Detailed information for compound 437832

Basic information

Technical information
  • TDR Targets ID: 437832
  • Name: methyl 4-[[[6-cyano-1-[(3-methylimidazol-4-yl )methyl]-3,4-dihydro-2H-quinolin-3-yl]-(3-met hylimidazol-4-yl)sulfonylamino]methyl]piperid ine-1-carboxylate
  • MW: 566.675 | Formula: C27H34N8O4S
  • H donors: 0 H acceptors: 6 LogP: 1.4 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)N1CCC(CC1)CN(S(=O)(=O)c1cncn1C)C1CN(Cc2cncn2C)c2c(C1)cc(cc2)C#N
  • InChi: 1S/C27H34N8O4S/c1-31-18-29-13-24(31)17-34-16-23(11-22-10-21(12-28)4-5-25(22)34)35(40(37,38)26-14-30-19-32(26)2)15-20-6-8-33(9-7-20)27(36)39-3/h4-5,10,13-14,18-20,23H,6-9,11,15-17H2,1-3H3
  • InChiKey: FGRXOXYZOVUHMP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 4-[[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-(3-methylimidazol-4-yl)sulfonyl-amino]methyl]piperidine-1-carboxylate
  • 4-[[[6-cyano-1-[(3-methyl-4-imidazolyl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-[(3-methyl-4-imidazolyl)sulfonyl]amino]methyl]-1-piperidinecarboxylic acid methyl ester
  • 4-[[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-(3-methylimidazol-4-yl)sulfonyl-amino]methyl]piperidine-1-carboxylic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni DNA helicase recq1 0.0009 0.0005 0.0005
Schistosoma mansoni histamine h1 receptor 0.038 0.3389 0.3389
Onchocerca volvulus 0.038 0.3389 0.3829
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0033 0.0033
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0078 0.0078
Trypanosoma cruzi nucleobase transporter, putative 0.0116 0.098 0.0956
Trypanosoma brucei unspecified product 0.0116 0.098 0.0956
Echinococcus granulosus neuropeptide Y receptor 0.038 0.3389 0.3389
Schistosoma mansoni opsin-like receptor 0.038 0.3389 0.3389
Schistosoma mansoni biogenic amine (dopamine) receptor 0.038 0.3389 0.3389
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0005 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0026
Onchocerca volvulus 0.038 0.3389 0.3829
Brugia malayi ORL1-like opioid receptor 0.038 0.3389 0.3389
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0115 0.0287
Leishmania major adenosine kinase-like protein 0.0126 0.1068 0.1045
Echinococcus multilocularis neuropeptide receptor 0.038 0.3389 0.3389
Echinococcus granulosus G protein coupled receptor 139 0.038 0.3389 0.3389
Brugia malayi Nucleoside transporter family protein 0.0669 0.6024 0.6024
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0115 0.0115
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0001 0.0001
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0118 0.0994 0.0971
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0012 0.0026 0.0039
Leishmania major tagatose-6-phosphate kinase-like protein 0.0126 0.1068 0.1045
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0012 0.0026 0.0039
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.038 0.3389 0.3389
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0437 0.3912 0.6493
Loa Loa (eye worm) STAT protein 0.014 0.1194 0.1194
Schistosoma mansoni amine GPCR 0.038 0.3389 0.3389
Loa Loa (eye worm) ubiquitin-activating enzyme 5 0.0012 0.0026 0.0026
Trypanosoma brucei adenosine transporter 2, putative 0.0116 0.098 0.0956
Trypanosoma brucei unspecified product 0.0116 0.098 0.0956
Echinococcus granulosus rhodopsin orphan GPCR 0.038 0.3389 0.3389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.038 0.3389 0.3389
Echinococcus granulosus neuropeptide receptor 0.038 0.3389 0.3389
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0286 0.2533 0.2514
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0009 0.0003 0.0003
Brugia malayi hypothetical protein 0.038 0.3389 0.3389
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0669 0.6024 0.6024
Schistosoma mansoni biogenic amine (dopamine) receptor 0.038 0.3389 0.3389
Echinococcus granulosus death domain containing protein 0.0015 0.0059 0.0059
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.0028 0.0172 0.0172
Echinococcus multilocularis g-protein coupled receptor 0.038 0.3389 0.3389
Echinococcus granulosus tumor protein p63 0.0367 0.3275 0.3275
Echinococcus granulosus orexin receptor type 2 0.038 0.3389 0.3389
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.038 0.3389 0.3389
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0286 0.2536 0.2536
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0437 0.3912 1
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0552 0.4964 0.4964
Echinococcus granulosus g-protein coupled receptor 0.038 0.3389 0.3389
Echinococcus multilocularis g protein coupled receptor 0.038 0.3389 0.3389
