Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0358 | 0.9193 | 0.9392 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0684 | 0.07 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0123 | 0.2957 | 0.3023 |
Brugia malayi | cAMP-dependent protein kinase catalytic subunit, putative | 0.0381 | 0.9781 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0242 | 0.6124 | 0.622 |
Leishmania major | protein kinase A catalytic subunit | 0.0381 | 0.9781 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0123 | 0.2957 | 0.2881 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0123 | 0.2957 | 0.3023 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0159 | 0.0162 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0159 | 0.0162 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0123 | 0.2957 | 0.3023 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0123 | 0.2957 | 0.3023 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0123 | 0.2957 | 0.3023 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0242 | 0.6124 | 0.6261 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0159 | 0.0162 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.035 | 0.8974 | 0.9175 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0381 | 0.9781 | 1 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0234 | 0.5905 | 0.5993 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 1 | 0.0381 | 0.9781 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0227 | 0.5722 | 0.5851 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0389 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0123 | 0.2957 | 0.3023 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0196 | 0.489 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0159 | 0.0162 |
Trichomonas vaginalis | AGC family protein kinase | 0.0358 | 0.9193 | 0.9392 |
Toxoplasma gondii | protein kinase domain-containing protein | 0.0015 | 0.0107 | 0.011 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0159 | 0.0162 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0358 | 0.9193 | 0.9399 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0123 | 0.2957 | 0.3023 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0015 | 0.0107 | 0.011 |
Trichomonas vaginalis | AGC family protein kinase | 0.0123 | 0.2957 | 0.2946 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0123 | 0.2957 | 0.3023 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0123 | 0.2957 | 0.3023 |
Schistosoma mansoni | serine/threonine kinase | 0.0123 | 0.2957 | 0.3023 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0123 | 0.2957 | 0.3023 |
Echinococcus granulosus | NDR protein kinase | 0.0123 | 0.2957 | 0.3023 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0123 | 0.2957 | 0.3023 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0123 | 0.2957 | 0.3023 |
Echinococcus multilocularis | nervana 2 | 0.0227 | 0.5722 | 0.5851 |
Echinococcus granulosus | protein kinase C gamma type | 0.0123 | 0.2957 | 0.3023 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0234 | 0.5905 | 0.5993 |
Trichomonas vaginalis | AGC family protein kinase | 0.0358 | 0.9193 | 0.9392 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0123 | 0.2957 | 0.3023 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0684 | 0.07 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0123 | 0.2957 | 0.3023 |
Giardia lamblia | Kinase, AGC PKA | 0.0381 | 0.9781 | 1 |
Brugia malayi | Hr1 repeat family protein | 0.0123 | 0.2957 | 0.3023 |
Plasmodium falciparum | cAMP-dependent protein kinase catalytic subunit | 0.0381 | 0.9781 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0196 | 0.489 | 0.4999 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0159 | 0.0162 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0123 | 0.2957 | 0.3023 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0123 | 0.2957 | 0.3023 |
Entamoeba histolytica | protein kinase, putative | 0.0358 | 0.9193 | 0.9184 |
Trichomonas vaginalis | AGC family protein kinase | 0.0358 | 0.9193 | 0.9392 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0242 | 0.6124 | 0.6082 |
Entamoeba histolytica | protein kinase, putative | 0.0358 | 0.9193 | 0.9184 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0242 | 0.6124 | 0.6261 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0381 | 0.9781 | 1 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0123 | 0.2957 | 0.3023 |
Brugia malayi | Protein kinase domain containing protein | 0.0123 | 0.2957 | 0.3023 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0381 | 0.9781 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0159 | 0.0162 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0234 | 0.5905 | 0.6037 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0159 | 0.0162 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0123 | 0.2957 | 0.3023 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.2957 | 0.3023 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0159 | 0.0162 |
Entamoeba histolytica | protein kinase, putative | 0.035 | 0.8974 | 0.8962 |
Echinococcus multilocularis | enhancer of mRNA decapping protein 4 | 0.0374 | 0.9598 | 0.9814 |
Leishmania major | protein kinase, putative | 0.0015 | 0.0107 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0159 | 0.0162 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0381 | 0.9781 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.1137 | 0.1163 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0381 | 0.9781 | 1 |
Leishmania major | protein kinase, putative | 0.0015 | 0.0107 | 0.011 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0123 | 0.2957 | 0.3023 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0227 | 0.5722 | 0.5851 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0123 | 0.2957 | 0.3023 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0159 | 0.0162 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0684 | 0.07 |
Leishmania major | protein kinase A catalytic subunit isoform 1 | 0.0381 | 0.9781 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0123 | 0.2957 | 0.3023 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.9781 | 1 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 2 | 0.0381 | 0.9781 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0381 | 0.9781 | 1 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0381 | 0.9781 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0123 | 0.2957 | 0.3023 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0123 | 0.2957 | 0.3023 |
