0043 0.0056 0.0462
Brugia malayi Guanylyl cyclase protein 23 0.046 0.1135 0.134
Schistosoma mansoni axis inhibition protein axin 0.0059 0.0098 0.0075
Chlamydia trachomatis neutral amino acid transporter 0.055 0.137 0.4151
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0023
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0059 0.0098 0.0066
Schistosoma mansoni glutamate receptor AMPA 0.0712 0.1788 0.2
Trichomonas vaginalis phosphofructokinase, putative 0.0221 0.0516 0.1675
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0146 0.0323 0.0282
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0023
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0076 0.0142 0.0122
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0023
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0099 0.5716
Brugia malayi PXA domain containing protein 0.0059 0.0098 0.0068
Schistosoma mansoni lamin 0.0083 0.0159 0.0144
Echinococcus multilocularis regulator of G protein signaling 3 0.0059 0.0098 0.0056
Schistosoma mansoni lamin 0.0083 0.0159 0.0144
Treponema pallidum glutamate transporter 0.055 0.137 0.4824
Entamoeba histolytica hypothetical protein, conserved 0.0043 0.0056 0.0462
Brugia malayi Receptor family ligand binding region containing protein 0.046 0.1135 0.134
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0043 0.0345
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0382 0.0934 1
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0043 0.0056 0.0023
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1242 0.3159 0.3563
Echinococcus granulosus regulator of G protein signaling 3 0.0059 0.0098 0.0056
Schistosoma mansoni glutamate receptor NMDA 0.0712 0.1788 0.2
Loa Loa (eye worm) hypothetical protein 0.0242 0.0572 0.0541
Echinococcus multilocularis lamin dm0 0.0083 0.0159 0.0116
Echinococcus granulosus expressed protein 0.1154 0.2933 0.2902
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0059 0.0098 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0152 0.0338 0.0348
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0047 0.038
Plasmodium vivax SET domain protein, putative 0.0152 0.0338 1
Loa Loa (eye worm) hypothetical protein 0.0489 0.121 0.1181
Onchocerca volvulus 0.046 0.1135 0.3478
Echinococcus granulosus glutamate receptor 2 0.122 0.3103 0.3073
Echinococcus granulosus nmda type glutamate receptor 0.046 0.1135 0.1097
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0043 0.0056 0.0016
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0043 0.0056 0.1417
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.0572 0.0531
Entamoeba histolytica phosphofructokinase, putative 0.0221 0.0516 0.4528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0032 0.0092
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.006 0.0099 0.0843
Echinococcus granulosus neutral amino acid transporter 0.1242 0.3159 0.313
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0159 0.0126
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0099 0.0312
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0164 0.0368 0.0383
Toxoplasma gondii exonuclease III APE 0.0039 0.0047 0.0884
Brugia malayi Glutamate receptor 1 precursor 0.076 0.1912 0.2292
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.0056 0.0016
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0047 0.0495
Schistosoma mansoni hypothetical protein 0.0171 0.0386 0.0404
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.0273 0.0274
Schistosoma mansoni hypothetical protein 0.0489 0.121 0.1342
Schistosoma mansoni hypothetical protein 0.0171 0.0386 0.0404
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0099 0.2503
Toxoplasma gondii endonuclease IV APN 0.0076 0.0142 0.3869
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.0056 0.0016
Echinococcus multilocularis regulator of G protein signaling 7 0.0059 0.0098 0.0056
Loa Loa (eye worm) hypothetical protein 0.046 0.1135 0.1106
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0382 0.0934 0.2728
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0059 0.0098 0.0066
Echinococcus granulosus Excitatory amino acid transporter 0.1242 0.3159 0.313
Echinococcus granulosus glutamate receptor 4 0.0048 0.0069 0.0026
Brugia malayi Pre-SET motif family protein 0.0152 0.0338 0.0362
Loa Loa (eye worm) CUTiclin-Like family member 0.0043 0.0056 0.0023
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0062 0.0513
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.101 0.2559 0.2879
Loa Loa (eye worm) hypothetical protein 0.046 0.1135 0.1106
Schistosoma mansoni metabotropic glutamate receptor 0.1645 0.4202 0.4751
Echinococcus multilocularis receptor type guanylyl cyclase 0.046 0.1135 0.1097
Schistosoma mansoni protein kinase 0.046 0.1135 0.1257
Trichomonas vaginalis DNA helicase recq, putative 0.0043 0.0055 0.0168
