Detailed information for compound 435875

Basic information

Technical information
  • TDR Targets ID: 435875
  • Name: (E)-3-[4-(1-benzofuran-2-carbonyl)phenyl]-N-h ydroxyprop-2-enamide
  • MW: 307.3 | Formula: C18H13NO4
  • H donors: 2 H acceptors: 3 LogP: 3.21 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)/C=C/c1ccc(cc1)C(=O)c1cc2c(o1)cccc2
  • InChi: 1S/C18H13NO4/c20-17(19-22)10-7-12-5-8-13(9-6-12)18(21)16-11-14-3-1-2-4-15(14)23-16/h1-11,22H,(H,19,20)/b10-7+
  • InChiKey: HAPQSKGIJIRDJS-JXMROGBWSA-N  

Network

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Synonyms

  • (E)-3-[4-(benzofuran-2-carbonyl)phenyl]prop-2-enehydroxamic acid
  • (E)-3-[4-[2-benzofuranyl(oxo)methyl]phenyl]-2-propenehydroxamic acid
  • (E)-3-[4-(1-benzofuran-2-ylcarbonyl)phenyl]-N-hydroxy-prop-2-enamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 2 References
Homo sapiens histone deacetylase 5 References
Homo sapiens histone deacetylase 10 References
Homo sapiens histone deacetylase 4 References
Homo sapiens histone deacetylase 8 References
Homo sapiens histone deacetylase 9 Starlite/ChEMBL References
Homo sapiens histone deacetylase 3 References
Homo sapiens histone deacetylase 7 References
Homo sapiens histone deacetylase 6 References
Homo sapiens histone deacetylase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC3 Get druggable targets OG5_126742 All targets in OG5_126742
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum histone deacetylase HDA2/Rpd3p Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Entamoeba histolytica histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Giardia lamblia Histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Babesia bovis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC2 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei gambiense histone deacetylase 1,histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi histone deacetylase 1 (HD1) Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K06067 histone deacetylase 1/2, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum ko:K01463 Hdac3 [EC:3.5.1.-], putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum RPD3/HD1 histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 3 (HD3) Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi histone deacetylase, putative histone deacetylase 3 428 aa 374 aa 30.5 %
Plasmodium falciparum histone deacetylase 1 histone deacetylase 8 286 aa 241 aa 44.8 %
Trypanosoma brucei histone deacetylase 2 histone deacetylase 2 488 aa 427 aa 29.0 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0136 0.2986 0.3038
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.2569 0.2569
Loa Loa (eye worm) oxidoreductase 0.0009 0.0025 0.0025
Brugia malayi Immunoglobulin I-set domain containing protein 0.0155 0.342 0.348
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0046 0.09 0.09
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0036 0.0665 0.0677
Echinococcus granulosus aldo keto reductase 0.0009 0.0025 0.0025
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0009 0.0025 0.0025
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0009 0.0025 0.0025
Plasmodium vivax thioredoxin reductase, putative 0.0392 0.8943 0.91
Loa Loa (eye worm) histone deacetylase 3 0.034 0.773 0.7866
Trypanosoma brucei aldo-keto reductase, putative 0.0009 0.0025 0.0025
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0036 0.0665 0.2164
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.01 0.2147 0.2185
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0136 0.2986 0.3038
Echinococcus granulosus aldo keto reductase 0.0009 0.0025 0.0025
Schistosoma mansoni Neurotrimin precursor (hNT) 0.001 0.0048 0.0048
Trichomonas vaginalis glutamate synthase, putative 0.0036 0.0665 0.0861
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0009 0.0025 0.0032
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0136 0.2986 0.2986
Trypanosoma cruzi histone deacetylase, putative 0.0431 0.9827 1
Entamoeba histolytica aldose reductase, putative 0.0009 0.0025 0.0032
Toxoplasma gondii aurora kinase 0.0118 0.2569 0.2614
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0136 0.2986 0.3038
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.034 0.773 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0036 0.0665 0.2164
Leishmania major histone deacetylase, putative 0.034 0.773 0.7866
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0009 0.0025 0.0025
Plasmodium vivax histone deacetylase 2, putative 0.0431 0.9827 1
Plasmodium falciparum aldo-keto reductase, putative 0.0009 0.0025 0.0025
Mycobacterium ulcerans hypothetical protein 0.0036 0.0665 0.2164
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0025 0.0025
