Detailed information for compound 436981

Basic information

Technical information
  • TDR Targets ID: 436981
  • Name: ethyl (E)-3-(4-bromoanilino)-2-(4-chloropheny l)prop-2-enoate
  • MW: 380.664 | Formula: C17H15BrClNO2
  • H donors: 1 H acceptors: 1 LogP: 5.77 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)/C(=C/Nc1ccc(cc1)Br)/c1ccc(cc1)Cl
  • InChi: 1S/C17H15BrClNO2/c1-2-22-17(21)16(12-3-7-14(19)8-4-12)11-20-15-9-5-13(18)6-10-15/h3-11,20H,2H2,1H3/b16-11+
  • InChiKey: QOUANOQLRGXGCG-LFIBNONCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-(4-bromoanilino)-2-(4-chlorophenyl)-2-propenoic acid ethyl ester
  • ethyl (E)-3-[(4-bromophenyl)amino]-2-(4-chlorophenyl)prop-2-enoate
  • (E)-3-(4-bromoanilino)-2-(4-chlorophenyl)acrylic acid ethyl ester
  • (E)-3-[(4-bromophenyl)amino]-2-(4-chlorophenyl)prop-2-enoic acid ethyl ester
  • (E)-3-[(4-bromophenyl)amino]-2-(4-chlorophenyl)acrylic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein coupled receptor 0.0133 0.045 0.056
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0133 0.045 0.045
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0133 0.045 0.1057
Brugia malayi larval opioid receptor 0.0133 0.045 0.0443
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0133 0.045 0.056
Schistosoma mansoni biogenic amine receptor 0.0133 0.045 0.1057
Loa Loa (eye worm) G-protein coupled receptor 0.0133 0.045 0.045
Trypanosoma cruzi cdc2-related kinase 1 0.0042 0.0021 0.0464
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0007
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0133 0.045 0.056
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0063 0.012 0.012
Trypanosoma cruzi cyclin, putative 0.0101 0.03 1
Brugia malayi putative neuropeptide receptor NPR1 0.0133 0.045 0.0443
Trypanosoma cruzi cdc2-related kinase 3 0.0042 0.0021 0.0464
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.045 0.056
Schistosoma mansoni hypothetical protein 0.0341 0.1438 0.3412
Schistosoma mansoni biogenic amine (5HT) receptor 0.0133 0.045 0.1057
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0021 0.0032
Trichomonas vaginalis CMGC family protein kinase 0.0042 0.0021 0.0055
Echinococcus multilocularis g protein coupled receptor 0.0133 0.045 0.056
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0117 0.0373 0.0366
Brugia malayi AKH receptor 0.0133 0.045 0.0443
Loa Loa (eye worm) hypothetical protein 0.0924 0.42 0.42
Loa Loa (eye worm) proprotein convertase 2 0.0218 0.0855 0.0855
Brugia malayi Tachykinin-like peptides receptor 99D 0.0133 0.045 0.0443
Brugia malayi hypothetical protein 0.0063 0.012 0.0113
Brugia malayi RE15519p 0.0133 0.045 0.0443
Onchocerca volvulus 0.0063 0.012 0.0891
Trichomonas vaginalis cyclins, putative 0.0101 0.03 0.1183
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0855 0.3423
Brugia malayi Serotonin receptor 0.0133 0.045 0.0443
Loa Loa (eye worm) hypothetical protein 0.2148 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0133 0.045 0.056
Brugia malayi Melatonin receptor type 1A 0.0133 0.045 0.0443
Echinococcus granulosus integrin alpha ps 0.0069 0.0148 0.0178
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0218 0.0855 0.2021
Onchocerca volvulus 0.0063 0.012 0.0891
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0133 0.045 0.056
Echinococcus multilocularis integrin alpha ps 0.0069 0.0148 0.0178
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Toxoplasma gondii hypothetical protein 0.0048 0.0048 0.2406
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0179 0.0667 0.2667
Brugia malayi ORL1-like opioid receptor 0.0133 0.045 0.0443
Schistosoma mansoni hypothetical protein 0.0133 0.045 0.1057
Echinococcus multilocularis histone lysine n methyltransferase setd8 0.0075 0.0175 0.0212
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0042 0.0021 0.0464
Echinococcus multilocularis neuropeptide Y receptor 0.0133 0.045 0.056
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0133 0.045 0.1057
Loa Loa (eye worm) hypothetical protein 0.0075 0.0175 0.0175