Echinococcus multilocularis expressed protein 0.1154 0.2933 0.2902
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0043 0.0056 0.0023
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0059 0.002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0056 0.0016
Brugia malayi hypothetical protein 0.0251 0.0594 0.0676
Echinococcus multilocularis transcription factor Dp 1 0.0076 0.0143 0.01
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1058 0.2684 0.266
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0273 0.2545
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0062 0.1196
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.0056 0.0016
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.0287 0.25
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.019
Schistosoma mansoni regulator of G protein signaling 0.0059 0.0098 0.0075
Brugia malayi metabotropic GABA-B receptor subtype 2 0.046 0.1135 0.134
Echinococcus multilocularis Excitatory amino acid transporter 0.1242 0.3159 0.313
Loa Loa (eye worm) 6-phosphofructokinase 0.0221 0.0516 0.0485
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0023
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0221 0.0516 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0059 0.0098 0.0068
Schistosoma mansoni lipoxygenase 0.0056 0.0088 0.0064
Loa Loa (eye worm) hypothetical protein 0.046 0.1135 0.1106
Plasmodium falciparum thrombospondin-related anonymous protein 0.0043 0.0056 0.1417
Echinococcus multilocularis metabotropic glutamate receptor 2 0.2699 0.6933 0.692
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.0015
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.006 0.0099 0.0191
Onchocerca volvulus 0.0083 0.0159 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0008 0.0013
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.0287 0.5552
Echinococcus granulosus receptor type guanylyl cyclase 0.046 0.1135 0.1097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0152 0.0338 0.0348
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.122 0.3103 0.3073
Loa Loa (eye worm) RGC/RGC protein kinase 0.046 0.1135 0.1106
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0152 0.0338 0.0296
Echinococcus multilocularis NMDA receptor 0.0873 0.2205 0.2172
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0062 0.0019
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1053 0.2671 0.2639
Schistosoma mansoni glutamate receptor kainate 0.124 0.3155 0.3558
Brugia malayi follicle stimulating hormone receptor 0.0242 0.0572 0.0649
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0098 0.0309
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0132 0.0287 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0098 0.0309
Loa Loa (eye worm) hypothetical protein 0.0076 0.0142 0.011
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0099 0.2503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0038 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0045 0.0134
Echinococcus granulosus excitatory amino acid transporter 2 0.1242 0.3159 0.313
Brugia malayi Bloom's syndrome protein homolog 0.0043 0.0055 0.0015
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0043 0.0345
Entamoeba histolytica hypothetical protein 0.0059 0.0098 0.0834
Echinococcus multilocularis tyrosine kinase 0.046 0.1135 0.1097
Echinococcus granulosus excitatory amino acid transporter 3 0.1242 0.3159 0.313
Brugia malayi Excitatory amino acid transporter 0.1242 0.3159 0.3822
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0152 0.0338 0.0348
Brugia malayi regulator of G-protein signaling rgs-7 0.0059 0.0098 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0032 0.0092
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.0056 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0015 0.0036
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0712 0.1788 0.1752
Schistosoma mansoni hypothetical protein 0.0043 0.0056 0.0027
Loa Loa (eye worm) hypothetical protein 0.0081 0.0155 0.0122
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.0572 0.0541
Trichomonas vaginalis phosphofructokinase, putative 0.0221 0.0516 0.1675
Echinococcus multilocularis nmda type glutamate receptor 0.0727 0.1827 0.1792
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0093 0.0185 0.0175
Echinococcus multilocularis beta adrenergic receptor kinase 0.0059 0.0098 0.0056
Schistosoma mansoni hypothetical protein 0.0544 0.1352 0.1505
Loa Loa (eye worm) excitatory amino acid transporter 0.1242 0.3159 0.3137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0008 0.0013
Toxoplasma gondii 6-phosphofructokinase 0.006 0.0099 0.2524
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0098 0.0309
Brugia malayi Pre-SET motif family protein 0.1058 0.2684 0.3239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0032 0.0092