Onchocerca volvulus 0.038 0.3389 0.3829
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.038 0.3389 0.3389
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0437 0.3912 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Echinococcus multilocularis adenylyltransferase and sulfurtransferase 0.0012 0.0026 0.0026
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0081 0.0662 0.0662
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0012 0.0026 0.0026
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0575 0.0575
Trypanosoma brucei nucleoside transporter 1, putative 0.0116 0.098 0.0956
Brugia malayi Sulfatase family protein 0.0009 0.0003 0.0003
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.008 0.0653 0.0738
Echinococcus multilocularis rhodopsin orphan GPCR 0.038 0.3389 0.3389
Brugia malayi hypothetical protein 0.038 0.3389 0.3389
Toxoplasma gondii autophagy-related protein 7 atg7, putative 0.0012 0.0026 0.0026
Trypanosoma brucei nucleoside transporter 1, putative 0.0116 0.098 0.0956
Onchocerca volvulus 0.038 0.3389 0.3829
Echinococcus multilocularis Smad4 0.0009 0.0001 0.0001
Trypanosoma cruzi nucleoside transporter-like, putative 0.0116 0.098 0.0956
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.038 0.3389 0.3389
Echinococcus granulosus neuropeptide receptor 0.038 0.3389 0.3389
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0973 0.0973
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0669 0.6024 0.6806
Toxoplasma gondii ThiF family protein 0.0012 0.0026 0.0026
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0078 0.0078
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0005 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0204 0.0334
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0005 0.0005
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0135 0.1157 0.1133
Brugia malayi 6-phosphofructokinase 0.0115 0.0973 0.0973
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0116 0.098 0.1622
Echinococcus granulosus serotonin receptor 0.038 0.3389 0.3389
Entamoeba histolytica nucleoside transporter, putative 0.0116 0.098 0.159
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Brugia malayi putative neuropeptide receptor NPR1 0.038 0.3389 0.3389
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0005 0.0005
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0012 0.0026 0.0026
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.038 0.3389 0.3389
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0116 0.098 0.1622
Brugia malayi hypothetical protein 0.0126 0.1068 0.1068
Trypanosoma cruzi nucleoside transporter-like, putative 0.0116 0.098 0.0956
Leishmania major tagatose-6-phosphate kinase-like protein 0.0126 0.1068 0.1045
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0115 0.013
Brugia malayi E1-like protein-activating enzyme Gsa7p/Apg7p containing protein 0.0012 0.0026 0.0026
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0078 0.0052
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0669 0.6024 1
Echinococcus granulosus tm gpcr rhodopsin 0.038 0.3389 0.3389
Schistosoma mansoni ubiquitin-activating enzyme E1 0.0012 0.0026 0.0026
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0299 0.0299
Loa Loa (eye worm) ube1-prov protein 0.0012 0.0026 0.0026
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0973 0.1578
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.038 0.3392 0.3392
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0204 0.0334
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0419 0.0419
Onchocerca volvulus 0.008 0.0653 0.0738
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0204 0.0334
Mycobacterium ulcerans fructokinase, PfkB 0.0126 0.1068 0.2725
Echinococcus multilocularis fmrfamide receptor 0.038 0.3389 0.3389
Schistosoma mansoni DNA helicase recq5 0.0009 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0017 0.0078 0.0078
Schistosoma mansoni amine GPCR 0.038 0.3389 0.3389
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.006 0.006
Brugia malayi ube1-prov protein 0.0012 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0017 0.0078 0.0078
Schistosoma mansoni biogenic amine (dopamine) receptor 0.038 0.3389 0.3389
Onchocerca volvulus 0.038 0.3389 0.3829
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0135 0.1157 0.1133
Echinococcus multilocularis tumor protein p63 0.0367 0.3275 0.3275
Loa Loa (eye worm) hypothetical protein 0.0669 0.6024 0.6024
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.0973 0.7486
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0419 0.0419
Schistosoma mansoni ribokinase 0.0126 0.1068 0.1068
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0204 0.0334
