Detailed information for compound 435954

Basic information

Technical information
  • TDR Targets ID: 435954
  • Name: 2-(1-adamantyl)-3-pyridin-3-yl-1,3-thiazolidi n-4-one
  • MW: 314.445 | Formula: C18H22N2OS
  • H donors: 0 H acceptors: 2 LogP: 3.73 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CSC(N1c1cccnc1)C12CC3CC(C2)CC(C1)C3
  • InChi: 1S/C18H22N2OS/c21-16-11-22-17(20(16)15-2-1-3-19-10-15)18-7-12-4-13(8-18)6-14(5-12)9-18/h1-3,10,12-14,17H,4-9,11H2
  • InChiKey: LIIUUVURTQBMEO-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-(1-adamantyl)-3-(3-pyridyl)thiazolidin-4-one
  • 2-(1-adamantyl)-3-(3-pyridyl)-4-thiazolidinone
  • 4-Thiazolidinone, 3-(pyridin-3-yl)-2-tricyclo[3.3.1.1~3,7~]dec-1-yl-
  • AIDS-471491
  • AIDS471491

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis slit 2 protein 0.0006 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Schistosoma mansoni ATPase 0.001 0.0027 0.0156
Leishmania major cathepsin L-like protease 0.0033 0.0117 0.2235
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0037 0.0133 0.0841
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0011 0.0031 0.0185
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0376 0.1498 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0165
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0262 0.1037 0.1028
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0058 0.0219 0.1445
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.001 0.0027 0.2289
Onchocerca volvulus 0.0037 0.0133 0.0841
Entamoeba histolytica type A flavoprotein, putative 0.001 0.0025 0.2063
Loa Loa (eye worm) hypothetical protein 0.0018 0.006 0.0399
Brugia malayi Cathepsin L-like precursor 0.0009 0.002 0.0136
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0037 0.0133 0.0891
Loa Loa (eye worm) animal heme peroxidase 0.0017 0.0055 0.0365
Brugia malayi hypothetical protein 0.003 0.0105 0.0701
Onchocerca volvulus 0.001 0.0025 0.0111
Trypanosoma cruzi oligopeptidase b 0.003 0.0106 0.2081
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0133 0.0869
Schistosoma mansoni hypothetical protein 0.0006 0.0008 0.003
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0006 0.0008 0.0001
Trypanosoma cruzi glyoxalase II 0.001 0.0025 0.0429
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0672 0.2686 0.2668
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0117 0.231
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0037 0.0133 0.0869
Schistosoma mansoni amine GPCR 0.0037 0.0133 0.0869
Onchocerca volvulus Cathepsin F homolog 0.0009 0.002 0.0082
Schistosoma mansoni cpg binding protein 0.0007 0.0015 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Mycobacterium tuberculosis Conserved protein 0.0024 0.0082 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Echinococcus granulosus dro:myosuppressin receptor 0.0037 0.0133 0.0869
Trichomonas vaginalis apoptosis inducing factor, putative 0.001 0.0025 0.0989
Onchocerca volvulus 0.0037 0.0133 0.0841
Onchocerca volvulus 0.0037 0.0133 0.0841
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0702
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.002 0.1633
Echinococcus multilocularis cathepsin L cysteine protease 0.0009 0.002 0.0112
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0133 0.0869
Trichomonas vaginalis cation-transporting ATPase, putative 0.0006 0.0008 0.0221
Mycobacterium leprae Probable lipase LipE 0.0024 0.0082 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0082 0.7643
Brugia malayi Cadherin domain containing protein 0.0006 0.0008 0.0055
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0037 0.0133 0.0869
Brugia malayi Cathepsin L-like precursor 0.0009 0.002 0.0136
Onchocerca volvulus Peroxidasin homolog 0.0017 0.0055 0.0313
Echinococcus multilocularis neurogenic locus notch protein 4 0.0006 0.0008 0.003
Brugia malayi Calcium binding EGF domain containing protein 0.0006 0.0008 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Plasmodium vivax vivapain-2 0.0009 0.002 0.1633
Brugia malayi Cadherin domain containing protein 0.0006 0.0008 0.0055
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0058 0.0219 0.1445
Trypanosoma cruzi P-type H+-ATPase, putative 0.0006 0.0008 0.0096
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0133 0.0869
Entamoeba histolytica metallo-beta-lactamase family protein 0.001 0.0025 0.2063
Onchocerca volvulus 0.001 0.0025 0.0111
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0007 0.0014 0.0068
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.001 0.0027 0.0477
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0365
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.002 0.0783
Schistosoma mansoni hypothetical protein 0.0099 0.0383 0.2541
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0007 0.0016 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0783
Mycobacterium ulcerans isocitrate lyase Icl 0.2493 1 1
Brugia malayi beta-lactamase family protein 0.0024 0.0082 0.0546
Schistosoma mansoni hypothetical protein 0.001 0.0025 0.0141
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.003 0.0106 0.0081
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0037 0.0133 0.0891
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0127 0.0494 0.1815
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0365
Loa Loa (eye worm) animal heme peroxidase 0.0017 0.0055 0.0365
Onchocerca volvulus 0.0024 0.0082 0.0494
Onchocerca volvulus 0.0037 0.0133 0.0841
Mycobacterium tuberculosis Probable esterase LipL 0.0024 0.0082 0.0071
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0783
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0783
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0027 0.1098
Mycobacterium tuberculosis Probable hydrolase 0.0024 0.0082 0.0071
Brugia malayi putative neuropeptide receptor 0.0037 0.0133 0.0891
Echinococcus granulosus fmrfamide receptor 0.0037 0.0133 0.0869
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0133 0.0869
Schistosoma mansoni opsin-like receptor 0.0037 0.0133 0.0869
Entamoeba histolytica hypothetical protein, conserved 0.003 0.0106 1
Echinococcus granulosus G protein coupled receptor 139 0.0037 0.0133 0.0869
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0783
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0133 0.0869
Echinococcus granulosus neuropeptide s receptor 0.0148 0.058 0.386
Onchocerca volvulus 0.0009 0.002 0.0082
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0024 0.0082 0.0071
Trypanosoma brucei calcium-translocating P-type ATPase 0.0011 0.0031 0.0562
Brugia malayi metallo-beta-lactamase superfamily protein 0.001 0.0025 0.0165
Schistosoma mansoni lamin 0.0007 0.0012 0.0057
Onchocerca volvulus 0.0024 0.0082 0.0494
Entamoeba histolytica hypothetical protein, conserved 0.001 0.0025 0.2063
Brugia malayi Serotonin receptor 0.0037 0.0133 0.0891
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) animal heme peroxidase 0.0017 0.0055 0.0365
Schistosoma mansoni zinc phosphodiesterase 0.001 0.0025 0.0141
Onchocerca volvulus 0.0029 0.0101 0.0623
Echinococcus granulosus protein jagged 2 0.0006 0.0008 0.003
Mycobacterium tuberculosis Probable peptidase 0.003 0.0106 0.0095
Echinococcus granulosus geminin 0.0041 0.0151 0.0983
Echinococcus granulosus dnaJ subfamily B 0.0099 0.0383 0.2541
Trypanosoma brucei calcium-transporting ATPase, putative 0.0007 0.0015 0.0226
