Detailed information for compound 436189

Basic information

Technical information
  • TDR Targets ID: 436189
  • Name: diphenyleneiodonium
  • MW: 314.549 | Formula: C12H8ClI
  • H donors: 0 H acceptors: 0 LogP: 4.85 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc2c(c1)[I+]c1c2cccc1.[Cl-]
  • InChi: 1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1
  • InChiKey: FCFZKAVCDNTYID-UHFFFAOYSA-M  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • EU-0100367

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum dihydroorotate dehydrogenase Starlite/ChEMBL References
Saccharomyces cerevisiae dihydroorotate dehydrogenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative Get druggable targets OG5_127289 All targets in OG5_127289
Candida albicans likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma brucei gambiense dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma congolense dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Schistosoma mansoni dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania donovani dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD Get druggable targets OG5_127289 All targets in OG5_127289
Schistosoma japonicum ko:K00226 dihydroorotate oxidase [EC1.3.3.1], putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative Get druggable targets OG5_127289 All targets in OG5_127289
Neospora caninum dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania mexicana dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania braziliensis dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Candida albicans likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin Get druggable targets OG5_127289 All targets in OG5_127289
Theileria parva dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania infantum dihydroorotate dehydrogenase;with=GeneDB:LmjF16.0530 Get druggable targets OG5_127289 All targets in OG5_127289
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 Get druggable targets OG5_127289 All targets in OG5_127289
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium berghei dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium falciparum dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Babesia bovis dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium knowlesi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium yoelii dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania major dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0157 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Schistosoma mansoni mixed-lineage leukemia protein mll 0.014 0.233 0.2693
Schistosoma mansoni gabp alpha 0.0084 0.1302 0.1503
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0454 0.0527
Onchocerca volvulus 0.009 0.1412 1
Echinococcus granulosus tar DNA binding protein 0.0076 0.1152 0.1242
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.009 0.1412 0.1523
Brugia malayi Ets-domain containing protein 0.0084 0.1302 0.1299
Brugia malayi hypothetical protein 0.0042 0.0501 0.0499
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0454 0.0527
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Echinococcus granulosus geminin 0.0388 0.6979 0.7538
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0091 0.0094
Loa Loa (eye worm) fli-1 protein 0.0257 0.4519 0.4517
Brugia malayi hypothetical protein 0.0286 0.5062 0.5061
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.009 0.1412 0.141
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0049 0.0632 0.0728
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0497 0.058
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.009 0.1412 0.141
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Onchocerca volvulus 0.0039 0.0454 0.3203
Echinococcus granulosus nAChR subunit 0.009 0.1412 0.1523
Echinococcus granulosus bloom syndrome protein 0.0047 0.0607 0.0653
Echinococcus multilocularis glycine receptor subunit alpha 1 0.009 0.1412 0.1523
Schistosoma mansoni nAChR subunit 0.009 0.1412 0.163
Brugia malayi Inositol-1 0.0041 0.0497 0.0495
Schistosoma mansoni ferritin light chain 0.0019 0.0084 0.0095
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0157 0.0215
Loa Loa (eye worm) hypothetical protein 0.003 0.0291 0.0288
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0078 0.0082
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0042 0.0501 0.0539
Trichomonas vaginalis DNA helicase recq, putative 0.0035 0.0382 0.0393
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0789 0.1075
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Schistosoma mansoni hypothetical protein 0.0062 0.0889 0.1026
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0789 0.085
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0324 0.0321
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.033 0.0328
Schistosoma mansoni cpg binding protein 0.007 0.1022 0.1179
Echinococcus multilocularis geminin 0.0388 0.6979 0.7538
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0078 0.0082
Trichomonas vaginalis ferritin, putative 0.0019 0.0084 0.0087
Loa Loa (eye worm) hypothetical protein 0.0049 0.0632 0.063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0091 0.0123
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0454 0.0519
Schistosoma mansoni dihydroorotate dehydrogenase 0.04 0.7205 0.8332
Echinococcus multilocularis GPCR, family 2 0.0019 0.0078 0.0081
