Detailed information for compound 437766

Basic information

Technical information
  • TDR Targets ID: 437766
  • Name: propan-2-yl 4-[[[6-cyano-1-[(3-methylimidazol -4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-p yridin-2-ylsulfonylamino]methyl]piperidine-1- carboxylate
  • MW: 591.724 | Formula: C30H37N7O4S
  • H donors: 0 H acceptors: 6 LogP: 3.04 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#Cc1ccc2c(c1)CC(CN2Cc1cncn1C)N(S(=O)(=O)c1ccccn1)CC1CCN(CC1)C(=O)OC(C)C
  • InChi: 1S/C30H37N7O4S/c1-22(2)41-30(38)35-12-9-23(10-13-35)18-37(42(39,40)29-6-4-5-11-33-29)26-15-25-14-24(16-31)7-8-28(25)36(19-26)20-27-17-32-21-34(27)3/h4-8,11,14,17,21-23,26H,9-10,12-13,15,18-20H2,1-3H3
  • InChiKey: IUJQRRMVCBZZFE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • isopropyl 4-[[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-(2-pyridylsulfonyl)amino]methyl]piperidine-1-carboxylate
  • 4-[[[6-cyano-1-[(3-methyl-4-imidazolyl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-(2-pyridylsulfonyl)amino]methyl]-1-piperidinecarboxylic acid isopropyl ester
  • propan-2-yl 4-[[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-pyridin-2-ylsulfonyl-amino]methyl]piperidine-1-carboxylate
  • 4-[[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-(2-pyridylsulfonyl)amino]methyl]piperidine-1-carboxylic acid isopropyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.0019 0.0116 0.0242
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0073 0.0134
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0073 0.0101
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0038 0.007
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0559 0.1335
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0171 0.0313
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0073 0.0098
Giardia lamblia Rab geranylgeranyltransferase 0.0193 0.332 1
Loa Loa (eye worm) carboxylesterase 0.003 0.0324 0.0466
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0038 0.0078
Loa Loa (eye worm) hypothetical protein 0.0238 0.4147 0.6077
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.6626 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0116 0.0266
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0033 0.0374 0.4749
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0018 0.0099 0.0106
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0038 0.0098
Schistosoma mansoni hypothetical protein 0.0021 0.0158 0.029
Trypanosoma brucei importin beta-1 subunit, putative 0.0018 0.0093 0.0211
Entamoeba histolytica hypothetical protein 0.0027 0.0264 0.0777
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0022 0.0025
Schistosoma mansoni bromodomain containing protein 0.0049 0.0667 0.1221
Brugia malayi CXXC zinc finger family protein 0.0022 0.0163 0.023
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.003 0.0324 0.0312
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0036 0.0436 0.0424
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0073 0.0134
Schistosoma mansoni hypothetical protein 0.0021 0.0158 0.029
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0135 0.2244 0.3285
Loa Loa (eye worm) glutaminase 2 0.0214 0.3717 0.5447
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0674 0.1234
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0087 0.1365 0.1354
Brugia malayi glutaminase DH11.1 0.0214 0.3717 0.5447
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0033 0.0374 0.0685
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0078
Brugia malayi Trypsin family protein 0.0022 0.0171 0.0242
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0171 0.0313
Trichomonas vaginalis D-aminoacylase, putative 0.0087 0.1365 0.2052
Echinococcus multilocularis glycoprotein Antigen 5 0.0022 0.0171 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0073 0.0098
Loa Loa (eye worm) hypothetical protein 0.0031 0.033 0.0475
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0073 0.0134
Plasmodium vivax hypothetical protein, conserved 0.0087 0.1365 0.41
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0668 0.1598
Trichomonas vaginalis D-aminoacylase, putative 0.0087 0.1365 0.2052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0073 0.0098
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0078
Echinococcus multilocularis GPCR, family 2 0.0021 0.0158 0.0169
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.1365 0.3282
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0116 0.0332
Brugia malayi PHD-finger family protein 0.002 0.0132 0.0185
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0089 0.0164
Trichomonas vaginalis spcc417.12 protein, putative 0.003 0.0324 0.048
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0087 0.1365 0.2499
Plasmodium vivax acyl-CoA synthetase, putative 0.0014 0.0027 0.0062
Echinococcus multilocularis Smad4 0.0018 0.0089 0.0095
Loa Loa (eye worm) hypothetical protein 0.0068 0.1013 0.1478
Loa Loa (eye worm) hypothetical protein 0.0017 0.0073 0.0098
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0073 0.0134
Loa Loa (eye worm) Smad1 0.0018 0.0089 0.0122
Onchocerca volvulus 0.0087 0.1365 0.2671
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.005 0.0685 0.1639
Brugia malayi exodeoxyribonuclease III family protein 0.0033 0.0374 0.054
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0036 0.0436 0.0649
Brugia malayi MH2 domain containing protein 0.026 0.456 0.6685
Brugia malayi Trypsin family protein 0.0022 0.0171 0.0242
Onchocerca volvulus 0.003 0.0324 0.0599
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0019 0.0116 0.0242
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0192 0.3296 0.4829
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0022 0.0171 0.0313
Brugia malayi Smad1 0.0018 0.0089 0.0122
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0021 0.0158 0.029
Schistosoma mansoni cpg binding protein 0.0022 0.0163 0.0298
Schistosoma mansoni zinc finger protein 0.0016 0.0058 0.0106
Echinococcus multilocularis geminin 0.0298 0.5262 0.5619
Echinococcus granulosus acetylcholinesterase 0.018 0.3084 0.5647
Brugia malayi Carboxylesterase family protein 0.003 0.0324 0.0466
Loa Loa (eye worm) hypothetical protein 0.003 0.0324 0.0466
Brugia malayi Trypsin family protein 0.0022 0.0171 0.0242
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0038 0.0049