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.045 0.056
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0133 0.045 0.0443
Echinococcus multilocularis sex peptide receptor 0.0133 0.045 0.056
Brugia malayi sulfakinin receptor protein 0.0133 0.045 0.0443
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Schistosoma mansoni furin-1 (S08 family) 0.0402 0.1725 0.4097
Onchocerca volvulus 0.0133 0.045 0.3491
Echinococcus multilocularis cyclin dependent kinase 5 0.0042 0.0021 0.0017
Loa Loa (eye worm) hypothetical protein 0.0041 0.0016 0.0016
Echinococcus granulosus peptide allatostatin:somatostatin 0.0133 0.045 0.056
Leishmania major chitinase 0.0074 0.0169 0.5533
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0667 0.2667
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0133 0.045 0.056
Brugia malayi Endochitinase 0.0074 0.0169 0.0162
Echinococcus granulosus biogenic amine 5HT receptor 0.0133 0.045 0.056
Trichomonas vaginalis cyclin B3, putative 0.0063 0.012 0.0456
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Trichomonas vaginalis CMGC family protein kinase 0.0042 0.0021 0.0055
Brugia malayi hypothetical protein 0.0063 0.012 0.0113
Echinococcus multilocularis orexin receptor type 2 0.0133 0.045 0.056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0562 0.2482 1
Echinococcus multilocularis 0.0746 0.3353 0.423
Echinococcus granulosus neuropeptide FF receptor 2 0.0133 0.045 0.056
Schistosoma mansoni histone-lysine n-methyltransferase seto7 0.0075 0.0175 0.0401
Loa Loa (eye worm) hypothetical protein 0.0085 0.0224 0.0224
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0296 0.0688
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0063 0.012 0.012
Loa Loa (eye worm) WD40 repeat protein 0.0307 0.1277 0.1277
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0042 0.0021 0.0021
Echinococcus granulosus neuropeptide Y receptor 0.0133 0.045 0.056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0562 0.2482 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0133 0.045 0.1057
Echinococcus multilocularis cyclin B3 1 0.0063 0.012 0.0143
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0133 0.045 0.056
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Onchocerca volvulus 0.0133 0.045 0.3491
Echinococcus granulosus neuropeptides capa receptor 0.0133 0.045 0.056
Echinococcus granulosus cyclin dependent kinase 0.0042 0.0021 0.0017
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Onchocerca volvulus 0.0133 0.045 0.3491
Schistosoma mansoni amine GPCR 0.0133 0.045 0.1057
Loa Loa (eye worm) integrin alpha pat-2 0.0238 0.0947 0.0947
Schistosoma mansoni hypothetical protein 0.0133 0.045 0.1057
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.045 0.056
Loa Loa (eye worm) hypothetical protein 0.0063 0.012 0.012
Schistosoma mansoni neuropeptide f receptor 76f 0.0133 0.045 0.1057
Brugia malayi cell division control protein 2 homolog 0.0042 0.0021 0.0014
Trichomonas vaginalis cyclin D, putative 0.0063 0.012 0.0456
Onchocerca volvulus 0.0063 0.012 0.0891
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0133 0.045 0.1057
Loa Loa (eye worm) melatonin receptor type 1A 0.0133 0.045 0.045
Echinococcus multilocularis cyclins 0.0063 0.012 0.0143
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0133 0.045 0.045
Trypanosoma cruzi cyclin, putative 0.0101 0.03 1
Echinococcus multilocularis allatostatin A receptor 0.0133 0.045 0.056
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0133 0.045 0.056
Echinococcus granulosus somatostatin receptor 0.0133 0.045 0.056
Schistosoma mansoni amine GPCR 0.0133 0.045 0.1057
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0133 0.045 0.1057
Onchocerca volvulus 0.0133 0.045 0.3491
Brugia malayi GnHR receptor homolog 0.0133 0.045 0.0443
Onchocerca volvulus 0.0133 0.045 0.3491
Brugia malayi hypothetical protein 0.0133 0.045 0.0443
Plasmodium falciparum apical sushi protein 0.0063 0.012 0.6737
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0101 0.03 1
Brugia malayi latrophilin 2 splice variant baaae 0.0439 0.1903 0.1897