Echinococcus multilocularis glycine receptor subunit beta 0.009 0.1412 0.1523
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Onchocerca volvulus 0.0021 0.0123 0.0851
Echinococcus granulosus dna polymerase eta 0.0023 0.0157 0.0167
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0812 0.081
Schistosoma mansoni acetylcholine receptor-related 0.0042 0.0501 0.0577
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0091 0.0123
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0123 0.013
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0091 0.0123
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0382 0.0527
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0078 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0155
Echinococcus granulosus intermediate filament protein 0.0033 0.033 0.0354
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0078 0.0081
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.04 0.7205 1
Schistosoma mansoni cpg binding protein 0.007 0.1022 0.1179
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0123 0.013
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0116 0.012
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0042 0.0501 0.0539
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.2429 0.3299
Schistosoma mansoni DNA polymerase eta 0.0023 0.0157 0.0179
Loa Loa (eye worm) hypothetical protein 0.0049 0.0632 0.063
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0157 0.0111
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0123 0.013
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0042 0.0501 0.0499
Schistosoma mansoni acetylcholine receptor subunit beta 0.0042 0.0501 0.0577
Schistosoma mansoni hypothetical protein 0.0021 0.0123 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1152 0.133
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0156 0.2644 0.272
Loa Loa (eye worm) hypothetical protein 0.0032 0.0311 0.0309
Schistosoma mansoni hypothetical protein 0.0477 0.8647 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0049 0.0632 0.063
Onchocerca volvulus 0.0033 0.033 0.2326
Onchocerca volvulus 0.0021 0.0123 0.0851
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0162 0.2742 0.296
Trichomonas vaginalis esterase, putative 0.0039 0.0454 0.0467
Schistosoma mansoni ferritin 0.0019 0.0084 0.0095
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0078 0.0076
Loa Loa (eye worm) hypothetical protein 0.0039 0.0454 0.0451
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0123 0.012
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0116 0.0054
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.009 0.1412 0.1523
Entamoeba histolytica hypothetical protein 0.0043 0.0534 0.1898
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0454 0.0467
Treponema pallidum NADH oxidase 0.002 0.0091 0.7158
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0382 0.0527
Onchocerca volvulus 0.009 0.1412 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0091 0.0104
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0116 0.0114
Schistosoma mansoni nAChR subunit 0.009 0.1412 0.163
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0454 0.0451
Entamoeba histolytica hypothetical protein 0.0049 0.0632 0.2258
Loa Loa (eye worm) RNA binding protein 0.0076 0.1152 0.115
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0078 0.0086
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0002
Schistosoma mansoni ferritin 0.0019 0.0084 0.0095
Loa Loa (eye worm) inositol-1 0.0041 0.0497 0.0495
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0156 0.2644 0.272
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0091 0.001
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0157 0.0162
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0157 0.0102
Loa Loa (eye worm) hypothetical protein 0.0021 0.0123 0.012
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.04 0.7205 0.7205
Echinococcus multilocularis dna polymerase eta 0.0023 0.0157 0.0167
Mycobacterium ulcerans hypothetical protein 0.0039 0.0454 0.0519
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0091 0.0123
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0032 0.0324 0.0347
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0497 0.0687
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.009 0.1412 0.1523
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0116 0.1079
Leishmania major hypothetical protein, conserved 0.003 0.0291 0.04
Onchocerca volvulus 0.0049 0.0632 0.4466
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0205 0.3563 0.3846
Schistosoma mansoni neurotransmitter gated ion channel 0.0049 0.0632 0.0728
Loa Loa (eye worm) ACC-1 protein 0.009 0.1412 0.141
Mycobacterium tuberculosis Conserved protein 0.0039 0.0454 0.0527
Schistosoma mansoni ets-related 0.0257 0.4519 0.5225
Leishmania major DNA polymerase eta, putative 0.0023 0.0157 0.0215
Echinococcus granulosus glycine receptor subunit alpha 1 0.009 0.1412 0.1523
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0454 0.0519
Loa Loa (eye worm) hypothetical protein 0.0049 0.0632 0.063
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0157 0.0167
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Onchocerca volvulus Putative nachr subunit 0.009 0.1412 1
Echinococcus multilocularis GA binding protein alpha chain 0.0084 0.1302 0.1403
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.009 0.1412 0.141