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0038 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0674 0.1234
Loa Loa (eye worm) hypothetical protein 0.0036 0.0436 0.0631
Schistosoma mansoni smad1 5 8 and 0.0018 0.0089 0.0164
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0038 0.0098
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0193 0.332 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0089 0.0095
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0403 0.0738
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0038 0.0136
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0046 0.0617 0.113
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0036 0.0436 0.0649
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0073 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0116 0.0242
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0116 0.0162
Mycobacterium tuberculosis Conserved protein 0.0087 0.1365 0.1354
Loa Loa (eye worm) glutathione reductase 0.0043 0.0559 0.0812
Echinococcus multilocularis carboxylesterase 5A 0.018 0.3084 0.3293
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0022 0.0025
Brugia malayi nuclear receptor NHR-88 0.0017 0.0073 0.0098
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0223
Onchocerca volvulus 0.0019 0.0116 0.0186
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0091
Onchocerca volvulus 0.0022 0.0171 0.0296
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0116 0.0162
Trypanosoma cruzi hypothetical protein, conserved 0.0087 0.1365 0.3282
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0461 0.1098
Leishmania major importin beta-1 subunit, putative 0.0015 0.0031 0.006
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0186 0.0198
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0668 0.1598
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0022 0.0024
Echinococcus multilocularis Mastin 0.0022 0.0171 0.0183
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0935 0.3884
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0461 0.0687
Loa Loa (eye worm) latrophilin receptor protein 2 0.0021 0.0158 0.0223
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0263 0.462 0.8459
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0073 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0073 0.0098
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0668 0.1598
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.012
Toxoplasma gondii exonuclease III APE 0.0033 0.0374 0.1539
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.0163 0.023
Loa Loa (eye worm) hypothetical protein 0.0022 0.0171 0.0242
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0135 0.2244 0.5406
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0171 0.0313
Mycobacterium ulcerans beta-lactamase 0.0087 0.1365 0.3626
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0559 0.1668
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0706 0.2113
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0038 0.0078
Echinococcus multilocularis enteropeptidase 0.0022 0.0171 0.0183
Echinococcus multilocularis neuroligin 0.003 0.0324 0.0346
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0171 0.0313
Brugia malayi hypothetical protein 0.003 0.0324 0.0466
Schistosoma mansoni Smad4 0.0018 0.0089 0.0164
Loa Loa (eye worm) hypothetical protein 0.0017 0.0073 0.0098
Brugia malayi ecdysteroid receptor 0.0017 0.0073 0.0098
Trichomonas vaginalis inositol monophosphatase, putative 0.0053 0.0745 0.1117
Loa Loa (eye worm) transcription factor SMAD2 0.026 0.456 0.6685
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0088 0.0197
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0038 0.0078
Schistosoma mansoni hypothetical protein 0.0022 0.0171 0.0313
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0038 0.007
Brugia malayi beta-lactamase family protein 0.0087 0.1365 0.1994
Brugia malayi MH1 domain containing protein 0.0018 0.0089 0.0122
Trichomonas vaginalis D-aminoacylase, putative 0.0087 0.1365 0.2052
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0668 0.1598
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0022 0.005
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0171 0.0313
Echinococcus multilocularis dna polymerase eta 0.0018 0.0088 0.0093
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0027 0.0264 0.0282
Brugia malayi Thioredoxin reductase 0.0043 0.0559 0.0812
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0135 0.2244 0.411
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0135 0.2244 0.3381
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.003
Brugia malayi Pre-SET motif family protein 0.0037 0.0436 0.0631
Onchocerca volvulus 0.005 0.0685 0.1318
Mycobacterium leprae Probable lipase LipE 0.0087 0.1365 0.7495
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0022 0.004
Echinococcus granulosus inositol monophosphatase 1 0.0053 0.0745 0.1365
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0461 0.0687
Trichomonas vaginalis DNA polymerase eta, putative 0.0018 0.0088 0.0123
Loa Loa (eye worm) hypothetical protein 0.003 0.0324 0.0466
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0461 0.1098
Schistosoma mansoni inositol monophosphatase 0.0053 0.0745 0.1365
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0238 0.4147 0.6077
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0088 0.0197
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.005 0.0685 0.1639
Loa Loa (eye worm) bromodomain containing protein 0.0013 0.0009 0.0004
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.003 0.0324 0.0593
Trypanosoma cruzi importin beta-1 subunit, putative 0.0015 0.0031 0.006
Echinococcus multilocularis BC026374 protein (S09 family) 0.003 0.0324 0.0346
Brugia malayi Carboxylesterase family protein 0.018 0.3084 0.4517
Trypanosoma brucei hypothetical protein, conserved 0.0087 0.1365 0.3282
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0038 0.0048
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0033 0.0374 0.0362
Mycobacterium ulcerans esterase/lipase LipP 0.0087 0.1365 0.3626
Echinococcus multilocularis zinc finger protein 0.0016 0.0058 0.0062
Brugia malayi hypothetical protein 0.0022 0.0171 0.0242
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0186 0.034
Loa Loa (eye worm) hypothetical protein 0.0087 0.1365 0.1994
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0068 0.1013 0.1478