Loa Loa (eye worm) hypothetical protein 0.0063 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Trichomonas vaginalis hypothetical protein 0.0179 0.0667 0.2667
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0133 0.045 0.045
Echinococcus multilocularis Furin 1 0.0218 0.0855 0.1071
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0667 0.2667
Loa Loa (eye worm) cyclin domain-containing protein 0.0063 0.012 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0667 0.2667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.045 0.1057
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0855 0.3423
Brugia malayi G-protein coupled receptor 0.0133 0.045 0.0443
Echinococcus granulosus orexin receptor type 2 0.0133 0.045 0.056
Loa Loa (eye worm) TYRA-2 protein 0.0133 0.045 0.045
Echinococcus granulosus fmrfamide receptor 0.0133 0.045 0.056
Brugia malayi proprotein convertase 2 0.0581 0.2573 0.2567
Schistosoma mansoni c4b-binding protein beta chain 0.0063 0.012 0.027
Trypanosoma cruzi cdc2-related kinase 1 0.0042 0.0021 0.0464
Echinococcus multilocularis cyclin dependent kinase 1 0.0042 0.0021 0.0017
Loa Loa (eye worm) latrophilin receptor protein 2 0.0203 0.0784 0.0784
Schistosoma mansoni hypothetical protein 0.0203 0.0784 0.1852
Loa Loa (eye worm) neuropeptide F receptor 0.0133 0.045 0.045
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0296 0.0688
Brugia malayi putative neuropeptide receptor 0.0133 0.045 0.0443
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0562 0.2482 0.3129
Echinococcus multilocularis g-protein coupled receptor 0.0133 0.045 0.056
Echinococcus granulosus alpha 1A adrenergic receptor 0.0133 0.045 0.056
Echinococcus granulosus cyclin B 0.0101 0.03 0.037
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0042 0.0021 0.0464
Leishmania major cyclin 0.0101 0.03 1
Echinococcus granulosus GPCR family 2 0.0203 0.0784 0.0982
Schistosoma mansoni histamine h1 receptor 0.0133 0.045 0.1057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.045 0.056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.045 0.1057
Echinococcus granulosus tm gpcr rhodopsin 0.0133 0.045 0.056
Giardia lamblia Cyclin A 0.0063 0.012 0.0695
Echinococcus granulosus g protein coupled receptor 0.0133 0.045 0.056
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1709 0.7918 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.01 0.0296 0.0365
Echinococcus granulosus Furin 1 0.0218 0.0855 0.1071
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Echinococcus granulosus cyclins 0.0063 0.012 0.0143
Trypanosoma brucei cdc2-related kinase 3 0.0042 0.0021 0.0095
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0179 0.0667 0.2667
Brugia malayi hypothetical protein 0.0133 0.045 0.0443
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0667 0.2667
Schistosoma mansoni hypothetical protein 0.0133 0.045 0.1057
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0133 0.045 0.0443
Echinococcus granulosus cyclin dependent kinase 1 0.0042 0.0021 0.0017
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0133 0.045 0.1057
Brugia malayi neuroendocrine convertase 1 precursor 0.0581 0.2573 0.2567
Brugia malayi hypothetical protein 0.0133 0.045 0.0443
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0133 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0101 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Echinococcus granulosus g-protein coupled receptor 0.0133 0.045 0.056
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0133 0.045 0.1057
Plasmodium falciparum cyclin 0.0063 0.012 0.6716
Echinococcus multilocularis C type lectin domian containing protein 0.0063 0.012 0.0143
Schistosoma mansoni neuropeptide F-like receptor 0.0133 0.045 0.1057
Echinococcus granulosus neuropeptide receptor 0.0133 0.045 0.056
Onchocerca volvulus 0.0063 0.012 0.0891
Schistosoma mansoni neuropeptide receptor 0.0133 0.045 0.1057
Trichomonas vaginalis cyclin B, putative 0.0101 0.03 0.1183
Loa Loa (eye worm) endoprotease bli-4 0.0924 0.42 0.42