Mycobacterium ulcerans beta lactamase-like protein 0.001 0.0025 0.0014
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Brugia malayi hypothetical protein 0.0037 0.0133 0.0891
Brugia malayi CXXC zinc finger family protein 0.0007 0.0014 0.0093
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.003 0.0105 0.0679
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0009 0.002 0.0136
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0165
Brugia malayi calcium ATPase 0.0006 0.0009 0.0059
Onchocerca volvulus Cathepsin L homolog 0.0009 0.002 0.0082
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0133 0.0869
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0009 0.002 0.0112
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0365
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.001 0.0027 0.1934
Schistosoma mansoni transmemberane protein 0.0058 0.0219 0.1445
Trypanosoma cruzi P-type H+-ATPase, putative 0.0006 0.0008 0.0096
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0133 0.0869
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.001 0.0027 0.0477
Schistosoma mansoni hypothetical protein 0.0037 0.0133 0.0869
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0133 0.0869
Trypanosoma cruzi cruzipain precursor, putative 0.0033 0.0117 0.231
Brugia malayi Calcium binding EGF domain containing protein 0.0006 0.0008 0.0055
Loa Loa (eye worm) fibroinase 0.0009 0.002 0.0136
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.003 0.0106 0.0364
Mycobacterium tuberculosis Conserved protein 0.0024 0.0082 0.0071
Brugia malayi Cathepsin L-like cysteine proteinase 0.0006 0.0009 0.006
Brugia malayi Blistered cuticle protein 3 0.0017 0.0055 0.0365
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0006 0.0008 0.0096
Brugia malayi Cathepsin L-like precursor 0.0009 0.002 0.0136
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0025 0.0989
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0031 0.1294
Leishmania major cathepsin L-like protease 0.0009 0.002 0.0246
Onchocerca volvulus 0.0037 0.0133 0.0841
Plasmodium falciparum cytosolic glyoxalase II 0.001 0.0025 0.2063
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0127 0.0494 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.002 0.0783
Echinococcus multilocularis beta LACTamase domain containing family member 0.0024 0.0082 0.0522
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.001 0.0025 0.0429
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0024 0.0082 0.0546
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0783
Onchocerca volvulus 0.0009 0.002 0.0082
Mycobacterium ulcerans lipase LipD 0.0024 0.0082 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0009 0.002 0.0783
Entamoeba histolytica prolyl oligopeptidase family protein 0.003 0.0106 1
Echinococcus granulosus ETHE1 protein 0.001 0.0025 0.0141
Echinococcus multilocularis acylamino acid releasing enzyme 0.003 0.0106 0.0683
Loa Loa (eye worm) Notch2 0.0006 0.0008 0.0055
Mycobacterium tuberculosis Conserved protein 0.001 0.0025 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.002 0.1633
Echinococcus multilocularis serotonin receptor 0.0037 0.0133 0.0869
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.001 0.0027 0.0384
Echinococcus granulosus g protein coupled receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0133 0.0869
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0037 0.0133 0.0891
Onchocerca volvulus Neuropeptide F receptor homolog 0.0037 0.0133 0.0841
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0025 0.0989
Echinococcus multilocularis cathepsin L cysteine protease 0.0009 0.002 0.0112
Mycobacterium ulcerans hydrolase 0.001 0.0025 0.0014
Echinococcus multilocularis neuropeptide s receptor 0.0148 0.058 0.386
Schistosoma mansoni ATPase 0.001 0.0027 0.0156
Trichomonas vaginalis beta lactamase domain, putative 0.001 0.0025 0.0989
Trypanosoma brucei transcription factor BTF3, putative 0.0008 0.002 0.0331
Loa Loa (eye worm) hypothetical protein 0.003 0.0106 0.0706
Brugia malayi Pre-SET motif family protein 0.0007 0.0016 0.0104
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0365
Brugia malayi GCC2 and GCC3 family protein 0.0006 0.0008 0.0055
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0006 0.0008 0.0000000081543
Onchocerca volvulus 0.0017 0.0055 0.0313
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.002 0.0783
Giardia lamblia Alanyl dipeptidyl peptidase 0.003 0.0106 1
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0133 0.0891
Schistosoma mansoni hypothetical protein 0.001 0.0025 0.0141
Trypanosoma cruzi transcription factor btf3, putative 0.0008 0.002 0.0331
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0365
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0082 0.3664
Echinococcus granulosus prolyl endopeptidase 0.003 0.0106 0.0683
Brugia malayi hypothetical protein 0.0037 0.0133 0.0891
Onchocerca volvulus 0.0007 0.0014 0.0038
Onchocerca volvulus Neurogenic locus notch homolog 0.0006 0.0008 0.0000000081543
Echinococcus granulosus somatostatin receptor 0.0037 0.0133 0.0869
Onchocerca volvulus 0.0037 0.0133 0.0841
Leishmania major P-type ATPase, putative 0.0011 0.0031 0.0471
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0011 0.0031 0.0185
Brugia malayi follicle stimulating hormone receptor 0.0092 0.0357 0.2383
Brugia malayi EGF-like domain containing protein 0.0006 0.0008 0.0055
Brugia malayi G-protein coupled receptor 0.0037 0.0133 0.0891
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0006 0.0008 0.003
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0058 0.0219 0.1445
Schistosoma mansoni intermediate filament proteins 0.0007 0.0012 0.0057
Echinococcus multilocularis ETHE1 protein 0.001 0.0025 0.0141
Brugia malayi Papain family cysteine protease containing protein 0.0004 0.0004 0.0025
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0117 0.231
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0546
Echinococcus multilocularis cpg binding protein 0.0007 0.0015 0.0079
Trypanosoma cruzi cysteine peptidase, putative 0.0009 0.002 0.034
Brugia malayi hypothetical protein 0.001 0.0025 0.0165
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0011 0.0031 0.0562
Echinococcus granulosus calcium transporting atpase 0.0011 0.0031 0.0185
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Echinococcus granulosus metallo beta lactamase domain containing protein 0.001 0.0025 0.0141
Toxoplasma gondii cathepsin CPL 0.0009 0.002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Brugia malayi beta-lactamase 0.0024 0.0082 0.0546
Schistosoma mansoni notch 0.0006 0.0008 0.003
Brugia malayi Cathepsin L-like precursor 0.0009 0.002 0.0136
Brugia malayi beta-lactamase family protein 0.0024 0.0082 0.0546
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0025 0.0989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0783
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0701
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0117 0.231
Mycobacterium tuberculosis Probable lipase LipE 0.0024 0.0082 0.0071
Loa Loa (eye worm) calcium ATPase 0.0006 0.0009 0.0059
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.003 0.0106 0.2081
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0011 0.0031 0.0185
Schistosoma mansoni hypothetical protein 0.0037 0.0133 0.0869
Onchocerca volvulus 0.0037 0.0133 0.0841