Trichomonas vaginalis | AGC family protein kinase | 0.0131 | 0.3176 | 0.3173 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0227 | 0.5722 | 0.5851 |
Brugia malayi | Protein kinase domain containing protein | 0.0123 | 0.2957 | 0.3023 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0234 | 0.5905 | 0.6037 |
Toxoplasma gondii | calcium dependent protein kinase CDPK7 | 0.0015 | 0.0107 | 0.011 |
Toxoplasma gondii | AGC kinase | 0.0381 | 0.9781 | 1 |
Toxoplasma gondii | protein kinase, cAMP-dependent, catalytic chain | 0.0381 | 0.9781 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0234 | 0.5905 | 0.6037 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0123 | 0.2957 | 0.3023 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0159 | 0.0162 |
Plasmodium falciparum | calcium-dependent protein kinase 7 | 0.0015 | 0.0107 | 0.011 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0116 | 0.2775 | 0.2758 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.1137 | 0.1163 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0358 | 0.9193 | 0.9392 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 1 | 0.0381 | 0.9781 | 1 |
Echinococcus granulosus | nervana 2 | 0.0227 | 0.5722 | 0.5851 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 2 | 0.0381 | 0.9781 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0159 | 0.0162 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0381 | 0.9781 | 1 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0123 | 0.2957 | 0.3023 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0123 | 0.2957 | 0.3023 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0381 | 0.9781 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0358 | 0.9193 | 0.9392 |
Echinococcus granulosus | protein kinase c iota type | 0.0123 | 0.2957 | 0.3023 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0242 | 0.6124 | 0.6261 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0242 | 0.6124 | 0.6082 |
Trichomonas vaginalis | AGC family protein kinase | 0.0358 | 0.9193 | 0.9392 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0242 | 0.6124 | 0.6261 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0381 | 0.9781 | 1 |
Leishmania major | serine/threonine-protein kinase a, putative | 0.0015 | 0.0107 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1137 | 0.1163 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0227 | 0.5722 | 0.5851 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0381 | 0.9781 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0123 | 0.2957 | 0.3023 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.1137 | 0.1163 |
Toxoplasma gondii | AGC kinase | 0.0381 | 0.9781 | 1 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0381 | 0.9781 | 1 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0015 | 0.0107 | 0.011 |
Trypanosoma brucei | protein kinase A catalytic subunit, putative | 0.0381 | 0.9781 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0123 | 0.2957 | 0.2946 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0381 | 0.9781 | 1 |
Echinococcus granulosus | enhancer of mRNA decapping protein 4 | 0.0374 | 0.9598 | 0.9814 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0234 | 0.5905 | 0.6037 |
Brugia malayi | protein kinase C II. | 0.0123 | 0.2957 | 0.3023 |
Trypanosoma cruzi | Protein kinase B | 0.0242 | 0.6124 | 0.622 |
Trichomonas vaginalis | AGC family protein kinase | 0.0123 | 0.2957 | 0.2946 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0123 | 0.2957 | 0.3023 |
Leishmania major | protein kinase A catalytic subunit isoform 2 | 0.0381 | 0.9781 | 1 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0381 | 0.9781 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0123 | 0.2957 | 0.3023 |
Echinococcus multilocularis | nervana 2 | 0.0227 | 0.5722 | 0.5851 |
Echinococcus granulosus | nervana 2 | 0.0227 | 0.5722 | 0.5851 |
Toxoplasma gondii | AGC kinase | 0.035 | 0.8974 | 0.9175 |
Entamoeba histolytica | protein kinase 2, putative | 0.0234 | 0.5905 | 0.586 |
Trichomonas vaginalis | AGC family protein kinase | 0.0358 | 0.9193 | 0.9392 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0381 | 0.9781 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0358 | 0.9193 | 0.9399 |
Leishmania major | folate/biopterin transporter, putative | 0.0015 | 0.0107 | 0.011 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0123 | 0.2957 | 0.3023 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.489 | 0.4999 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0159 | 0.0162 |
Plasmodium vivax | cAMP-dependent protein kinase catalytic subunit, putative | 0.0381 | 0.9781 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.035 | 0.8974 | 0.9175 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | 0 | Inhibition of rabbit microsomal COX at 10 uM | ChEMBL. | 17376692 |
Activity (ADMET) | = 20 % | Toxicity in rat assessed as incidence of hyperaemia at 100 mg/kg, po | ChEMBL. | 17376692 |
Activity (ADMET) | = 35 % | Toxicity in rat assessed as incidence of hyperaemia at 200 mg/kg, po | ChEMBL. | 17376692 |
Activity (ADMET) | = 45 % | Toxicity in rat assessed as incidence of ulcer at 100 mg/kg, po | ChEMBL. | 17376692 |
Activity (ADMET) | = 55 % | Toxicity in rat assessed as incidence of hyperaemia at 400 mg/kg, po | ChEMBL. | 17376692 |
Activity (ADMET) | = 55 % | Toxicity in rat assessed as incidence of ulcer at 200 mg/kg, po | ChEMBL. | 17376692 |
Activity (ADMET) | = 80 % | Toxicity in rat assessed as incidence of ulcer at 400 mg/kg, po | ChEMBL. | 17376692 |
ALD50 (ADMET) | > 1000 mg kg-1 | Toxicity in ip dosed Albino mouse | ChEMBL. | 17376692 |
ALD50 (ADMET) | > 1000 mg kg-1 | Toxicity in ip dosed Albino mouse | ChEMBL. | 17376692 |
ED50 (functional) | = 75.5 mg kg-1 | Antiinflammatory activity against carrageenan-induced paw edema in po dosed Albino rat assessed as oedema inhibition | ChEMBL. | 17376692 |
Inhibition (functional) | = 29.4 % | Antiinflammatory activity against carrageenan-induced paw edema in Albino rat assessed as oedema inhibition relative to control at 40 mg/kg, po | ChEMBL. | 17376692 |
Inhibition (functional) | = 46.5 % | Antiinflammatory activity against carrageenan-induced paw edema in Albino rat assessed as oedema inhibition relative to control at 80 mg/kg, po | ChEMBL. | 17376692 |
Inhibition (functional) | = 155 % | Antiinflammatory activity against carrageenan-induced paw edema in Albino rat assessed as oedema inhibition relative to control at 20 mg/kg, po | ChEMBL. | 17376692 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.