Detailed information for compound 435928

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 414.905 | Formula: C21H19ClN2O3S
  • H donors: 2 H acceptors: 2 LogP: 7.17 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(Nc2ccc(cc2)Cl)sc(c1C)/C(=N\O)/c1ccc(cc1)C
  • InChi: 1S/C21H19ClN2O3S/c1-12-4-6-14(7-5-12)18(24-26)19-13(2)17(21(25)27-3)20(28-19)23-16-10-8-15(22)9-11-16/h4-11,23,26H,1-3H3/b24-18-
  • InChiKey: RBPUPUYDXPCPCW-MOHJPFBDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.022 0.1662
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0035 0.0218 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.022 0.0606
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0035 0.0218 0.5241
Trypanosoma brucei calcium-translocating P-type ATPase 0.0028 0.0132 0.074
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0842 1 1
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0179 0.1238
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0035 0.0218 0.0223
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0028 0.0132 0.0166
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0179 0.7953
Echinococcus multilocularis nervana 2 0.0317 0.3627 0.371
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0028 0.0132 0.074
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0035 0.0218 1
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0035 0.0218 0.0273
Loa Loa (eye worm) beta-lactamase 0.0035 0.022 0.0606
Echinococcus granulosus nervana 2 0.0195 0.2148 0.2698
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0317 0.3627 0.371
Plasmodium falciparum heat shock protein 90 0.0032 0.0179 0.4179
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0179 0.1225
Brugia malayi E1-E2 ATPase family protein 0.0022 0.0062 0.0213
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.022 0.014
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0028 0.0132 0.0166
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.022 0.014
Loa Loa (eye worm) hypothetical protein 0.0035 0.022 0.0606
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0459 0.0576
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0049 0.0389 0.0398
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0028 0.0132 0.0166
Trypanosoma brucei heat shock protein, putative 0.0032 0.0179 0.1238
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0035 0.0218 0.9876
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0028 0.0132 0.0497
Echinococcus granulosus gamma secretase subunit aph 1 0.0258 0.2919 0.3667
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0035 0.0218 0.1641
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0035 0.0218 0.0223
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.022 0.014
Onchocerca volvulus 0.0195 0.2148 0.5924
Mycobacterium tuberculosis Conserved protein 0.0035 0.022 0.014
Loa Loa (eye worm) calcium ATPase 0.002 0.0031 0.0086
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0035 0.0218 0.0273
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.022 0.0276
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0035 0.0218 0.1998
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0378 0.0474
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.022 0.014
Leishmania major hypothetical protein, conserved 0.0035 0.022 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0405 0.1117
Loa Loa (eye worm) hypothetical protein 0.0035 0.022 0.0606
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0035 0.0218 0.4756
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0824 0.9775 1
Echinococcus multilocularis nervana 2 0.0195 0.2148 0.2198
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0035 0.0218 0.5241
Echinococcus multilocularis nervana 2 0.0195 0.2148 0.2198
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0179 0.1612
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0035 0.0218 0.1816
Echinococcus granulosus heat shock protein 0.0032 0.0179 0.0225
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0049 0.0389 0.0489
Trichomonas vaginalis heat shock protein, putative 0.0026 0.01 0.1978
Trichomonas vaginalis heat shock protein, putative 0.0026 0.01 0.1978
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0035 0.0218 0.5241
Loa Loa (eye worm) sugar transporter 0.0049 0.0389 0.1073
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0389 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0459 0.1572
Echinococcus multilocularis heat shock protein 90 0.0026 0.01 0.0102
Brugia malayi gamma-secretase subunit aph-1 0.0258 0.2919 1
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0035 0.0218 0.0138
Trichomonas vaginalis cation-transporting ATPase, putative 0.0035 0.0218 0.5241
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0378 0.1041
Mycobacterium ulcerans beta-lactamase 0.0035 0.022 0.014