Brugia malayi calcium ATPase 0.0006 0.0008 0.0056
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.003 0.0106 0.0683
Echinococcus granulosus lamin 0.0007 0.0012 0.0057
Schistosoma mansoni cathepsin F (C01 family) 0.0009 0.002 0.0112
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Schistosoma mansoni lamin 0.0007 0.0012 0.0057
Brugia malayi Dopamine receptor protein 1 0.0037 0.0133 0.0891
Schistosoma mansoni na+/k+ atpase alpha subunit 0.003 0.0105 0.0679
Leishmania major cathepsin L-like protease 0.0009 0.002 0.0246
Echinococcus granulosus beta LACTamase domain containing family member 0.0024 0.0082 0.0522
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Onchocerca volvulus Prolyl endopeptidase homolog 0.003 0.0106 0.0655
Brugia malayi G protein-coupled receptor F59B2.13 0.0037 0.0133 0.0891
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0082 0.1591
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0011 0.0031 0.0562
Schistosoma mansoni microtubule-associated protein tau 0.0167 0.0656 0.4368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0117 0.231
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0262 0.1037 0.1015
Schistosoma mansoni amine GPCR 0.0037 0.0133 0.0869
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0546
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0411 0.1635 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0058 0.0219 0.1445
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0117 0.231
Loa Loa (eye worm) hypothetical protein 0.0097 0.0374 0.25
Brugia malayi prolyl oligopeptidase family protein 0.003 0.0106 0.0706
Brugia malayi prolyl oligopeptidase family protein 0.003 0.0106 0.0706
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0133 0.0869
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0082 0.3664
Echinococcus multilocularis nervana 2 0.0058 0.0219 0.1445
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0152 0.0598 0.0588
Mycobacterium ulcerans hypothetical protein 0.0024 0.0082 0.0071
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0701
Entamoeba histolytica cysteine proteinase, putative 0.0006 0.0009 0.052
Echinococcus multilocularis neurogenic locus notch protein 0.0006 0.0008 0.003
Schistosoma mansoni hypothetical protein 0.0006 0.0008 0.003
Onchocerca volvulus Huntingtin homolog 0.003 0.0105 0.065
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0011 0.0031 0.0086
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0025 0.0084 0.006
Echinococcus multilocularis notch 0.0006 0.0008 0.003
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0133 0.0869
Toxoplasma gondii NAC domain-containing protein 0.0008 0.002 0.0044
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.003 0.0106 0.0683
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0117 0.231
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0058 0.0219 0.1445
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0133 0.0869
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.2493 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0037 0.0133 0.0869
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Schistosoma mansoni adenoreceptor 0.0037 0.0133 0.0869
Echinococcus granulosus alpha 1A adrenergic receptor 0.0037 0.0133 0.0869
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0117 0.231
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0011 0.0031 0.0185
Onchocerca volvulus Peroxidasin homolog 0.0017 0.0055 0.0313
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0133 0.0869
Brugia malayi Melatonin receptor type 1A 0.0037 0.0133 0.0891
Schistosoma mansoni amine GPCR 0.0037 0.0133 0.0869
Leishmania major cysteine peptidase A (CPA) 0.0009 0.002 0.0246
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Brugia malayi hypothetical protein 0.0037 0.0133 0.0891
Echinococcus granulosus g protein coupled receptor 0.0037 0.0133 0.0869
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0007 0.0013 0.0871
Echinococcus multilocularis dro:myosuppressin receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Echinococcus granulosus cathepsin l1 0.0006 0.0009 0.0036
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0048 0.0179 0.1174
Echinococcus multilocularis protein jagged 1 0.0006 0.0008 0.003
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0011 0.0031 0.0185
Echinococcus multilocularis protein jagged 1 0.0006 0.0008 0.003
Entamoeba histolytica cysteine protease, putative 0.0009 0.002 0.1633
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.001 0.0025 0.0429
Loa Loa (eye worm) hypothetical protein 0.003 0.0106 0.0706
Echinococcus granulosus 7tm_1 domain containing protein 0.0037 0.0133 0.0869
Echinococcus multilocularis lamin dm0 0.0007 0.0012 0.0057
Brugia malayi Na,K-ATPase alpha subunit 0.003 0.0105 0.0702
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0011 0.0031 0.0185
Brugia malayi intermediate filament protein 0.0007 0.0012 0.0081
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0546
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0365
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0672 0.2686 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0133 0.0869
Entamoeba histolytica metallo-beta-lactamase family protein 0.001 0.0025 0.2063
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0011 0.0031 0.0185
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.001 0.0025 0.0062
Schistosoma mansoni neuropeptide receptor 0.0037 0.0133 0.0869
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0031 0.1294
Echinococcus multilocularis G protein coupled receptor 139 0.0037 0.0133 0.0869
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.003 0.0105 0.0702
Echinococcus granulosus histone lysine methyltransferase setb 0.0007 0.0016 0.008
Schistosoma mansoni neuropeptide receptor 0.0037 0.0133 0.0869
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.002 0.0783
Trypanosoma brucei oligopeptidase b 0.003 0.0106 0.2081
Brugia malayi neuropeptide F receptor 0.0037 0.0133 0.0891
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0006 0.0009 0.0249
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0027 0.1098
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0127 0.0494 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Brugia malayi G-protein coupled receptor 0.0037 0.0133 0.0891
Onchocerca volvulus 0.0009 0.002 0.0082
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0011 0.0031 0.0209
Schistosoma mansoni neuropeptide receptor 0.0037 0.0133 0.0869
Leishmania major cleavage and polyadenylation specificity factor, putative 0.001 0.0025 0.0337
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0365
Schistosoma mansoni biogenic amine receptor 0.0037 0.0133 0.0869
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0037 0.0133 0.0869
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0007 0.0016 0.008
Brugia malayi ORL1-like opioid receptor 0.0037 0.0133 0.0891
Schistosoma mansoni amine GPCR 0.0037 0.0133 0.0869
Echinococcus multilocularis nervana 2 0.0048 0.0179 0.1174
Onchocerca volvulus 0.0037 0.0133 0.0841
Brugia malayi G protein-coupled receptor 0.0037 0.0133 0.0891
Schistosoma mansoni growth hormone secretagogue receptor 0.0037 0.0133 0.0869
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0783
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Trichomonas vaginalis beta lactamase domain, putative 0.001 0.0025 0.0989