Echinococcus multilocularis glutamate receptor 2 0.122 0.3103 0.3073
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0088 0.0046
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.0056 0.0016
Giardia lamblia GTOR 0.0045 0.0062 0.3372
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.1255 0.3194 0.3165
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0043 0.0056 0.1149
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0132 0.0287 0.25
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0032 0.0092
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0489 0.121 0.1431
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0047 0.0014
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0221 0.0516 1
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0098 0.0309
Echinococcus multilocularis musashi 0.0083 0.0159 0.0116
Echinococcus granulosus metabotropic glutamate receptor 2 0.2699 0.6933 0.692
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0047 0.038
Chlamydia trachomatis glutamate symporter 0.1242 0.3159 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0038 0.0302
Schistosoma mansoni z-protein (S1r protein) 0.0059 0.0098 0.0075
Echinococcus granulosus excitatory amino acid transporter 2 0.1242 0.3159 0.313
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0059 0.0098 0.0309
Loa Loa (eye worm) hypothetical protein 0.0038 0.0043 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0043 0.0128
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0048 0.0005
Loa Loa (eye worm) hypothetical protein 0.0059 0.0098 0.0066
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0043 0.0828
Echinococcus granulosus regulator of G protein signaling 7 0.0059 0.0098 0.0056
Echinococcus multilocularis glutamate receptor 4 0.0048 0.0069 0.0026
Schistosoma mansoni survival motor neuron protein 0.0049 0.0073 0.0046
Brugia malayi hypothetical protein 0.0043 0.0056 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0032 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0021 0.0055
Echinococcus granulosus lamin dm0 0.0083 0.0159 0.0116
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0059 0.0098 0.0056
Echinococcus multilocularis 6 phosphofructokinase 0.0221 0.0516 0.0475
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0023
Loa Loa (eye worm) glutamate receptor 2 0.0712 0.1788 0.1761
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.17 0.4346 0.4322
Schistosoma mansoni glutamate receptor NMDA 0.1172 0.2978 0.3357
Echinococcus multilocularis glutamate receptor 2 0.076 0.1912 0.1877
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1242 0.3159 0.313
Echinococcus multilocularis regulator of G protein signaling 0.0059 0.0098 0.0056
Brugia malayi intermediate filament protein 0.0083 0.0159 0.0142
Echinococcus multilocularis excitatory amino acid transporter 2 0.1242 0.3159 0.313
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0038 0.0302
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0098 0.0075
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0142 0.3852
Toxoplasma gondii aldehyde dehydrogenase 0.0127 0.0273 0.796
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0062 0.0513
Brugia malayi Metabotropic glutamate receptor precursor. 0.3188 0.8198 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0044 0.0011
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0059 0.0098 0.0075
Echinococcus multilocularis neutral amino acid transporter A 0.1242 0.3159 0.313
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0132 0.0287 0.029
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0345 0.0837 0.0798
Echinococcus multilocularis regulator of G protein signaling 3 0.0059 0.0098 0.0056
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0062 0.0513
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0099 0.0312
Schistosoma mansoni tyrosine kinase 0.046 0.1135 0.1257
Echinococcus granulosus regulator of G protein signaling 7 0.0059 0.0098 0.0056
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0382 0.0934 0.285
Mycobacterium ulcerans 6-phosphofructokinase 0.0221 0.0516 0.5291
Loa Loa (eye worm) hypothetical protein 0.3884 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0023
Loa Loa (eye worm) hypothetical protein 0.0048 0.0069 0.0036
Schistosoma mansoni ATP-binding cassette transporter 0.0712 0.1788 0.2
Entamoeba histolytica elongation factor-2 kinase, putative 0.0043 0.0056 0.0462
Echinococcus multilocularis sodium:dicarboxylate symporter 0.055 0.137 0.1333
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0088 0.0046
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0873 0.2205 0.2172
Brugia malayi Glutamate receptor 2 precursor 0.076 0.1912 0.2292
Schistosoma mansoni metabotropic glutamate receptor 0.2699 0.6933 0.7862
