Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | spleen tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma japonicum | ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Echinococcus granulosus | tyrosine protein kinase shark | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma japonicum | ko:K05855 spleen tyrosine kinase, putative | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Echinococcus multilocularis | tyrosine protein kinase shark | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0152 | 0.483 | 0.8343 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0171 | 0.5716 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0171 | 0.5716 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0094 | 0.2147 | 0.1843 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0152 | 0.483 | 0.8343 |
Echinococcus multilocularis | adenosine deaminase | 0.0171 | 0.5716 | 0.555 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0152 | 0.483 | 0.4631 |
Plasmodium vivax | adenosine deaminase, putative | 0.0171 | 0.5716 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0171 | 0.5716 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0171 | 0.5716 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0152 | 0.483 | 0.8451 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3134 | 0.5169 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0152 | 0.483 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0171 | 0.5716 | 0.555 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0152 | 0.483 | 0.8343 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0171 | 0.5716 | 1 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0171 | 0.5716 | 1 |
Treponema pallidum | adenosine deaminase | 0.0171 | 0.5716 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0264 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0258 | 0.972 | 0.9709 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.5716 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0152 | 0.483 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0152 | 0.483 | 0.8343 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0094 | 0.2147 | 0.1843 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0152 | 0.483 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0094 | 0.2147 | 0.1843 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3134 | 0.5169 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0171 | 0.5716 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0094 | 0.2147 | 0.1843 |
Leishmania major | adenine aminohydrolase | 0.0171 | 0.5716 | 1 |
Schistosoma mansoni | adenosine deaminase | 0.0171 | 0.5716 | 0.555 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0152 | 0.483 | 0.4631 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3134 | 0.5169 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3134 | 0.5169 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0152 | 0.483 | 0.8451 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0171 | 0.5716 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0152 | 0.483 | 0.8343 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0152 | 0.483 | 0.8343 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0171 | 0.5716 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0152 | 0.483 | 0.8343 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0152 | 0.483 | 0.4631 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0171 | 0.5716 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0264 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0171 | 0.5716 | 0.555 |
Brugia malayi | Adenosylhomocysteinase | 0.0152 | 0.483 | 0.8343 |
Mycobacterium ulcerans | adenosine deaminase | 0.0171 | 0.5716 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0171 | 0.5716 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 71 nM | Inhibition of recombinant Syk | ChEMBL. | 19254842 |
IC50 (binding) | = 0.071 uM | Inhibitory activity against spleen tyrosine kinase (SYK) | ChEMBL. | 12668002 |
IC50 (binding) | = 0.071 uM | Inhibitory activity against spleen tyrosine kinase (SYK) | ChEMBL. | 12668002 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.