Detailed information for compound 435902

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 391.47 | Formula: C21H25N7O
  • H donors: 3 H acceptors: 4 LogP: 3.31 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1CCN(CC1)c1nc(nc(n1)Nc1ccccc1)Nc1ccccc1
  • InChi: 1S/C21H25N7O/c29-16-15-27-11-13-28(14-12-27)21-25-19(22-17-7-3-1-4-8-17)24-20(26-21)23-18-9-5-2-6-10-18/h1-10,29H,11-16H2,(H2,22,23,24,25,26)
  • InChiKey: HRMKLBZLJUBGSL-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0067 0.0742 0.2041
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0001 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0077 0.1034
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0251 0.3338 0.3338
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.011 0.1476
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0077 0.0075
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0025 0.0161 0.0363
Mycobacterium ulcerans lipase LipD 0.0024 0.0147 0.0436
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0041 0.0382 0.0276
Echinococcus multilocularis musashi 0.0049 0.0498 0.0498
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0067 0.0742 0.0742
Mycobacterium tuberculosis Probable lipase LipD 0.0024 0.0147 0.0145
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0008
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.011 0.0102
Schistosoma mansoni disulfide oxidoreductase 0.0067 0.0742 0.0742
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0067 0.0742 0.169
Loa Loa (eye worm) hypothetical protein 0.0052 0.0544 0.0544
Leishmania major hypothetical protein, conserved 0.0024 0.0147 0.0147
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0251 0.3338 0.3338
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0067 0.0742 0.0735
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0067 0.0742 0.169
Brugia malayi beta-lactamase 0.0024 0.0147 0.0147
Schistosoma mansoni tar DNA-binding protein 0.0119 0.1477 0.1477
Brugia malayi ImpB/MucB/SamB family protein 0.0032 0.0261 0.0261
Trypanosoma brucei glucosidase, putative 0.0025 0.0161 0.0161
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0024 0.0147 0.0147
Trypanosoma cruzi NADH dehydrogenase, putative 0.0067 0.0742 0.0742
Trypanosoma cruzi trypanothione reductase, putative 0.0723 1 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0019 0.0077 0.1034
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0077 0.0226
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0067 0.0742 0.0742
Plasmodium vivax SET domain protein, putative 0.0041 0.0382 0.0382
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.011 0.011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.011 0.011
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0147 0.0147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0064 0.0706 0.0706
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0372 0.0372
Schistosoma mansoni alpha-glucosidase 0.0098 0.1185 0.1185
Schistosoma mansoni glutamate synthase 0.0067 0.0742 0.0742
Echinococcus granulosus glutamate synthase 0.0067 0.0742 0.0742
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0077 0.0077
Schistosoma mansoni DNA polymerase eta 0.0032 0.0261 0.0261
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0544 0.0544
Brugia malayi intermediate filament protein 0.0049 0.0498 0.0498
Schistosoma mansoni tar DNA-binding protein 0.0119 0.1477 0.1477
Plasmodium falciparum thioredoxin reductase 0.0723 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Loa Loa (eye worm) intermediate filament protein 0.0049 0.0498 0.0498
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0251 0.3338 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0088 0.1042 0.3119
Schistosoma mansoni glutamate synthase 0.0067 0.0742 0.0742
Loa Loa (eye worm) RNA binding protein 0.0119 0.1477 0.1477
Loa Loa (eye worm) hypothetical protein 0.0035 0.0292 0.0292
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0044 0.0432 0.0432
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0215 0.2831 0.2831
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0147
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0067 0.0742 0.0741
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0762 0.0762
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0067 0.0742 0.0741
Mycobacterium ulcerans aldehyde dehydrogenase 0.0088 0.1042 0.3119
Trypanosoma brucei trypanothione reductase 0.0723 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0077 0.0077
Mycobacterium leprae Probable lipase LipE 0.0024 0.0147 0.0215
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0001 0.0001
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0067 0.0742 0.0742
Schistosoma mansoni tar DNA-binding protein 0.0119 0.1477 0.1477
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0044 0.0432 0.5816
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0088 0.1042 0.1041