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0048 0.0005
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0043 0.0012
Chlamydia trachomatis endonuclease IV 0.0076 0.0142 0.014
Loa Loa (eye worm) hypothetical protein 0.0949 0.2401 0.2376
Loa Loa (eye worm) RecQ helicase 0.0043 0.0055 0.0022
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0062 0.0034
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0393 0.0962 0.0923
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0023
Loa Loa (eye worm) hypothetical protein 0.0059 0.0098 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0038 0.0111
Loa Loa (eye worm) hypothetical protein 0.0653 0.1636 0.1609
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.046 0.1135 0.3478
Echinococcus granulosus histone lysine methyltransferase setb 0.0152 0.0338 0.0296
Brugia malayi hypothetical protein 0.0059 0.0098 0.0068
Loa Loa (eye worm) RGC/RGC protein kinase 0.046 0.1135 0.1106
Brugia malayi von Willebrand factor type A domain containing protein 0.0043 0.0056 0.0016
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.17 0.4346 0.4322
Onchocerca volvulus Poor gastrulation protein homolog 0.0489 0.121 0.3719
Brugia malayi phosphofructokinase 0.0221 0.0516 0.058
Echinococcus granulosus transcription factor Dp 1 0.0076 0.0143 0.01
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0043 0.0056 0.1149
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0132 0.0287 0.25
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0038 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0098 0.0309
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0062 0.0029
Brugia malayi Zona pellucida-like domain containing protein 0.0043 0.0056 0.0016
Echinococcus granulosus voltage dependent calcium channel subunit 0.1053 0.2671 0.2639
Trichomonas vaginalis DNA helicase recq1, putative 0.0043 0.0055 0.0168
Echinococcus granulosus tyrosine kinase 0.046 0.1135 0.1097
Onchocerca volvulus 0.0083 0.0159 0.0331
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0059 0.0098 0.0056
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0273 0.2545
Brugia malayi metabotropic glutamate receptor type 2 0.1645 0.4202 0.51
Brugia malayi PXA domain containing protein 0.0059 0.0098 0.0068
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0076 0.0142 0.0306
Loa Loa (eye worm) hypothetical protein 0.046 0.1135 0.1106
Schistosoma mansoni regulator of G protein signaling 0.0059 0.0098 0.0075
Loa Loa (eye worm) hypothetical protein 0.0059 0.0098 0.0066
Echinococcus multilocularis Excitatory amino acid transporter 0.1242 0.3159 0.313
Toxoplasma gondii phosphofructokinase PFKII 0.006 0.0099 0.2524
Echinococcus granulosus sodium:dicarboxylate symporter 0.1242 0.3159 0.313
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.055 0.137 0.1333
Echinococcus multilocularis bloom syndrome protein 0.0043 0.0055 0.0012
Treponema pallidum 76K protein 0.0043 0.0056 0.0034
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0873 0.2205 0.2172
Loa Loa (eye worm) hypothetical protein 0.0466 0.1151 0.1122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0015 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0038 0.0111
Loa Loa (eye worm) hypothetical protein 0.0038 0.0044 0.0011
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0023
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0059 0.0098 0.0068
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0132 0.0287 0.0245
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0132 0.0287 0.0245
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.17 0.4346 0.4322
Onchocerca volvulus 0.046 0.1135 0.3478
Schistosoma mansoni ap endonuclease 0.0039 0.0047 0.0017
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0382 0.0934 0.3236
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0023
Loa Loa (eye worm) hypothetical protein 0.0059 0.0098 0.0066
Brugia malayi Cache domain containing protein 0.0466 0.1151 0.1359
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0047 0.038
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.055 0.137 0.1524
Echinococcus multilocularis nmda type glutamate receptor 0.046 0.1135 0.1097
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0132 0.0287 0.0255
Echinococcus multilocularis atrial natriuretic peptide receptor 0.046 0.1135 0.1097
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0043 0.0056 0.0171
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.17 0.4346 0.4322
Onchocerca volvulus 0.0164 0.0368 0.1006
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0062 0.019
Echinococcus granulosus 6 phosphofructokinase 0.0221 0.0516 0.0475
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0127 0.0273 0.0231
Echinococcus multilocularis regulator of G protein signaling 7 0.0059 0.0098 0.0056