Toxoplasma gondii P-type ATPase PMA1 0.0006 0.0008 0.0001
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.003 0.0106 0.2005
Trypanosoma cruzi oligopeptidase b 0.003 0.0106 0.2081
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0037 0.0133 0.0891
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0117 0.231
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0024 0.0082 0.0071
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.003 0.0106 0.0683
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0048 0.0179 0.1174
Brugia malayi Animal haem peroxidase family protein 0.0017 0.0055 0.0365
Mycobacterium ulcerans hypothetical protein 0.001 0.0025 0.0014
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0037 0.0133 0.0869
Onchocerca volvulus 0.0037 0.0133 0.0841
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0133 0.0869
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0048 0.0179 0.1174
Loa Loa (eye worm) prolyl oligopeptidase 0.003 0.0106 0.0706
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0037 0.0133 0.0869
Brugia malayi GnHR receptor homolog 0.0037 0.0133 0.0891
Onchocerca volvulus Peroxidase homolog 0.0017 0.0055 0.0313
Trichomonas vaginalis cation-transporting ATPase, putative 0.001 0.0027 0.1098
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0133 0.0891
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0783
Brugia malayi hypothetical protein 0.0037 0.0133 0.0891
Loa Loa (eye worm) notch protein 0.0006 0.0008 0.0055
Brugia malayi beta-NAC-like protein 0.0008 0.002 0.0133
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0099
Echinococcus multilocularis geminin 0.0041 0.0151 0.0983
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0181
Toxoplasma gondii histone lysine methyltransferase SET1 0.0013 0.004 0.0118
Plasmodium vivax vivapain-2 0.0009 0.002 0.1633
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0007 0.0016 0.0028
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0411 0.1635 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0376 0.1498 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Onchocerca volvulus Chorion peroxidase homolog 0.0017 0.0055 0.0313
Brugia malayi Animal haem peroxidase family protein 0.0017 0.0055 0.0365
Onchocerca volvulus 0.0037 0.0133 0.0841
Echinococcus granulosus neuropeptide FF receptor 2 0.0037 0.0133 0.0869
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0133 0.0869
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0024 0.0082 0.0071
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0376 0.1498 1
Echinococcus multilocularis lamin 0.0007 0.0012 0.0057
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0133 0.0869
Onchocerca volvulus 0.0058 0.0219 0.1419
Echinococcus granulosus neuropeptide receptor 0.0037 0.0133 0.0869
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0037 0.0133 0.0869
Trypanosoma brucei P-type H+-ATPase, putative 0.0006 0.0008 0.0096
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Leishmania major calcium-translocating P-type ATPase 0.001 0.0027 0.0384
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0011 0.0031 0.0021
Echinococcus multilocularis peroxidasin 0.0017 0.0055 0.0342
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0007 0.0015 0.0099
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.001 0.0025 0.2063
Trypanosoma cruzi major cysteine proteinase, putative 0.0026 0.0089 0.1738
Echinococcus granulosus peptide allatostatin:somatostatin 0.0037 0.0133 0.0869
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0037 0.0133 0.0869
Leishmania major cathepsin L-like protease 0.0009 0.002 0.0246
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0783
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0037 0.0133 0.0891
Mycobacterium ulcerans glyoxalase II, GloB 0.001 0.0025 0.0014
Echinococcus granulosus nervana 2 0.0058 0.0219 0.1445
Toxoplasma gondii P-type ATPase4, putative 0.0011 0.0031 0.0086
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.001 0.0027 0.0477
Onchocerca volvulus 0.0007 0.0012 0.0027
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Schistosoma mansoni cpg binding protein 0.0007 0.0014 0.0068
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.001 0.0025 0.0165
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.006
Trypanosoma cruzi Calcium ATPase SERCA-like 0.001 0.0027 0.0477
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Brugia malayi cathepsin L-like precursor 0.0006 0.0009 0.006
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0439
Loa Loa (eye worm) prolyl oligopeptidase 0.0376 0.1498 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Plasmodium falciparum calcium-transporting ATPase 0.0011 0.0031 0.27
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.001 0.0025 0.0429
Chlamydia trachomatis dehyroquinate synthase 0.0262 0.1037 0.3804
Echinococcus multilocularis protein jagged 2 0.0006 0.0008 0.003
Echinococcus granulosus acylamino acid releasing enzyme 0.003 0.0106 0.0683
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.001 0.0025 0.0141
Entamoeba histolytica prolyl oligopeptidase family protein 0.003 0.0106 1
Loa Loa (eye worm) animal heme peroxidase 0.0017 0.0055 0.0365
Schistosoma mansoni hypothetical protein 0.0006 0.0008 0.003
Echinococcus granulosus protein jagged 1 0.0006 0.0008 0.003
Echinococcus multilocularis dnaJ subfamily B 0.0099 0.0383 0.2541
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0411 0.1635 0.6051
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0037 0.0133 0.0891
Schistosoma mansoni myosin xvIII 0.0037 0.0133 0.0869
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0783
Echinococcus multilocularis zinc phosphodiesterase 0.001 0.0025 0.0141
Loa Loa (eye worm) hypothetical protein 0.003 0.0106 0.0706
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0026 0.0089 0.0592
Echinococcus granulosus peroxidasin 0.0017 0.0055 0.0342
Trichomonas vaginalis beta lactamase domain, putative 0.001 0.0025 0.0989
Onchocerca volvulus 0.0037 0.0133 0.0841
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Schistosoma mansoni alpha-1 adrenergic receptor 0.0037 0.0133 0.0869
Schistosoma mansoni notch 0.0006 0.0008 0.003
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0011 0.0031 0.0185
Echinococcus multilocularis nervana 2 0.0048 0.0179 0.1174
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0127 0.0494 0.3283
Leishmania major oligopeptidase b 0.003 0.0106 0.2005
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0058 0.0219 0.1445
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0007 0.0016 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0783
Brugia malayi Dopamine receptor 0.0037 0.0133 0.0891
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Brugia malayi larval opioid receptor 0.0037 0.0133 0.0891
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0783
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.003 0.0105 0.993
Brugia malayi EGF-like domain containing protein 0.0006 0.0008 0.0055
Echinococcus granulosus lamin dm0 0.0007 0.0012 0.0057
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0546
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0082 0.1591
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.002 0.0783
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0016
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.001 0.0027 0.0477
