Detailed information for compound 437821

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 619.503 | Formula: C24H20Cl2N8O4S2
  • H donors: 4 H acceptors: 7 LogP: 3.84 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: ClCC(=O)Nc1scc(n1)Cc1nnc(n1NC(=O)c1ccc(cc1)Cl)SCC(=O)NNC(=O)c1ccccc1
  • InChi: 1S/C24H20Cl2N8O4S2/c25-11-19(35)28-23-27-17(12-39-23)10-18-29-32-24(34(18)33-22(38)15-6-8-16(26)9-7-15)40-13-20(36)30-31-21(37)14-4-2-1-3-5-14/h1-9,12H,10-11,13H2,(H,30,36)(H,31,37)(H,33,38)(H,27,28,35)
  • InChiKey: HJQYXADEUQKZTJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0052 0.0524 0.0509
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0736 0.0733
Trypanosoma cruzi nucleobase transporter, putative 0.0072 0.0767 0.0762
Loa Loa (eye worm) hypothetical protein 0.0416 0.4928 0.5112
Leishmania major adenosine kinase-like protein 0.0092 0.1004 0.1008
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0092 0.1004 0.1996
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Leishmania major adenosine kinase-like protein 0.0092 0.1004 0.1008
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0259 0.0266
Loa Loa (eye worm) hypothetical protein 0.0148 0.1683 0.1746
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.0524 0.054
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.1248 0.1245
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0019 0.0127 0.0096
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0185 0.2137 0.2215
Brugia malayi RE15519p 0.0185 0.2137 0.2217
Loa Loa (eye worm) hypothetical protein 0.0213 0.247 0.2563
Brugia malayi Tachykinin-like peptides receptor 99D 0.0185 0.2137 0.2217
Echinococcus multilocularis somatostatin receptor 0.0185 0.2137 0.2135
Leishmania major ribokinase, putative 0.0092 0.1004 0.1008
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0185 0.2137 0.2215
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.0082
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0278 0.3257 0.3255
Schistosoma mansoni adenosine kinase 0.0805 0.964 1
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0524 0.054
Schistosoma mansoni amine GPCR 0.0185 0.2137 0.2215
Echinococcus granulosus neuropeptides capa receptor 0.0185 0.2137 0.2215
Echinococcus granulosus neuropeptide FF receptor 2 0.0185 0.2137 0.2215
Brugia malayi hypothetical protein 0.0185 0.2137 0.2217
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0736 0.0729
Brugia malayi AKH receptor 0.0185 0.2137 0.2217
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0072 0.0767 0.0762
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Schistosoma mansoni hypothetical protein 0.0016 0.0084 0.0084
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0424 0.5027 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0241 0.2807 0.2912
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0344 0.4054 0.4052
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0424 0.5027 0.5197
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0185 0.2137 0.2217
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0146 0.1663 0.1726
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Brugia malayi hypothetical protein 0.0072 0.0767 0.0796
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0424 0.5027 1
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0072 0.0069
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0084 0.0087
Brugia malayi G protein-coupled receptor F59B2.13 0.0185 0.2137 0.2217
Loa Loa (eye worm) hypothetical protein 0.0034 0.0306 0.0317
Schistosoma mansoni neuropeptide receptor 0.0185 0.2137 0.2215
Trypanosoma brucei adenosine transporter 2 0.0072 0.0767 0.0762
Toxoplasma gondii endonuclease IV APN 0.0079 0.0848 0.0877
Schistosoma mansoni growth hormone secretagogue receptor 0.0185 0.2137 0.2215
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0497 0.0515
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0198 0.0203
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Onchocerca volvulus 0.0714 0.8529 1
Onchocerca volvulus Ribokinase homolog 0.0092 0.1004 0.1177
Schistosoma mansoni hypothetical protein 0.0185 0.2137 0.2215
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0084 0.0087
Echinococcus granulosus neuropeptide receptor 0.0185 0.2137 0.2215
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0185 0.2137 0.2135
Brugia malayi Serotonin receptor 0.0185 0.2137 0.2217
Echinococcus multilocularis neuropeptide Y receptor 0.0185 0.2137 0.2135
Schistosoma mansoni hypothetical protein 0.0185 0.2137 0.2215
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1248 0.2482
Loa Loa (eye worm) neuropeptide F receptor 0.0185 0.2137 0.2217
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0424 0.5027 0.5197
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0072 0.0767 0.0762
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Brugia malayi hypothetical protein 0.0185 0.2137 0.2217
Trypanosoma brucei ribokinase, putative 0.0092 0.1004 0.1008
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0524 0.0521
Echinococcus multilocularis neuropeptides capa receptor 0.0185 0.2137 0.2135
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0072 0.0075
Echinococcus granulosus tm gpcr rhodopsin 0.0185 0.2137 0.2215
Onchocerca volvulus 0.0185 0.2137 0.2506
Trypanosoma cruzi nucleoside transporter 1, putative 0.0072 0.0767 0.0762
Onchocerca volvulus Neuropeptide F receptor homolog 0.0185 0.2137 0.2506
Entamoeba histolytica nucleoside transporter, putative 0.0416 0.4928 0.9802
Brugia malayi hypothetical protein 0.0036 0.0329 0.0341
Trypanosoma brucei adenosine transporter 2, putative 0.0072 0.0767 0.0762
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0131 0.1483 0.1539