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0067 0.0742 0.1961
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0067 0.0742 0.0742
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0039 0.0361 0.0361
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0067 0.0742 0.0742
Mycobacterium tuberculosis Conserved protein 0.0024 0.0147 0.0145
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.011 0.011
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0067 0.0742 0.0742
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0251 0.3338 0.3338
Loa Loa (eye worm) hypothetical protein 0.0068 0.0762 0.0762
Loa Loa (eye worm) hypothetical protein 0.0033 0.0266 0.0266
Brugia malayi hypothetical protein 0.01 0.1211 0.1211
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0067 0.0742 0.2222
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0044 0.0432 0.0432
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0251 0.3338 0.3338
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0586 0.8065 0.8065
Plasmodium falciparum ferrodoxin reductase-like protein 0.0067 0.0742 0.0735
Echinococcus granulosus neuropeptide s receptor 0.0336 0.4538 0.4538
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0049 0.0498 0.0498
Trypanosoma brucei unspecified product 0.0014 0.0001 0.0001
Trypanosoma brucei DNA polymerase eta, putative 0.0032 0.0261 0.0261
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0019 0.0077 0.0226
Leishmania major alpha glucosidase II subunit, putative 0.0025 0.0161 0.0161
Echinococcus multilocularis lysosomal alpha glucosidase 0.0114 0.1408 0.1408
Schistosoma mansoni sulfide quinone reductase 0.0067 0.0742 0.0742
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0147 0.0147
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0147 0.0332
Toxoplasma gondii selenide, water dikinase 0.0067 0.0742 0.064
Loa Loa (eye worm) hypothetical protein 0.0048 0.0485 0.0485
Trichomonas vaginalis set domain proteins, putative 0.0325 0.4386 1
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0067 0.0742 0.0741
Trichomonas vaginalis penicillin-binding protein, putative 0.0024 0.0147 0.0332
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0067 0.0742 0.0742
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0049 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0171 0.2214 0.2214
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0067 0.0742 0.2222
Loa Loa (eye worm) programmed cell death 8 0.0067 0.0742 0.0742
Brugia malayi beta-lactamase family protein 0.0024 0.0147 0.0147
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0088 0.1042 0.1042
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0067 0.0742 0.064
Brugia malayi Intermediate filament tail domain containing protein 0.0049 0.0498 0.0498
Trichomonas vaginalis maltase-glucoamylase, putative 0.0025 0.0161 0.0363
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0067 0.0742 0.0741
Echinococcus multilocularis dna polymerase eta 0.0032 0.0261 0.0261
Onchocerca volvulus 0.0024 0.0147 0.0162
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0041 0.0382 0.0382
Onchocerca volvulus 0.0024 0.0147 0.0162
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0008
Echinococcus granulosus transcription factor Dp 1 0.0026 0.0168 0.0168
Schistosoma mansoni glutamate synthase 0.0067 0.0742 0.0742
Echinococcus granulosus thioredoxin glutathione reductase 0.0723 1 1
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0067 0.0742 0.1961
Schistosoma mansoni hypothetical protein 0.0068 0.0762 0.0762
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0044 0.0432 0.0432
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0251 0.3338 0.3338
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0024 0.0147 0.0436
Toxoplasma gondii aldehyde dehydrogenase 0.0088 0.1042 0.0943
Echinococcus multilocularis GPCR, family 2 0.0068 0.0762 0.0762
Schistosoma mansoni sulfide quinone reductase 0.0067 0.0742 0.0742
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0251 0.3338 0.3338
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.011 0.0325
Schistosoma mansoni hypothetical protein 0.0068 0.0762 0.0762
Onchocerca volvulus 0.0035 0.0292 0.0498
Schistosoma mansoni alpha-glucosidase 0.0098 0.1185 0.1185
Echinococcus granulosus lamin 0.0049 0.0498 0.0498
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0064 0.0706 0.0706
Trichomonas vaginalis penicillin-binding protein, putative 0.0024 0.0147 0.0332
Onchocerca volvulus 0.0123 0.1539 0.3392
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0161 0.0363
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0067 0.0742 0.0742
Mycobacterium ulcerans esterase/lipase LipP 0.0024 0.0147 0.0436
Plasmodium vivax acyl-CoA synthetase, putative 0.0014 0.0008 0.0008
Entamoeba histolytica disulphide oxidoreductase, putative 0.0067 0.0742 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0044 0.0432 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Leishmania major DNA polymerase eta, putative 0.0032 0.0261 0.0261