Echinococcus multilocularis cyclin dependent kinase 1 0.0046 0.09 0.09
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0025 0.0025
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0036 0.0665 0.0861
Onchocerca volvulus 0.0009 0.0025 0.0063
Entamoeba histolytica aldose reductase, putative 0.0009 0.0025 0.0032
Echinococcus granulosus histone deacetylase 8 0.0175 0.3902 0.3902
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0036 0.0665 0.0861
Brugia malayi glutamate synthase 0.0036 0.0665 0.0677
Echinococcus multilocularis roundabout 2 0.0015 0.0177 0.0177
Onchocerca volvulus 0.0009 0.0025 0.0063
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0036 0.0665 0.0861
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0136 0.2986 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0009 0.0025 0.0025
Loa Loa (eye worm) histone deacetylase 11 0.0175 0.3902 0.397
Trypanosoma brucei cdc2-related kinase 1 0.0046 0.09 0.0916
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0036 0.0665 0.0719
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.034 0.773 1
Trichomonas vaginalis histone deacetylase, putative 0.034 0.773 1
Onchocerca volvulus Tyrosine kinase homolog 0.0144 0.3183 0.8158
Plasmodium falciparum thioredoxin reductase 0.0136 0.2986 0.3038
Brugia malayi serine/threonine-protein kinase 6 0.0118 0.2569 0.2614
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0136 0.2986 0.3038
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0009 0.0025 0.0032
Echinococcus granulosus voltage gated potassium channel subunit 0.0009 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0263 0.5925 0.603
Echinococcus multilocularis basement membrane specific heparan sulfate 0.001 0.0048 0.0048
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0036 0.0665 0.0861
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0665 0.0677
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0036 0.0665 0.0861
Loa Loa (eye worm) hypothetical protein 0.0036 0.0665 0.0677
Toxoplasma gondii NADPH-glutathione reductase 0.0136 0.2986 0.3038
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0036 0.0665 0.0861
Trypanosoma cruzi histone deacetylase, putative 0.0175 0.3902 0.397
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0036 0.0665 0.0677
Trypanosoma cruzi aldo-keto reductase 0.0009 0.0025 0.0025
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0009 0.0025 0.0025
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0036 0.0665 0.0677
Plasmodium vivax aldehyde reductase, putative 0.0009 0.0025 0.0025
Trichomonas vaginalis mercuric reductase, putative 0.0136 0.2986 0.3863
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0009 0.0025 0.0032
Schistosoma mansoni aldo-keto reductase 0.0009 0.0025 0.0025
Echinococcus granulosus cyclin dependent kinase 5 0.0046 0.09 0.09
Trypanosoma cruzi trypanothione reductase, putative 0.0136 0.2986 0.3038
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0036 0.0665 0.0861
Echinococcus multilocularis histone deacetylase 6 0.0431 0.9827 0.9827
Schistosoma mansoni aldo-keto reductase 0.0009 0.0025 0.0025
Trichomonas vaginalis aldo/keto reductase, putative 0.0009 0.0025 0.0032
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0036 0.0665 0.2164
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Echinococcus granulosus twitchin 0.0014 0.0149 0.0149
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0009 0.0025 0.0025
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0009 0.0025 0.0025
Echinococcus granulosus histone deacetylase 1 0.034 0.773 0.773
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0136 0.2986 0.3038
Trypanosoma cruzi aurora B kinase, putative 0.0118 0.2569 0.2614
Echinococcus multilocularis cyclin dependent kinase 1 0.0046 0.09 0.09
Loa Loa (eye worm) hypothetical protein 0.0013 0.012 0.0122
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0025
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0025 0.0025
Toxoplasma gondii histone deacetylase HDAC2 0.034 0.773 0.7866
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0036 0.0665 0.0677
Leishmania major hypothetical protein, conserved 0.0036 0.0665 0.0677
Echinococcus granulosus defective proboscis extension response 0.001 0.0048 0.0048
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0025 0.0025
Echinococcus multilocularis histone deacetylase 6 0.0438 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0136 0.2986 0.3038
Echinococcus multilocularis aurora kinase A 0.0118 0.2569 0.2569
Trichomonas vaginalis histone deacetylase, putative 0.034 0.773 1
Trypanosoma cruzi histone deacetylase 1, putative 0.034 0.773 0.7866