Echinococcus granulosus fmrfamide receptor 0.0185 0.2137 0.2215
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0424 0.5027 0.5214
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0259 0.0449
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0092 0.1004 0.1001
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.0524 0.0521
Brugia malayi Dopamine receptor protein 2 0.0185 0.2137 0.2217
Echinococcus granulosus orexin receptor type 2 0.0185 0.2137 0.2215
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0259 0.0376
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0003 0.0003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0329 0.0326
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0329 0.0338
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0185 0.2137 0.2215
Mycobacterium tuberculosis Adenosine kinase 0.0092 0.1004 0.6024
Schistosoma mansoni amine GPCR 0.0185 0.2137 0.2215
Loa Loa (eye worm) hypothetical protein 0.0025 0.0198 0.0206
Brugia malayi Serotonin receptor 0.0185 0.2137 0.2217
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0329 0.0338
Brugia malayi hypothetical protein 0.0148 0.1683 0.1746
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.1248 0.1263
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.0082
Schistosoma mansoni hypothetical protein 0.0185 0.2137 0.2215
Brugia malayi Dopamine receptor protein 1 0.0185 0.2137 0.2217
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0216 0.2511 0.2944
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0185 0.2137 0.2217
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0084 0.0082
Schistosoma mansoni hypothetical protein 0.0011 0.003 0.0028
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0147 0.1666 1
Brugia malayi Nucleoside transporter family protein 0.0416 0.4928 0.5112
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0185 0.2137 0.2215
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0084 0.0051
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0497 0.0515
Brugia malayi Death domain containing protein 0.0015 0.0072 0.0075
Entamoeba histolytica hypothetical protein 0.0036 0.0329 0.0588
Plasmodium vivax protein kinase Crk2 0.0052 0.0524 0.091
Schistosoma mansoni opsin-like receptor 0.0185 0.2137 0.2215
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0524 0.1041
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0185 0.2137 0.2215
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0198 0.017
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0416 0.4928 0.5111
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0259 0.0515
Toxoplasma gondii nucleoside transporter protein 0.0072 0.0767 0.0793
Echinococcus granulosus sex peptide receptor 0.0185 0.2137 0.2215
Trypanosoma cruzi adenosine kinase, putative 0.0805 0.964 1
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0144 0.0287
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0424 0.5027 0.5197
Echinococcus granulosus dro:myosuppressin receptor 0.0185 0.2137 0.2215
Onchocerca volvulus 0.0185 0.2137 0.2506
Trypanosoma brucei unspecified product 0.0072 0.0767 0.0762
Brugia malayi Melatonin receptor type 1A 0.0185 0.2137 0.2217
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0524 0.1041
Brugia malayi 6-phosphofructokinase 0.0112 0.1248 0.1294
Onchocerca volvulus 0.0185 0.2137 0.2506
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.2137 0.2135
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0019 0.0127 0.0096
Echinococcus multilocularis g protein coupled receptor 0.0185 0.2137 0.2135
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0259 0.051
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0424 0.5027 0.5214
Schistosoma mansoni neuropeptide receptor 0.0185 0.2137 0.2215
Trypanosoma brucei adenosine transporter 2 0.0072 0.0767 0.0762
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0185 0.2137 0.2135
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Echinococcus granulosus neuropeptide Y receptor 0.0185 0.2137 0.2215
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0084 0.0082
Schistosoma mansoni biogenic amine receptor 0.0185 0.2137 0.2215
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0524 0.1041
Loa Loa (eye worm) hypothetical protein 0.0052 0.0524 0.0544
Echinococcus multilocularis neuropeptide receptor 0.0185 0.2137 0.2135
Echinococcus granulosus death domain containing protein 0.0015 0.0072 0.0072
Echinococcus granulosus equilibrative nucleoside transporter 0.0416 0.4928 0.5111
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0185 0.2137 0.2506
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0424 0.5027 0.5197
Entamoeba histolytica kinase, PfkB family 0.0092 0.1004 0.194
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0185 0.2137 0.2217
Schistosoma mansoni opsin-like receptor 0.0185 0.2137 0.2215
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0052 0.0524 0.054
Trypanosoma cruzi adenosine kinase, putative 0.0092 0.1004 0.1008
Brugia malayi larval opioid receptor 0.0185 0.2137 0.2217
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0084 0.0081
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Trypanosoma brucei adenosine transporter, putative 0.0072 0.0767 0.0762
Leishmania major tagatose-6-phosphate kinase-like protein 0.0092 0.1004 0.1008
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0185 0.2137 0.2217
Trypanosoma cruzi nucleobase transporter, putative 0.0072 0.0767 0.0762
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0424 0.5027 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.2137 0.2215
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0131 0.1483 0.1508