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0019 0.0077 0.0075
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0001 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.011 0.0247
Onchocerca volvulus 0.0325 0.4386 1
Giardia lamblia Glutamate synthase 0.0067 0.0742 0.2222
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0067 0.0742 0.2041
Treponema pallidum thioredoxin reductase (trxB) 0.0067 0.0742 0.1961
Schistosoma mansoni lamin 0.0049 0.0498 0.0498
Echinococcus multilocularis thioredoxin glutathione reductase 0.0723 1 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0251 0.3338 0.3264
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0024 0.0146 0.0146
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0762 0.0762
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0742 0.169
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0001 0.0001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0068 0.0762 0.0762
Echinococcus granulosus fetal alzheimer antigen falz 0.0015 0.0019 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0119 0.1477 0.1477
Brugia malayi Pre-SET motif family protein 0.0286 0.383 0.383
Brugia malayi TAR-binding protein 0.0119 0.1477 0.1477
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0706 0.0706
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0067 0.0742 0.0741
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0014 0.0008 0.0007
Plasmodium falciparum glutathione reductase 0.0723 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0147
Echinococcus granulosus intermediate filament protein 0.0049 0.0498 0.0498
Plasmodium vivax thioredoxin reductase, putative 0.0723 1 1
Schistosoma mansoni hypothetical protein 0.0035 0.0296 0.0296
Onchocerca volvulus 0.0035 0.0296 0.0509
Schistosoma mansoni survival motor neuron protein 0.0035 0.0296 0.0296
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0067 0.0742 0.169
Schistosoma mansoni bromodomain containing protein 0.0043 0.0406 0.0406
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0047 0.0461 0.0461
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0251 0.3338 1
Mycobacterium tuberculosis Probable reductase 0.0067 0.0742 0.0741
Echinococcus multilocularis lamin dm0 0.0049 0.0498 0.0498
Trichomonas vaginalis esterase, putative 0.0024 0.0147 0.0332
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0067 0.0742 0.0742
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0723 1 1
Schistosoma mansoni hypothetical protein 0.0014 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0067 0.0742 0.0742
Echinococcus granulosus lamin dm0 0.0049 0.0498 0.0498
Entamoeba histolytica thioredoxin reductase, putative 0.0067 0.0742 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0067 0.0742 0.0742
Trichomonas vaginalis glutamate synthase, putative 0.0067 0.0742 0.169
Leishmania major trypanothione reductase 0.0723 1 1
Brugia malayi RNA binding protein 0.0119 0.1477 0.1477
Mycobacterium ulcerans glutamate synthase subunit beta 0.0067 0.0742 0.2222
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0024 0.0146 0.0146
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0742 0.169
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0064 0.0706 0.0706
Loa Loa (eye worm) hypothetical protein 0.0033 0.0266 0.0266
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0077 0.0226
Echinococcus granulosus geminin 0.0233 0.3082 0.3082
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0067 0.0742 0.0742
Schistosoma mansoni hypothetical protein 0.0068 0.0762 0.0762
Loa Loa (eye worm) hypothetical protein 0.0019 0.0077 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0161 0.0161
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0067 0.0742 0.064
Trichomonas vaginalis glutamate synthase, putative 0.0067 0.0742 0.169
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0067 0.0742 0.2041
Schistosoma mansoni intermediate filament proteins 0.0049 0.0498 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Loa Loa (eye worm) glutathione reductase 0.0723 1 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0025 0.0161 0.0363
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0067 0.0742 0.0742
Trichomonas vaginalis apoptosis inducing factor, putative 0.0067 0.0742 0.169
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0067 0.0742 0.169
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0064 0.0706 0.0706
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0067 0.0742 0.0742
Echinococcus granulosus beta LACTamase domain containing family member 0.0024 0.0147 0.0147
Brugia malayi Glycosyl hydrolases family 31 protein 0.0025 0.0161 0.0161
Echinococcus granulosus dna polymerase kappa 0.0014 0.0001 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.011 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0161 0.0161