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0378 0.0474
Trypanosoma cruzi P-type H+-ATPase, putative 0.0022 0.0062 0.0427
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0028 0.0132 0.0166
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.022 0.0276
Mycobacterium tuberculosis Conserved protein 0.0035 0.022 0.014
Schistosoma mansoni endoplasmin 0.0032 0.0179 0.0225
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.022 0.014
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0317 0.3627 0.4555
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Schistosoma mansoni glucose transport protein 0.0049 0.0389 0.0489
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.022 0.014
Onchocerca volvulus 0.0317 0.3627 1
Echinococcus multilocularis gamma secretase subunit aph 1 0.0258 0.2919 0.2986
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0317 0.3627 0.371
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0035 0.0218 0.1641
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0035 0.0218 0.5241
Echinococcus multilocularis heat shock protein 90 0.0032 0.0179 0.0184
Schistosoma mansoni glucose transport protein 0.0049 0.0389 0.0489
Echinococcus multilocularis geminin 0.0674 0.7961 0.8144
Trypanosoma brucei heat shock protein, putative 0.0032 0.0179 0.1238
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Echinococcus granulosus Na:K ATPase alpha subunit 0.0079 0.0747 0.0939
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.2105 0.2644
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0028 0.0132 0.0135
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0035 0.0218 0.5241
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0378 0.0386
Trypanosoma brucei heat shock protein, putative 0.0032 0.0179 0.1238
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0195 0.2148 0.2698
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0035 0.0218 0.4756
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0035 0.0218 0.0223
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0049 0.0389 0.0489
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0028 0.0132 0.0166
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.022 0.0225
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.022 0.5295
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0049 0.0389 0.0398
Plasmodium vivax P-type ATPase4, putative 0.0035 0.0218 0.1823
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.01 0.2412
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0028 0.0132 0.287
Loa Loa (eye worm) hypothetical protein 0.0055 0.0459 0.1265
Brugia malayi beta-lactamase family protein 0.0035 0.022 0.0752
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2534 0.2473
Trichomonas vaginalis cation-transporting ATPase, putative 0.0035 0.0218 0.5241
Loa Loa (eye worm) E1-E2 ATPase 0.0022 0.0062 0.0172
Brugia malayi Na,K-ATPase alpha subunit 0.0086 0.0833 0.2852
Plasmodium falciparum calcium-transporting ATPase 0.0028 0.0132 0.287
Toxoplasma gondii facilitative glucose transporter GT1 0.0049 0.0389 1
Echinococcus multilocularis calcium transporting atpase 0.0028 0.0132 0.0135
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0028 0.0132 0.0166
Onchocerca volvulus 0.0048 0.0378 0.1041
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0459 0.0469
Trypanosoma brucei Aph-1 protein, putative 0.0101 0.1009 1
Echinococcus granulosus geminin 0.0674 0.7961 1
Brugia malayi heat shock protein 90 0.0032 0.0179 0.0615
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0378 0.0386
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0179 0.7953
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0049 0.0389 0.0489
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0028 0.0132 0.0166
Brugia malayi beta-lactamase family protein 0.0035 0.022 0.0752
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0459 0.0469
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0035 0.0218 0.0273
Echinococcus multilocularis nervana 2 0.0317 0.3627 0.371
Schistosoma mansoni hypothetical protein 0.0049 0.0389 0.0489
Plasmodium vivax calcium-transporting ATPase, putative 0.0035 0.0218 0.1823
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.01 0.0126
Schistosoma mansoni gamma-secretase subunit aph-1 0.0258 0.2919 0.3667
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0179 0.1612
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0079 0.0747 0.0764
Loa Loa (eye worm) hypothetical protein 0.0086 0.0833 0.2296
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.022 0.2018
Echinococcus granulosus calcium transporting atpase 0.0028 0.0132 0.0166
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0179 0.1238
Loa Loa (eye worm) hypothetical protein 0.0035 0.022 0.0606
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0179 0.0495