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0855 0.3423
Echinococcus granulosus cyclins 0.0063 0.012 0.0143
Schistosoma mansoni opsin-like receptor 0.0133 0.045 0.1057
Schistosoma mansoni amine GPCR 0.0133 0.045 0.1057
Echinococcus granulosus cyclin b3 0.0063 0.012 0.0143
Brugia malayi Calcitonin receptor-like protein seb-1 0.0643 0.2866 0.2861
Echinococcus multilocularis G protein coupled receptor 139 0.0333 0.14 0.1761
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0042 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0667 0.2667
Trypanosoma brucei cdc2-related kinase 1 0.0042 0.0021 0.0095
Brugia malayi hypothetical protein 0.0133 0.045 0.0443
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Trichomonas vaginalis CMGC family protein kinase 0.0042 0.0021 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.045 0.056
Echinococcus granulosus neuropeptides capa receptor 0.0133 0.045 0.056
Schistosoma mansoni adenoreceptor 0.0133 0.045 0.1057
Trypanosoma cruzi cdc2-related kinase 3 0.0042 0.0021 0.0464
Echinococcus multilocularis fmrfamide receptor 0.0133 0.045 0.056
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0118 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0063 0.012 0.0143
Echinococcus multilocularis cyclins 0.0063 0.012 0.0143
Onchocerca volvulus Putative endochitinase 0.0074 0.0169 0.1276
Schistosoma mansoni biogenic amine (5HT) receptor 0.0133 0.045 0.1057
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0667 0.2667
Loa Loa (eye worm) hypothetical protein 0.0063 0.012 0.012
Echinococcus granulosus G protein coupled receptor kinase 1 0.009 0.0247 0.0303
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.045 0.056
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Onchocerca volvulus Putative endochitinase 0.0074 0.0169 0.1276
Entamoeba histolytica chitinase, putative 0.0074 0.0169 0.5315
Loa Loa (eye worm) hypothetical protein 0.0063 0.012 0.012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0133 0.045 0.056
Echinococcus granulosus tm gpcr rhodopsin 0.0133 0.045 0.056
Brugia malayi G protein-coupled receptor 0.0133 0.045 0.0443
Onchocerca volvulus 0.0063 0.012 0.0891
Onchocerca volvulus 0.0133 0.045 0.3491
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Onchocerca volvulus 0.0133 0.045 0.3491
Trichomonas vaginalis cyclin A, putative 0.0101 0.03 0.1183
Trichomonas vaginalis cyclin D, putative 0.0063 0.012 0.0456
Mycobacterium ulcerans chitinase/cellulase 0.0063 0.0118 1
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0021 0.0032
Echinococcus granulosus cyclins 0.0063 0.012 0.0143
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0133 0.045 0.056
Brugia malayi Protein set-1 0.0075 0.0175 0.0168
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0203 0.0784 0.0982
Brugia malayi G protein-coupled receptor F59B2.13 0.0133 0.045 0.0443
Brugia malayi hypothetical protein 0.0133 0.045 0.0443
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1709 0.7918 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.045 0.056
Echinococcus granulosus protein will die slowly 0.0307 0.1277 0.1605
Trypanosoma cruzi CYC2-like cyclin, putative 0.0101 0.03 1
Onchocerca volvulus 0.0133 0.045 0.3491
Trichomonas vaginalis cyclins, putative 0.0101 0.03 0.1183
Echinococcus granulosus tachykinin peptides receptor 99D 0.0133 0.045 0.056
Onchocerca volvulus Putative endochitinase 0.0074 0.0169 0.1276
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0133 0.045 0.1057
Schistosoma mansoni hypothetical protein 0.0307 0.1277 0.3027
Plasmodium vivax SET domain protein, putative 0.0075 0.0175 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0133 0.045 0.0443
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0855 0.3423
Onchocerca volvulus 0.0133 0.045 0.3491
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0133 0.045 0.1057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.045 0.056
Loa Loa (eye worm) hypothetical protein 0.0439 0.1903 0.1903
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0133 0.045 0.056