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0015 0.0019 0.0019
Brugia malayi latrophilin 2 splice variant baaae 0.0147 0.1874 0.1874
Schistosoma mansoni aldehyde dehydrogenase 0.0088 0.1042 0.1042
Brugia malayi PHD-finger family protein 0.0017 0.0041 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0251 0.3338 0.3338
Echinococcus granulosus microtubule associated protein 2 0.0465 0.636 0.636
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0251 0.3338 0.3338
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0067 0.0742 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0067 0.0742 0.0742
Echinococcus multilocularis dna polymerase kappa 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0147
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0742 0.0742
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0251 0.3338 0.3337
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0067 0.0742 0.0742
Brugia malayi glutamate synthase 0.0067 0.0742 0.0742
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0155 0.199 0.1989
Loa Loa (eye worm) hypothetical protein 0.0019 0.0077 0.0077
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0261 0.0261
Toxoplasma gondii thioredoxin reductase 0.0723 1 1
Giardia lamblia Thioredoxin reductase 0.0067 0.0742 0.2222
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0067 0.0742 0.0742
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0019 0.0077 0.0226
Loa Loa (eye worm) calpain family protein 1 0.0047 0.0461 0.0461
Echinococcus multilocularis neuropeptide receptor A26 0.0336 0.4538 0.4538
Brugia malayi Bromodomain containing protein 0.0051 0.0517 0.0517
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0067 0.0742 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0024 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0023 0.0127 0.0127
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0067 0.0742 0.0742
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0049 0.0494 0.0494
Brugia malayi beta-lactamase family protein 0.0024 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0047 0.0461 0.0461
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0067 0.0742 0.2041
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0067 0.0742 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0025 0.0161 0.2163
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0742 0.0742
Schistosoma mansoni hypothetical protein 0.0233 0.3082 0.3082
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0067 0.0742 0.0735
Loa Loa (eye worm) hypothetical protein 0.0023 0.0127 0.0127
Treponema pallidum oxidoreductase 0.0067 0.0742 0.1961
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0067 0.0742 0.0742
Echinococcus granulosus survival motor neuron protein 1 0.0171 0.2214 0.2214
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0067 0.0742 0.064
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0251 0.3338 0.3337
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0147 0.0215
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0762 0.0762
Brugia malayi hypothetical protein 0.0171 0.2214 0.2214
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0742 0.169
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0251 0.3338 0.3338
Schistosoma mansoni tar DNA-binding protein 0.0119 0.1477 0.1477
Schistosoma mansoni alpha glucosidase 0.0025 0.0161 0.0161
Echinococcus multilocularis tar DNA binding protein 0.0119 0.1477 0.1477
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0251 0.3338 0.3332
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.011 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Echinococcus granulosus neutral alpha glucosidase AB 0.0025 0.0161 0.0161
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0762 0.0762
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0762 0.0762
Plasmodium falciparum thioredoxin reductase 0.0251 0.3338 0.3332
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0147 0.0147
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0147 0.0332
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.011 0.0108
Echinococcus multilocularis neutral alpha glucosidase AB 0.0025 0.0161 0.0161
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0251 0.3338 0.3338
Mycobacterium tuberculosis Probable oxidoreductase 0.0251 0.3338 0.3337
Brugia malayi cytoplasmic intermediate filament protein 0.0026 0.0176 0.0176
Loa Loa (eye worm) calpain family protein 1 0.0033 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0008
Loa Loa (eye worm) TAR-binding protein 0.0119 0.1477 0.1477
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0139
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0742 0.169
Echinococcus multilocularis glutamate synthase 0.0067 0.0742 0.0742
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0251 0.3338 0.3338
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0251 0.3338 1
