Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group I, member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | nuclear receptor subfamily 1, group I, member 2 | 434 aa | 427 aa | 25.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0022 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0022 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0022 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0022 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0022 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0022 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0022 | 0.5 | 0.5 | |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0022 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 27 % | Antagonist activity at human LXRbeta by transient transfection assay | ChEMBL. | 17215127 |
Activity (functional) | = 27 % | Antagonist activity at human LXRbeta by transient transfection assay | ChEMBL. | 17215127 |
Activity (functional) | = 96 % | Antagonist activity at human PXR by transient transfection assay | ChEMBL. | 17215127 |
Activity (functional) | = 96 % | Antagonist activity at human PXR by transient transfection assay | ChEMBL. | 17215127 |
EC50 (functional) | = -6.8 | Antagonist activity at human PXR by transient transfection assay | ChEMBL. | 17215127 |
EC50 (functional) | = -5.6 | Antagonist activity at human LXRbeta by transient transfection assay | ChEMBL. | 17215127 |
IC50 (binding) | = -6.5 | Displacement of [N-methyl-3H]-GW0438X from human PXR | ChEMBL. | 17215127 |
Log EC50 (functional) | = 5.6 | Antagonist activity at human LXRbeta by transient transfection assay | ChEMBL. | 17215127 |
Log EC50 (functional) | = 6.8 | Antagonist activity at human PXR by transient transfection assay | ChEMBL. | 17215127 |
Log IC50 (binding) | = 6.5 | Displacement of [N-methyl-3H]-GW0438X from human PXR | ChEMBL. | 17215127 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.