Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | cytochrome P450 | 0.0064 | 0.2003 | 0.0283 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | g protein coupled receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0058 | 0.177 | 0.7604 |
Brugia malayi | Cytochrome P450 family protein | 0.0064 | 0.2003 | 0.0283 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0064 | 0.2003 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0058 | 0.177 | 0.7604 |
Brugia malayi | Cytochrome P450 family protein | 0.0083 | 0.2785 | 0.1233 |
Echinococcus granulosus | sex peptide receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Schistosoma mansoni | cytochrome P450 | 0.0064 | 0.2003 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | orexin receptor type 2 | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0064 | 0.2003 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0064 | 0.2003 | 0.5 |
Echinococcus multilocularis | orexin receptor type 2 | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0058 | 0.177 | 0.7604 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0083 | 0.2785 | 1 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | cytochrome P450 | 0.0064 | 0.2003 | 0.2003 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0058 | 0.177 | 0.7604 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0064 | 0.2003 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | neuropeptide s receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0058 | 0.177 | 0.7604 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0064 | 0.2003 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0072 | 0.2328 | 1 |
Echinococcus granulosus | allatostatin A receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0083 | 0.2785 | 0.2785 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0058 | 0.177 | 0.7604 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0064 | 0.2003 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0058 | 0.177 | 0.177 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | serotonin receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0058 | 0.177 | 0.177 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0064 | 0.2003 | 0.5 |
Echinococcus multilocularis | fmrfamide receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Onchocerca volvulus | 0.0212 | 0.8027 | 1 | |
Echinococcus granulosus | neuropeptide Y receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | g protein coupled receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Brugia malayi | Cytochrome P450 family protein | 0.0083 | 0.2785 | 0.1233 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0058 | 0.177 | 0.177 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0064 | 0.2003 | 0.5 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0058 | 0.177 | 0.7604 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0064 | 0.2003 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0064 | 0.2003 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.0058 | 0.177 | 0.7604 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0083 | 0.2785 | 1 |
Echinococcus granulosus | neuropeptide receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | g-protein coupled receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0064 | 0.2003 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | somatostatin receptor | 0.0058 | 0.177 | 0.7604 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.2003 | 1 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | 0.0064 | 0.2003 | 0.8605 | |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus multilocularis | neuropeptide receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | serotonin receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0058 | 0.177 | 0.7604 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0064 | 0.2003 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0083 | 0.2785 | 1 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0072 | 0.2328 | 1 |
Echinococcus granulosus | g protein coupled receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus multilocularis | sex peptide receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | g-protein coupled receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0064 | 0.2003 | 0.5 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0261 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | hypothetical protein | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.8027 | 0.8027 |
Echinococcus multilocularis | neuropeptide receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0211 | 0.0211 |
Brugia malayi | cyclic AMP-response element binding protein 1 gamma 1, putative | 0.0212 | 0.8027 | 0.7602 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0064 | 0.2003 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0064 | 0.2003 | 0.5 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | g protein coupled receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | somatostatin receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Mycobacterium leprae | putative cytochrome p450 | 0.0064 | 0.2003 | 0.5 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0083 | 0.2785 | 0.2785 |
Echinococcus multilocularis | g protein coupled receptor | 0.0058 | 0.177 | 0.7604 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0064 | 0.2003 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0064 | 0.2003 | 0.8605 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus multilocularis | g protein coupled receptor | 0.0058 | 0.177 | 0.7604 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0064 | 0.2003 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | allatostatin A receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Trypanosoma brucei | cytochrome P450, putative | 0.0083 | 0.2785 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0064 | 0.2003 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | fmrfamide receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0064 | 0.2003 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0058 | 0.177 | 0.177 |
Echinococcus granulosus | neuropeptide receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0064 | 0.2003 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0058 | 0.177 | 0.7604 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0064 | 0.2003 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Leishmania major | cytochrome p450-like protein | 0.0083 | 0.2785 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.177 | 0.177 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Echinococcus multilocularis | fmrfamide receptor | 0.0058 | 0.177 | 0.7604 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0083 | 0.2785 | 0.2785 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0058 | 0.177 | 0.7604 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.0058 | 0.177 | 0.7604 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0064 | 0.2003 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | Inhibition of [3H]DA uptake in human NET expressed in COS1 cell membrane | ChEMBL. | 17446076 | |
Ki (functional) | Inhibition of [3H]DA uptake in human DAT expressed in COS1 cell membrane | ChEMBL. | 17446076 | |
Ki (functional) | Inhibition of [3H]SER uptake in human SERT expressed in COS1 cell membrane | ChEMBL. | 17446076 | |
Ki (functional) | 0 | Inhibition of [3H]DA uptake in human DAT expressed in COS1 cell membrane | ChEMBL. | 17446076 |
Ki (functional) | 0 | Inhibition of [3H]SER uptake in human SERT expressed in COS1 cell membrane | ChEMBL. | 17446076 |
Ki (functional) | 0 | Inhibition of [3H]DA uptake in human NET expressed in COS1 cell membrane | ChEMBL. | 17446076 |
Ki (binding) | = 1660 uM | Displacement of [125I]RTI55 from human DAT expressed in COS1 cell membrane | ChEMBL. | 17446076 |
Ki (binding) | = 1660 uM | Displacement of [125I]RTI55 from human DAT expressed in COS1 cell membrane | ChEMBL. | 17446076 |
Ki (binding) | = 2540 uM | Displacement of [125I]RTI55 from human NET expressed in COS1 cell membrane | ChEMBL. | 17446076 |
Ki (binding) | = 2540 uM | Displacement of [125I]RTI55 from human NET expressed in COS1 cell membrane | ChEMBL. | 17446076 |
Ki (binding) | = 4680 uM | Displacement of [125I]RTI55 from human SERT expressed in COS1 cell membrane | ChEMBL. | 17446076 |
Ki (binding) | = 4680 uM | Displacement of [125I]RTI55 from human SERT expressed in COS1 cell membrane | ChEMBL. | 17446076 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.