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0016 0.0028 0.0036
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0123 0.0147
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0078 0.0076
Schistosoma mansoni polycystin 1-related 0.0021 0.0123 0.0139
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0382 0.0527
Schistosoma mansoni hypothetical protein 0.0388 0.6979 0.8071
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0042 0.0501 0.0499
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0157 0.0167
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0162 0.2742 0.2821
Schistosoma mansoni hypothetical protein 0.0019 0.0078 0.0087
Echinococcus granulosus muscleblind protein 0.051 0.9258 1
Schistosoma mansoni rab6-interacting 0.0021 0.0123 0.0139
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0454 0.0627
Brugia malayi Doublecortin family protein 0.0021 0.0123 0.012
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0078 0.0105
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0156 0.2644 0.272
Leishmania major hypothetical protein, conserved 0.0039 0.0454 0.0627
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0028 0.0036
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0091 0.001
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0091 0.0096
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0091 0.0019
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0091 0.0123
Echinococcus multilocularis ferritin 0.0019 0.0084 0.0088
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0042 0.0501 0.0499
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0156 0.2644 0.3667
Trichomonas vaginalis DNA helicase recq1, putative 0.0047 0.0607 0.0624
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0123 0.013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0078 0.0081
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Loa Loa (eye worm) hypothetical protein 0.051 0.9258 0.9258
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.009 0.1412 0.163
Onchocerca volvulus 0.0066 0.0951 0.6733
Schistosoma mansoni apoferritin-2 0.0019 0.0084 0.0095
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0205 0.3563 0.3846
Toxoplasma gondii exonuclease III APE 0.0021 0.0116 0.0158
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0042 0.0501 0.0499
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0091 0.0123
Brugia malayi beta-lactamase family protein 0.0039 0.0454 0.0451
Schistosoma mansoni survival motor neuron protein 0.0058 0.0811 0.0935
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0048 0.0045
Loa Loa (eye worm) hypothetical protein 0.0072 0.1072 0.107
Brugia malayi TAR-binding protein 0.0076 0.1152 0.115
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0078 0.0082
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.5062 0.5467
Mycobacterium tuberculosis Conserved protein 0.0039 0.0454 0.0527
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0534 0.0574
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.009 0.1412 0.1523
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0028 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0454 0.0467
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0812 0.1022
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0091 0.001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0102 0.0107
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0162 0.2742 0.296
Schistosoma mansoni cpg binding protein 0.0066 0.0951 0.1098
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.04 0.7205 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0291 0.04
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.009 0.1412 0.141
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0454 0.0627
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0091 0.0123
Onchocerca volvulus 0.009 0.1412 1
Brugia malayi Thioredoxin reductase 0.0057 0.0789 0.0787
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0162 0.2742 0.296
Plasmodium vivax glutathione reductase, putative 0.0057 0.0789 0.1075
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0078 0.0075
Giardia lamblia Sgs1 DNA helicase, putative 0.0032 0.0324 1
Schistosoma mansoni nAChR subunit 0.009 0.1412 0.163
Entamoeba histolytica hypothetical protein 0.0043 0.0534 0.1898
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0091 0.0104
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0078 0.0082
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.009 0.1412 0.1523
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0078 0.0075
Brugia malayi isocitrate dehydrogenase 0.0019 0.0078 0.0076
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0291 0.0298
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Schistosoma mansoni ferritin 0.0019 0.0084 0.0095
Brugia malayi hypothetical protein 0.0042 0.0501 0.0499
Echinococcus granulosus ferritin 0.0019 0.0084 0.0088
Loa Loa (eye worm) hypothetical protein 0.0039 0.0454 0.0451
Mycobacterium leprae Probable lipase LipE 0.0039 0.0454 0.0519
Plasmodium falciparum thioredoxin reductase 0.0057 0.0789 0.0998
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0002
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0497 0.0535
Brugia malayi hypothetical protein 0.0042 0.0501 0.0499
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.009 0.1412 0.141