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0935 0.0998
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0436 0.1038
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0461 0.0687
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0238 0.4147 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0022 0.0025
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0087 0.1365 0.1354
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0088 0.0165
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0073 0.0134
Mycobacterium tuberculosis Probable dehydrogenase 0.0098 0.1579 0.1569
Schistosoma mansoni survival motor neuron protein 0.0044 0.0575 0.1053
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0036 0.0436 0.1296
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.017 0.2896 0.3093
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.0045 0.0588 0.0628
Trypanosoma cruzi lanosterol synthase, putative 0.0036 0.0436 0.1038
Loa Loa (eye worm) glutaminase 0.0214 0.3717 0.5447
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0098 0.1579 0.1569
Loa Loa (eye worm) hypothetical protein 0.0216 0.3746 0.5489
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0135 0.2244 0.6754
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.005 0.0685 0.0731
Loa Loa (eye worm) hypothetical protein 0.0087 0.1365 0.1994
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0935 0.2461
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0461 0.1098
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.003 0.0324 0.0593
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0022 0.004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0021 0.0158 0.0169
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0461 0.0687
Loa Loa (eye worm) hypothetical protein 0.0022 0.0171 0.0242
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0073 0.0098
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0135 0.2244 0.3285
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0116 0.0266
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0036 0.0436 0.1296
Schistosoma mansoni hypothetical protein 0.0298 0.5262 0.9635
Echinococcus multilocularis beta LACTamase domain containing family member 0.0087 0.1365 0.1457
Mycobacterium tuberculosis Probable lipase LipE 0.0087 0.1365 0.1354
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0036 0.0436 0.1296
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0073 0.0134
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0193 0.332 0.5006
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0048 0.0642 0.3159
Schistosoma mansoni hypothetical protein 0.0046 0.0617 0.113
Toxoplasma gondii hypothetical protein 0.005 0.0685 0.2838
Echinococcus granulosus protein prenyltransferase alpha subunit 0.005 0.0685 0.1254
Trypanosoma cruzi protein farnesyltransferase, putative 0.0135 0.2244 0.5406
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.017 0.2896 0.4242
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.005 0.0685 0.1639
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0193 0.332 0.608
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0033 0.0374 0.1111
Echinococcus granulosus snurportin 1 0.0192 0.3296 0.6035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0297 0.0427
Leishmania major 4-coumarate:coa ligase-like protein 0.0019 0.0116 0.0266
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0021 0.0158 0.0223
Echinococcus granulosus enteropeptidase 0.0022 0.0171 0.0313
Schistosoma mansoni coup transcription factor 0.0017 0.0073 0.0134
Brugia malayi Carboxylesterase family protein 0.003 0.0324 0.0466
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0033 0.0374 0.0889
Schistosoma mansoni smad1 5 8 and 0.0018 0.0089 0.0164
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0674 0.1234
Entamoeba histolytica hypothetical protein 0.0027 0.0264 0.0777
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0073 0.0078
Mycobacterium tuberculosis Conserved protein 0.0087 0.1365 0.1354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0436 0.0799
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0135 0.2244 0.3381
Echinococcus granulosus importin subunit beta 1 0.0018 0.0093 0.0171
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0033 0.0374 0.1111
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0461 0.0687
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0022 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0685 0.1639
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0022 0.0025
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.003 0.0324 0.048
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0935 0.1712
Loa Loa (eye worm) hypothetical protein 0.0018 0.0093 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0073 0.0098
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0087 0.1365 0.1994
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0053 0.0745 0.1786
Echinococcus granulosus glycoprotein Antigen 5 0.0022 0.0171 0.0313
Echinococcus granulosus dna polymerase kappa 0.0018 0.0088 0.016
Echinococcus granulosus acetylcholinesterase 0.018 0.3084 0.5647
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0706 0.2113
Schistosoma mansoni hypothetical protein 0.0022 0.0171 0.0313
Schistosoma mansoni ap endonuclease 0.0033 0.0374 0.0685
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0022 0.004
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0018 0.0088 0.0123
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0461 0.0687
Mycobacterium ulcerans glutaminase 0.0214 0.3717 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0073 0.0098
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0171 0.0313
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0073 0.0134
Plasmodium vivax SET domain protein, putative 0.0037 0.0436 0.1298
Trichomonas vaginalis set domain proteins, putative 0.0287 0.5049 0.7617
Schistosoma mansoni BC026374 protein (S09 family) 0.003 0.0324 0.0593
Brugia malayi beta-lactamase family protein 0.0087 0.1365 0.1994
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0073 0.0134
Echinococcus granulosus transmembrane protease serine 3 0.0022 0.0171 0.0313
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0171 0.0313
Brugia malayi Importin beta-1 subunit 0.0018 0.0093 0.0128