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0036 0.0665 0.0677
Brugia malayi Fibronectin type III domain containing protein 0.001 0.0048 0.0049
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0136 0.2986 0.3038
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0036 0.0665 0.0677
Giardia lamblia Kinase, CMGC CDK 0.0046 0.09 0.1165
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0665 0.0677
Plasmodium falciparum serine/threonine protein kinase, putative 0.0118 0.2569 0.2614
Plasmodium vivax ferrodoxin reductase, putative 0.0036 0.0665 0.0677
Schistosoma mansoni protein kinase 0.0118 0.2569 0.2569
Brugia malayi histone deacetylase 1 (HD1) 0.034 0.773 0.7866
Giardia lamblia Kinase, CMGC CDK 0.0046 0.09 0.1165
Schistosoma mansoni glutamate synthase 0.0036 0.0665 0.0665
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0136 0.2986 0.3038
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.2986 0.332
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0118 0.2569 0.3323
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.001 0.0048 0.0048
Trypanosoma cruzi histone deacetylase, putative 0.0431 0.9827 1
Echinococcus multilocularis neuroglian 0.0012 0.0105 0.0105
Loa Loa (eye worm) glutathione reductase 0.0392 0.8943 0.91
Echinococcus granulosus histone deacetylase 6 0.0431 0.9827 0.9827
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0118 0.2569 0.2614
Echinococcus multilocularis histone deacetylase 6 0.0431 0.9827 0.9827
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0025 0.0025
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0036 0.0665 0.0677
Loa Loa (eye worm) histone deacetylase 0.0431 0.9827 1
Schistosoma mansoni glutamate synthase 0.0036 0.0665 0.0665
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0025 0.0025
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0036 0.0665 0.0719
Brugia malayi hypothetical protein 0.001 0.0048 0.0049
Echinococcus granulosus thioredoxin glutathione reductase 0.0392 0.8943 0.8943
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.2986 0.332
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0025 0.0025
Echinococcus multilocularis aldo keto reductase 0.0009 0.0025 0.0025
Brugia malayi serine/threonine protein kinase 6 0.0118 0.2569 0.2614
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0025 0.0032
Schistosoma mansoni histone deacetylase 1 2 3 0.0175 0.3902 0.3902
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0025 0.0025
Toxoplasma gondii aldose reductase, putative 0.0009 0.0025 0.0025
Plasmodium vivax histone deacetylase, putative 0.0175 0.3902 0.397
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0036 0.0665 0.0861
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0255 0.5752 0.5853
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0118 0.2569 0.3323
Entamoeba histolytica protein kinase , putative 0.0118 0.2569 0.3323
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.0025 0.0032
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0136 0.2986 0.3038
Brugia malayi Thioredoxin reductase 0.0392 0.8943 0.91
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0136 0.2986 0.3038
Giardia lamblia Thioredoxin reductase 0.0036 0.0665 0.0861
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0036 0.0665 0.0861
Schistosoma mansoni sulfide quinone reductase 0.0036 0.0665 0.0665
Schistosoma mansoni nephrin 0.0012 0.0105 0.0105
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0036 0.0665 0.0719
Echinococcus multilocularis voltage gated potassium channel subunit 0.0009 0.0025 0.0025
Leishmania major aldo-keto reductase-like protein 0.0009 0.0025 0.0025
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0036 0.0665 0.2164
Schistosoma mansoni pol-related 0.0009 0.0025 0.0025
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0136 0.2986 1
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0009 0.0025 0.0025
Entamoeba histolytica alcohol dehydrogenase, putative 0.0009 0.0025 0.0032
Leishmania major hypothetical protein, conserved 0.0036 0.0665 0.0677
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0136 0.2986 0.3038
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Trypanosoma cruzi NADH dehydrogenase, putative 0.0036 0.0665 0.0677
Toxoplasma gondii histone deacetylase HDAC3 0.034 0.773 0.7866
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0036 0.0665 0.2164
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.2986 0.332
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0009 0.0025 0.0025
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0036 0.0665 0.0861
Echinococcus granulosus hypothetical protein 0.0009 0.0025 0.0025
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0036 0.0665 0.0665