Leishmania major trypanothione reductase 0.0057 0.0789 0.1092
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0042 0.0501 0.0499
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0022 0.0027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.4402 0.6067
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0497 0.0687
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0078 0.0075
Schistosoma mansoni nAChR subunit 0.0042 0.0501 0.0577
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0157 0.0215
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0042 0.0501 0.0499
Plasmodium falciparum glutathione reductase 0.002 0.0091 0.0019
Schistosoma mansoni ferritin light chain 0.0019 0.0084 0.0095
Brugia malayi Cation transporter family protein 0.009 0.1412 0.141
Leishmania major dihydroorotate dehydrogenase 0.04 0.7205 1
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Schistosoma mansoni DNA helicase recq1 0.0032 0.0324 0.0371
Entamoeba histolytica hypothetical protein 0.0043 0.0534 0.1898
Echinococcus granulosus glycine receptor subunit alpha 1 0.009 0.1412 0.1523
Echinococcus multilocularis nAChR subunit 0.0049 0.0632 0.068
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0497 0.0535
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0811 0.0808
Schistosoma mansoni inositol monophosphatase 0.0041 0.0497 0.0572
Brugia malayi beta-lactamase family protein 0.0039 0.0454 0.0451
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0789 0.1092
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.04 0.7205 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0116 0.0366
Loa Loa (eye worm) GABA receptor subunit 0.0049 0.0632 0.063
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.033 0.0328
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0097 0.0094
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1152 0.115
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Echinococcus multilocularis RUN 0.0021 0.0123 0.013
Schistosoma mansoni lipoxygenase 0.006 0.0845 0.0974
Brugia malayi Zinc finger, C2H2 type family protein 0.0156 0.2644 0.2642
Loa Loa (eye worm) glutathione reductase 0.0057 0.0789 0.0787
Loa Loa (eye worm) histone methyltransferase 0.002 0.0102 0.0099
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0157 0.0215
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0454 0.0519
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0091 0.0123
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0116 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0156 0.2644 0.272
Loa Loa (eye worm) hypothetical protein 0.0032 0.0324 0.0321
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0324 0.0321
Loa Loa (eye worm) hypothetical protein 0.0049 0.0632 0.063
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0324 0.0446
Loa Loa (eye worm) hypothetical protein 0.0039 0.0454 0.0451
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0078 0.0105
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0091 0.0094
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0454 0.0522
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0022 0.0027
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0497 0.0687
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.009 0.1412 0.163
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1152 0.115
Schistosoma mansoni neurotransmitter gated ion channel 0.0042 0.0501 0.0577
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0032 0.0324 0.0347
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.009 0.1412 0.141
Entamoeba histolytica recQ family DNA helicase 0.0016 0.0028 0.0043
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.009 0.1412 0.1523
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0091 0.0123
Loa Loa (eye worm) beta-lactamase 0.0039 0.0454 0.0451
Brugia malayi Muscleblind-like protein 0.051 0.9258 0.9258
Echinococcus granulosus glycine receptor subunit alpha 1 0.009 0.1412 0.1523
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.009 0.1412 0.1523
Loa Loa (eye worm) hypothetical protein 0.0041 0.0491 0.0489
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0116 0.0045
Loa Loa (eye worm) acetylcholine receptor protein 0.0042 0.0501 0.0499
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Brugia malayi hypothetical protein 0.0043 0.0534 0.0531
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0534 0.0574
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0205 0.3563 0.3561
Echinococcus multilocularis glycine receptor subunit beta 0.009 0.1412 0.1523
Toxoplasma gondii histone lysine methyltransferase SET1 0.0125 0.2052 0.2845
Toxoplasma gondii thioredoxin reductase 0.0057 0.0789 0.1092
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0205 0.3563 0.3561
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0454 0.0451
Loa Loa (eye worm) hypothetical protein 0.0049 0.0632 0.063
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0789 0.085
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0078 0.0082
Schistosoma mansoni lamin 0.0033 0.033 0.0379
Echinococcus multilocularis glycine receptor subunit alpha 1 0.009 0.1412 0.1523
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0116 0.0045
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.009 0.1412 0.1523
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0497 0.058
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0123 0.013