Onchocerca volvulus 0.0035 0.022 0.0606
Brugia malayi mbt repeat family protein 0.0048 0.0378 0.1293
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0317 0.3627 0.371
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0035 0.0218 0.9876
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Schistosoma mansoni ATPase 0.0035 0.0218 0.0273
Mycobacterium ulcerans heat shock protein 90 0.0026 0.01 0.002
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0378 0.0474
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.01 0.0811
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0075 0.0695 0.1918
Schistosoma mansoni hypothetical protein 0.0674 0.7961 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0317 0.3627 0.4555
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Plasmodium vivax hypothetical protein, conserved 0.0035 0.022 0.1916
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0086 0.0833 0.2296
Trichomonas vaginalis cation-transporting ATPase, putative 0.0022 0.0062 0.0923
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.022 0.014
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0179 0.1238
Onchocerca volvulus 0.0086 0.0833 0.2296
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0035 0.0218 0.1998
Mycobacterium ulcerans hypothetical protein 0.0035 0.022 0.014
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0035 0.0218 0.5241
Trypanosoma brucei heat shock protein, putative 0.0032 0.0179 0.1238
Echinococcus granulosus nervana 2 0.0195 0.2148 0.2698
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0179 0.3587
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0195 0.2148 0.2698
Brugia malayi beta-lactamase 0.0035 0.022 0.0752
Mycobacterium leprae Probable lipase LipE 0.0035 0.022 0.0121
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.01 0.0811
Trypanosoma brucei heat shock protein, putative 0.0032 0.0179 0.1238
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Loa Loa (eye worm) hypothetical protein 0.0035 0.0218 0.06
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0035 0.0218 0.1998
Loa Loa (eye worm) hypothetical protein 0.0035 0.022 0.0606
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0028 0.0132 0.2145
Leishmania major calcium-translocating P-type ATPase 0.0035 0.0218 0.9876
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Loa Loa (eye worm) MBCTL1 0.0055 0.0459 0.1265
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0378 0.0474
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0049 0.0389 0.0398
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0179 0.1612
Echinococcus granulosus General substrate transporter 0.0045 0.033 0.0415
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.2105 0.2153
Echinococcus granulosus heat shock protein 90 0.0026 0.01 0.0126
Onchocerca volvulus 0.0035 0.022 0.0606
Echinococcus multilocularis endoplasmin 0.0026 0.01 0.0102
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0317 0.3627 0.4555
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0075 0.0695 0.2383
Mycobacterium ulcerans lipase LipD 0.0035 0.022 0.014
Leishmania major calcium motive p-type ATPase, putative 0.0028 0.0132 0.4453
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.022 0.0752
Plasmodium falciparum hexose transporter 0.0049 0.0389 1
Echinococcus multilocularis heat shock protein 0.0032 0.0179 0.0184
Schistosoma mansoni ATPase 0.0035 0.0218 0.0273
Echinococcus granulosus nervana 2 0.0317 0.3627 0.4555
Trypanosoma cruzi Aph-1 protein, putative 0.0101 0.1009 1
Schistosoma mansoni hypothetical protein 0.0674 0.7961 1
Echinococcus granulosus nervana 2 0.0317 0.3627 0.4555
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Echinococcus granulosus heat shock protein 90 0.0032 0.0179 0.0225
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0028 0.0132 0.0135
Loa Loa (eye worm) hypothetical protein 0.0062 0.054 0.1489
Trichomonas vaginalis esterase, putative 0.0035 0.022 0.5295
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.022 0.5295
Brugia malayi Membrane calcium atpase protein 3 0.0028 0.0132 0.0453
Toxoplasma gondii ABC1 family protein 0.0035 0.022 0.4816
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.01 0.5
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0028 0.0132 0.1135
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0195 0.2148 0.2698
Loa Loa (eye worm) endoplasmin 0.0032 0.0179 0.0495
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0258 0.2919 0.8049
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0035 0.0218 1
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0179 0.4179
Toxoplasma gondii P-type ATPase4, putative 0.0035 0.0218 0.4756
Leishmania major P-type ATPase, putative 0.0028 0.0132 0.4453
Brugia malayi Sugar transporter family protein 0.0049 0.0389 0.1333