Brugia malayi hypothetical protein 0.0133 0.045 0.0443
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0667 0.2667
Brugia malayi hypothetical protein 0.0063 0.012 0.0113
Loa Loa (eye worm) hypothetical protein 0.0363 0.1538 0.1538
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.045 0.1057
Loa Loa (eye worm) hypothetical protein 0.0063 0.0118 0.0118
Echinococcus multilocularis cyclin dependent kinase 1 0.0042 0.0021 0.0017
Trypanosoma cruzi cyclin 6, putative 0.0101 0.03 1
Brugia malayi Latrophilin receptor protein 2 0.0203 0.0784 0.0777
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0133 0.045 0.0443
Plasmodium falciparum SET domain protein, putative 0.0075 0.0175 1
Echinococcus granulosus dro:myosuppressin receptor 0.0133 0.045 0.056
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0562 0.2482 0.3129
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.045 0.1057
Echinococcus multilocularis neuropeptide FF receptor 2 0.0133 0.045 0.056
Schistosoma mansoni cyclins 0.0063 0.012 0.0269
Trichomonas vaginalis cyclin B, putative 0.0101 0.03 0.1183
Echinococcus multilocularis protein will die slowly 0.0307 0.1277 0.1605
Echinococcus granulosus serotonin receptor 0.0133 0.045 0.056
Loa Loa (eye worm) hypothetical protein 0.0101 0.03 0.03
Brugia malayi hypothetical protein 0.0133 0.045 0.0443
Onchocerca volvulus 0.0101 0.03 0.2306
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Echinococcus multilocularis g protein coupled receptor 0.0133 0.045 0.056
Loa Loa (eye worm) chitinase I 0.0074 0.0169 0.0169
Echinococcus granulosus g protein coupled receptor 0.0133 0.045 0.056
Echinococcus multilocularis cyclin B 0.0101 0.03 0.037
Schistosoma mansoni amine GPCR 0.0133 0.045 0.1057
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0924 0.42 1
Schistosoma mansoni opsin-like receptor 0.0133 0.045 0.1057
Echinococcus granulosus histone lysine n methyltransferase setd8 0.0075 0.0175 0.0212
Brugia malayi Cyclin, N-terminal domain containing protein 0.0101 0.03 0.0293
Brugia malayi Protein kinase domain containing protein 0.0042 0.0021 0.0014
Brugia malayi hypothetical protein 0.0063 0.012 0.0113
Entamoeba histolytica cyclin family protein 0.0063 0.012 0.3555
Loa Loa (eye worm) subtilase 0.004 0.0007 0.0007
Brugia malayi endoprotease bli-4 precursor 0.0924 0.42 0.4196
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0133 0.045 0.3491
Onchocerca volvulus 0.0063 0.012 0.0891
Echinococcus granulosus integrin alpha 3 0.0118 0.0381 0.0472
Schistosoma mansoni cyclin B 0.0101 0.03 0.0698
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Brugia malayi celfurPC protein 0.0746 0.3353 0.3348
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Brugia malayi hypothetical protein 0.0063 0.012 0.0113
Brugia malayi Cyclin, N-terminal domain containing protein 0.0101 0.03 0.0293
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.045 0.056
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0133 0.045 0.1057
Plasmodium vivax apical sushi protein, putative 0.0063 0.012 0.6737
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0203 0.0784 0.0982
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0063 0.012 0.0143
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0133 0.045 0.056
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0133 0.045 0.0443
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0042 0.0021 0.0021
Trichomonas vaginalis WD repeat domain, putative 0.0307 0.1277 0.5128
Giardia lamblia Hypothetical protein 0.0063 0.012 0.0695
Onchocerca volvulus 0.0063 0.012 0.0891
Schistosoma mansoni integrin alpha-ps 0.0069 0.0148 0.0335
Loa Loa (eye worm) hypothetical protein 0.0063 0.012 0.012
Toxoplasma gondii rhoptry neck protein RON9 0.0063 0.012 0.6737
Trichomonas vaginalis cyclins, putative 0.0063 0.012 0.0456
Echinococcus multilocularis serotonin receptor 0.0133 0.045 0.056
Echinococcus granulosus neuropeptide receptor 0.0333 0.14 0.1761
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0855 0.3423
Echinococcus multilocularis cyclin b3 0.0063 0.012 0.0143