Echinococcus multilocularis muscleblind protein 1 0.051 0.9258 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0084 0.1302 0.1299
Onchocerca volvulus 0.0042 0.0501 0.3537
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1152 0.1242
Schistosoma mansoni rab6-interacting 0.0021 0.0123 0.0139
Loa Loa (eye worm) hypothetical protein 0.0033 0.033 0.0328
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.2429 0.3299
Entamoeba histolytica hypothetical protein 0.0043 0.0534 0.1898
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.009 0.1412 0.163
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.009 0.1412 0.1523
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0091 0.0123
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0812 0.0874
Schistosoma mansoni DNA helicase recq5 0.0032 0.0324 0.0371
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0078 0.0105
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0157 0.0179
Brugia malayi excitatory GABA receptor EXP-1A 0.009 0.1412 0.141
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0015 0.0014
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.009 0.1412 0.141
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0027 0.0026
Brugia malayi hypothetical protein 0.003 0.0291 0.0288
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.04 0.7205 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1152 0.115
Echinococcus multilocularis muscleblind protein 0.051 0.9258 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.2157 0.2917
Echinococcus granulosus cpg binding protein 0.007 0.1022 0.1101
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0162 0.2742 0.2821
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0116 0.0123
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.04 0.7205 0.7205
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.009 0.1412 0.1523
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0157 0.0215
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.009 0.1412 0.1523
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.2157 0.2917
Leishmania major DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Echinococcus granulosus dnaJ subfamily B 0.0477 0.8647 0.934
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0091 0.0019
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0491 0.0489
Loa Loa (eye worm) hypothetical protein 0.0049 0.0632 0.063
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0847 0.0845
Loa Loa (eye worm) hypothetical protein 0.055 1 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.033 0.0379
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0091 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.0632 0.063
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0497 0.0687
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0042 0.0501 0.0499
Brugia malayi RNA binding protein 0.0076 0.1152 0.115
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0042 0.0501 0.0539
Onchocerca volvulus 0.009 0.1412 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Loa Loa (eye worm) hypothetical protein 0.0049 0.0632 0.063
Trypanosoma brucei unspecified product 0.0016 0.0022 0.0027
Onchocerca volvulus 0.0049 0.0632 0.4466
Loa Loa (eye worm) hypothetical protein 0.0039 0.0454 0.0451
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0048 0.0045
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.009 0.1412 0.141
Loa Loa (eye worm) hypothetical protein 0.0286 0.5062 0.5061
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0291 0.0381
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0157 0.0179
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0013
Onchocerca volvulus 0.009 0.1412 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0003 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0454 0.0467
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0416 0.0466
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.2157 0.2917
Schistosoma mansoni nAChR subunit 0.009 0.1412 0.163
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0019 0.0084 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0157 0.0155
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0091 0.0123
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.009 0.1412 0.141
Echinococcus granulosus dna polymerase kappa 0.0023 0.0157 0.0167
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.5062 0.5467
Brugia malayi Ets-domain containing protein 0.0084 0.1302 0.1299
Brugia malayi glutathione reductase 0.0057 0.0789 0.0787
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0044 0.0548 0.0659
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1152 0.133
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0157 0.0102
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0157 0.0215
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0049 0.0632 0.063
Mycobacterium ulcerans lipase LipD 0.0039 0.0454 0.0519
Schistosoma mansoni hypothetical protein 0.0388 0.6979 0.8071
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0416 0.0474
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0078 0.0105
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0812 0.103
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0091 0.0123
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1152 0.133
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.2157 0.2917
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0116 0.0158
