Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.006 | 0.3651 | 0.3033 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0068 | 0.4118 | 0.4118 |
Echinococcus multilocularis | cpg binding protein | 0.0034 | 0.1911 | 0.1911 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.006 | 0.3651 | 0.3529 |
Brugia malayi | flavodoxin family protein | 0.006 | 0.3651 | 0.3651 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0158 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0158 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.1793 | 0.1793 |
Brugia malayi | diaphorase | 0.0018 | 0.0888 | 0.0888 |
Entamoeba histolytica | type A flavoprotein, putative | 0.006 | 0.3651 | 0.5 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.006 | 0.3651 | 0.3033 |
Leishmania major | p450 reductase, putative | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0098 | 0.6067 | 0.6067 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.036 | 0.036 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0158 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0098 | 0.6067 | 0.6067 |
Loa Loa (eye worm) | flavodoxin family protein | 0.006 | 0.3651 | 0.3651 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.1911 | 0.1911 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.006 | 0.3651 | 0.3529 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0018 | 0.0888 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0158 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0018 | 0.0888 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.1793 | 1 | |
Leishmania major | cytochrome P450 reductase, putative | 0.014 | 0.8831 | 0.8717 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0158 | 1 | 1 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0018 | 0.0888 | 0.0888 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0158 | 1 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0032 | 0.1793 | 0.1793 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0158 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.006 | 0.3651 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.014 | 0.8831 | 0.8809 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.006 | 0.3651 | 0.3033 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0352 | 0.0352 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.006 | 0.3651 | 0.3033 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.006 | 0.3651 | 0.3033 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0018 | 0.0888 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0158 | 1 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0078 | 0.482 | 0.482 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0098 | 0.6067 | 0.6067 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.006 | 0.3651 | 0.3033 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0018 | 0.0888 | 0.0888 |
Plasmodium vivax | flavodoxin domain containing protein | 0.014 | 0.8831 | 0.8717 |
Onchocerca volvulus | 0.0018 | 0.0888 | 0.4951 | |
Mycobacterium tuberculosis | Possible oxygenase | 0.0018 | 0.0888 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.006 | 0.3651 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.014 | 0.8831 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.006 | 0.3651 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.006 | 0.3651 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0234 | 0.0234 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.006 | 0.3651 | 0.3033 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0018 | 0.0888 | 0.0888 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.008 | 0.4898 | 0.4898 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0158 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0098 | 0.6067 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0158 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0158 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0158 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0158 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.006 | 0.3651 | 0.3033 |
Chlamydia trachomatis | Na(+)-translocating NADH-quinone reductase subunit F | 0.0018 | 0.0888 | 0.1463 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0234 | 0.0234 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0078 | 0.482 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.036 | 0.036 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0018 | 0.0888 | 0.0888 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0018 | 0.0888 | 0.0888 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.006 | 0.3648 | 0.7018 |
Echinococcus granulosus | cpg binding protein | 0.0034 | 0.1911 | 0.1911 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 1 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.006 | 0.3651 | 0.3529 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0234 | 0.0234 |
Brugia malayi | FAD binding domain containing protein | 0.0098 | 0.6067 | 0.6067 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0234 | 0.0234 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0018 | 0.0888 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0158 | 1 | 1 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0018 | 0.0888 | 0.0888 |
Loa Loa (eye worm) | diaphorase | 0.0018 | 0.0888 | 0.0888 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0078 | 0.482 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.006 | 0.3651 | 0.3529 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0158 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.006 | 0.3651 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0158 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0032 | 0.1793 | 0.1793 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.1911 | 0.1911 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0158 | 1 | 1 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0018 | 0.0888 | 0.0888 |
Schistosoma mansoni | cytochrome B5 | 0.0018 | 0.0888 | 0.0888 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0016 | 0.0016 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0234 | 0.0234 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.036 | 0.036 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0018 | 0.0888 | 0.0888 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.014 | 0.8831 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0098 | 0.6067 | 0.6067 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.