Trypanosoma cruzi histone deacetylase 1, putative 0.034 0.773 0.7866
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0036 0.0665 0.0677
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0025 0.0025
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0118 0.2569 0.2569
Leishmania major histone deacetylase, putative 0.0431 0.9827 1
Trichomonas vaginalis glutamate synthase, putative 0.0036 0.0665 0.0861
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0036 0.0665 0.0665
Trypanosoma cruzi histone deacetylase, putative 0.0431 0.9827 1
Trichomonas vaginalis glutathione reductase, putative 0.0136 0.2986 0.3863
Schistosoma mansoni potassium channel beta 0.0009 0.0025 0.0025
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0025 0.0025
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0136 0.2986 1
Toxoplasma gondii thioredoxin reductase 0.0392 0.8943 0.91
Brugia malayi histone deacetylase 11 0.0175 0.3902 0.397
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0136 0.2986 0.3038
Echinococcus granulosus aldo keto reductase 0.0009 0.0025 0.0025
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0036 0.0665 0.0665
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0118 0.2569 0.3323
Trichomonas vaginalis histone deacetylase, putative 0.034 0.773 1
Brugia malayi glutathione reductase 0.0392 0.8943 0.91
Loa Loa (eye worm) AUR protein kinase 0.0118 0.2569 0.2614
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0036 0.0665 0.2164
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0046 0.09 0.0916
Entamoeba histolytica histone deacetylase, putative 0.034 0.773 1
Trypanosoma brucei trypanothione reductase 0.0392 0.8943 0.91
Trichomonas vaginalis AGC family protein kinase 0.0118 0.2569 0.3323
Entamoeba histolytica protein kinase domain containing protein 0.0118 0.2569 0.3323
Trichomonas vaginalis histone deacetylase, putative 0.034 0.773 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0036 0.0665 0.0861
Toxoplasma gondii histone deacetylase HDAC1 0.0431 0.9827 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0009 0.0025 0.0032
Trypanosoma brucei NADH dehydrogenase 0.0036 0.0665 0.0677
Trichomonas vaginalis AGC family protein kinase 0.0118 0.2569 0.3323
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0036 0.0665 0.0719
Toxoplasma gondii histone deacetylase HDAC4 0.0175 0.3902 0.397
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0025 0.0025
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0009 0.0025 0.0025
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0036 0.0665 0.0677
Echinococcus multilocularis aldo keto reductase 0.0009 0.0025 0.0025
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0046 0.09 0.0916
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0036 0.0665 0.0677
Plasmodium falciparum protein kinase 5 0.0046 0.09 0.0916
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0025 0.0025
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0036 0.0665 0.0665
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0136 0.2986 0.3038
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0036 0.0665 0.0665
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0136 0.2986 0.2986
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0036 0.0665 0.0677
Leishmania major prostaglandin f synthase, putative 0.0009 0.0025 0.0025
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0036 0.0665 0.0677
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0009 0.0025 0.0025
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0118 0.2569 0.2569
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0136 0.2986 0.3038
Echinococcus multilocularis histone deacetylase 7 0.0431 0.9827 0.9827
Leishmania major trypanothione reductase 0.0392 0.8943 0.91
Echinococcus multilocularis Immunoglobulin 0.001 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0175 0.3902 0.397
Loa Loa (eye worm) histone deacetylase 1 0.034 0.773 0.7866
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0048 0.0049
Onchocerca volvulus 0.0009 0.0025 0.0063
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0013 0.012 0.012
Entamoeba histolytica thioredoxin reductase, putative 0.0036 0.0665 0.0861
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0036 0.0665 0.0719
Loa Loa (eye worm) AUR protein kinase 0.0118 0.2569 0.2614
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0036 0.0665 0.0719
Brugia malayi Histone deacetylase family protein 0.0431 0.9827 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.2986 1
Echinococcus multilocularis histone deacetylase 3 0.034 0.773 0.773
Mycobacterium ulcerans ferredoxin reductase 0.0036 0.0665 0.2164
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0036 0.0665 0.0677