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0077 0.0077
Echinococcus multilocularis calpain family protein 1, d 0.0033 0.0266 0.0266
Mycobacterium ulcerans dehydrogenase 0.0067 0.0742 0.2222
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0064 0.0706 0.0706
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0067 0.0742 0.2222
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0049 0.0494 0.0494
Echinococcus granulosus GPCR family 2 0.0068 0.0762 0.0762
Mycobacterium tuberculosis Probable hydrolase 0.0024 0.0147 0.0145
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0762 0.0762
Brugia malayi calpain family protein 1 0.0047 0.0461 0.0461
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0067 0.0742 0.0742
Trypanosoma brucei NADH dehydrogenase 0.0067 0.0742 0.0742
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0114 0.1408 0.1408
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0001 0.0001
Leishmania major DNA polymerase eta, putative 0.0023 0.0125 0.0125
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0544 0.0544
Schistosoma mansoni hypothetical protein 0.0147 0.1874 0.1874
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0147
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.011 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0147 0.0147
Chlamydia trachomatis thioredoxin reductase 0.0067 0.0742 0.2206
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0067 0.0742 0.2041
Mycobacterium ulcerans monoxygenase 0.0067 0.0742 0.2222
Loa Loa (eye worm) hypothetical protein 0.0215 0.2831 0.2831
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0026 0.0176 0.0176
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0024 0.0147 0.0145
Trichomonas vaginalis mercuric reductase, putative 0.0251 0.3338 0.7609
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0025 0.0161 0.0052
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0049 0.0494 0.0494
Echinococcus granulosus lysosomal alpha glucosidase 0.0114 0.1408 0.1408
Mycobacterium ulcerans hypothetical protein 0.0024 0.0147 0.0436
Echinococcus multilocularis transcription factor Dp 1 0.0026 0.0168 0.0168
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0001 0.0001
Echinococcus multilocularis calpain A 0.0049 0.0494 0.0494
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0077 0.0077
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0067 0.0742 0.0741
Toxoplasma gondii ABC1 family protein 0.0024 0.0147 0.0038
Brugia malayi Glycosyl hydrolases family 31 protein 0.0114 0.1408 0.1408
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0067 0.0742 0.2222
Brugia malayi Thioredoxin reductase 0.0723 1 1
Mycobacterium ulcerans hypothetical protein 0.0067 0.0742 0.2222
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0035 0.0296 0.0296
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0025 0.0161 0.0161
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0044 0.0432 0.0432
Onchocerca volvulus 0.0024 0.0147 0.0162
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0251 0.3338 0.3338
Trypanosoma cruzi trypanothione reductase, putative 0.0251 0.3338 0.3338
Mycobacterium ulcerans beta-lactamase 0.0024 0.0147 0.0436
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0024 0.0147 0.0145
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0184 0.24 0.24
Loa Loa (eye worm) beta-lactamase 0.0024 0.0147 0.0147
Mycobacterium tuberculosis Probable esterase LipL 0.0024 0.0147 0.0145
Loa Loa (eye worm) hypothetical protein 0.0147 0.1874 0.1874
Schistosoma mansoni ap endonuclease 0.0022 0.011 0.011
Onchocerca volvulus 0.0067 0.0742 0.1545
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0125 0.0016
Loa Loa (eye worm) hypothetical protein 0.0047 0.0461 0.0461
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0067 0.0742 0.0742
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0027 0.0192 0.0192
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0119 0.1477 0.1477
Loa Loa (eye worm) thioredoxin reductase 0.0723 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0077 0.0226
Mycobacterium ulcerans aldehyde dehydrogenase 0.0088 0.1042 0.3119
Leishmania major hypothetical protein, conserved 0.0067 0.0742 0.0742
Brugia malayi hypothetical protein 0.0123 0.1539 0.1539
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0251 0.3338 0.3338
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0147
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0251 0.3338 1
Schistosoma mansoni cellular tumor antigen P53 0.0035 0.0292 0.0292
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0372 0.0372
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0161 0.0363
Onchocerca volvulus Huntingtin homolog 0.01 0.1211 0.2631
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0008
Toxoplasma gondii NADPH-glutathione reductase 0.0251 0.3338 0.3264
Onchocerca volvulus 0.0049 0.0498 0.0978
Leishmania major NADH dehydrogenase, putative 0.0067 0.0742 0.0742
