Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | cytochrome P450 | 0.0098 | 0.2124 | 0.0989 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0098 | 0.2124 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | neuropeptide receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.5049 | 0.5049 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus multilocularis | fmrfamide receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0064 | 0.1259 | 0.5929 |
Trypanosoma brucei | cytochrome P450, putative | 0.0125 | 0.2803 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0098 | 0.2124 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0098 | 0.2124 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0125 | 0.2803 | 0.2803 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0064 | 0.1259 | 0.5929 |
Mycobacterium leprae | putative cytochrome p450 | 0.0098 | 0.2124 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0098 | 0.2124 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | hypothetical protein | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | g protein coupled receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0098 | 0.2124 | 0.5 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0098 | 0.2124 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0098 | 0.2124 | 0.2124 |
Echinococcus multilocularis | 0.0098 | 0.2124 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0098 | 0.2124 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0125 | 0.2803 | 0.2803 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.032 | 0.032 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0064 | 0.1259 | 0.5929 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0125 | 0.2803 | 1 |
Echinococcus multilocularis | fmrfamide receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | sex peptide receptor | 0.0064 | 0.1259 | 0.5929 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0125 | 0.2803 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | g protein coupled receptor | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0064 | 0.1259 | 0.1259 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | g protein coupled receptor | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.041 | 1 | 1 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0064 | 0.1259 | 0.5929 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0098 | 0.2124 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0098 | 0.2124 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0098 | 0.2124 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0064 | 0.1259 | 0.5929 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0098 | 0.2124 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0064 | 0.1259 | 0.1259 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0098 | 0.2124 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | serotonin receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | neuropeptide receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | neuropeptide receptor | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0098 | 0.2124 | 0.5 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0064 | 0.1259 | 0.5929 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0098 | 0.2124 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0098 | 0.2124 | 0.5 |
Echinococcus multilocularis | g-protein coupled receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0064 | 0.1259 | 0.5929 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0125 | 0.2803 | 1 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0098 | 0.2124 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0064 | 0.1259 | 0.1259 |
Brugia malayi | Cytochrome P450 family protein | 0.0125 | 0.2803 | 0.1766 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0098 | 0.2124 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.2124 | 1 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | allatostatin A receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0072 | 0.1464 | 0.6893 |
Echinococcus granulosus | allatostatin A receptor | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0064 | 0.1259 | 0.5929 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0098 | 0.2124 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0064 | 0.1259 | 0.1259 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0098 | 0.2124 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0064 | 0.1259 | 0.1259 |
Echinococcus multilocularis | serotonin receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0064 | 0.1259 | 0.5929 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0098 | 0.2124 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0125 | 0.2803 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Brugia malayi | cyclic AMP-response element binding protein 1 gamma 1, putative | 0.0214 | 0.5049 | 0.4336 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | sex peptide receptor | 0.0064 | 0.1259 | 0.5929 |
Brugia malayi | Cytochrome P450 family protein | 0.0098 | 0.2124 | 0.0989 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0064 | 0.1259 | 0.5929 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0098 | 0.2124 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | fmrfamide receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus multilocularis | serotonin receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | g protein coupled receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | orexin receptor type 2 | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | neuropeptide receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | neuropeptide s receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | somatostatin receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0064 | 0.1259 | 0.5929 |
Echinococcus granulosus | g protein coupled receptor | 0.0064 | 0.1259 | 0.5929 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0098 | 0.2124 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0064 | 0.1259 | 0.5929 |
Brugia malayi | Cytochrome P450 family protein | 0.0125 | 0.2803 | 0.1766 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0064 | 0.1259 | 0.1259 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus granulosus | g-protein coupled receptor | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0098 | 0.2124 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus multilocularis | somatostatin receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0064 | 0.1259 | 0.5929 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0098 | 0.2124 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0064 | 0.1259 | 0.1259 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0064 | 0.1259 | 0.5929 |
Echinococcus multilocularis | orexin receptor type 2 | 0.0064 | 0.1259 | 0.5929 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0125 | 0.2803 | 0.2803 |
Onchocerca volvulus | 0.0214 | 0.5049 | 1 | |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0072 | 0.1464 | 0.6893 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 64 % | Cell viability in human RPMI 8226 ECACC 87012702 cancer cells at 100 uM after 24 hrs by MTT assay | ChEMBL. | 17331732 |
Activity (functional) | = 64 % | Cell viability in human RPMI 8226 ECACC 87012702 cancer cells at 100 uM after 24 hrs by MTT assay | ChEMBL. | 17331732 |
Activity (functional) | = 74 % | Cell viability in HSF cells at 100 uM after 24 hrs by MTT assay | ChEMBL. | 17331732 |
Activity (functional) | = 76 % | Cell viability in human RPMI 8226 ECACC 87012702 cancer cells at 50 uM after 24 hrs by MTT assay | ChEMBL. | 17331732 |
Activity (functional) | = 76 % | Cell viability in human RPMI 8226 ECACC 87012702 cancer cells at 50 uM after 24 hrs by MTT assay | ChEMBL. | 17331732 |
Activity (ADMET) | = 84 % | Cell viability in HSF cells at 50 uM after 24 hrs by MTT assay | ChEMBL. | 17331732 |
Activity (functional) | = 94 % | Cell viability in human RPMI 8226 ECACC 87012702 cancer cells at 1 uM after 24 hrs by MTT assay | ChEMBL. | 17331732 |
Activity (functional) | = 94 % | Cell viability in human RPMI 8226 ECACC 87012702 cancer cells at 1 uM after 24 hrs by MTT assay | ChEMBL. | 17331732 |
Activity (ADMET) | = 98 % | Cell viability in HSF cells at 1 uM after 24 hrs by MTT assay | ChEMBL. | 17331732 |
Inhibition (ADMET) | = 0 % | Cytotoxicity against Vero cells at 10 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (ADMET) | = 0 % | Cytotoxicity against Vero cells at 50 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (functional) | = 0 % | Cytotoxicity against human LS180 cells at 10 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (functional) | = 0 % | Cytotoxicity against human HeLa cells at 50 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (functional) | = 0 % | Cytotoxicity against human HeLa cells at 50 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (functional) | = 5 % | Cytotoxicity against human LS180 cells at 50 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (functional) | = 8 % | Cytotoxicity against human HeLa cells at 10 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (functional) | = 8 % | Cytotoxicity against human HeLa cells at 10 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (functional) | = 16 % | Cytotoxicity against human T47D cells at 10 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (functional) | = 16 % | Cytotoxicity against human T47D cells at 10 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (functional) | = 25 % | Anticancer activity against human A549 cells at 10 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (functional) | = 25 % | Anticancer activity against human A549 cells at 10 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (functional) | = 27 % | Cytotoxicity against human T47D cells at 50 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (functional) | = 27 % | Anticancer activity against human A549 cells at 50 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (functional) | = 27 % | Cytotoxicity against human T47D cells at 50 ug/ml after 72 hrs | ChEMBL. | 17331732 |
Inhibition (functional) | = 27 % | Anticancer activity against human A549 cells at 50 ug/ml after 72 hrs | ChEMBL. | 17331732 |
LD50 (ADMET) | Acute toxicity in mouse | ChEMBL. | 17331732 | |
LD50 (ADMET) | 0 | Acute toxicity in mouse | ChEMBL. | 17331732 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.