Loa Loa (eye worm) hypothetical protein 0.034 0.773 0.7866
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0036 0.0665 0.0677
Loa Loa (eye worm) oxidoreductase 0.0009 0.0025 0.0025
Schistosoma mansoni histone deacetylase 4 5 0.0431 0.9827 0.9827
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0036 0.0665 0.0677
Trichomonas vaginalis aldo/keto reductase, putative 0.0009 0.0025 0.0032
Entamoeba histolytica protein kinase, putative 0.0118 0.2569 0.3323
Trichomonas vaginalis CMGC family protein kinase 0.0046 0.09 0.1165
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0136 0.2986 0.3038
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0049
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0136 0.2986 0.2986
Plasmodium falciparum glutathione reductase 0.0136 0.2986 0.3038
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Schistosoma mansoni hypothetical protein 0.0036 0.0665 0.0665
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0036 0.0665 0.0719
Onchocerca volvulus 0.0141 0.3107 0.7962
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0392 0.8943 1
Schistosoma mansoni glutamate synthase 0.0036 0.0665 0.0665
Brugia malayi cell division control protein 2 homolog 0.0046 0.09 0.0916
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0155 0.342 0.348
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0025 0.0025
Trypanosoma cruzi cdc2-related kinase 1 0.0046 0.09 0.0916
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0009 0.0025 0.0025
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0036 0.0665 0.0665
Trypanosoma cruzi trypanothione reductase, putative 0.0392 0.8943 0.91
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0049
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0036 0.0665 0.0665
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0036 0.0665 0.2164
Echinococcus granulosus cyclin dependent kinase 0.0046 0.09 0.09
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0036 0.0665 0.2164
Brugia malayi NADH-dependent xylose reductase 0.0009 0.0025 0.0025
Plasmodium falciparum histone deacetylase 2 0.0431 0.9827 1
Entamoeba histolytica disulphide oxidoreductase, putative 0.0036 0.0665 0.0861
Loa Loa (eye worm) hypothetical protein 0.0015 0.0177 0.018
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0036 0.0665 0.0677
Echinococcus multilocularis thioredoxin glutathione reductase 0.0392 0.8943 0.8943
Onchocerca volvulus 0.0009 0.0025 0.0063
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0036 0.0665 0.0665
Schistosoma mansoni histone deacetylase hda2 0.0438 1 1
Onchocerca volvulus 0.0009 0.0025 0.0063
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0036 0.0665 0.0861
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Trichomonas vaginalis CMGC family protein kinase 0.0046 0.09 0.1165
Plasmodium falciparum histone deacetylase, putative 0.0431 0.9827 1
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0036 0.0665 0.0677
Leishmania major NADH dehydrogenase, putative 0.0036 0.0665 0.0677
Echinococcus granulosus aurora kinase A 0.0118 0.2569 0.2569
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0049
Entamoeba histolytica cell division protein kinase 2, putative 0.0046 0.09 0.1165
Entamoeba histolytica cell division protein kinase 2, putative 0.0046 0.09 0.1165
Brugia malayi histone deacetylase 3 (HD3) 0.034 0.773 0.7866
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0136 0.2986 0.3038
Loa Loa (eye worm) oxidoreductase 0.0009 0.0025 0.0025
Mycobacterium tuberculosis Probable reductase 0.0036 0.0665 0.0719
Trypanosoma brucei histone deacetylase 4 0.0431 0.9827 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0856 0.0871
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Giardia lamblia NADH oxidase lateral transfer candidate 0.0136 0.2986 0.3863
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0049
Trypanosoma brucei histone deacetylase 3 0.0431 0.9827 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0046 0.09 0.0916
Entamoeba histolytica aldose reductase, putative 0.0009 0.0025 0.0032
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Trypanosoma brucei histone deacetylase 1 0.034 0.773 0.7866
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0136 0.2986 1
Echinococcus multilocularis Immunoglobulin 0.001 0.0048 0.0048
Loa Loa (eye worm) oxidoreductase 0.0009 0.0025 0.0025
Toxoplasma gondii aldo-keto reductase 0.0009 0.0025 0.0025
Echinococcus multilocularis histone deacetylase 0.0431 0.9827 0.9827
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0036 0.0665 0.0665
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0136 0.2986 0.3038
Leishmania major histone deacetylase, putative 0.034 0.773 0.7866