Onchocerca volvulus 0.0133 0.045 0.3491
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0133 0.045 0.056
Schistosoma mansoni hypothetical protein 0.0203 0.0784 0.1852
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.01 0.0296 0.0296
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0203 0.0784 0.0777
Brugia malayi Dopamine receptor 0.0133 0.045 0.0443
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0133 0.045 0.056
Echinococcus multilocularis neuropeptides capa receptor 0.0133 0.045 0.056
Loa Loa (eye worm) hypothetical protein 0.0063 0.012 0.012
Mycobacterium tuberculosis Possible chitinase 0.0063 0.0118 1
Echinococcus multilocularis somatostatin receptor 0.0133 0.045 0.056
Brugia malayi hypothetical protein 0.0063 0.012 0.0113
Echinococcus multilocularis fmrfamide receptor 0.0133 0.045 0.056
Toxoplasma gondii histone lysine methyltransferase SET8 0.0075 0.0175 1
Onchocerca volvulus 0.0133 0.045 0.3491
Brugia malayi hypothetical protein 0.0133 0.045 0.0443
Schistosoma mansoni biogenic amine receptor 0.0133 0.045 0.1057
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0667 0.2667
Trichomonas vaginalis cyclin B, putative 0.0101 0.03 0.1183
Brugia malayi Serotonin receptor 0.0133 0.045 0.0443
Echinococcus multilocularis neuropeptide s receptor 0.0133 0.045 0.056
Echinococcus multilocularis cyclin dependent kinase 0.0042 0.0021 0.0017
Echinococcus multilocularis serotonin receptor 0.0133 0.045 0.056
Schistosoma mansoni neuropeptide F-like receptor 0.0133 0.045 0.1057
Onchocerca volvulus 0.0133 0.045 0.3491
Schistosoma mansoni amine GPCR 0.0133 0.045 0.1057
Brugia malayi hypothetical protein 0.0133 0.045 0.0443
Mycobacterium leprae Possible secreted protease 0.004 0.0007 0.5
Echinococcus granulosus cyclin dependent kinase 5 0.0042 0.0021 0.0017
Echinococcus granulosus neuroendocrine convertase 2 0.0581 0.2573 0.3243
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0042 0.0021 0.0017
Giardia lamblia Furin precursor putative serine protease 0.0179 0.0667 0.4531
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0667 0.2667
Toxoplasma gondii rhoptry neck protein RON1 0.0063 0.012 0.6737
Echinococcus multilocularis cyclins 0.0063 0.012 0.0143
Plasmodium falciparum protein kinase 5 0.0042 0.0021 0.0809
Brugia malayi Cyclin, N-terminal domain containing protein 0.0063 0.012 0.0113
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0133 0.045 0.056
Trypanosoma brucei RNA helicase, putative 0.0341 0.1438 1
Onchocerca volvulus 0.0133 0.045 0.3491
Brugia malayi Dopamine receptor protein 1 0.0133 0.045 0.0443
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0667 0.2667
Brugia malayi follicle stimulating hormone receptor 0.0133 0.045 0.0443
Giardia lamblia High cysteine membrane protein Group 2 0.0343 0.1448 1
Echinococcus granulosus tm gpcr rhodopsin 0.0133 0.045 0.056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.045 0.1057
Echinococcus multilocularis beta adrenergic receptor kinase 0.01 0.0296 0.0365
Schistosoma mansoni myosin xvIII 0.0133 0.045 0.1057
Onchocerca volvulus 0.0133 0.045 0.3491
Echinococcus multilocularis G-protein coupled receptor, putative 0.0133 0.045 0.056
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0133 0.045 0.1057
Echinococcus multilocularis neuropeptides capa receptor 0.0133 0.045 0.056
Plasmodium vivax protein kinase Crk2 0.0042 0.0021 0.0809
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0063 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Schistosoma mansoni neuropeptide receptor 0.0133 0.045 0.1057
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0133 0.045 0.1057
Onchocerca volvulus Neuropeptide F receptor homolog 0.0133 0.045 0.3491
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.045 0.056
Entamoeba histolytica cyclin family protein 0.0063 0.012 0.3555
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0133 0.045 0.056
Loa Loa (eye worm) hypothetical protein 0.0063 0.012 0.012
Echinococcus multilocularis cyclins 0.0063 0.012 0.0143
Schistosoma mansoni integrin alpha 0.0154 0.0551 0.1298