Echinococcus multilocularis neuropeptide receptor A26 0.0148 0.058 0.386
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0082 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0783
Brugia malayi Pre-SET motif family protein 0.005 0.0189 0.126
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0009 0.002 0.0783
Leishmania major cathepsin L-like protease 0.0009 0.002 0.0246
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0025 0.0989
Leishmania major calcium motive p-type ATPase, putative 0.0011 0.0031 0.0471
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0029 0.0101 0.009
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.2493 1 1
Brugia malayi Muscle positioning protein 4 0.0006 0.0008 0.0055
Entamoeba histolytica prolyl oligopeptidase family protein 0.003 0.0106 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0133 0.0869
Onchocerca volvulus 0.0037 0.0133 0.0841
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0011 0.0031 0.27
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0005 0.0005 0.002
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.001 0.0027 0.1934
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0136
Mycobacterium ulcerans hydrolase 0.001 0.0025 0.0014
Plasmodium vivax calcium-transporting ATPase, putative 0.0011 0.0031 0.27
Onchocerca volvulus 0.0017 0.0055 0.0313
Schistosoma mansoni hypothetical protein 0.0037 0.0133 0.0869
Echinococcus multilocularis fat cadherin tumor suppressor 0.0006 0.0008 0.003
Echinococcus granulosus tachykinin peptides receptor 99D 0.0037 0.0133 0.0869
Echinococcus multilocularis prolyl endopeptidase 0.003 0.0106 0.0683
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.001 0.0027 0.0156
Trichomonas vaginalis set domain proteins, putative 0.0057 0.0217 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0365
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0262 0.1037 0.1028
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0133 0.0869
Brugia malayi hypothetical protein 0.0037 0.0133 0.0891
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0037 0.0133 0.0891
Echinococcus granulosus slit 2 protein 0.0006 0.0008 0.003
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0058 0.0219 0.1445
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0006 0.0008 0.0055
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.001 0.0025 0.0429
Onchocerca volvulus 0.0037 0.0133 0.0841
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.001 0.0025 0.0429
Brugia malayi hypothetical protein 0.0037 0.0133 0.0891
Giardia lamblia Hydroxyacylglutathione hydrolase 0.001 0.0025 0.1696
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.003 0.0106 0.4794
Echinococcus granulosus allatostatin A receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0133 0.0891
Echinococcus multilocularis cysteine protease 0.0009 0.002 0.0112
Loa Loa (eye worm) CXXC zinc finger family protein 0.0007 0.0014 0.0093
Trichomonas vaginalis penicillin-binding protein, putative 0.0024 0.0082 0.3664
Schistosoma mansoni amine GPCR 0.0037 0.0133 0.0869
Brugia malayi Dopamine receptor protein 2 0.0037 0.0133 0.0891
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.001 0.0025 0.1696
Schistosoma mansoni hypothetical protein 0.0006 0.0008 0.003
Loa Loa (eye worm) TYRA-2 protein 0.0037 0.0133 0.0891
Loa Loa (eye worm) hypothetical protein 0.0004 0.0002 0.0016
Brugia malayi hypothetical protein 0.0037 0.0133 0.0891
Schistosoma mansoni hypothetical protein 0.0006 0.0008 0.003
Brugia malayi ethe1-prov protein 0.001 0.0025 0.0165
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Mycobacterium tuberculosis Probable lipase LipD 0.0024 0.0082 0.0071
Plasmodium vivax unspecified product 0.001 0.0025 0.2063
Brugia malayi EGF-like domain containing protein 0.0006 0.0008 0.0055
Mycobacterium ulcerans beta-lactamase 0.0024 0.0082 0.0071
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0024 0.0082 0.0546
Plasmodium vivax SET domain protein, putative 0.0007 0.0016 0.1165
Brugia malayi EGF-like domain containing protein 0.0006 0.0008 0.0055
Brugia malayi Cathepsin L-like precursor 0.0009 0.002 0.0136
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.003 0.0105 0.0679
Onchocerca volvulus Peroxidase homolog 0.0017 0.0055 0.0313
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0006 0.0009 0.0059
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0011 0.0031 0.0562
Echinococcus granulosus fibropellin Ia 0.0006 0.0008 0.003
Toxoplasma gondii prolyl endopeptidase 0.003 0.0106 0.0364
Echinococcus granulosus neural cadherin 0.0006 0.0008 0.003
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0376 0.1498 1
Mycobacterium ulcerans hypothetical protein 0.001 0.0025 0.0014
Schistosoma mansoni zinc phosphodiesterase 0.001 0.0025 0.0141
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0037 0.0133 0.0869
Giardia lamblia Hydroxyacylglutathione hydrolase 0.001 0.0025 0.1696
Entamoeba histolytica transcription factor BTF3, putative 0.0008 0.002 0.1591
Echinococcus multilocularis calcium transporting atpase 0.0011 0.0031 0.0185
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0546
Plasmodium falciparum peptidase, putative 0.003 0.0106 1
Schistosoma mansoni hypothetical protein 0.0041 0.0151 0.0983
Toxoplasma gondii ABC1 family protein 0.0024 0.0082 0.0275
Brugia malayi E1-E2 ATPase family protein 0.0007 0.0013 0.0084
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.2493 1 1
Echinococcus granulosus orexin receptor type 2 0.0037 0.0133 0.0869
Plasmodium vivax hypothetical protein, conserved 0.003 0.0106 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0009 0.002 0.1633
Trypanosoma brucei P-type H+-ATPase, putative 0.0006 0.0008 0.0096
Loa Loa (eye worm) hypothetical protein 0.0007 0.0016 0.0104
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.001 0.0025 0.0337
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0133 0.0869
Echinococcus granulosus cpg binding protein 0.0007 0.0015 0.0079
Mycobacterium tuberculosis Conserved hypothetical protein 0.001 0.0025 0.0014
Echinococcus granulosus nervana 2 0.0058 0.0219 0.1445
Schistosoma mansoni opsin-like receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Schistosoma mansoni laminin gamma-3 chain 0.0006 0.0008 0.003
Echinococcus granulosus neurogenic locus notch protein 4 0.0006 0.0008 0.003
Trichomonas vaginalis cation-transporting ATPase, putative 0.001 0.0027 0.1098
Entamoeba histolytica dipeptidyl-peptidase, putative 0.003 0.0106 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0127 0.0494 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0024 0.0082 0.0522
Onchocerca volvulus 0.0024 0.0082 0.0494
Mycobacterium tuberculosis Possible hydrolase 0.001 0.0025 0.0014
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Echinococcus multilocularis nervana 2 0.0058 0.0219 0.1445
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0133 0.0869
Brugia malayi Delta serrate ligand family protein 0.0006 0.0008 0.0055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.002 0.0783
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0009 0.002 0.1633
Onchocerca volvulus 0.0009 0.002 0.0082
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.003 0.0106 0.0683
Echinococcus multilocularis neuropeptide FF receptor 2 0.0037 0.0133 0.0869
Leishmania major hypothetical protein, conserved 0.0024 0.0082 0.1509
