Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | epidermal growth factor receptor | 0.0098 | 0.4937 | 0.501 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0098 | 0.4937 | 0.501 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.2826 | 0.2792 |
Schistosoma mansoni | tyrosine kinase | 0.0098 | 0.4937 | 0.501 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2826 | 0.2868 |
Brugia malayi | hypothetical protein | 0.012 | 0.6242 | 0.4906 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0216 | 0.017 |
Echinococcus multilocularis | insulin receptor | 0.0059 | 0.2623 | 0.2662 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0216 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6242 | 0.6225 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0181 | 0.9853 | 0.9853 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2826 | 0.2868 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0059 | 0.2623 | 0.2662 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.2826 | 0.2868 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0216 | 0.0219 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0181 | 0.9853 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0181 | 0.9853 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0047 | 0.0048 |
Schistosoma mansoni | tyrosine kinase | 0.0059 | 0.2623 | 0.2662 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0181 | 0.9853 | 0.9801 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0172 | 0.929 | 1 |
Onchocerca volvulus | 0.0167 | 0.9001 | 0.9049 | |
Echinococcus granulosus | epidermal growth factor receptor | 0.0181 | 0.9853 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6242 | 0.6225 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.2826 | 0.0274 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.2826 | 0.2868 |
Schistosoma mansoni | tyrosine kinase | 0.0059 | 0.2623 | 0.2662 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.2826 | 0.2792 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0098 | 0.4937 | 0.501 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0216 | 0.017 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.2826 | 0.0274 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.4816 | 0.4888 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.2826 | 0.2792 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2826 | 0.2868 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2826 | 0.2868 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.4816 | 0.4888 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.4816 | 0.4888 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0059 | 0.2623 | 0.2662 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2826 | 0.2868 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0047 | 0.0048 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0059 | 0.2623 | 0.2589 |
Echinococcus multilocularis | 0.0056 | 0.2457 | 0.2493 | |
Brugia malayi | RNA binding protein | 0.0062 | 0.2826 | 0.0274 |
Echinococcus granulosus | insulin receptor | 0.0059 | 0.2623 | 0.2662 |
Schistosoma mansoni | tyrosine kinase | 0.0098 | 0.4937 | 0.501 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0184 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 31.2 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP | ChEMBL. | 16302797 |
IC50 (binding) | = 41.9 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione | ChEMBL. | 16302797 |
IC50 (binding) | = 46.1 nM | Inhibition of human VEGFR2 in presence of 1 uM ATP | ChEMBL. | 17416531 |
IC50 (binding) | = 46.1 nM | Inhibition of human VEGFR2 in presence of 1 uM ATP | ChEMBL. | 17416531 |
IC50 (binding) | = 188 nM | Inhibition of human VEGFR2 in presence of 1 mM ATP | ChEMBL. | 17416531 |
IC50 (binding) | = 188 nM | Inhibition of human VEGFR2 in presence of 1 mM ATP | ChEMBL. | 17416531 |
IC50 (binding) | = 256.3 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma | ChEMBL. | 16302797 |
IC50 (binding) | > 10000 nM | Inhibition of human EGFR in presence of 1 uM ATP | ChEMBL. | 17416531 |
IC50 (binding) | > 10000 nM | Inhibition of human EGFR in presence of 1 mM ATP | ChEMBL. | 17416531 |
IC50 (binding) | > 10000 nM | Inhibition of human EGFR in presence of 1 uM ATP | ChEMBL. | 17416531 |
IC50 (binding) | > 10000 nM | Inhibition of human EGFR in presence of 1 mM ATP | ChEMBL. | 17416531 |
Inhibition (binding) | = -27 % | Inhibition of human EGFR in presence of 1 mM ATP at <10000 nM | ChEMBL. | 17416531 |
Inhibition (binding) | = -27 % | Inhibition of human EGFR in presence of 1 mM ATP at <10000 nM | ChEMBL. | 17416531 |
Inhibition (binding) | = 0 % | Inhibition of human VEGFR2 in presence of 1 mM ATP at <10000 nM | ChEMBL. | 17416531 |
Inhibition (binding) | = 0 % | Inhibition of human VEGFR2 in presence of 1 mM ATP at <10000 nM | ChEMBL. | 17416531 |
Inhibition (binding) | = 34 % | Inhibition of human EGFR in presence of 1 uM ATP at <10000 nM | ChEMBL. | 17416531 |
Inhibition (binding) | = 34 % | Inhibition of human EGFR in presence of 1 uM ATP at <10000 nM | ChEMBL. | 17416531 |
Ratio (binding) | > 1 | Ratio of IC50 for EGFR in presence of 1 mM ATP to IC50 for EGFR in presence of 1 uM ATP | ChEMBL. | 17416531 |
Ratio (binding) | = 4.1 | Ratio of IC50 for VEGFR2 in presence of 1 mM ATP to IC50 for VEGFR2 in presence of 1 uM ATP | ChEMBL. | 17416531 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.