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0001 0.0001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0024 0.0147 0.0147
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0286 0.383 0.383
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0215 0.2831 0.2831
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0024 0.0139 0.0139
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0251 0.3338 0.3338
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0067 0.0742 0.0742
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0251 0.3338 0.3338
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0064 0.0706 0.0706
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0067 0.0742 0.0742
Mycobacterium ulcerans ferredoxin reductase 0.0067 0.0742 0.2222
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0251 0.3338 0.3338
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0067 0.0742 0.2222
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0251 0.3338 0.3338
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0067 0.0742 0.0742
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0088 0.1042 0.1042
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0001 0.0018
Echinococcus granulosus tar DNA binding protein 0.0119 0.1477 0.1477
Loa Loa (eye worm) PHD-finger family protein 0.0014 0.0001 0.0001
Plasmodium vivax ferrodoxin reductase, putative 0.0067 0.0742 0.0742
Plasmodium falciparum glutathione reductase 0.0251 0.3338 0.3332
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.011 0.0325
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0251 0.3338 0.3338
Mycobacterium ulcerans hypothetical protein 0.0019 0.0077 0.0226
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0067 0.0742 0.0742
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0742 0.169
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0077 0.0077
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0067 0.0742 0.0742
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0041 0.0382 0.0382
Echinococcus granulosus calpain A 0.0049 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.01 0.1211 0.1211
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0067 0.0742 0.0741
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0251 0.3338 0.3337
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0067 0.0742 0.0742
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.011 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0706 0.0706
Echinococcus multilocularis neuropeptide s receptor 0.0336 0.4538 0.4538
Onchocerca volvulus 0.0049 0.0498 0.0978
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0067 0.0742 0.0742
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0161 0.0363
Mycobacterium tuberculosis Conserved protein 0.0024 0.0147 0.0145
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0251 0.3338 0.3332
Loa Loa (eye worm) hypothetical protein 0.0032 0.0261 0.0261
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0019 0.0077 0.0226
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0044 0.0432 0.0432
Schistosoma mansoni ap endonuclease 0.0022 0.011 0.011
Mycobacterium tuberculosis Conserved protein 0.0024 0.0147 0.0145
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0544 0.0544
Echinococcus multilocularis tumor protein p63 0.0236 0.313 0.313
Leishmania major hypothetical protein, conserved 0.0067 0.0742 0.0742
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0067 0.0742 0.0742
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0125 0.0125
Trichomonas vaginalis glutathione reductase, putative 0.0251 0.3338 0.7609
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0044 0.0432 0.0432
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0161 0.0363
Brugia malayi Pre-SET motif family protein 0.0041 0.0382 0.0382
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0251 0.3338 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0024 0.0147 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Trichomonas vaginalis sucrase-isomaltase, putative 0.0025 0.0161 0.0363
Plasmodium vivax glutathione reductase, putative 0.0723 1 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0477 0.0477
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0015 0.0019 0.0019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0762 0.0762
Loa Loa (eye worm) hypothetical protein 0.0024 0.0147 0.0147
Echinococcus granulosus dna polymerase eta 0.0032 0.0261 0.0261
Echinococcus granulosus tumor protein p63 0.0236 0.313 0.313
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0147 0.0332
Onchocerca volvulus 0.0033 0.0266 0.0438
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0014 0.0008 0.002
Echinococcus multilocularis microtubule associated protein 2 0.0465 0.636 0.636
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0067 0.0742 0.064
Echinococcus multilocularis survival motor neuron protein 1 0.0171 0.2214 0.2214