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.0973 0.744
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0437 0.3912 0.3912
Trypanosoma brucei adenosine transporter 2 0.0116 0.098 0.0956
Mycobacterium ulcerans endonuclease IV 0.0081 0.0662 0.1687
Giardia lamblia Ubiquitin-conjugating enzyme E1 0.0012 0.0026 0.0039
Trypanosoma cruzi adenosine kinase, putative 0.1104 1 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0437 0.3912 0.6493
Trichomonas vaginalis ribokinase, putative 0.0126 0.1068 0.1769
Leishmania major adenosine kinase-like protein 0.0126 0.1068 0.1045
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0973 0.1611
Echinococcus granulosus NEDD8 activating enzyme E1 regulatory subunit 0.0012 0.0026 0.0026
Schistosoma mansoni ubiquitin-activating enzyme E1-related 0.0012 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0172 0.0428
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0286 0.2536 0.2536
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0012 0.0026 0.0026
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0437 0.3912 0.3912
Brugia malayi Pax transcription factor protein 2 0.0264 0.2332 0.2332
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0115 0.0698
Toxoplasma gondii ThiF family protein 0.0012 0.0026 0.0026
Echinococcus multilocularis neuropeptides capa receptor 0.038 0.3389 0.3389
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0286 0.2536 0.4206
Mycobacterium tuberculosis Possible molybdopterin biosynthesis protein MoeY 0.0012 0.0026 0.018
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0575 0.0575
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0633 0.0633
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.038 0.3389 0.3389
Onchocerca volvulus 0.0077 0.0622 0.0703
Plasmodium falciparum ubiquitin-activating enzyme 0.0012 0.0026 0.0054
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0078 0.0078
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0012 0.0026 0.0039
Echinococcus multilocularis neuropeptide s receptor 0.038 0.3389 0.3389
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0012 0.0026 0.0039
Trypanosoma cruzi nucleoside transporter 1, putative 0.0116 0.098 0.0956
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0437 0.3912 0.3896
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0126 0.1068 0.2725
Echinococcus multilocularis ubiquitin modifier activating enzyme 1 0.0012 0.0026 0.0026
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0669 0.6024 1
Trypanosoma cruzi adenosine kinase, putative 0.1104 1 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0575 0.055
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.1116 0.1116
Schistosoma mansoni hypothetical protein 0.0017 0.0078 0.0078
Toxoplasma gondii hypothetical protein 0.0012 0.0026 0.0026
Toxoplasma gondii endonuclease IV APN 0.0081 0.0662 0.0662
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0115 0.0865
Leishmania major nucleoside transporter 1, putative 0.0116 0.098 0.0956
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Brugia malayi phosphofructokinase 0.0115 0.0973 0.0973
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1068 0.1769
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.038 0.3389 0.3389
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0973 0.0949
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0012 0.0026 0.0054
Echinococcus multilocularis somatostatin receptor 0.038 0.3389 0.3389
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0437 0.3912 0.3896
Loa Loa (eye worm) G-protein coupled receptor 0.038 0.3389 0.3389
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0437 0.3912 0.3912
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0135 0.1157 0.1157
Trypanosoma cruzi nucleoside transporter 1, putative 0.0116 0.098 0.0956
Trichomonas vaginalis ubiquitin-activating enzyme E1 X, putative 0.0012 0.0026 0.0039
Entamoeba histolytica nucleoside transporter, putative 0.0116 0.098 0.159
Schistosoma mansoni neuropeptide f receptor 76f 0.038 0.3389 0.3389
Toxoplasma gondii ThiF family protein 0.0012 0.0026 0.0026
Trypanosoma brucei ribokinase, putative 0.0126 0.1068 0.1045
Schistosoma mansoni neuropeptide F-like receptor 0.038 0.3389 0.3389
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.003 0.0004
Schistosoma mansoni equilibrative nucleoside transporter 0.0116 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0026
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0059 0.0059
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.0973 0.2073
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.038 0.3389 0.3389