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.009 0.1412 0.141
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0078 0.0105
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0497 0.0512
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0091 0.0123
Echinococcus granulosus glycine receptor subunit beta 0.009 0.1412 0.1523
Onchocerca volvulus 0.0058 0.0811 0.5734
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0091 0.0103
Loa Loa (eye worm) RecQ helicase 0.0047 0.0607 0.0604
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.009 0.1412 0.141
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0205 0.3563 0.3846
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0847 0.0845
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0157 0.0215
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0454 0.0467
Plasmodium falciparum dihydroorotate dehydrogenase 0.04 0.7205 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0812 0.0874
Echinococcus granulosus lamin dm0 0.0033 0.033 0.0354
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.009 0.1412 0.1523
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0028 0.0253 0.0328
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0534 0.0615
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0157 0.0155
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0454 0.0527
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.009 0.1412 0.1523
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.04 0.7205 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0157 0.0516
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0078 0.0105
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0026
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.009 0.1412 0.141
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.006 0.0845 0.091
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0015 0.0014
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0162 0.2742 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.009 0.1412 0.1523
Schistosoma mansoni nAChR subunit 0.009 0.1412 0.163
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0042 0.0501 0.0539
Schistosoma mansoni hypothetical protein 0.0043 0.0534 0.0615
Echinococcus multilocularis expressed protein 0.0019 0.0084 0.0088
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0078 0.0087
Loa Loa (eye worm) hypothetical protein 0.051 0.9258 0.9258
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0291 0.04
Schistosoma mansoni nAChR subunit 0.009 0.1412 0.163
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.009 0.1412 0.141
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0951 0.0949
Schistosoma mansoni hypothetical protein 0.0019 0.0078 0.0087
Echinococcus multilocularis nAChR subunit 0.009 0.1412 0.1523
Onchocerca volvulus 0.0042 0.0501 0.3537
Brugia malayi hypothetical protein 0.0021 0.0123 0.012
Schistosoma mansoni ap endonuclease 0.0021 0.0116 0.0132
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0789 0.0787
Echinococcus multilocularis lamin 0.0033 0.033 0.0354
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0497 0.0687
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.2429 0.3293
Brugia malayi hypothetical protein 0.0021 0.0123 0.012
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0091 0.0123
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0454 0.0522
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.009 0.1412 0.141
Schistosoma mansoni lipoxygenase 0.0021 0.0123 0.0139
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0291 0.0298
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0049 0.0632 0.063
Schistosoma mansoni hypothetical protein 0.0019 0.0078 0.0087
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0454 0.0608
Schistosoma mansoni hypothetical protein 0.0041 0.0491 0.0565
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.009 0.1412 0.141
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0078 0.0081
Echinococcus granulosus expressed protein 0.0019 0.0084 0.0088
Echinococcus multilocularis musashi 0.0033 0.033 0.0354
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0497 0.0512
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0032 0.0324 0.0321
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0324 0.0446
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0812 0.1022
Schistosoma mansoni apoferritin-2 0.0019 0.0084 0.0095
Trypanosoma brucei trypanothione reductase 0.0057 0.0789 0.1092
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.009 0.1412 0.141
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Brugia malayi Bloom's syndrome protein homolog 0.0047 0.0607 0.0604
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.009 0.1412 0.163
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.009 0.1412 0.141
Echinococcus multilocularis bloom syndrome protein 0.0047 0.0607 0.0653
Toxoplasma gondii ABC1 family protein 0.0039 0.0454 0.0627
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0205 0.3563 0.4118
Brugia malayi MH2 domain containing protein 0.0144 0.2418 0.2416
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0116 0.0158
Brugia malayi Cation transporter family protein 0.009 0.1412 0.141
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0032 0.0324 0.0347
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0019 0.0084 0.0009