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0036 0.0665 0.0665
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0036 0.0665 0.0677
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0036 0.0665 0.0861
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0136 0.2986 0.332
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0036 0.0665 0.2164
Plasmodium vivax histone deacetylase, putative 0.0431 0.9827 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0009 0.0025 0.0025
Schistosoma mansoni histone deacetylase 0.034 0.773 0.773
Brugia malayi serine/threonine kinase 12 0.0118 0.2569 0.2614
Echinococcus granulosus glutamate synthase 0.0036 0.0665 0.0665
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0036 0.0665 0.0677
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.09 0.09
Trichomonas vaginalis histone deacetylase, putative 0.034 0.773 1
Echinococcus granulosus histone deacetylase 7 0.0431 0.9827 0.9827
Onchocerca volvulus 0.0009 0.0025 0.0063
Schistosoma mansoni cell adhesion molecule 0.0013 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0049
Echinococcus granulosus neuroglian 0.0012 0.0105 0.0105
Echinococcus granulosus Immunoglobulin 0.001 0.0048 0.0048
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0036 0.0665 0.0665
Trypanosoma brucei aldo/keto reductase, putative 0.0009 0.0025 0.0025
Mycobacterium ulcerans monoxygenase 0.0036 0.0665 0.2164
Trypanosoma cruzi cdc2-related kinase 3 0.0046 0.09 0.0916
Echinococcus multilocularis glutamate synthase 0.0036 0.0665 0.0665
Mycobacterium ulcerans glutamate synthase subunit beta 0.0036 0.0665 0.2164
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0036 0.0665 0.0677
Entamoeba histolytica protein kinase, putative 0.0118 0.2569 0.3323
Giardia lamblia Aurora kinase 0.0118 0.2569 0.3323
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0665 0.0677
Leishmania major hypothetical protein, conserved 0.0036 0.0665 0.0677
Echinococcus granulosus histone deacetylase 3 0.034 0.773 0.773
Giardia lamblia Aldose reductase 0.0009 0.0025 0.0032
Trichomonas vaginalis aldo/keto reductase, putative 0.0009 0.0025 0.0032
Echinococcus multilocularis aldo keto reductase 0.0009 0.0025 0.0025
Echinococcus granulosus roundabout 2 0.0015 0.0177 0.0177
Trichomonas vaginalis AGC family protein kinase 0.0118 0.2569 0.3323
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0025 0.0025
Onchocerca volvulus Histone deacetylase 10 homolog 0.0175 0.3902 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0177 0.018
Mycobacterium tuberculosis Probable dehydrogenase 0.0036 0.0665 0.0719
Plasmodium vivax protein kinase Crk2 0.0046 0.09 0.0916
Trypanosoma brucei histone deacetylase 2 0.0175 0.3902 0.397
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0136 0.2986 1
Echinococcus multilocularis cyclin dependent kinase 0.0046 0.09 0.09
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0136 0.2986 0.3038
Plasmodium vivax histone deacetylase 1, putative 0.034 0.773 0.7866
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0049
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0136 0.2986 0.3038
Trypanosoma cruzi NADH dehydrogenase, putative 0.0036 0.0665 0.0677
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0136 0.2986 0.3038
Brugia malayi Histone deacetylase 1 0.034 0.773 0.7866
Trypanosoma cruzi cdc2-related kinase 3 0.0046 0.09 0.0916
Loa Loa (eye worm) programmed cell death 8 0.0036 0.0665 0.0677
Onchocerca volvulus 0.0009 0.0025 0.0063
Trichomonas vaginalis CMGC family protein kinase 0.0046 0.09 0.1165
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0036 0.0665 0.0665
Leishmania major histone deacetylase, putative 0.0431 0.9827 1
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0036 0.0665 0.0719
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0136 0.2986 0.3038
Toxoplasma gondii histone deacetylase HDAC5 0.0175 0.3902 0.397
Schistosoma mansoni sulfide quinone reductase 0.0036 0.0665 0.0665
Schistosoma mansoni disulfide oxidoreductase 0.0036 0.0665 0.0665
Giardia lamblia Aldose reductase 0.0009 0.0025 0.0032
Trypanosoma brucei aurora B kinase 0.0118 0.2569 0.2614
Echinococcus multilocularis histone deacetylase 8 0.0175 0.3902 0.3902
Brugia malayi Protein kinase domain containing protein 0.0046 0.09 0.0916
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0025 0.0025
Trypanosoma brucei histone deacetylase, putative 0.0431 0.9827 1
Schistosoma mansoni vesicular amine transporter 0.001 0.0048 0.0048
Echinococcus granulosus histone deacetylase 6 0.0431 0.9827 0.9827
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0036 0.0665 0.0677
Plasmodium falciparum glutathione reductase 0.0392 0.8943 0.91
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0036 0.0665 0.0677