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0424 0.5027 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.2137 0.2215
Leishmania major nucleobase transporter 0.0072 0.0767 0.0762
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0084 0.0084
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.1248 0.1292
Schistosoma mansoni hypothetical protein 0.0016 0.0084 0.0084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.2137 0.2135
Leishmania major nucleobase transporter 0.0072 0.0767 0.0762
Loa Loa (eye worm) hypothetical protein 0.0078 0.0838 0.0869
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0185 0.2137 0.2135
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0185 0.2137 0.2135
Echinococcus granulosus g protein coupled receptor 0.0185 0.2137 0.2215
Trypanosoma brucei nucleoside transporter 1, putative 0.0072 0.0767 0.0762
Schistosoma mansoni hypothetical protein 0.0016 0.0084 0.0084
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.0082
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0144 0.0866
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0062 0.0649 0.1229
Loa Loa (eye worm) phosphofructokinase 0.0112 0.1248 0.1294
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0424 0.5027 0.5197
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0185 0.2137 0.2217
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0072 0.0072
Schistosoma mansoni protein kinase 0.0073 0.0774 0.08
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0424 0.5027 0.5026
Echinococcus granulosus bloom syndrome protein 0.0022 0.0159 0.0162
Echinococcus granulosus adenosine kinase 0.0805 0.964 1
Brugia malayi Ectopic membrane ruffles in embryo protein 1 0.0062 0.0649 0.0673
Brugia malayi 6-phosphofructokinase 0.0112 0.1248 0.1294
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0072 0.0767 0.1526
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0259 0.0515
Loa Loa (eye worm) hypothetical protein 0.0416 0.4928 0.5112
Trypanosoma cruzi ribokinase, putative 0.0092 0.1004 0.1008
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0072 0.0075
Schistosoma mansoni adenosine kinase 0.0805 0.964 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0003 0.000000000051884
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Brugia malayi phosphofructokinase 0.0112 0.1248 0.1294
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0072 0.0767 0.0762
Brugia malayi follicle stimulating hormone receptor 0.0422 0.5004 0.5191
Loa Loa (eye worm) hypothetical protein 0.0148 0.1683 0.1746
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0259 0.0266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.2137 0.2215
Entamoeba histolytica hypothetical protein 0.0036 0.0329 0.0588
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0003 0.0003
Loa Loa (eye worm) ectopic membrane ruffles in embryo protein 1 0.0062 0.0649 0.0673
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0736 0.0729
Echinococcus granulosus alpha 1A adrenergic receptor 0.0185 0.2137 0.2215
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0185 0.2137 0.2215
Loa Loa (eye worm) hypothetical protein 0.0015 0.0072 0.0075
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0497 0.0515
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.1248 0.1294
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0185 0.2137 0.2135
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0524 0.0543
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0736 0.076
Echinococcus granulosus hypothetical protein 0.0185 0.2137 0.2215
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Brugia malayi MH2 domain containing protein 0.0119 0.1339 0.1389
Brugia malayi hypothetical protein 0.0025 0.0198 0.0206
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0185 0.2137 0.2135
Echinococcus multilocularis GPCR, family 2 0.0016 0.0084 0.0081
Echinococcus granulosus Ankyrin 0.0015 0.0074 0.0074
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0198 0.017
Schistosoma mansoni amine GPCR 0.0185 0.2137 0.2215
Plasmodium falciparum protein kinase 5 0.0052 0.0524 0.1036
Loa Loa (eye worm) hypothetical protein 0.0072 0.0767 0.0796
Giardia lamblia Hypothetical protein 0.0416 0.4928 0.9803
Toxoplasma gondii nucleoside transporter protein 0.0072 0.0767 0.0793
Trypanosoma brucei unspecified product 0.0072 0.0767 0.0762
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0424 0.5027 0.5197
Entamoeba histolytica nucleoside transporter, putative 0.0072 0.0767 0.1467
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.1248 0.7489
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0524 0.0509
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0524 0.0509
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0131 0.1483 0.1508
Brugia malayi Uncoordinated protein 44 0.0015 0.0072 0.0075
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0424 0.5027 0.5197
Loa Loa (eye worm) hypothetical protein 0.0021 0.0144 0.015
Echinococcus granulosus neuropeptides capa receptor 0.0185 0.2137 0.2215
Echinococcus granulosus adenylate cyclase 9 0.0078 0.0838 0.0866
Schistosoma mansoni opsin-like receptor 0.0185 0.2137 0.2215
Trypanosoma cruzi nucleoside transporter-like, putative 0.0072 0.0767 0.0762
Brugia malayi Adenylyl cyclase protein 0.0078 0.0838 0.0869
Echinococcus multilocularis neuropeptide FF receptor 2 0.0185 0.2137 0.2135
Schistosoma mansoni amine GPCR 0.0185 0.2137 0.2215
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0524 0.0543
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0003 0.0003
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0072 0.0767 0.0762
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0524 0.0509
