Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group I, member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | nuclear receptor subfamily 1, group I, member 2 | 434 aa | 427 aa | 25.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0022 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0022 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0022 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0022 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0022 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0022 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0022 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0022 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0022 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0022 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0022 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0022 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0022 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 58 % | Antagonist activity at human LXRbeta by transient transfection assay | ChEMBL. | 17215127 |
Activity (functional) | = 58 % | Antagonist activity at human LXRbeta by transient transfection assay | ChEMBL. | 17215127 |
Activity (functional) | = 98 % | Antagonist activity at human PXR by transient transfection assay | ChEMBL. | 17215127 |
Activity (functional) | = 98 % | Antagonist activity at human PXR by transient transfection assay | ChEMBL. | 17215127 |
EC50 (functional) | = -8 | Antagonist activity at human PXR by transient transfection assay | ChEMBL. | 17215127 |
EC50 (functional) | = -6.2 | Antagonist activity at human LXRbeta by transient transfection assay | ChEMBL. | 17215127 |
IC50 (binding) | = -7.7 | Displacement of [N-methyl-3H]-GW0438X from human PXR | ChEMBL. | 17215127 |
Log EC50 (functional) | = 6.2 | Antagonist activity at human LXRbeta by transient transfection assay | ChEMBL. | 17215127 |
Log EC50 (functional) | = 8 | Antagonist activity at human PXR by transient transfection assay | ChEMBL. | 17215127 |
Log IC50 (binding) | = 7.7 | Displacement of [N-methyl-3H]-GW0438X from human PXR | ChEMBL. | 17215127 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.