Plasmodium falciparum glutathione reductase 0.0043 0.0559 0.1668
Toxoplasma gondii HEAT repeat-containing protein 0.0018 0.0093 0.0365
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0135 0.2244 0.3381
Brugia malayi RNA, U transporter 1 0.0051 0.0704 0.1024
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0087 0.1365 0.1354
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0046 0.0617 0.0659
Trypanosoma brucei membrane transporter protein, putative 0.0049 0.0668 0.1598
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0036 0.0436 0.0798
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.005 0.0685 0.1639
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.4408 0.6461
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0022 0.0171 0.0313
Leishmania major geranylgeranyltransferase, putative 0.0036 0.0436 0.1038
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0033 0.0374 0.0942
Mycobacterium ulcerans lipase LipD 0.0087 0.1365 0.3626
Brugia malayi hypothetical protein 0.0027 0.0264 0.0378
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0087 0.1365 0.3626
Echinococcus multilocularis dna polymerase kappa 0.0018 0.0088 0.0093
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0073 0.0134
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0461 0.0667
Trypanosoma brucei unspecified product 0.0018 0.0088 0.0197
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0036 0.0436 0.0798
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0033 0.0374 0.0889
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.005 0.0685 0.2048
Plasmodium falciparum geranylgeranyltransferase, putative 0.0036 0.0436 0.1296
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0135 0.2244 0.6754
Leishmania major protein farnesyltransferase alpha subunit, putative 0.005 0.0685 0.1639
Plasmodium falciparum thioredoxin reductase 0.0043 0.0559 0.1668
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0038 0.0078
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0073 0.0134
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0461 0.1371
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.005 0.0685 0.2048
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0098 0.1579 0.8783
Brugia malayi Carboxylesterase family protein 0.003 0.0324 0.0466
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.2223 0.2374
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0193 0.332 0.3546
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0685 0.1639
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0048 0.0642 0.0631
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0078
Schistosoma mansoni terminal deoxycytidyl transferase 0.0018 0.0088 0.016
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0089 0.0095
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0436 0.0466
Echinococcus multilocularis importin subunit beta 1 0.0018 0.0093 0.01
Mycobacterium tuberculosis Probable esterase LipL 0.0087 0.1365 0.1354
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0038 0.0078
Plasmodium falciparum thioredoxin reductase 0.0015 0.0038 0.0098
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0018 0.0088 0.012
Echinococcus multilocularis survival motor neuron protein 1 0.0216 0.3746 0.4
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0935 0.2461
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0073 0.0078
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0935 0.1712
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0087 0.1365 0.2499
Loa Loa (eye worm) hypothetical protein 0.0022 0.0171 0.0242
Leishmania major hypothetical protein, conserved 0.0049 0.0668 0.1598
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0036 0.0436 0.0631
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0036 0.0436 0.0798
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0706 0.1691
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0088 0.0075
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0088 0.012
Schistosoma mansoni hypothetical protein 0.0192 0.3296 0.6035
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0073 0.0098
Trichomonas vaginalis penicillin-binding protein, putative 0.0087 0.1365 0.2052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0073 0.0098
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0135 0.2244 0.3381
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0036 0.0436 0.1796
Trypanosoma brucei DNA polymerase eta, putative 0.0018 0.0088 0.0197
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0053 0.0745 0.1117
Onchocerca volvulus 0.0241 0.4211 0.8333
Schistosoma mansoni hypothetical protein 0.0027 0.0264 0.0483
Schistosoma mansoni alpha glucosidase 0.0038 0.0461 0.0843
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0073 0.0098
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0014 0.0027 0.0014
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0038 0.0049
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0038 0.0032
Echinococcus multilocularis snurportin 1 0.0192 0.3296 0.352
Brugia malayi hypothetical protein 0.0033 0.0372 0.0537
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0089 0.0164
Toxoplasma gondii histone lysine methyltransferase SET1 0.0044 0.0578 0.2391
Entamoeba histolytica acyl-coA synthetase, putative 0.0019 0.0116 0.0332
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Schistosoma mansoni importin beta-1 0.0018 0.0093 0.0171
Schistosoma mansoni hypothetical protein 0.0044 0.0575 0.1053
Giardia lamblia DINP protein human, muc B family 0.0018 0.0088 0.0246
Brugia malayi steroid hormone receptor 0.0017 0.0073 0.0098
Onchocerca volvulus 0.0022 0.0171 0.0296
Trypanosoma cruzi DNA polymerase eta, putative 0.0018 0.0088 0.0197
Mycobacterium tuberculosis Probable reductase 0.0098 0.1579 0.1569
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0049 0.0668 0.0713
Echinococcus granulosus carboxylesterase 5A 0.018 0.3084 0.5647
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0038 0.0078
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0461 0.0843
Schistosoma mansoni smad 0.0018 0.0089 0.0164
Onchocerca volvulus 0.003 0.0324 0.0599
Brugia malayi hypothetical protein 0.0051 0.0706 0.1028
Echinococcus granulosus dnaJ subfamily B 0.0309 0.5461 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.1365 0.1994
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0193 0.332 0.4864