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.2137 0.2215
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0079 0.0848 0.4626
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0259 0.0515
Trichomonas vaginalis ribokinase, putative 0.0092 0.1004 0.1996
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0072 0.0767 0.1526
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.1248 0.2074
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0087
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0144 0.0169
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0424 0.5027 1
Echinococcus multilocularis sex peptide receptor 0.0185 0.2137 0.2135
Trypanosoma brucei adenosine transporter 2, putative 0.0072 0.0767 0.0762
Schistosoma mansoni netrin receptor unc5 0.0015 0.0072 0.0072
Brugia malayi Protein kinase domain containing protein 0.0052 0.0524 0.0543
Schistosoma mansoni hypothetical protein 0.0185 0.2137 0.2215
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0416 0.4928 0.9803
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0084 0.0023
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0079 0.0848 0.5092
Mycobacterium ulcerans endonuclease IV 0.0079 0.0848 0.1688
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0736 0.1403
Echinococcus multilocularis g protein coupled receptor 0.0185 0.2137 0.2135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.2137 0.2215
Brugia malayi GnHR receptor homolog 0.0185 0.2137 0.2217
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0072 0.0767 0.1526
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0078 0.0838 0.0982
Echinococcus multilocularis dro:myosuppressin receptor 0.0185 0.2137 0.2135
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0071 0.007
Onchocerca volvulus 0.0078 0.0838 0.0982
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0079 0.0848 0.1683
Brugia malayi hypothetical protein 0.0416 0.4928 0.5112
Echinococcus multilocularis g-protein coupled receptor 0.0185 0.2137 0.2135
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0131 0.1483 0.1508
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0185 0.2137 0.2215
Echinococcus multilocularis g protein coupled receptor 0.0185 0.2137 0.2135
Echinococcus granulosus somatostatin receptor 0.0185 0.2137 0.2215
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.2137 0.2135
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0185 0.2137 0.2135
Schistosoma mansoni biogenic amine receptor 0.0185 0.2137 0.2215
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0424 0.5027 0.5214
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0185 0.2137 0.2215
Schistosoma mansoni adenoreceptor 0.0185 0.2137 0.2215
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0084 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.2137 0.2215
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0381 0.0378
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0424 0.5027 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0185 0.2137 0.2215
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0424 0.5027 0.5197
Loa Loa (eye worm) neuropeptide F receptor 0.0185 0.2137 0.2217
Loa Loa (eye worm) melatonin receptor type 1A 0.0185 0.2137 0.2217
Schistosoma mansoni neuropeptide receptor 0.0185 0.2137 0.2215
Loa Loa (eye worm) hypothetical protein 0.0309 0.3633 0.3768
Loa Loa (eye worm) G-protein coupled receptor 0.0185 0.2137 0.2217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.2137 0.2215
Echinococcus granulosus neuropeptide receptor A26 0.0185 0.2137 0.2215
Echinococcus multilocularis fmrfamide receptor 0.0185 0.2137 0.2135
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0278 0.3257 0.6478
Brugia malayi putative neuropeptide receptor 0.0185 0.2137 0.2217
Leishmania major hypothetical protein, conserved 0.0025 0.0198 0.017
Echinococcus multilocularis adenylate cyclase 9 0.0078 0.0838 0.0835
Brugia malayi hypothetical protein 0.0185 0.2137 0.2217
Mycobacterium ulcerans fructokinase, PfkB 0.0092 0.1004 0.1996
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0259 0.0515
Brugia malayi hypothetical protein 0.0185 0.2137 0.2217
Brugia malayi hypothetical protein 0.0185 0.2137 0.2217
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.1248 0.1263
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Echinococcus granulosus serotonin receptor 0.0185 0.2137 0.2215
Onchocerca volvulus 0.0185 0.2137 0.2506
Loa Loa (eye worm) G-protein coupled receptor 0.0185 0.2137 0.2217
Leishmania major putative PfkB family sugar kinase 0.0092 0.1004 0.1008
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1248 0.2482
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0185 0.2137 0.2135
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0424 0.5027 0.5197
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0259 0.0515
Loa Loa (eye worm) RecQ helicase 0.0022 0.0159 0.0165
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0084 0.0162
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0422 0.5004 0.5191
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.2137 0.2135
Echinococcus granulosus g protein coupled receptor 0.0185 0.2137 0.2215
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0736 0.076
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0185 0.2137 0.2217
Loa Loa (eye worm) hypothetical protein 0.0327 0.3847 0.3991
Leishmania major nucleoside transporter 1, putative 0.0072 0.0767 0.0762
Leishmania major tagatose-6-phosphate kinase-like protein 0.0092 0.1004 0.1008
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0035 0.007
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0185 0.2137 0.2217