Echinococcus multilocularis cyclin dependent kinase 5 0.0046 0.09 0.09
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0046 0.09 0.0916
Trichomonas vaginalis AGC family protein kinase 0.0118 0.2569 0.3323
Echinococcus multilocularis histone deacetylase 1 0.034 0.773 0.773
Toxoplasma gondii selenide, water dikinase 0.0036 0.0665 0.0677
Echinococcus granulosus histone deacetylase 0.0431 0.9827 0.9827
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0046 0.09 0.0916
Giardia lamblia Glutamate synthase 0.0036 0.0665 0.0861
Trichomonas vaginalis histone deacetylase, putative 0.034 0.773 1
Trypanosoma cruzi cdc2-related kinase 1 0.0046 0.09 0.0916
Leishmania major protein kinase, putative 0.0118 0.2569 0.2614
Plasmodium falciparum thioredoxin reductase 0.0392 0.8943 0.91
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0046 0.09 0.0916
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0036 0.0665 0.0719
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0036 0.0665 0.0677
Mycobacterium ulcerans dehydrogenase 0.0036 0.0665 0.2164
Loa Loa (eye worm) histone deacetylase 7A 0.0431 0.9827 1
Echinococcus multilocularis aldo keto reductase 0.0009 0.0025 0.0025
Trypanosoma cruzi aldo/keto reductase, putative 0.0009 0.0025 0.0025
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0036 0.0665 0.0861
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0009 0.0025 0.0025
Trypanosoma cruzi histone deacetylase, putative 0.0175 0.3902 0.397
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0036 0.0665 0.2164
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.01 0.2147 0.2185
Plasmodium falciparum ferrodoxin reductase-like protein 0.0036 0.0665 0.0677
Schistosoma mansoni histone deacetylase 0.034 0.773 0.773
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0036 0.0665 0.0861
Loa Loa (eye worm) thioredoxin reductase 0.0392 0.8943 0.91
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0136 0.2986 1
Onchocerca volvulus 0.0036 0.0665 0.1705
Echinococcus granulosus cyclin dependent kinase 1 0.0046 0.09 0.09
Treponema pallidum NADH oxidase 0.0136 0.2986 1
Trypanosoma brucei cdc2-related kinase 3 0.0046 0.09 0.0916
Schistosoma mansoni histone deacetylase 4 5 0.0431 0.9827 0.9827
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.09 0.09
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0009 0.0025 0.0025
Plasmodium falciparum aldehyde reductase, putative 0.0009 0.0025 0.0025
Trypanosoma brucei prostaglandin f synthase 0.0009 0.0025 0.0025
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.034 0.773 1
Brugia malayi Histone deacetylase family protein 0.0431 0.9827 1
Giardia lamblia Histone deacetylase 0.034 0.773 1
Schistosoma mansoni histone deacetylase hda2 0.0175 0.3902 0.3902
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0036 0.0665 0.2164
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0036 0.0665 0.0861
Trichomonas vaginalis aldo-keto reductase, putative 0.0009 0.0025 0.0032
Loa Loa (eye worm) oxidoreductase 0.0009 0.0025 0.0025
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0009 0.0025 0.0025
Trichomonas vaginalis apoptosis inducing factor, putative 0.0036 0.0665 0.0861
Plasmodium falciparum histone deacetylase 1 0.034 0.773 0.7866
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0036 0.0665 0.0677
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0136 0.2986 0.3038
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0036 0.0665 0.2164
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0036 0.0665 0.0719
Mycobacterium ulcerans NADH dehydrogenase 0.0036 0.0665 0.2164
Plasmodium vivax glutathione reductase, putative 0.0392 0.8943 0.91
Loa Loa (eye worm) AUR protein kinase 0.0118 0.2569 0.2614

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 1.1 uM Inhibition of HDAC in HeLa cells assessed as induction of human histone H3 hyperacetylation ChEMBL. 17691763
EC50 (binding) = 1.1 uM Inhibition of HDAC in HeLa cells assessed as induction of human histone H3 hyperacetylation ChEMBL. 17691763
IC50 (binding) = 0.45 uM Inhibition of HDAC in HeLa cells ChEMBL. 17691763
IC50 (binding) = 0.45 uM Inhibition of HDAC in HeLa cells ChEMBL. 17691763
IC50 (binding) = 0.52 uM Inhibition of recombinant HDAC1 in HeLa cells ChEMBL. 17691763
IC50 (binding) = 0.52 uM Inhibition of recombinant HDAC1 in HeLa cells ChEMBL. 17691763
IC50 (functional) = 2.6 uM Cytotoxicity against HeLa cells ChEMBL. 17691763
IC50 (functional) = 2.6 uM Cytotoxicity against HeLa cells ChEMBL. 17691763

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17691763

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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