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0062 0.0023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0023
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.0273 0.2545
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0043 0.0056 0.1174
Echinococcus multilocularis geminin 0.0171 0.0386 0.0345
Loa Loa (eye worm) hypothetical protein 0.0059 0.0098 0.0066
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.055 0.137 0.1524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0008 0.0014
Echinococcus granulosus Regulator of G protein signaling 20 0.0059 0.0098 0.0056
Onchocerca volvulus 0.0105 0.0216 0.0516
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0043 0.0345
Schistosoma mansoni tyrosine kinase 0.046 0.1135 0.1257
Brugia malayi hypothetical protein 0.046 0.1135 0.134
Leishmania major extracellular receptor, putative 0.046 0.1135 1
Entamoeba histolytica hypothetical protein 0.0059 0.0098 0.0834
Entamoeba histolytica hypothetical protein 0.046 0.1135 1
Entamoeba histolytica phosphofructokinase, putative 0.0221 0.0516 0.4528
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1242 0.3159 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.006 0.0099 0.2524
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1242 0.3159 0.313
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0949 0.2401 0.2376
Schistosoma mansoni hypothetical protein 0.0043 0.0056 0.0027
Echinococcus granulosus bloom syndrome protein 0.0043 0.0055 0.0012
Echinococcus granulosus voltage dependent calcium channel subunit 0.2315 0.5938 0.5921
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0873 0.2205 0.2172
Echinococcus granulosus regulator of G protein signaling 3 0.0059 0.0098 0.0056
Echinococcus granulosus glutamate NMDA receptor subunit 0.0712 0.1788 0.1752
Loa Loa (eye worm) hypothetical protein 0.046 0.1135 0.1106
Echinococcus multilocularis lamin 0.0083 0.0159 0.0116
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.2728 0.7008 0.854
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0127 0.0273 0.2376
Plasmodium vivax thrombospondin-related anonymous protein 0.0043 0.0056 0.1149
Schistosoma mansoni axis inhibition protein axin 0.0059 0.0098 0.0075
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.17 0.4346 0.4322
Loa Loa (eye worm) glutamate receptor 0.1185 0.3012 0.2989
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0032 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0008 0.0014
Brugia malayi 6-phosphofructokinase 0.0221 0.0516 0.058
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0221 0.0516 0.1712
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1099 0.2789 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0338 0.0306
Echinococcus multilocularis excitatory amino acid transporter 3 0.1242 0.3159 0.313
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0098 0.0309
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0093 0.0185 0.0143
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0043 0.0128
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0949 0.2401 0.2376
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0093 0.0185 0.0143
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0062 0.0513
Echinococcus multilocularis axis inhibition protein axin 0.0059 0.0098 0.0056
Loa Loa (eye worm) hypothetical protein 0.0105 0.0216 0.0184
Entamoeba histolytica phosphofructokinase, putative 0.0221 0.0516 0.4528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0014 0.0033
Loa Loa (eye worm) hypothetical protein 0.0048 0.0069 0.0036
Schistosoma mansoni 6-phosphofructokinase 0.0221 0.0516 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0038 0.0111
Loa Loa (eye worm) hypothetical protein 0.0048 0.0069 0.0036
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0132 0.0287 0.25
Echinococcus granulosus Excitatory amino acid transporter 0.1242 0.3159 0.313
Schistosoma mansoni glutamate receptor AMPA 0.0712 0.1788 0.2
Echinococcus granulosus beta-adrenergic receptor kinase 0.0059 0.0098 0.0056
Echinococcus granulosus glutamate receptor 1 0.0048 0.0069 0.0026
Loa Loa (eye worm) hypothetical protein 0.0105 0.0216 0.0184
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0159 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0014 0.0033
Echinococcus multilocularis Regulator of G protein signaling 20 0.0059 0.0098 0.0056
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0023
Loa Loa (eye worm) hypothetical protein 0.0083 0.0159 0.0126
Treponema pallidum hypothetical protein 0.0043 0.0056 0.0034

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 20 nM In vitro inhibitory concentration on chloroquine resistant Plasmodium falciparum W2 strain ChEMBL. 14998331

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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