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0092 0.1004 0.194
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0084 0.0081
Schistosoma mansoni neuropeptide f receptor 76f 0.0185 0.2137 0.2215
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0278 0.3254 0.3351
Echinococcus granulosus g protein coupled receptor 0.0185 0.2137 0.2215
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0198 0.0389
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.2137 0.2135
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Trypanosoma brucei cdc2-related kinase 1 0.0052 0.0524 0.0509
Schistosoma mansoni hypothetical protein 0.0034 0.0306 0.0314
Onchocerca volvulus 0.0185 0.2137 0.2506
Brugia malayi isocitrate dehydrogenase 0.0016 0.0084 0.0087
Schistosoma mansoni ribokinase 0.0092 0.1004 0.1039
Schistosoma mansoni neuropeptide F-like receptor 0.0185 0.2137 0.2215
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.2137 0.2135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.2137 0.2215
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0084 0.0051
Onchocerca volvulus 0.0185 0.2137 0.2506
Loa Loa (eye worm) adenylyl cyclase 3 0.0078 0.0838 0.0869
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.1004 0.1996
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.0524 0.054
Leishmania major adenosine kinase, putative 0.0805 0.964 1
Onchocerca volvulus 0.0052 0.0524 0.0615
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0416 0.4928 0.9803
Brugia malayi STAT protein, DNA binding domain containing protein 0.0135 0.1532 0.159
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1248 0.2482
Loa Loa (eye worm) hypothetical protein 0.0416 0.4928 0.5112
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0185 0.2137 0.2215
Trichomonas vaginalis ribokinase, putative 0.0092 0.1004 0.1996
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0424 0.5027 1
Schistosoma mansoni hypothetical protein 0.0015 0.0072 0.0072
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0185 0.2137 0.2215
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0072 0.0069
Toxoplasma gondii NEDD8-activating enzyme E1 catalytic subunit 0.0062 0.0649 0.067
Onchocerca volvulus 0.0185 0.2137 0.2506
Loa Loa (eye worm) hypothetical protein 0.0092 0.1004 0.1041
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Echinococcus multilocularis NEDD8 activating enzyme E1 catalytic subunit 0.0062 0.0649 0.0646
Trichomonas vaginalis ribokinase, putative 0.0092 0.1004 0.1996
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0084 0.0087
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0259 0.0515
Brugia malayi hypothetical protein 0.0185 0.2137 0.2217
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0524 0.1041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.2137 0.2215
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.1248 0.2429
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0524 0.0509
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0736 0.0763
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0424 0.5027 0.5214
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0131 0.1483 0.1508
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0084 0.0051
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0185 0.2137 0.2215
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.3633 0.3767
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0424 0.5027 0.5197
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1339 0.1389
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0416 0.4928 0.9803
Echinococcus granulosus transcription factor Dp 1 0.004 0.0381 0.0392
Brugia malayi hypothetical protein 0.0016 0.009 0.0093
Echinococcus multilocularis adenosine kinase 0.0805 0.964 0.9639
Onchocerca volvulus 0.0185 0.2137 0.2506
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0278 0.3254 0.3351
Trypanosoma brucei adenosine transporter 2, putative 0.0072 0.0767 0.0762
Loa Loa (eye worm) STAT protein 0.0135 0.1532 0.159
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.0811 0.0839
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.0062 0.0649 0.067
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.1248 0.1292
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0524 0.0521
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0259 0.051
Entamoeba histolytica ribokinase, putative 0.0092 0.1004 0.194
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0092 0.1004 0.1039
Brugia malayi hypothetical protein 0.0185 0.2137 0.2217
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0147 0.1666 1
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0072 0.0767 0.1526
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0185 0.2137 0.2215
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0424 0.5027 1
Trypanosoma brucei cdc2-related kinase 3 0.0052 0.0524 0.0509
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0003 0.0006
Echinococcus granulosus neuropeptide receptor 0.0185 0.2137 0.2215
Schistosoma mansoni biogenic amine (5HT) receptor 0.0185 0.2137 0.2215
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.1248 0.1294
Brugia malayi putative neuropeptide receptor NPR1 0.0185 0.2137 0.2217
Trypanosoma brucei nucleoside transporter 1, putative 0.0072 0.0767 0.0762
Trypanosoma cruzi nucleoside transporter 1, putative 0.0072 0.0767 0.0762
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0198 0.017
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0306 0.0317
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0424 0.5027 1
Echinococcus multilocularis G protein coupled receptor 139 0.0185 0.2137 0.2135
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.1248 0.1292
