Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0157 | 0.0083 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0157 | 0.0083 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0157 | 0.0083 | 0.0102 |
Echinococcus multilocularis | rho associated protein kinase | 0.031 | 0.1984 | 0.3363 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0136 | 0.0136 |
Brugia malayi | Hr1 repeat family protein | 0.0426 | 0.3428 | 0.3428 |
Echinococcus granulosus | protein kinase c iota type | 0.0255 | 0.1307 | 0.2181 |
Loa Loa (eye worm) | hypothetical protein | 0.0698 | 0.6805 | 0.6805 |
Brugia malayi | C1-like domain containing protein | 0.0165 | 0.0188 | 0.0188 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0271 | 0.1504 | 0.2526 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0616 | 0.5783 | 0.5783 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0324 | 0.2161 | 0.3674 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0353 | 0.2522 | 0.4303 |
Echinococcus multilocularis | protein kinase c iota type | 0.0255 | 0.1307 | 0.2181 |
Trichomonas vaginalis | AGC family protein kinase | 0.0157 | 0.0083 | 1 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0155 | 0.0058 | 0.0058 |
Trichomonas vaginalis | AGC family protein kinase | 0.0157 | 0.0083 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0155 | 0.0058 | 0.6725 |
Trichomonas vaginalis | AGC family protein kinase | 0.0155 | 0.0058 | 0.6725 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0155 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0799 | 0.8053 | 0.8053 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0616 | 0.5783 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0425 | 0.341 | 0.5855 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0165 | 0.0188 | 0.0188 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0504 | 0.4393 | 0.7572 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0426 | 0.3428 | 0.3428 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0426 | 0.3428 | 0.5887 |
Loa Loa (eye worm) | hypothetical protein | 0.0853 | 0.8729 | 0.8729 |
Trichomonas vaginalis | AGC family protein kinase | 0.0157 | 0.0083 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0155 | 0.0058 | 0.0058 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0158 | 0.0096 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0698 | 0.6805 | 0.6805 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0157 | 0.0083 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0157 | 0.0083 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0355 | 0.2547 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0157 | 0.0083 | 0.0083 |
Echinococcus granulosus | protein kinase C gamma type | 0.0324 | 0.2161 | 0.3674 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0425 | 0.341 | 0.5855 |
Onchocerca volvulus | 0.0698 | 0.6805 | 1 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0155 | 0.0058 | 0.6725 |
Schistosoma mansoni | serine/threonine protein kinase | 0.031 | 0.1984 | 0.3363 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0616 | 0.5783 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0426 | 0.3428 | 0.5887 |
Brugia malayi | Protein kinase c protein 2 | 0.0274 | 0.1538 | 0.1538 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0158 | 0.0096 | 0.0066 |
Brugia malayi | Protein kinase domain containing protein | 0.0155 | 0.0058 | 0.0058 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0426 | 0.3428 | 0.5887 |
Entamoeba histolytica | protein kinase, putative | 0.0157 | 0.0083 | 0.0102 |
Onchocerca volvulus | 0.0306 | 0.1931 | 0.2692 | |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0174 | 0.029 | 0.029 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0425 | 0.341 | 0.5855 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0955 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0425 | 0.341 | 0.5855 |
Brugia malayi | Protein kinase domain containing protein | 0.0157 | 0.0083 | 0.0083 |
Trichomonas vaginalis | AGC family protein kinase | 0.0157 | 0.0083 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0255 | 0.1307 | 0.2181 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0096 | 0.0096 |
Schistosoma mansoni | protein kinase C mu | 0.0165 | 0.0188 | 0.0228 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.1345 | 0.1345 |
Brugia malayi | protein kinase C II. | 0.0616 | 0.5783 | 0.5783 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0698 | 0.6805 | 0.6805 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0271 | 0.1504 | 0.2526 |
Onchocerca volvulus | 0.0163 | 0.0162 | 0.0038 | |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0155 | 0.0058 | 0.0058 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0155 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0165 | 0.0188 | 0.0188 |
Brugia malayi | Protein kinase domain containing protein | 0.0155 | 0.0058 | 0.0058 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.031 | 0.1984 | 0.3363 |
Toxoplasma gondii | AGC kinase | 0.0155 | 0.0058 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0157 | 0.0083 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0155 | 0.0058 | 0.0058 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0616 | 0.5783 | 1 |
Onchocerca volvulus | 0.031 | 0.1984 | 0.277 | |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0158 | 0.0096 | 0.0066 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 9 mg kg-1 | Dose required to produce an acute inflammatory response of the algal poly saccharide carrageenan into the pleural cavity of rat. | ChEMBL. | 3941408 |
Inhibition (functional) | = 0 % | Compound was tested for inhibition of mouse connective tissue cell (L) growth at a concentration of 100 uM | ChEMBL. | 3941408 |
Inhibition (functional) | < 5 % | Inhibition of lymphocyte-mediated cytolysis at a concentratioon of 100 uM in [51Cr]- labelled EL4 leukemia cells | ChEMBL. | 3941408 |
Inhibition (functional) | = 6 % | Compound was tested for inhibition of human sternal marrow cell (D98) growth at a concentration of 100 uM | ChEMBL. | 3941408 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.