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0053 0.0745 0.2231
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0073 0.0078
Echinococcus granulosus GPCR family 2 0.0021 0.0158 0.029
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0019 0.0116 0.0242
Echinococcus granulosus cpg binding protein 0.0024 0.0212 0.0388
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0018 0.0088 0.0197
Leishmania major hypothetical protein, conserved 0.0049 0.0668 0.1598
Loa Loa (eye worm) hypothetical protein 0.003 0.0324 0.0466
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0436 0.0799
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0036 0.0436 0.0798
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0033 0.0374 0.0889
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0073 0.0078
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0098 0.1579 0.1569
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0706 0.2113
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.005 0.0685 0.1254
Plasmodium vivax importin-beta 2, putative 0.0018 0.0093 0.0264
Schistosoma mansoni alpha-glucosidase 0.0147 0.2471 0.4524
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0461 0.0687
Schistosoma mansoni neuroligin 3 (S09 family) 0.003 0.0324 0.0593
Schistosoma mansoni acetylcholinesterase 0.003 0.0324 0.0593
Leishmania major farnesyltransferase beta subunit 0.0135 0.2244 0.5406
Loa Loa (eye worm) hypothetical protein 0.0049 0.0674 0.098
Trichomonas vaginalis ap endonuclease, putative 0.0033 0.0374 0.0556
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0193 0.332 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.018 0.3084 0.5647
Schistosoma mansoni multidrug resistance protein 0.0049 0.0668 0.1223
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.017 0.2896 0.5304
Plasmodium falciparum acyl-CoA synthetase 0.0014 0.0027 0.0062
Loa Loa (eye worm) hypothetical protein 0.0017 0.0073 0.0098
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0053 0.0745 0.3091
Trichomonas vaginalis penicillin-binding protein, putative 0.0087 0.1365 0.2052
Schistosoma mansoni thyroid hormone receptor 0.015 0.2534 0.464
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0559 0.0812
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0135 0.2244 0.411
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0171 0.0313
Schistosoma mansoni hypothetical protein 0.0021 0.0158 0.029
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.003
Loa Loa (eye worm) hypothetical protein 0.0051 0.0706 0.1028
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.003 0.0324 0.0312
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Onchocerca volvulus 0.0037 0.0436 0.0823
Echinococcus multilocularis acetylcholinesterase 0.018 0.3084 0.3293
Schistosoma mansoni hypothetical protein 0.0021 0.0158 0.029
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0044 0.0575 0.0835
Schistosoma mansoni ap endonuclease 0.0033 0.0374 0.0685
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0018 0.0088 0.0093
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0073 0.0134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.017 0.2896 0.5304
Toxoplasma gondii hypothetical protein 0.0143 0.2398 1
Brugia malayi Carboxylesterase family protein 0.003 0.0324 0.0466
Brugia malayi latrophilin 2 splice variant baaae 0.0046 0.0617 0.0897
Echinococcus multilocularis cpg binding protein 0.0024 0.0212 0.0226
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0053 0.0745 0.1786
Loa Loa (eye worm) hypothetical protein 0.0263 0.462 0.6772
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0171 0.0313
Giardia lamblia Prenyltransferase 0.0135 0.2244 0.6754
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0073 0.0101
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0073 0.0078
Brugia malayi beta-lactamase 0.0087 0.1365 0.1994
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0033 0.0374 0.1111
Onchocerca volvulus 0.0022 0.0171 0.0296
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0193 0.332 0.608
Loa Loa (eye worm) hypothetical protein 0.0087 0.1365 0.1994
Mycobacterium tuberculosis Probable hydrolase 0.0087 0.1365 0.1354
Plasmodium vivax glutathione reductase, putative 0.0043 0.0559 0.1668
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0053 0.0745 0.1948
Loa Loa (eye worm) hypothetical protein 0.0017 0.0073 0.0098
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0027 0.0263 0.0482
Schistosoma mansoni hypothetical protein 0.0309 0.5461 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.0636 0.1164
Onchocerca volvulus 0.0017 0.0073 0.0101
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0073 0.0078
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0089 0.0122
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0935 0.1712
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.2909 0.3106
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0116 0.0104
Echinococcus granulosus BC026374 protein S09 family 0.003 0.0324 0.0593
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Brugia malayi Inositol-1 0.0053 0.0745 0.1085
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0018 0.0088 0.016
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0087 0.1365 0.1994
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0073 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.017 0.2896 0.5304
Trypanosoma brucei lanosterol synthase 0.0036 0.0436 0.1038
Trypanosoma brucei MATE efflux family protein, putative 0.0049 0.0668 0.1598
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0109 0.1782 1
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0193 0.332 0.4864
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0053 0.0745 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0171 0.0313
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0706 0.1691
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.0088 0.0165
Leishmania major C-8 sterol isomerase-like protein 0.0238 0.4147 1
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0073 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0073 0.0098
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0036 0.0436 0.1038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0073 0.0098
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0033 0.0374 0.04
Onchocerca volvulus 0.003 0.0324 0.0599
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.2909 0.426