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.0811 0.0808
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0045 0.0438 0.0871
Onchocerca volvulus 0.0185 0.2137 0.2506
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0084 0.0085
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0416 0.4928 0.4927
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0052 0.0524 0.0509
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0736 0.0763
Onchocerca volvulus 0.0185 0.2137 0.2506
Schistosoma mansoni biogenic amine (5HT) receptor 0.0185 0.2137 0.2215
Echinococcus granulosus tm gpcr rhodopsin 0.0185 0.2137 0.2215
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.2137 0.2215
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.003 0.0028
Schistosoma mansoni myosin xvIII 0.0185 0.2137 0.2215
Trypanosoma cruzi nucleoside transporter 1, putative 0.0072 0.0767 0.0762
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.2137 0.2215
Echinococcus granulosus tumor protein p63 0.0356 0.4206 0.4362
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0736 0.0729
Loa Loa (eye worm) hypothetical protein 0.0278 0.3257 0.3378
Trypanosoma brucei purine nucleoside transporter 0.0072 0.0767 0.0762
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0072 0.0767 0.0762
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0084 0.0084
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.2137 0.2215
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0259 0.0376
Entamoeba histolytica fructokinase, putative 0.0092 0.1004 0.194
Echinococcus granulosus peptide allatostatin:somatostatin 0.0185 0.2137 0.2215
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0159 0.0165
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0416 0.4928 0.5778
Trypanosoma brucei ribokinase, putative 0.0092 0.1004 0.1008
Loa Loa (eye worm) hypothetical protein 0.005 0.0497 0.0515
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0424 0.5027 0.5215
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0103 0.0104
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0424 0.5027 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0185 0.2137 0.2135
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0079 0.0848 0.1565
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0084 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.2137 0.2215
Loa Loa (eye worm) hypothetical protein 0.0052 0.0517 0.0536
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0424 0.5027 0.5
Toxoplasma gondii kinase, pfkB family protein 0.0805 0.964 1
Onchocerca volvulus 0.0185 0.2137 0.2506
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0185 0.2137 0.2215
Trypanosoma cruzi adenosine kinase, putative 0.0092 0.1004 0.1008
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0524 0.054
Schistosoma mansoni neuropeptide F-like receptor 0.0185 0.2137 0.2215
Echinococcus granulosus NEDD8 activating enzyme E1 catalytic subunit 0.0062 0.0649 0.067
Echinococcus multilocularis fmrfamide receptor 0.0185 0.2137 0.2135
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.0524 0.0521
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0072 0.0072
Schistosoma mansoni biogenic amine receptor 0.0185 0.2137 0.2215
Brugia malayi hypothetical protein 0.0185 0.2137 0.2217
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0185 0.2137 0.2135
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0084 0.0051
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0278 0.3257 0.3378
Onchocerca volvulus 0.0092 0.1004 0.1177
Plasmodium falciparum NEDD8-activating enzyme E1 catalytic subunit, putative 0.0019 0.0127 0.0247
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0185 0.2137 0.2217
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.0085
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.2137 0.2215
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0278 0.3257 0.3376
Onchocerca volvulus 0.0185 0.2137 0.2506
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0159 0.0156
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0278 0.3254 0.3351
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0185 0.2137 0.2215
Trypanosoma brucei purine nucleoside transporter 0.0072 0.0767 0.0762
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0072 0.0767 0.0762
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Echinococcus granulosus ribokinase 0.0092 0.1004 0.1039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0185 0.2137 0.2215
Brugia malayi hypothetical protein 0.0185 0.2137 0.2217
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0416 0.4928 0.4927
Trypanosoma brucei adenosine transporter, putative 0.0072 0.0767 0.0762
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.0524 0.0543
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.1248 0.7251
Echinococcus granulosus GPCR family 2 0.0016 0.0084 0.0084
Echinococcus multilocularis geminin 0.0344 0.4057 0.4055
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0736 0.0729
Echinococcus multilocularis ribokinase 0.0092 0.1004 0.1001
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0185 0.2137 0.2135
Schistosoma mansoni hypothetical protein 0.0036 0.0329 0.0338
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0146 0.1663 0.3309
Brugia malayi sulfakinin receptor protein 0.0185 0.2137 0.2217
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0198 0.0389
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0159 0.0316
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0185 0.2137 0.2215
Toxoplasma gondii kinase, pfkB family protein 0.0092 0.1004 0.1039
Brugia malayi neuropeptide F receptor 0.0185 0.2137 0.2217
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0092 0.1004 0.194