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.009 0.1412 0.1523
Schistosoma mansoni hypothetical protein 0.0019 0.0078 0.0087
Loa Loa (eye worm) hypothetical protein 0.0049 0.0632 0.063
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.2157 0.2917
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0091 0.001
Schistosoma mansoni lamin 0.0033 0.033 0.0379
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0205 0.3563 0.3846
Trypanosoma brucei unspecified product 0.0016 0.0022 0.0027
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.04 0.7205 1
Echinococcus granulosus glycine receptor subunit beta 0.009 0.1412 0.1523
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0157 0.0155
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0027 0.0026
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.009 0.1412 0.141
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.04 0.7205 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0091 0.0123
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.04 0.7205 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0847 0.0845
Onchocerca volvulus 0.0039 0.0454 0.3203
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0291 0.04
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0091 0.0019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0454 0.0451
Loa Loa (eye worm) hypothetical protein 0.0021 0.0123 0.012
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0049 0.0632 0.063
Trichomonas vaginalis DNA helicase recq, putative 0.0047 0.0607 0.0624
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0091 0.0089
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0454 0.0527
Schistosoma mansoni nAChR subunit 0.0042 0.0501 0.0577
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.009 0.1412 0.141
Brugia malayi intermediate filament protein 0.0033 0.033 0.0328
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0049 0.0632 0.0728
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0027 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0022 0.0027
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0738 0.0736
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0497 0.0512
Brugia malayi hypothetical protein 0.0042 0.0501 0.0499
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0454 0.0467
Onchocerca volvulus 0.0039 0.0454 0.3203
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0116 0.0158
Brugia malayi Fli-1 protein 0.0257 0.4519 0.4517
Brugia malayi hypothetical protein 0.002 0.0089 0.0086
Loa Loa (eye worm) ACC-1 protein 0.009 0.1412 0.141
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0497 0.1764
Loa Loa (eye worm) hypothetical protein 0.0039 0.0454 0.0451
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0042 0.0501 0.0499
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0157 0.0167
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0116 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0078 0.0081
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0789 0.0998
Loa Loa (eye worm) hypothetical protein 0.0019 0.0078 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1152 0.133
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0205 0.3563 0.4118
Echinococcus granulosus nAChR subunit 0.0049 0.0632 0.068
Brugia malayi beta-lactamase 0.0039 0.0454 0.0451
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0157 0.0111
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0091 0.0096
Schistosoma mansoni hypothetical protein 0.0058 0.0811 0.0935
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.2429 0.3299
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0091 0.0123
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0116 0.012
Echinococcus multilocularis cpg binding protein 0.007 0.1022 0.1101
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Loa Loa (eye worm) LGC-31 protein 0.009 0.1412 0.141
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0042 0.0501 0.0539
Giardia lamblia DINP protein human, muc B family 0.0023 0.0157 0.2834
Mycobacterium tuberculosis Conserved protein 0.0039 0.0454 0.0527
Schistosoma mansoni inositol monophosphatase 0.0041 0.0497 0.0572
Mycobacterium tuberculosis Probable reductase 0.013 0.2157 0.2917
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0116 0.0054
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.009 0.1412 0.163
Echinococcus granulosus RUN 0.0021 0.0123 0.013
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.2157 0.2911
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0032 0.0324 0.0347
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.04 0.7205 1
Onchocerca volvulus 0.009 0.1412 1
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0123 0.0062
Brugia malayi CXXC zinc finger family protein 0.0066 0.0951 0.0949
Loa Loa (eye worm) intermediate filament protein 0.0033 0.033 0.0328
Plasmodium falciparum glutathione reductase 0.0057 0.0789 0.0998
Schistosoma mansoni loxhd1 0.0021 0.0123 0.0139
Echinococcus multilocularis lamin dm0 0.0033 0.033 0.0354
Echinococcus granulosus GPCR family 2 0.0019 0.0078 0.0081
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0091 0.0123
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0454 0.0527
Entamoeba histolytica recQ family helicase, putative 0.0035 0.0382 0.1341
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0091 0.0123
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0116 0.0114