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0073 0.0134
Mycobacterium leprae conserved hypothetical protein 0.0087 0.1365 0.7495
Schistosoma mansoni hypothetical protein 0.0023 0.0186 0.034
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0135 0.2244 0.9358
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0089 0.0122
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0171 0.0183
Echinococcus granulosus survival motor neuron protein 1 0.0216 0.3746 0.6859
Mycobacterium tuberculosis Conserved protein 0.0087 0.1365 0.1354
Schistosoma mansoni hypothetical protein 0.0133 0.2223 0.4071
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0073 0.0134
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0068 0.1013 0.1478
Loa Loa (eye worm) trypsin family protein 0.0022 0.0171 0.0242
Onchocerca volvulus 0.0022 0.0171 0.0296
Trypanosoma brucei C-8 sterol isomerase, putative 0.0238 0.4147 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0674 0.072
Mycobacterium tuberculosis Carboxylesterase LipT 0.003 0.0324 0.0312
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.005 0.0685 0.0731
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0049 0.0668 0.1223
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0018 0.0088 0.0075
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0436 0.1799
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.005 0.0685 0.0996
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0022 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0036 0.0436 0.1296
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.005 0.0685 0.1639
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.052 0.9365 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0109 0.1782 0.1772
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0053 0.0745 0.1117
Onchocerca volvulus 0.003 0.0324 0.0599
Mycobacterium ulcerans hypothetical protein 0.0087 0.1365 0.3626
Trypanosoma brucei trypanothione reductase 0.0043 0.0559 0.1335
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0038 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0668 0.1598
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0461 0.0687
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.003
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0935 0.2244
Leishmania major trypanothione reductase 0.0043 0.0559 0.1335
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0038 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0436 0.1038
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0073 0.0078
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.005 0.0685 0.1639
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0559 0.1024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0073 0.0098
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0109 0.1782 0.1772
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0135 0.2244 0.3381
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0073 0.0078
Brugia malayi hypothetical protein 0.0216 0.3746 0.5489
Loa Loa (eye worm) hypothetical protein 0.0022 0.0171 0.0242
Entamoeba histolytica hypothetical protein 0.0027 0.0264 0.0777
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0031 0.0037
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0171 0.0313
Mycobacterium tuberculosis Probable lipase LipD 0.0087 0.1365 0.1354
Loa Loa (eye worm) hypothetical protein 0.0017 0.0073 0.0098
Schistosoma mansoni transcription factor LCR-F1 0.0027 0.0264 0.0483
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0038 0.0026
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0013 0.0006 0.0006
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0135 0.2244 0.6754
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0073 0.0101
Echinococcus multilocularis dnaJ subfamily B 0.0309 0.5461 0.5832
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.2909 0.3106
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0022 0.004
Brugia malayi Bromodomain containing protein 0.0058 0.083 0.121
Loa Loa (eye worm) hypothetical protein 0.0193 0.332 0.4864
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0078
Onchocerca volvulus 0.0263 0.462 0.9146
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0935 0.0924
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0078
Loa Loa (eye worm) hypothetical protein 0.0087 0.1365 0.1994
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.2909 0.5326
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0022 0.0171 0.0183
Schistosoma mansoni hypothetical protein 0.0298 0.5262 0.9635
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0073 0.0098
Brugia malayi Pre-SET motif family protein 0.0252 0.4408 0.6461
Onchocerca volvulus 0.0022 0.0163 0.0279
Onchocerca volvulus 0.0087 0.1365 0.2671
Echinococcus granulosus Mastin 0.0022 0.0171 0.0313
Loa Loa (eye worm) hypothetical protein 0.0022 0.0171 0.0242
Onchocerca volvulus 0.0022 0.0171 0.0296
Trichomonas vaginalis esterase, putative 0.0087 0.1365 0.2052
Mycobacterium ulcerans hypothetical protein 0.0022 0.0171 0.0391
Giardia lamblia Rab geranylgeranyltransferase 0.0036 0.0436 0.1296
Echinococcus granulosus beta LACTamase domain containing family member 0.0087 0.1365 0.2499
Loa Loa (eye worm) hypothetical protein 0.0383 0.6819 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Mycobacterium ulcerans carboxylesterase, LipT 0.003 0.0324 0.0805
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0135 0.2244 0.2397
Brugia malayi Calcitonin receptor-like protein seb-1 0.0068 0.1013 0.1478
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0559 0.0597
Entamoeba histolytica acyl-CoA synthetase, putative 0.0019 0.0116 0.0332
Echinococcus multilocularis para nitrobenzyl esterase 0.003 0.0324 0.0346
Echinococcus granulosus zinc finger protein 0.0016 0.0058 0.0106
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0098 0.1579 0.1569
Loa Loa (eye worm) carboxylesterase 0.018 0.3084 0.4517
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.017 0.2896 0.5304
Loa Loa (eye worm) hypothetical protein 0.0046 0.0617 0.0897
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.017 0.2896 0.5304
Schistosoma mansoni DNA polymerase eta 0.0018 0.0088 0.016
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0088 0.012
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0706 0.1691