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0092 0.1004 0.6024
Echinococcus multilocularis neuropeptide receptor A26 0.0185 0.2137 0.2135
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0159 0.0316
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Brugia malayi Dopamine receptor 0.0185 0.2137 0.2217
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0278 0.3257 0.3378
Echinococcus multilocularis serotonin receptor 0.0185 0.2137 0.2135
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0293 0.3437 0.3565
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0072 0.0072
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0278 0.3257 0.6478
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1339 0.1389
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0424 0.5027 0.5214
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0416 0.4928 0.5778
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.1248 0.2482
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0259 0.0515
Echinococcus multilocularis orexin receptor type 2 0.0185 0.2137 0.2135
Brugia malayi cell division control protein 2 homolog 0.0052 0.0524 0.0543
Echinococcus multilocularis neuropeptide Y receptor 0.0185 0.2137 0.2135
Schistosoma mansoni hypothetical protein 0.0344 0.4057 0.4207
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0524 0.0978
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0293 0.3437 0.3565
Leishmania major ubiquitin activating enzyme, putative 0.0019 0.0127 0.0096
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0185 0.2137 0.2215
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0524 0.0978
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0185 0.2137 0.2215
Onchocerca volvulus 0.0185 0.2137 0.2506
Entamoeba histolytica hypothetical protein 0.0036 0.0329 0.0588
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0185 0.2137 0.2135
Echinococcus granulosus 7TM GPCR rhodopsin 0.0185 0.2137 0.2215
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0424 0.5027 0.5026
Onchocerca volvulus 0.0185 0.2137 0.2506
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0072 0.0767 0.1526
Schistosoma mansoni neuropeptide receptor 0.0185 0.2137 0.2215
Echinococcus multilocularis Ankyrin 0.0015 0.0074 0.0071
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0424 0.5027 0.5214
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0084 0.0085
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0076
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0185 0.2137 0.2135
Loa Loa (eye worm) hypothetical protein 0.0092 0.1004 0.1041
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0278 0.3254 0.3351
Giardia lamblia Ribokinase 0.0092 0.1004 0.1996
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Trypanosoma cruzi nucleoside transporter-like, putative 0.0072 0.0767 0.0762
Brugia malayi hypothetical protein 0.0125 0.141 0.1463
Onchocerca volvulus 0.0241 0.2807 0.3291
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0424 0.5027 1
Onchocerca volvulus 0.0075 0.0797 0.0935
Trypanosoma brucei NEDD8 activating enzyme subunit, putative 0.0019 0.0127 0.0096
Mycobacterium ulcerans hypothetical protein 0.0021 0.0144 0.0287
Echinococcus granulosus g-protein coupled receptor 0.0185 0.2137 0.2215
Onchocerca volvulus 0.0185 0.2137 0.2506
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0084 0.0085
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0424 0.5027 0.5197
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0185 0.2137 0.2215
Echinococcus granulosus allatostatin A receptor 0.0185 0.2137 0.2215
Brugia malayi G-protein coupled receptor 0.0185 0.2137 0.2217
Loa Loa (eye worm) TYRA-2 protein 0.0185 0.2137 0.2217
Mycobacterium ulcerans epimerase 0.0021 0.0144 0.0287
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0144 0.015
Trypanosoma brucei adenosine kinase, putative 0.0805 0.964 1
Mycobacterium tuberculosis Ribokinase RbsK 0.0092 0.1004 0.6024
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0185 0.2137 0.2217
Echinococcus granulosus cyclin dependent kinase 0.0052 0.0524 0.054
Trypanosoma cruzi adenosine kinase, putative 0.0805 0.964 1
Onchocerca volvulus 0.0185 0.2137 0.2506
Echinococcus granulosus neuropeptide s receptor 0.0185 0.2137 0.2215
Brugia malayi hypothetical protein 0.0092 0.1004 0.1041
Entamoeba histolytica hypothetical protein 0.0036 0.0329 0.0588
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Brugia malayi neuropeptide F receptor 0.0185 0.2137 0.2217
Brugia malayi G protein-coupled receptor 0.0185 0.2137 0.2217
Echinococcus multilocularis neuropeptide receptor 0.0185 0.2137 0.2135
Brugia malayi G-protein coupled receptor 0.0185 0.2137 0.2217
Echinococcus granulosus tm gpcr rhodopsin 0.0185 0.2137 0.2215
Schistosoma mansoni alpha-1 adrenergic receptor 0.0185 0.2137 0.2215
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Plasmodium vivax ubiquitin-activating enzyme E1C, putative 0.0019 0.0127 0.0109
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0185 0.2137 0.2215
Echinococcus granulosus rhodopsin orphan GPCR 0.0185 0.2137 0.2215
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0019 0.0127 0.0252
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0424 0.5027 0.5214
Schistosoma mansoni equilibrative nucleoside transporter 0.0072 0.0767 0.0793
Mycobacterium leprae Probable adenosine kinase adk 0.0092 0.1004 0.5647
Schistosoma mansoni amine GPCR 0.0185 0.2137 0.2215
Loa Loa (eye worm) hypothetical protein 0.0018 0.0105 0.0109
Schistosoma mansoni histamine h1 receptor 0.0185 0.2137 0.2215
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0084 0.0087