Brugia malayi RNA recognition motif domain containing protein 0.0119 0.1477 0.1477
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0233 0.3082 0.3082
Schistosoma mansoni aldehyde dehydrogenase 0.0088 0.1042 0.1042
Echinococcus multilocularis lysosomal alpha glucosidase 0.0114 0.1408 0.1408
Loa Loa (eye worm) hypothetical protein 0.0019 0.0077 0.0077
Onchocerca volvulus Huntingtin homolog 0.01 0.1211 0.2631
Brugia malayi Calcitonin receptor-like protein seb-1 0.0215 0.2831 0.2831
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0044 0.0432 0.0432
Brugia malayi calpain family protein 1 0.0047 0.0461 0.0461
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0025 0.0161 0.2163
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0044 0.0432 0.0432
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0067 0.0742 0.064
Trypanosoma cruzi NADH dehydrogenase, putative 0.0067 0.0742 0.0742
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0077 0.0077
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0067 0.0742 0.0742
Leishmania major DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0049 0.0494 0.0494
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0077 0.0226
Echinococcus multilocularis geminin 0.0233 0.3082 0.3082
Loa Loa (eye worm) hypothetical protein 0.0026 0.0169 0.0169
Mycobacterium ulcerans NADH dehydrogenase 0.0067 0.0742 0.2222
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0382 0.0382
Onchocerca volvulus 0.0041 0.0382 0.0708
Trypanosoma brucei hypothetical protein, conserved 0.0067 0.0742 0.0742
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0067 0.0742 0.0741
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0001 0.0001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0251 0.3338 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0067 0.0742 1
Echinococcus granulosus neuropeptide receptor A26 0.0336 0.4538 0.4538
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0067 0.0742 0.169
Loa Loa (eye worm) hypothetical protein 0.01 0.1211 0.1211
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0077 0.1034
Trichomonas vaginalis alpha-glucosidase, putative 0.0025 0.0161 0.0363
Brugia malayi Bromodomain containing protein 0.0026 0.0169 0.0169
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0024 0.0147 0.0147
Schistosoma mansoni lamin 0.0049 0.0498 0.0498
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0024 0.0147 0.0147
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0184 0.24 0.24
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0024 0.0139 0.0139
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0088 0.1042 0.1042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.011 0.011
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0067 0.0742 0.0742
Echinococcus multilocularis lamin 0.0049 0.0498 0.0498
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0067 0.0742 0.0741
Treponema pallidum NADH oxidase 0.0251 0.3338 1
Mycobacterium tuberculosis Probable lipase LipE 0.0024 0.0147 0.0145
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0067 0.0742 0.0742
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0067 0.0742 0.2222
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0706 0.0706
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0251 0.3338 0.3338
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0251 0.3338 0.3338
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0251 0.3338 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0067 0.0742 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0067 0.0742 0.2222
Mycobacterium tuberculosis Probable dehydrogenase 0.0067 0.0742 0.0741
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0251 0.3338 0.3338
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0067 0.0742 0.2222
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0067 0.0742 0.0741
Giardia lamblia NADH oxidase lateral transfer candidate 0.0251 0.3338 1
Onchocerca volvulus 0.0066 0.0732 0.1521
Schistosoma mansoni microtubule-associated protein tau 0.0465 0.636 0.636
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0067 0.0742 0.1961
Loa Loa (eye worm) hypothetical protein 0.0123 0.1539 0.1539
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0251 0.3338 0.3338

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 22 % Growth inhibition of human HCT116 cells at 10 uM after 72 hrs by SRB assay ChEMBL. 17157510
Inhibition (functional) = 22 % Growth inhibition of human HCT116 cells at 10 uM after 72 hrs by SRB assay ChEMBL. 17157510
Inhibition (functional) = 76.1 % Growth inhibition of human HT29 cells at 10 uM after 72 hrs by SRB assay ChEMBL. 17157510
Inhibition (functional) = 76.1 % Growth inhibition of human HT29 cells at 10 uM after 72 hrs by SRB assay ChEMBL. 17157510

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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