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0078 0.0078
Brugia malayi follicle stimulating hormone receptor 0.0624 0.5618 0.5618
Echinococcus granulosus rhodopsin orphan GPCR 0.038 0.3389 0.3389
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0078 0.0052
Brugia malayi MH1 domain containing protein 0.0009 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.038 0.3389 0.3389
Schistosoma mansoni biogenic amine receptor 0.038 0.3389 0.3389
Toxoplasma gondii nucleoside transporter protein 0.0116 0.098 0.098
Brugia malayi Tachykinin-like peptides receptor 99D 0.038 0.3389 0.3389
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0302 0.2675 0.2675
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0274 0.2424 0.402
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0411 0.0411
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0204 0.0334
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0437 0.3912 0.3896
Brugia malayi CG1749-PA 0.0012 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0059 0.0059
Echinococcus granulosus tm gpcr rhodopsin 0.038 0.3389 0.3389
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0286 0.2536 0.2536
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.028 0.028
Loa Loa (eye worm) ectopic membrane ruffles in embryo protein 1 0.038 0.3392 0.3392
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0669 0.6024 1
Leishmania major nucleobase transporter 0.0116 0.098 0.0956
Brugia malayi GnHR receptor homolog 0.038 0.3389 0.3389
Brugia malayi Death domain containing protein 0.0015 0.0059 0.0059
Mycobacterium ulcerans hypothetical protein 0.0012 0.0026 0.006
Echinococcus granulosus ubiquitin modifier activating enzyme 6 0.0012 0.0026 0.0026
Trichomonas vaginalis ubiquitin-activating enzyme E1b, putative 0.0012 0.0026 0.0039
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0437 0.3912 0.3896
Loa Loa (eye worm) hypothetical protein 0.0219 0.1921 0.1921
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0172 0.0146
Loa Loa (eye worm) hypothetical protein 0.0054 0.0411 0.0411
Brugia malayi hypothetical protein 0.038 0.3389 0.3389
Schistosoma mansoni hypothetical protein 0.0037 0.0261 0.0261
Brugia malayi neuropeptide F receptor 0.038 0.3389 0.3389
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0078 0.0078
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0204 0.0204
Echinococcus multilocularis ubiquitin modifier activating enzyme 6 0.0012 0.0026 0.0026
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0973 0.1578
Mycobacterium ulcerans hypothetical protein 0.0021 0.0115 0.0287
Schistosoma mansoni biogenic amine (5HT) receptor 0.038 0.3389 0.3389
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0437 0.3912 0.6493
Schistosoma mansoni hypothetical protein 0.038 0.3389 0.3389
Giardia lamblia Ubiquitin-activating enzyme E1 1 0.0012 0.0026 0.0039
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.038 0.3389 0.3389
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0126 0.1068 0.1068
Brugia malayi hypothetical protein 0.038 0.3389 0.3389
Echinococcus multilocularis adenosine kinase 0.1104 1 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0437 0.3912 0.5
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0081 0.0662 0.509
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Trypanosoma brucei adenosine transporter 2, putative 0.0116 0.098 0.0956
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.038 0.3389 0.3389
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0078 0.0078
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0059 0.0059
Echinococcus multilocularis orexin receptor type 2 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0172 0.0428
Loa Loa (eye worm) pax transcription factor protein 2 0.0264 0.2332 0.2332
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Brugia malayi hypothetical protein 0.0129 0.1099 0.1099
Echinococcus multilocularis geminin 0.0366 0.326 0.326
Echinococcus multilocularis rhodopsin orphan GPCR 0.038 0.3389 0.3389
Onchocerca volvulus 0.038 0.3389 0.3829
Brugia malayi hypothetical protein 0.038 0.3389 0.3389
Giardia lamblia Molybdopterin biosynthesis MoeB protein 0.0012 0.0026 0.0039
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0059 0.0086
Brugia malayi G-protein coupled receptor 0.038 0.3389 0.3389
Onchocerca volvulus 0.038 0.3389 0.3829
Echinococcus granulosus smad 0.0009 0.0001 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0001 0.0001
Echinococcus multilocularis neuropeptide receptor 0.038 0.3389 0.3389
Onchocerca volvulus Ribokinase homolog 0.0126 0.1068 0.1207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.038 0.3389 0.3389