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.04 0.7205 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0454 0.0627
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0454 0.0527
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0016 0.0028 0.0036
Brugia malayi Cation transporter family protein 0.009 0.1412 0.141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0205 0.3563 0.4118
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0454 0.0488
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2418 0.2416
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0091 0.001
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0535 0.9719 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.009 0.1412 0.1523
Echinococcus granulosus arachidonate 5 lipoxygenase 0.006 0.0845 0.091
Trypanosoma brucei unspecified product 0.0023 0.0157 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0454 0.0527
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0116 0.0158
Schistosoma mansoni ap endonuclease 0.0021 0.0116 0.0132
Onchocerca volvulus 0.0033 0.033 0.2326
Treponema pallidum bacterioferrin (TpF1) 0.0019 0.0084 0.6369
Loa Loa (eye worm) hypothetical protein 0.0032 0.0319 0.0317
Schistosoma mansoni blooms syndrome DNA helicase 0.0031 0.03 0.0344
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0027 0.0028
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0162 0.2742 0.296
Echinococcus granulosus GA binding protein alpha chain 0.0084 0.1302 0.1403
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.009 0.1412 0.141
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0116 0.0139
Loa Loa (eye worm) hypothetical protein 0.0042 0.0501 0.0499
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0123 0.013
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.009 0.1412 0.163
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0241 0.0331
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.009 0.1412 0.141
Schistosoma mansoni neurotransmitter gated ion channel 0.0042 0.0501 0.0577
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0032 0.0324 0.0344
Schistosoma mansoni nAChR subunit 0.009 0.1412 0.163
Loa Loa (eye worm) hypothetical protein 0.009 0.1412 0.141
Schistosoma mansoni ferritin 0.0019 0.0084 0.0095
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0812 0.0936
Plasmodium falciparum thioredoxin reductase 0.002 0.0091 0.0019
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.009 0.1412 0.141
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0078 0.0082
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0812 0.1124
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0291 0.04
Onchocerca volvulus 0.0042 0.0501 0.3537
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1152 0.133
Brugia malayi hypothetical protein 0.0042 0.0501 0.0499
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.006 0.0847 0.0845
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0157 0.0215
Echinococcus granulosus lamin 0.0033 0.033 0.0354
Echinococcus multilocularis dnaJ subfamily B 0.0477 0.8647 0.934
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0091 0.0123
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0102 0.0107
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2418 0.2416
Mycobacterium ulcerans beta-lactamase 0.0039 0.0454 0.0519
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0454 0.0488

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = -7.3 Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -7.2 Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -7.2 Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -7.1 Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -7.1 Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -7 Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = -6 Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 0.06 nM Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 0.06 nM Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 0.07 nM Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 0.08 nM Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 0.09 nM Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 0.1 nM Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 1 nM Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay ChEMBL. 19734910
IC50 (functional) = 2.7 uM Antimalarial activity against Plasmodium falciparum DD2 by [3H]hypoxanthine uptake ChEMBL. 19097788
IC50 (functional) = 3 uM Antimalarial activity against Plasmodium falciparum DD2 expressing Saccharomyces cerevisiae DHOD by [3H]hypoxanthine uptake ChEMBL. 19097788
IC50 (functional) = 3.3 uM Inhibition of 3 nM PMA-stimulated superoxide anion generation in rat neutrophils ChEMBL. 17320246
IC50 (functional) = 5.8 uM Inhibition of 0.3 uM fMLP-stimulated superoxide anion generation in rat neutrophils ChEMBL. 17320246
IC50 (binding) > 10 uM Inhibition of Plasmodium falciparum DHOD ChEMBL. 19097788
IC50 (binding) > 10 uM Inhibition of Saccharomyces cerevisiae DHOD ChEMBL. 19097788
Inhibition (binding) Inhibition of bovine milk xanthine oxidase assessed as hypoxanthine-stimulated ROS generation by measuring H2O2 production at 25 to 50 uM by fluorescence assay ChEMBL. 24466406

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 19097788

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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