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.003 0.0324 0.0593
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0078
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0935 0.2461
Toxoplasma gondii thioredoxin reductase 0.0043 0.0559 0.2312
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0038 0.0032
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0073 0.0134
Schistosoma mansoni cpg binding protein 0.0024 0.0212 0.0388
Brugia malayi glutathione reductase 0.0043 0.0559 0.0812
Loa Loa (eye worm) inositol-1 0.0053 0.0745 0.1085
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0171 0.0313
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0073 0.0134
Echinococcus granulosus geminin 0.0298 0.5262 0.9635
Brugia malayi MH2 domain containing protein 0.0018 0.0089 0.0122
Echinococcus granulosus neuroligin 0.003 0.0324 0.0593
Echinococcus granulosus GTP binding nuclear protein Ran 0.0013 0.0006 0.0011
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0022 0.0025
Onchocerca volvulus 0.003 0.0324 0.0599
Echinococcus granulosus smad 0.0018 0.0089 0.0164
Brugia malayi Carboxylesterase family protein 0.018 0.3084 0.4517
Trichomonas vaginalis ap endonuclease, putative 0.0033 0.0374 0.0556
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0073 0.0098
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0193 0.332 1
Toxoplasma gondii ABC1 family protein 0.0087 0.1365 0.5681
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0019 0.0116 0.0242
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0098 0.1571 0.4722
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0559 0.0547
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0021 0.0158 0.0169
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.017 0.2896 0.4242
Schistosoma mansoni cpg binding protein 0.0024 0.0212 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0073 0.0098
Onchocerca volvulus 0.0044 0.0575 0.1099
Entamoeba histolytica hypothetical protein 0.0027 0.0264 0.0777
Echinococcus multilocularis thyroid hormone receptor alpha 0.015 0.2534 0.2706
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0038 0.0136
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.2223 0.4071
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0038 0.0078
Schistosoma mansoni smad1 5 8 and 0.0018 0.0089 0.0164
Leishmania major hypothetical protein, conserved 0.0051 0.0706 0.1691
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0098 0.1579 0.1569
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0706 0.2928
Trypanosoma cruzi protein farnesyltransferase, putative 0.0135 0.2244 0.5406
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0089 0.0164
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0036 0.0436 0.1796
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0073 0.0098
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.017 0.2896 0.3093
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0033 0.0374 0.1111
Brugia malayi Trypsin family protein 0.0263 0.462 0.6772
Echinococcus granulosus Smad4 0.0018 0.0089 0.0164
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0073 0.0098
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0193 0.332 0.5006
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0033 0.0374 0.054
Loa Loa (eye worm) hypothetical protein 0.018 0.3084 0.4517
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0143 0.2398 0.3613
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0053 0.0745 0.1786
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0022 0.0171 0.0313
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0383 0.6819 1
Brugia malayi Bromodomain containing protein 0.0029 0.0296 0.0426
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0027 0.0264 0.0483
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0038 0.0098
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0171 0.0313
Loa Loa (eye worm) hypothetical protein 0.0033 0.0379 0.0548
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0162
Loa Loa (eye worm) hypothetical protein 0.003 0.0324 0.0466
Leishmania major DNA polymerase eta, putative 0.0018 0.0088 0.0197
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0019 0.0116 0.0104
Echinococcus granulosus family S9 non peptidase ue S09 family 0.003 0.0324 0.0593
Trypanosoma brucei glucosidase, putative 0.0038 0.0461 0.1098
Loa Loa (eye worm) acetylcholinesterase 1 0.018 0.3084 0.4517
Loa Loa (eye worm) hypothetical protein 0.0053 0.0748 0.1089
Brugia malayi nuclear hormone receptor 0.0017 0.0073 0.0098
Loa Loa (eye worm) MH2 domain-containing protein 0.026 0.456 0.6685
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0073 0.0098
Onchocerca volvulus 0.0099 0.1582 0.3103
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0162
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0018 0.0099 0.0182
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0461 0.0687
Echinococcus granulosus para nitrobenzyl esterase 0.003 0.0324 0.0593
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0685 0.1639
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0116 0.0162
Entamoeba histolytica hypothetical protein 0.0015 0.0031 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0073 0.0098
Loa Loa (eye worm) hypothetical protein 0.003 0.0324 0.0466
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0036 0.0436 0.0465
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0038 0.0098
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.003 0.0324 0.0346
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0078
Echinococcus granulosus dna polymerase eta 0.0018 0.0088 0.016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0162
Trypanosoma brucei importin beta-1 subunit, putative 0.0018 0.0093 0.0211
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0022 0.0025
Entamoeba histolytica deoxycytidyl transferase, putative 0.0018 0.0088 0.0246
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0053 0.0745 0.1786
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0073 0.0134
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0088 0.0197
Loa Loa (eye worm) hypothetical protein 0.018 0.3084 0.4517
Treponema pallidum exodeoxyribonuclease (exoA) 0.0033 0.0374 1
Giardia lamblia Rab geranylgeranyltransferase 0.005 0.0685 0.2048
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0171 0.0313
Schistosoma mansoni ran 0.0013 0.0006 0.0011