Brugia malayi EGF-like domain containing protein 0.0006 0.0008 0.0055
Trypanosoma cruzi transcription factor btf3, putative 0.0008 0.002 0.0331
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0127 0.0494 0.3283
Leishmania major metallo-beta-lactamase family-like protein 0.001 0.0025 0.0337
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0011 0.0031 0.0185
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0117 0.231
Echinococcus multilocularis serotonin receptor 0.0037 0.0133 0.0869
Echinococcus granulosus sex peptide receptor 0.0037 0.0133 0.0869
Mycobacterium ulcerans Zn-dependent glyoxylase 0.001 0.0025 0.0014
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.001 0.0025 0.0141
Trypanosoma cruzi glyoxalase II 0.001 0.0025 0.0429
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0117 0.231
Echinococcus granulosus neurogenic locus notch protein 0.0006 0.0008 0.003
Schistosoma mansoni hypothetical protein 0.0037 0.0133 0.0869
Plasmodium falciparum basic transcription factor 3b, putative 0.0008 0.002 0.1591
Trichomonas vaginalis beta lactamase domain, putative 0.001 0.0025 0.0989
Schistosoma mansoni cathepsin F (C01 family) 0.0009 0.002 0.0112
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0037 0.0133 0.0891
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0037 0.0133 0.0869
Schistosoma mansoni hypothetical protein 0.0006 0.0008 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Entamoeba histolytica dipeptidyl-peptidase, putative 0.003 0.0106 1
Echinococcus granulosus Na:K ATPase alpha subunit 0.003 0.0105 0.0679
Onchocerca volvulus 0.0007 0.0012 0.0027
Leishmania major basic transcription factor 3a, putative 0.0008 0.002 0.0238
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0365
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.001 0.0025 0.0062
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.001 0.0025 0.0165
Onchocerca volvulus 0.0037 0.0133 0.0841
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0133 0.0869
Schistosoma mansoni peroxidasin 0.0017 0.0055 0.0342
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Trichomonas vaginalis beta lactamase domain, putative 0.001 0.0025 0.0989
Trichomonas vaginalis D-aminoacylase, putative 0.0024 0.0082 0.3664
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0007 0.0016 0.008
Mycobacterium ulcerans hydrolase 0.001 0.0025 0.0014
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0006 0.0009 0.0504
Loa Loa (eye worm) intermediate filament protein 0.0007 0.0012 0.0081
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Echinococcus multilocularis neural cadherin 0.0006 0.0008 0.003
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0026 0.0089 0.0592
Echinococcus multilocularis cysteine protease 0.0009 0.002 0.0112
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.005 0.0189 0.126
Onchocerca volvulus Huntingtin homolog 0.003 0.0105 0.065
Brugia malayi putative neuropeptide receptor NPR1 0.0037 0.0133 0.0891
Brugia malayi Cathepsin L-like precursor 0.0006 0.0009 0.006
Echinococcus granulosus neurogenic locus protein delta 0.0006 0.0008 0.003
Entamoeba histolytica alkyl sulfatase, putative 0.001 0.0025 0.2063
Onchocerca volvulus 0.0037 0.0133 0.0841
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0006 0.0008 0.0056
Schistosoma mansoni 3-dehydroquinate synthase 0.0262 0.1037 0.6918
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Echinococcus multilocularis allatostatin A receptor 0.0037 0.0133 0.0869
Brugia malayi Tachykinin-like peptides receptor 99D 0.0037 0.0133 0.0891
Echinococcus multilocularis G-protein coupled receptor, putative 0.0037 0.0133 0.0869
Echinococcus granulosus delta-like protein 1 0.0006 0.0008 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0133 0.0869
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0092 0.0357 0.2383
Onchocerca volvulus 0.0057 0.0217 0.14
Trypanosoma brucei prolyl oligopeptidase, putative 0.003 0.0106 0.2081
Schistosoma mansoni neuropeptide receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0007 0.0012 0.0081
Mycobacterium ulcerans hypothetical protein 0.001 0.0025 0.0014
Plasmodium vivax P-type ATPase4, putative 0.0011 0.0031 0.27
Schistosoma mansoni slit 0.0006 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0165
Trichomonas vaginalis A-type flavoprotein 0.001 0.0025 0.0989
Brugia malayi hypothetical protein 0.0037 0.0133 0.0891
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.001 0.0027 0.1098
Onchocerca volvulus 0.0037 0.0133 0.0841
Trypanosoma cruzi P-type H+-ATPase, putative 0.0006 0.0008 0.0096
Loa Loa (eye worm) ctsf protein 0.0009 0.002 0.0136
Brugia malayi neuropeptide F receptor 0.0037 0.0133 0.0891
Toxoplasma gondii hypothetical protein 0.003 0.0106 0.0364
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0127 0.0494 1
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0117 0.231
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0005 0.0005 0.0094
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0133 0.0869
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0133 0.0869
Onchocerca volvulus Cathepsin L homolog 0.0009 0.002 0.0082
Echinococcus granulosus intermediate filament protein 0.0007 0.0012 0.0057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Schistosoma mansoni opsin-like receptor 0.0037 0.0133 0.0869
Echinococcus multilocularis orexin receptor type 2 0.0037 0.0133 0.0869
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0133 0.0869
Mycobacterium tuberculosis Conserved hypothetical protein 0.001 0.0025 0.0014
Brugia malayi Papain family cysteine protease containing protein 0.0004 0.0004 0.0025
Brugia malayi prolyl oligopeptidase family protein 0.0376 0.1498 1
Loa Loa (eye worm) E1-E2 ATPase 0.0006 0.0008 0.0056
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0672 0.2686 0.2679
Brugia malayi hypothetical protein 0.0037 0.0133 0.0891
Echinococcus multilocularis somatostatin receptor 0.0037 0.0133 0.0869
Schistosoma mansoni hypothetical protein 0.001 0.0025 0.0141
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0037 0.0133 0.0869
Brugia malayi Serotonin receptor 0.0037 0.0133 0.0891
Brugia malayi Animal haem peroxidase family protein 0.0017 0.0055 0.0365
Brugia malayi Cathepsin L-like precursor 0.0009 0.002 0.0136
Mycobacterium tuberculosis Conserved protein 0.001 0.0025 0.0014
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0027 0.1098
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0011 0.0031 0.0185
Echinococcus granulosus transcription factor btf3 0.0008 0.002 0.0109
Mycobacterium tuberculosis Conserved protein 0.001 0.0025 0.0014
Echinococcus granulosus cathepsin l cysteine peptidase 0.0009 0.002 0.0112
Trypanosoma cruzi glyoxalase II 0.001 0.0025 0.0429
Echinococcus granulosus g-protein coupled receptor 0.0037 0.0133 0.0869
Trichomonas vaginalis beta lactamase domain, putative 0.001 0.0025 0.0989
Brugia malayi Animal haem peroxidase family protein 0.0017 0.0055 0.0365
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0365
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.001 0.0025 0.2063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0007 0.0016 0.008
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0133 0.0869
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.001 0.0025 0.0111
Onchocerca volvulus 0.0007 0.0016 0.005
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0133 0.0869