Entamoeba histolytica cyclin, putative 0.0063 0.012 0.3555
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Brugia malayi hypothetical protein 0.0063 0.012 0.0113
Brugia malayi hypothetical protein 0.0133 0.045 0.0443
Trichomonas vaginalis cyclins, putative 0.0101 0.03 0.1183
Echinococcus multilocularis neuropeptide receptor A26 0.0133 0.045 0.056
Onchocerca volvulus 0.0063 0.012 0.0891
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Schistosoma mansoni neuropeptide receptor 0.0133 0.045 0.1057
Onchocerca volvulus 0.0133 0.045 0.3491
Echinococcus granulosus G protein coupled receptor 139 0.0133 0.045 0.056
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0133 0.045 0.045
Schistosoma mansoni hypothetical protein 0.0439 0.1903 0.452
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0133 0.045 0.056
Schistosoma mansoni growth hormone secretagogue receptor 0.0133 0.045 0.1057
Echinococcus granulosus neuropeptide receptor A26 0.0133 0.045 0.056
Echinococcus multilocularis neuropeptide Y receptor 0.0133 0.045 0.056
Echinococcus granulosus biogenic amine 5HT receptor 0.0133 0.045 0.056
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0667 0.2667
Onchocerca volvulus 0.0307 0.1277 1
Schistosoma mansoni hypothetical protein 0.0179 0.0667 0.1574
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0179 0.0667 0.2667
Trypanosoma brucei mitotic cyclin 6 0.0101 0.03 0.2046
Brugia malayi Dopamine receptor protein 2 0.0133 0.045 0.0443
Loa Loa (eye worm) G-protein coupled receptor 0.0133 0.045 0.045
Echinococcus multilocularis integrin alpha ps 0.0069 0.0148 0.0178
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0643 0.2866 0.2866
Schistosoma mansoni hypothetical protein 0.0203 0.0784 0.1852
Brugia malayi Will die slowly protein 0.0307 0.1277 0.127
Trichomonas vaginalis cyclin B, putative 0.0101 0.03 0.1183
Trichomonas vaginalis cyclin B, putative 0.0063 0.012 0.0456
Brugia malayi neuropeptide F receptor 0.0133 0.045 0.0443
Echinococcus granulosus c4b binding protein beta chain 0.0063 0.012 0.0143
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0133 0.045 0.056
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0133 0.045 0.056
Brugia malayi neuropeptide F receptor 0.0133 0.045 0.0443
Echinococcus multilocularis GPCR, family 2 0.0203 0.0784 0.0982
Echinococcus granulosus 7tm_1 domain containing protein 0.0133 0.045 0.056
Brugia malayi G-protein coupled receptor 0.0133 0.045 0.0443
Schistosoma mansoni hypothetical protein 0.0133 0.045 0.1057
Loa Loa (eye worm) microfilarial chitinase 0.0063 0.0118 0.0118
Echinococcus granulosus hypothetical protein 0.0133 0.045 0.056
Loa Loa (eye worm) cuticular endochitinase 0.0074 0.0169 0.0169
Echinococcus multilocularis cyclins 0.0063 0.012 0.0143
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.045 0.1057
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Giardia lamblia G2/mitotic-specific cyclin B 0.0101 0.03 0.1956
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.045 0.056
Echinococcus granulosus neuropeptide s receptor 0.0133 0.045 0.056
Schistosoma mansoni alpha-1 adrenergic receptor 0.0133 0.045 0.1057
Schistosoma mansoni opsin-like receptor 0.0133 0.045 0.1057
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0218 0.0855 0.3423
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.045 0.056
Trichomonas vaginalis cyclins, putative 0.0053 0.0072 0.0263
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.045 0.056
Echinococcus granulosus sex peptide receptor 0.0133 0.045 0.056
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0133 0.045 0.056
Loa Loa (eye worm) hypothetical protein 0.0203 0.0784 0.0784
Echinococcus granulosus cyclin B3 1 0.0063 0.012 0.0143
Echinococcus granulosus neuropeptide Y receptor 0.0133 0.045 0.056
Schistosoma mansoni hypothetical protein 0.0203 0.0784 0.1852
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Onchocerca volvulus Putative endochitinase 0.0074 0.0169 0.1276
Brugia malayi Sushi domain 0.0063 0.012 0.0113
