Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1476 | 0.1476 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0031 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1476 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1476 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0031 | 0 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0031 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Leishmania major | prostaglandin f synthase, putative | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 0 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1476 | 0.1476 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0031 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1476 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1476 | 0.1476 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1476 | 0.1476 |
Giardia lamblia | Aldose reductase | 0.0031 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0031 | 0 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1476 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1476 | 0.1476 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Onchocerca volvulus | 0.0031 | 0 | 0.5 | |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0031 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 75 nM | Antimalarial activity against Plasmodium falciparum K1 | ChEMBL. | 17722901 |
ED50 (functional) | = 75 nM | Antimalarial activity against Plasmodium falciparum K1 | ChEMBL. | 17722901 |
ED50 (functional) | = 460 nM | Antimalarial activity against Plasmodium falciparum 3D7 | ChEMBL. | 17722901 |
ED50 (functional) | = 460 nM | Antimalarial activity against Plasmodium falciparum 3D7 | ChEMBL. | 17722901 |
Inhibition (binding) | = 28 % | Inhibition of plasmodium falciparum protein farnesyltransferase at 0.5 nM by scintillation proximity assay | ChEMBL. | 17722901 |
Inhibition (binding) | = 90 % | Inhibition of plasmodium falciparum protein farnesyltransferase at 5 nM by scintillation proximity assay | ChEMBL. | 17722901 |
Inhibition (binding) | = 99 % | Inhibition of plasmodium falciparum protein farnesyltransferase at 50 nM by scintillation proximity assay | ChEMBL. | 17722901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.