Brugia malayi RE15519p 0.0037 0.0133 0.0891
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0046 0.0285
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0133 0.0869
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0025 0.0989
Echinococcus multilocularis neurogenic locus notch protein 0.0006 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Brugia malayi hypothetical protein 0.0037 0.0133 0.0891
Loa Loa (eye worm) blistered cuticle protein 3 0.0017 0.0055 0.0365
Schistosoma mansoni notch 0.0006 0.0008 0.003
Brugia malayi sulfakinin receptor protein 0.0037 0.0133 0.0891
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) beta-lactamase 0.0024 0.0082 0.0546
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0672 0.2686 1
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.001 0.0025 0.0429
Echinococcus granulosus notch 0.0006 0.0008 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Entamoeba histolytica hypothetical protein 0.0008 0.002 0.1591
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.003 0.0106 0.2081
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0006 0.0008 0.0096
Echinococcus multilocularis fibropellin Ia 0.0006 0.0008 0.003
Brugia malayi prolyl oligopeptidase family protein 0.0127 0.0494 0.33
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0117 0.231
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.003 0.0106 0.4794
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.006
Loa Loa (eye worm) hypothetical protein 0.0006 0.0009 0.006
Schistosoma mansoni biogenic amine receptor 0.0037 0.0133 0.0869
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.001 0.0025 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0106 0.4794
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0106 0.2081
Echinococcus granulosus microtubule associated protein 2 0.0167 0.0656 0.4368
Plasmodium vivax basic transcription factor 3b, putative 0.0008 0.002 0.1591
Echinococcus granulosus neuropeptide receptor A26 0.0148 0.058 0.386
Giardia lamblia Alanyl dipeptidyl peptidase 0.003 0.0106 1
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0133 0.0891
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0365
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.001 0.0027 0.0477
Brugia malayi EGF-like domain containing protein 0.0006 0.0008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.1466
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Entamoeba histolytica metallo-beta-lactamase family protein 0.001 0.0025 0.2063
Leishmania major metallo-beta-lactamase family protein-like protein 0.001 0.0025 0.0337
Schistosoma mansoni notch 0.0006 0.0008 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0133 0.0869
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0048 0.0179 0.1174
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.001 0.0025 0.0429
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.001 0.0025 0.0429
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.003 0.0106 0.2081
Brugia malayi Intermediate filament tail domain containing protein 0.0007 0.0012 0.0081
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0411 0.1635 0.1626
Echinococcus multilocularis microtubule associated protein 2 0.0167 0.0656 0.4368
Trypanosoma brucei prolyl endopeptidase 0.003 0.0106 0.2081
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0546
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.003 0.0106 0.0095
Brugia malayi hypothetical protein 0.0017 0.0055 0.0365
Entamoeba histolytica alkyl sulfatase, putative 0.001 0.0025 0.2063
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0009 0.002 0.0112
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Schistosoma mansoni transcription factor btf3 0.0008 0.002 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0025 0.0989
Echinococcus granulosus g protein coupled receptor 0.0037 0.0133 0.0869
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0783
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0025 0.0989
Mycobacterium tuberculosis Conserved protein 0.0024 0.0082 0.0071
Mycobacterium tuberculosis Beta lactamase like protein 0.001 0.0025 0.0014
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0007 0.0015 0.0226
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.001 0.0027 0.2289
Loa Loa (eye worm) cysteine protease 0.0009 0.002 0.0136
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0165
Brugia malayi hypothetical protein 0.0097 0.0374 0.25
Brugia malayi notch-like transmembrane receptor 0.0006 0.0008 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.002 0.0763
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.001 0.0025 0.2063
Entamoeba histolytica type A flavoprotein, putative 0.001 0.0025 0.2063
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.001 0.0025 0.0429
Brugia malayi Animal haem peroxidase family protein 0.0017 0.0055 0.0365
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.001 0.0027 0.0156
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0082 0.1591
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0009 0.002 0.0136
Schistosoma mansoni histamine h1 receptor 0.0037 0.0133 0.0869
Schistosoma mansoni cell polarity protein 0.0006 0.0008 0.003
Schistosoma mansoni cathepsin F (C01 family) 0.0006 0.0009 0.0036
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0011 0.0031 0.0185
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0133 0.0869
Echinococcus granulosus zinc phosphodiesterase 0.001 0.0025 0.0141
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.001 0.0027 0.007
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0011 0.0031 0.0185
Mycobacterium ulcerans esterase/lipase LipP 0.0024 0.0082 0.0071
Echinococcus multilocularis sex peptide receptor 0.0037 0.0133 0.0869
Echinococcus granulosus metallo beta lactamase domain containing protein 0.001 0.0025 0.0141
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.001 0.0027 0.0384
Trypanosoma cruzi prolyl endopeptidase 0.003 0.0106 0.2081
Trypanosoma brucei glyoxalase II 0.001 0.0025 0.0429
Leishmania major calcium-transporting ATPase, putative 0.0011 0.0031 0.0471
Leishmania major hypothetical protein, conserved 0.001 0.0025 0.0337
Schistosoma mansoni notch 0.0006 0.0008 0.003
Brugia malayi Cathepsin L-like precursor 0.0006 0.0009 0.006
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0037 0.0133 0.0869
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0037 0.0133 0.0869
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0127 0.0494 1
Onchocerca volvulus Putative hydrolase PNKD 0.001 0.0025 0.0111
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Echinococcus granulosus protein jagged 2 0.0006 0.0008 0.003
Brugia malayi Calcium binding EGF domain containing protein 0.0006 0.0008 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0133 0.0869
Leishmania major cathepsin L-like protease 0.0033 0.0117 0.2235
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.001 0.0025 0.0165
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0058 0.0219 0.1445
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) melatonin receptor type 1A 0.0037 0.0133 0.0891
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Mycobacterium tuberculosis Conserved hypothetical protein 0.001 0.0025 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0006 0.0009 0.0249
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.002 0.0763