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0437 0.3912 0.3896
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Brugia malayi isocitrate dehydrogenase 0.0017 0.0078 0.0078
Onchocerca volvulus 0.0054 0.0411 0.0464
Echinococcus granulosus biogenic amine 5HT receptor 0.038 0.3389 0.3389
Mycobacterium ulcerans molybdopterin biosynthesis-like protein MoeZ 0.0012 0.0026 0.006
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0126 0.0126
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0126 0.0126
Brugia malayi neuropeptide F receptor 0.038 0.3389 0.3389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.038 0.3389 0.3389
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0078 0.0078
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0026
Echinococcus granulosus neuropeptide FF receptor 2 0.038 0.3389 0.3389
Schistosoma mansoni smad1 5 8 and 0.0009 0.0001 0.0001
Onchocerca volvulus 0.038 0.3389 0.3829
Schistosoma mansoni Smad4 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Adenosine kinase 0.0126 0.1068 0.8222
Schistosoma mansoni peptide (allatostatin)-like receptor 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.0037 0.0261 0.0261
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0012 0.0026 0.0054
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.0973 0.0973
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0172 0.0376
Echinococcus granulosus thyrotropin releasing hormone receptor 0.038 0.3389 0.3389
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0437 0.3912 0.6493
Loa Loa (eye worm) hypothetical protein 0.0116 0.098 0.098
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0151 0.1296 0.1296
Schistosoma mansoni smad 0.0009 0.0001 0.0001
Loa Loa (eye worm) RecQ helicase 0.0023 0.0126 0.0126
Echinococcus multilocularis neuropeptide Y receptor 0.038 0.3389 0.3389
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.003 0.0004
Toxoplasma gondii nucleoside transporter protein 0.0116 0.098 0.098
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0437 0.3912 0.6479
Schistosoma mansoni clathrin coat associated protein ap-50 0.0012 0.0026 0.0026
Brugia malayi Serotonin/octopamine receptor family protein 7 0.038 0.3389 0.3389
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0861 0.7777 0.7777
Trypanosoma brucei ribokinase, putative 0.0126 0.1068 0.1045
Echinococcus granulosus g protein coupled receptor 0.038 0.3389 0.3389
Plasmodium falciparum autophagy-related protein 7, putative 0.0012 0.0026 0.0054
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0116 0.098 0.0956
Trypanosoma brucei purine nucleoside transporter 0.0116 0.098 0.0956
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.038 0.3389 0.3389
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0017 0.0078 0.0078
Echinococcus multilocularis neuropeptides capa receptor 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Echinococcus granulosus allatostatin A receptor 0.038 0.3389 0.3389
Loa Loa (eye worm) TYRA-2 protein 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Echinococcus granulosus somatostatin receptor 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.0669 0.6024 0.6024
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.0973 0.2481
Schistosoma mansoni hypothetical protein 0.0366 0.326 0.326
Onchocerca volvulus Putative pyridoxal kinase 0.0126 0.1068 0.1207
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.038 0.3389 0.3389
Echinococcus multilocularis neuropeptide receptor A26 0.038 0.3389 0.3389
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0126 0.1068 0.1068
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0081 0.0662 0.0662
Brugia malayi Smad1 0.0009 0.0001 0.0001
Echinococcus granulosus neuropeptides capa receptor 0.038 0.3389 0.3389
Trypanosoma brucei adenosine transporter 2, putative 0.0116 0.098 0.0956
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0058 0.0058
Echinococcus granulosus biogenic amine 5HT receptor 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.0055 0.0419 0.0419
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0286 0.2533 0.4203
Echinococcus granulosus adenosine kinase 0.1104 1 1
Schistosoma mansoni amine GPCR 0.038 0.3389 0.3389
Echinococcus granulosus 7tm_1 domain containing protein 0.038 0.3389 0.3389
Echinococcus multilocularis tachykinin peptides receptor 99D 0.038 0.3389 0.3389
Echinococcus multilocularis Ankyrin 0.0015 0.006 0.006
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0437 0.3912 0.3896
Echinococcus multilocularis serotonin receptor 0.038 0.3389 0.3389
Brugia malayi Dopamine receptor protein 2 0.038 0.3389 0.3389
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.038 0.3389 0.3389