Schistosoma mansoni inositol monophosphatase 0.0053 0.0745 0.1365
Loa Loa (eye worm) hypothetical protein 0.0121 0.2003 0.2931
Onchocerca volvulus 0.0087 0.1365 0.2671
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.003
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0116 0.0242
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0461 0.19
Echinococcus multilocularis transmembrane protease serine 3 0.0022 0.0171 0.0183
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0036 0.0436 0.0649
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0031 0.0037
Brugia malayi Latrophilin receptor protein 2 0.0021 0.0158 0.0223
Plasmodium vivax geranylgeranyltransferase, putative 0.0036 0.0436 0.1296
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.2909 0.426
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0116 0.0242
Schistosoma mansoni alpha-glucosidase 0.0147 0.2471 0.4524
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0036 0.0436 0.0631
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0033 0.0374 0.0889
Brugia malayi Trypsin-like protease protein 5 0.0022 0.0171 0.0242
Schistosoma mansoni glutaminase 0.0214 0.3717 0.6807
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0461 0.0492
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0036 0.0436 0.1038
Loa Loa (eye worm) hypothetical protein 0.003 0.0324 0.0466
Schistosoma mansoni ran 0.0013 0.0006 0.0011
Brugia malayi MH1 domain containing protein 0.0018 0.0089 0.0122
Trichomonas vaginalis importin beta-1, putative 0.0015 0.0031 0.0037
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0109 0.1782 0.1772
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0171 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0022 0.0171 0.0242
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0461 0.1371
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.005 0.0685 0.2048
Echinococcus multilocularis smad 0.0018 0.0089 0.0095
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0068 0.101 0.1849
Trichomonas vaginalis glutaminase, putative 0.0214 0.3717 0.5606
Plasmodium falciparum importin beta, putative 0.0018 0.0093 0.0264
Loa Loa (eye worm) hypothetical protein 0.0036 0.0436 0.0631
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.0116 0.0242
Trypanosoma cruzi membrane transporter protein, putative 0.0049 0.0668 0.1598
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Trypanosoma brucei membrane transporter protein, putative 0.0049 0.0668 0.1598
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0038 0.0098
Schistosoma mansoni thyroid hormone receptor 0.015 0.2534 0.464
Trypanosoma brucei membrane transporter protein, putative 0.0049 0.0668 0.1598
Loa Loa (eye worm) carboxylesterase 0.003 0.0324 0.0466
Loa Loa (eye worm) hypothetical protein 0.0017 0.0073 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0073 0.0098
Loa Loa (eye worm) PHD-finger family protein 0.0016 0.005 0.0064
Trypanosoma cruzi lanosterol synthase, putative 0.0036 0.0436 0.1038
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0038 0.0078
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0461 0.0667
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0038 0.0078
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.005 0.0685 0.1025
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0036 0.0436 0.0631
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0073 0.0098
Leishmania major hypothetical protein, conserved 0.0087 0.1365 0.3282
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.005 0.0685 0.0996
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Echinococcus multilocularis acetylcholinesterase 0.018 0.3084 0.3293
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0021 0.0158 0.029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0073 0.0134
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0135 0.2244 0.3381
Leishmania major DNA polymerase kappa, putative 0.0018 0.0088 0.0197
Schistosoma mansoni gliotactin 0.003 0.0324 0.0593
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0073 0.0134
Loa Loa (eye worm) hypothetical protein 0.0263 0.462 0.6772
Loa Loa (eye worm) beta-lactamase 0.0087 0.1365 0.1994
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0038 0.0041
Echinococcus granulosus fetal alzheimer antigen falz 0.0018 0.0099 0.0182
Loa Loa (eye worm) hypothetical protein 0.003 0.0324 0.0466
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0193 0.332 0.5006
Schistosoma mansoni cercarial elastase (S01 family) 0.0022 0.0171 0.0313
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0073 0.0098
Loa Loa (eye worm) hypothetical protein 0.0087 0.1365 0.1994
Plasmodium falciparum glutathione reductase 0.0015 0.0038 0.0098
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0036 0.0436 0.0465
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0027 0.0263 0.0281
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0263 0.462 0.8459
Brugia malayi MH2 domain containing protein 0.0018 0.0089 0.0122
Onchocerca volvulus 0.0287 0.5049 1
Echinococcus multilocularis inositol monophosphatase 1 0.0053 0.0745 0.0796

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Toxicity in BALB/c mouse at 50 mg/kg, po ChEMBL. 17606674
ED50 (functional) = 16 nM Antiplasmodial activity against Plasmodium falciparum by [3H]hypoxanthine uptake ChEMBL. 17606674
ED50 (functional) = 50 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 17722901
ED50 (functional) = 50 nM Antimalarial activity against Plasmodium falciparum K1 ChEMBL. 17722901
ED50 (functional) = 50 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 17722901
ED50 (functional) = 50 nM Antimalarial activity against Plasmodium falciparum K1 ChEMBL. 17722901
Inhibition (binding) = 36 % Inhibition of plasmodium falciparum protein farnesyltransferase at 5 nM by scintillation proximity assay ChEMBL. 17722901
Inhibition (binding) = 90 % Inhibition of plasmodium falciparum protein farnesyltransferase at 0.5 nM by scintillation proximity assay ChEMBL. 17722901
Inhibition (binding) = 97 % Inhibition of plasmodium falciparum protein farnesyltransferase at 50 nM by scintillation proximity assay ChEMBL. 17722901
permeability (ADMET) = 1 10'-6 cm/s Permeability from apical to basolateral side in human Caco-2 cells ChEMBL. 17606674

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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