Entamoeba histolytica cyclin, putative 0.0101 0.03 1
Echinococcus multilocularis neuropeptide receptor 0.0133 0.045 0.056
Brugia malayi endochitinase 0.0074 0.0169 0.0162
Onchocerca volvulus Putative endochitinase 0.0074 0.0169 0.1276
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0133 0.045 0.1057
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.004 0.0007 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0133 0.045 0.056
Brugia malayi GCC2 and GCC3 family protein 0.0063 0.012 0.0113
Brugia malayi endochitinase 0.0074 0.0169 0.0162
Echinococcus multilocularis neuropeptide receptor 0.0333 0.14 0.1761
Echinococcus multilocularis c4b binding protein beta chain 0.0063 0.012 0.0143
Trichomonas vaginalis cyclins, putative 0.0101 0.03 0.1183
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.004 0.0007 0.5
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Echinococcus granulosus allatostatin A receptor 0.0133 0.045 0.056
Echinococcus granulosus 7TM GPCR rhodopsin 0.0133 0.045 0.056
Echinococcus granulosus C type lectin domian containing protein 0.0063 0.012 0.0143
Loa Loa (eye worm) neuropeptide F receptor 0.0133 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0121 0.0394 0.0394
Echinococcus multilocularis cyclins 0.0063 0.012 0.0143
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.045 0.056
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.012 0.0456
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0117 0.0373 0.0373
Onchocerca volvulus 0.0133 0.045 0.3491
Onchocerca volvulus 0.0133 0.045 0.3491
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0133 0.045 0.056
Onchocerca volvulus 0.0063 0.012 0.0891
Echinococcus granulosus furin 0.0924 0.42 0.5301
Echinococcus multilocularis integrin alpha 3 0.0118 0.0381 0.0472
Brugia malayi Integrin alpha pat-2 precursor 0.0154 0.0551 0.0544
Schistosoma mansoni cyclin B3 0.0063 0.012 0.0269
Echinococcus granulosus cyclins 0.0063 0.012 0.0143
Brugia malayi pregnancy-associated plasma protein-A 0.0063 0.012 0.0113
Schistosoma mansoni neuropeptide receptor 0.0333 0.14 0.3322
Echinococcus multilocularis G protein coupled receptor kinase 1 0.009 0.0247 0.0303
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Echinococcus multilocularis g protein coupled receptor 0.0133 0.045 0.056
Echinococcus multilocularis cyclins 0.0063 0.012 0.0143
Schistosoma mansoni biogenic amine receptor 0.0133 0.045 0.1057
Onchocerca volvulus 0.0063 0.012 0.0891
Echinococcus multilocularis neuroendocrine convertase 2 0.0581 0.2573 0.3243
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.045 0.056
Loa Loa (eye worm) hypothetical protein 0.0133 0.045 0.045
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0042 0.0021 0.0809
Echinococcus granulosus cyclins 0.0063 0.012 0.0143
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.045 0.1057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.045 0.1057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.045 0.1057

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 50 ug ml-1 Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by MTT method ChEMBL. 17418583
MIC (functional) > 50 ug ml-1 Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT method ChEMBL. 17418583
MIC (functional) > 50 ug ml-1 Antibacterial activity against Pseudomonas fluorescens ATCC 13525 after 24 hrs by MTT method ChEMBL. 17418583
MIC (functional) > 50 ug ml-1 Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by MTT method ChEMBL. 17418583
MIC (functional) > 50 ug ml-1 Antifungal activity against Aspergillus niger ATCC 16404 after 48 hrs by MTT method ChEMBL. 17418583
MIC (functional) > 50 ug ml-1 Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by MTT method ChEMBL. 17418583
MIC (functional) > 50 ug ml-1 Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT method ChEMBL. 17418583
MIC (functional) > 50 ug ml-1 Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by MTT method ChEMBL. 17418583

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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