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0131 0.1483 0.1508
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.1248 0.2429
Echinococcus multilocularis tumor protein p63 0.0356 0.4206 0.4204
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0259 0.0515
Chlamydia trachomatis endonuclease IV 0.0079 0.0848 0.1236
Schistosoma mansoni hypothetical protein 0.0016 0.0084 0.0084
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0524 0.1041
Echinococcus granulosus G protein coupled receptor 139 0.0185 0.2137 0.2215
Leishmania major nucleoside transporter 1, putative 0.0072 0.0767 0.0762
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0424 0.5027 0.5214
Echinococcus multilocularis neuropeptides capa receptor 0.0185 0.2137 0.2135
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.2137 0.2135
Entamoeba histolytica nucleoside transporter, putative 0.0072 0.0767 0.1467
Trypanosoma brucei adenosine transporter 2, putative 0.0072 0.0767 0.0762
Echinococcus multilocularis allatostatin A receptor 0.0185 0.2137 0.2135
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0424 0.5027 1
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.1248 0.1263
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0198 0.0253
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1248 0.2482
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0278 0.3254 0.6473
Toxoplasma gondii nucleoside transporter protein 0.0072 0.0767 0.0793
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0185 0.2137 0.2135
Trypanosoma cruzi nucleobase transporter, putative 0.0072 0.0767 0.0762
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0072 0.0767 0.0762
Brugia malayi hypothetical protein 0.0185 0.2137 0.2217
Echinococcus multilocularis serotonin receptor 0.0185 0.2137 0.2135
Brugia malayi Adenosine kinase-like 0.0805 0.964 1
Echinococcus multilocularis neuropeptide s receptor 0.0185 0.2137 0.2135
Brugia malayi ORL1-like opioid receptor 0.0185 0.2137 0.2217
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.0524 0.054
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.1248 0.2429
Echinococcus granulosus 7tm_1 domain containing protein 0.0185 0.2137 0.2215
Brugia malayi Protein kinase domain containing protein 0.0015 0.0079 0.0082
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0416 0.4928 0.9803
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.3633 0.3631
Loa Loa (eye worm) hypothetical protein 0.0185 0.2137 0.2217
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.3633 0.3767
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0524 0.0541
Onchocerca volvulus 0.0185 0.2137 0.2506
Onchocerca volvulus Putative pyridoxal kinase 0.0092 0.1004 0.1177
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0259 0.0266
Echinococcus granulosus biogenic amine 5HT receptor 0.0185 0.2137 0.2215
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0079 0.0848 0.088
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0084 0.0506
Brugia malayi Pax transcription factor protein 2 0.0241 0.2807 0.2912
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0127 0.0247
Brugia malayi Ribokinase 0.0092 0.1004 0.1041
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0424 0.5027 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0185 0.2137 0.2135
Trypanosoma brucei adenosine kinase, putative 0.0805 0.964 1
Schistosoma mansoni hypothetical protein 0.0344 0.4057 0.4207
Echinococcus multilocularis rhodopsin orphan GPCR 0.0185 0.2137 0.2135
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0424 0.5027 0.5197
Echinococcus granulosus biogenic amine 5HT receptor 0.0185 0.2137 0.2215
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0072 0.0767 0.0762
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0424 0.5027 1
Trypanosoma brucei adenosine transporter 2, putative 0.0072 0.0767 0.0762
Echinococcus granulosus neuropeptide Y receptor 0.0185 0.2137 0.2215
Echinococcus granulosus geminin 0.0344 0.4057 0.4207
Loa Loa (eye worm) hypothetical protein 0.0805 0.964 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0848 0.088
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0072 0.0085

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) 0 Cytotoxicity against Vero-C1008 cells at 6.25 to 50 ug/mL by neutral red uptake assay ChEMBL. 17442576
Activity (ADMET) 0 Cytotoxicity against VeroC1008 cells at 6.25 to 50 ug/ml by neutral red uptake assay ChEMBL. 17291769
IC50 (binding) = 640 nM Inhibition of human cdk5/p25 by SPA ChEMBL. 17291769
IC50 (binding) = 640 nM Inhibition of human cdk5/p25 by SPA ChEMBL. 17291769
Inhibition (functional) = 20 % Antibacterial activity against Salmonella typhi at 50 to 100 uM after 24 hrs by well diffusion method ChEMBL. 17442576
Inhibition (functional) = 21 % Antibacterial activity against Staphylococcus aureus at 50 to 100 uM after 24 hrs by well diffusion method ChEMBL. 17442576
Inhibition (functional) = 21 % Antibacterial activity against Escherichia coli at 50 to 100 uM after 24 hrs by well diffusion method ChEMBL. 17442576
Inhibition (functional) = 21 % Antibacterial activity against Escherichia coli at 50 to 100 uM after 24 hrs by well diffusion method ChEMBL. 17442576
Inhibition (functional) = 26 % Antibacterial activity against Pseudomonas aeruginosa at 50 to 100 uM after 24 hrs by well diffusion method ChEMBL. 17442576
MIC (functional) < 6.25 ug ml-1 Antitubercular activity against Mycobacterium tuberculosis H37Rv by MABA assay ChEMBL. 17442576
MIC (functional) < 6.25 ug ml-1 Antitubercular activity against Mycobacterium tuberculosis H37Rv by MABA assay ChEMBL. 17442576

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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