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0079 0.0747 0.0939
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0179 0.3587
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0035 0.0218 0.5241
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.002 0.0031 0.0106
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0049 0.0389 0.0489
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0079 0.0747 1
Onchocerca volvulus 0.0035 0.022 0.0606
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0075 0.0695 0.0601
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.022 0.0606
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.022 0.014
Trypanosoma brucei heat shock protein, putative 0.0032 0.0179 0.1238
Trichomonas vaginalis cation-transporting ATPase, putative 0.0035 0.0218 0.5241
Echinococcus multilocularis General substrate transporter 0.0045 0.033 0.0338
Brugia malayi Endoplasmin precursor 0.0032 0.0179 0.0615
Loa Loa (eye worm) hypothetical protein 0.0035 0.022 0.0606
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0028 0.0132 0.1135
Echinococcus granulosus endoplasmin 0.0026 0.01 0.0126
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0378 0.0474
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0317 0.3627 0.4555
Loa Loa (eye worm) hypothetical protein 0.0048 0.0378 0.1041
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.022 0.014
Mycobacterium leprae conserved hypothetical protein 0.0035 0.022 0.0121
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.022 0.0276
Trypanosoma cruzi P-type H+-ATPase, putative 0.0022 0.0062 0.0427
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.022 0.5295
Plasmodium vivax hexose transporter 0.0049 0.0389 1
Brugia malayi mbt repeat family protein 0.0048 0.0378 0.1293
Schistosoma mansoni heat shock protein 0.0032 0.0179 0.0225
Trypanosoma cruzi Aph-1 protein, putative 0.0101 0.1009 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0459 0.0576
Leishmania major calcium-transporting ATPase, putative 0.0028 0.0132 0.4453
Trypanosoma brucei heat shock protein, putative 0.0032 0.0179 0.1238
Treponema pallidum heat shock protein 90 0.0026 0.01 0.5
Trichomonas vaginalis heat shock protein, putative 0.0026 0.01 0.1978
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0086 0.0833 0.0758
Loa Loa (eye worm) hypothetical protein 0.0317 0.3627 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.022 0.2018
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0317 0.3627 0.4555
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0035 0.0218 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.022 0.5295
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Schistosoma mansoni transmemberane protein 0.0317 0.3627 0.4555
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0195 0.2148 0.2198
Schistosoma mansoni glucose transport protein 0.0049 0.0389 0.0489
Trypanosoma brucei heat shock protein, putative 0.0032 0.0179 0.1238
Schistosoma mansoni hypothetical protein 0.0295 0.3361 0.4221
Schistosoma mansoni endoplasmin 0.0032 0.0179 0.0225
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.01 0.002
Mycobacterium tuberculosis Conserved protein 0.0035 0.022 0.014
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0028 0.0132 0.0453
Schistosoma mansoni heat shock protein 0.0032 0.0179 0.0225
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0459 0.0576
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0086 0.0833 0.1046
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.022 0.5295
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0035 0.0218 0.1641
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0179 0.1612
Loa Loa (eye worm) hypothetical protein 0.0317 0.3627 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0049 0.0389 0.0398
Mycobacterium ulcerans proteasome PrcA 0.0842 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0561 0.1546
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0179 0.1612
Leishmania major heat shock protein 83-1 0.0032 0.0179 0.7449
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0378 0.1041

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 13 % Antiinflammatory activity in Albino rat assessed as protection against carrageenin-induced hind paw oedema at 10 mg/kg, po after 3 hrs ChEMBL. 17336429
Activity (functional) = 29 % Antiinflammatory activity in Albino rat assessed as protection against carrageenin-induced hind paw oedema at 20 mg/kg, po after 3 hrs ChEMBL. 17336429
Activity (functional) = 42 % Antiinflammatory activity in Albino rat assessed as protection against carrageenin-induced hind paw oedema at 40 mg/kg, po after 3 hrs ChEMBL. 17336429

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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