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0037 0.0133 0.0869
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0262 0.1037 0.1028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Trichomonas vaginalis penicillin-binding protein, putative 0.0024 0.0082 0.3664
Schistosoma mansoni neuropeptide f receptor 76f 0.0037 0.0133 0.0869
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0133 0.0869
Echinococcus granulosus neuropeptide receptor 0.0037 0.0133 0.0869
Onchocerca volvulus 0.0009 0.002 0.0082
Onchocerca volvulus Dual oxidase homolog 0.0017 0.0055 0.0313
Loa Loa (eye worm) hypothetical protein 0.0058 0.0219 0.1466
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0037 0.0133 0.0869
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.003 0.0106 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0133 0.0869
Schistosoma mansoni septate junction protein 0.0006 0.0008 0.003
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0011 0.0031 0.27
Echinococcus multilocularis transcription factor btf3 0.0008 0.002 0.0109
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0133 0.0869
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0037 0.0133 0.0891
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0133 0.0869
Brugia malayi metallo-beta-lactamase superfamily protein 0.001 0.0025 0.0165
Echinococcus granulosus cathepsin L cysteine proteinase 0.0009 0.002 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0117 0.231
Onchocerca volvulus 0.0048 0.0179 0.1148
Echinococcus granulosus nervana 2 0.0048 0.0179 0.1174
Brugia malayi prolyl oligopeptidase family protein 0.003 0.0106 0.0706
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.002 0.0783
Brugia malayi AKH receptor 0.0037 0.0133 0.0891
Leishmania major cathepsin L-like protease 0.0009 0.002 0.0246
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.003 0.0106 0.2078
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.002 0.0136
Onchocerca volvulus 0.0009 0.002 0.0082
Echinococcus multilocularis g-protein coupled receptor 0.0037 0.0133 0.0869
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0011 0.0031 0.0086
Echinococcus granulosus neurogenic locus notch protein 0.0006 0.0008 0.003
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0027 0.1098
Onchocerca volvulus 0.0017 0.0055 0.0313
Echinococcus multilocularis neurogenic locus protein delta 0.0006 0.0008 0.003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0007 0.0016 0.008
Echinococcus granulosus 7TM GPCR rhodopsin 0.0037 0.0133 0.0869
Mycobacterium ulcerans hypothetical protein 0.001 0.0025 0.0014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0133 0.0869
Schistosoma mansoni peroxidasin 0.0017 0.0055 0.0342
Loa Loa (eye worm) hypothetical protein 0.0023 0.0078 0.0524
Schistosoma mansoni biogenic amine receptor 0.0037 0.0133 0.0869
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0117 0.231
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0133 0.0869
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0024 0.0082 0.0522
Trichomonas vaginalis cation-transporting ATPase, putative 0.001 0.0027 0.1098
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0365
Echinococcus granulosus serotonin receptor 0.0037 0.0133 0.0869
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0133 0.0869
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.003 0.0106 0.2005
Mycobacterium leprae Isocitrate lyase 0.1169 0.468 0.4667
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.001 0.0025 0.0165
Echinococcus granulosus protein jagged 1 0.0006 0.0008 0.003
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0037 0.0133 0.0869
Echinococcus granulosus hypothetical protein 0.0037 0.0133 0.0869
Onchocerca volvulus 0.0006 0.0009 0.0005
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.001 0.0025 0.0141
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0133 0.0869
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.002 0.0783
Mycobacterium ulcerans isocitrate lyase AceAb 0.2493 1 1
Leishmania major cathepsin L-like protease 0.0033 0.0117 0.2235
Onchocerca volvulus 0.0037 0.0133 0.0841
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0024 0.0082 0.0071
Schistosoma mansoni notch 0.0006 0.0008 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0009 0.002 0.0783
Echinococcus granulosus cathepsin l1 0.0009 0.002 0.0112
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.003 0.0106 0.2081
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0055
Echinococcus multilocularis musashi 0.0007 0.0012 0.0057
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0056
Brugia malayi EGF-like domain containing protein 0.0006 0.0008 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.002 0.0763
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0133 0.0869
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0011 0.0031 0.0185
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0365
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0133 0.0869
Schistosoma mansoni hypothetical protein 0.0006 0.0008 0.003
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.001 0.0027 0.2289
Mycobacterium tuberculosis Possible hydrolase 0.001 0.0025 0.0014
Brugia malayi Membrane calcium atpase protein 3 0.0011 0.0031 0.0209
Echinococcus granulosus Dipeptidyl peptidase 9 0.0127 0.0494 0.3283
Loa Loa (eye worm) ICD-1 protein 0.0008 0.002 0.0133
Loa Loa (eye worm) hypothetical protein 0.0006 0.0012 0.0078
Schistosoma mansoni hypothetical protein 0.0041 0.0151 0.0983
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0006 0.0008 0.0056
Trichomonas vaginalis esterase, putative 0.0024 0.0082 0.3664
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0106 0.2081
Echinococcus multilocularis neurogenic locus protein delta 0.0006 0.0008 0.003
Brugia malayi Peroxidasin 0.0017 0.0055 0.0365
Onchocerca volvulus 0.0009 0.002 0.0082
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.001 0.0025 0.0141
Echinococcus granulosus nervana 2 0.0048 0.0179 0.1174
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0007 0.0015 0.0099
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0009 0.002 0.1633
Schistosoma mansoni cpg binding protein 0.0007 0.0015 0.0079
Loa Loa (eye worm) hypothetical protein 0.0037 0.0133 0.0891

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Antiviral activity against influenza virus H3N2 in MDCK cells ChEMBL. 17321639
CC50 (ADMET) = 105 uM Cytotoxicity against CEM cells ChEMBL. 17321639
CC50 (ADMET) = 105 uM Cytotoxicity against CEM cells ChEMBL. 17321639
EC50 (functional) >= 32 uM Antiviral activity against HIV1 3B in CEM cells ChEMBL. 17321639
EC50 (functional) > 63 uM Antiviral activity against HIV2 ROD in CEM cells ChEMBL. 17321639
IC50 (binding) >= 636 uM Inhibition of HIV1 reverse transcriptase using Poly rC.dG template ChEMBL. 17321639
IC50 (binding) >= 636 uM Inhibition of HIV1 reverse transcriptase using Poly rA.dT template ChEMBL. 17321639
IC50 (binding) >= 636 uM Inhibition of HIV1 reverse transcriptase using Poly rC.dG template ChEMBL. 17321639
IC50 (binding) >= 636 uM Inhibition of HIV1 reverse transcriptase using Poly rA.dT template ChEMBL. 17321639
Ratio CC50/EC50 (functional) <= 3 Selectivity index, ratio of CC50 for CEM cells to EC50 for HIV1 infected CEM cells ChEMBL. 17321639

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.