Onchocerca volvulus 0.038 0.3389 0.3829
Echinococcus granulosus tachykinin peptides receptor 99D 0.038 0.3389 0.3389
Echinococcus multilocularis G protein coupled receptor 139 0.038 0.3389 0.3389
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0437 0.3912 0.3912
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Brugia malayi N-terminal motif family protein 0.0179 0.1552 0.1552
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0437 0.3912 0.6493
Leishmania major ubiquitin activating enzyme, putative 0.0118 0.0994 0.0971
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0419 0.0419
Leishmania major nucleobase transporter 0.0116 0.098 0.0956
Echinococcus multilocularis adenylate cyclase 9 0.008 0.0653 0.0653
Plasmodium falciparum ubiquitin-activating enzyme E1 0.0012 0.0026 0.0054
Plasmodium vivax ubiquitin-activating enzyme E1C, putative 0.0118 0.0994 0.2491
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0101 0.0246
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0223 0.1952 0.2206
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0118 0.0994 0.0971
Schistosoma mansoni opsin-like receptor 0.038 0.3389 0.3389
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0078 0.0078
Brugia malayi sulfakinin receptor protein 0.038 0.3389 0.3389
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.038 0.3389 0.3389
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0204 0.0458
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.1116 0.1116
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0012 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.038 0.3389 0.3389
Trypanosoma brucei purine nucleoside transporter 0.0116 0.098 0.0956
Loa Loa (eye worm) hypothetical protein 0.0015 0.0059 0.0059
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0116 0.098 0.1622
Giardia lamblia Molybdopterin biosynthesis MoeB protein 0.0012 0.0026 0.0039
Echinococcus multilocularis alpha 1A adrenergic receptor 0.038 0.3389 0.3389
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0001 0.0001
Brugia malayi MH2 domain containing protein 0.0009 0.0001 0.0001
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0078 0.0052
Echinococcus granulosus fmrfamide receptor 0.038 0.3389 0.3389
Leishmania major adenosine kinase, putative 0.1104 1 1
Loa Loa (eye worm) Smad1 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0437 0.3912 0.3912
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0012 0.0026 0.0039
Echinococcus granulosus equilibrative nucleoside transporter 0.0669 0.6024 0.6024
Schistosoma mansoni biogenic amine receptor 0.038 0.3389 0.3389
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0012 0.0026 0.0039
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.038 0.3389 0.3389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.038 0.3389 0.3389
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0116 0.098 0.0956
Echinococcus multilocularis ubiquitin modifier activating enzyme ATG7 0.0012 0.0026 0.0026
Schistosoma mansoni adenosine kinase 0.1104 1 1
Schistosoma mansoni hypothetical protein 0.038 0.3389 0.3389
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0669 0.6024 0.6024
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0973 0.0973
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0973 0.0973
Brugia malayi hypothetical protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0973 0.0973
Schistosoma mansoni myosin xvIII 0.038 0.3389 0.3389
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0973 0.0973
Brugia malayi RE15519p 0.038 0.3389 0.3389
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.0973 0.0949
Trypanosoma brucei adenosine kinase, putative 0.1104 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.038 0.3389 0.3389
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0078 0.058
Entamoeba histolytica fructokinase, putative 0.0126 0.1068 0.1737
Schistosoma mansoni rhodopsin-like orphan GPCR 0.038 0.3389 0.3389
Echinococcus granulosus neuropeptide s receptor 0.038 0.3389 0.3389
Brugia malayi Melatonin receptor type 1A 0.038 0.3389 0.3389
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0575 0.055
Giardia lamblia Ribokinase 0.0126 0.1068 0.1769
Schistosoma mansoni adenoreceptor 0.038 0.3389 0.3389
Entamoeba histolytica recQ family helicase, putative 0.0012 0.003 0.0007
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0437 0.3912 0.3912
Echinococcus multilocularis rhodopsin orphan GPCR 0.038 0.3389 0.3389
Echinococcus multilocularis serotonin receptor 0.038 0.3389 0.3389
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.0018 0.0085 0.0085
Entamoeba histolytica hypothetical protein 0.0039 0.028 0.0424
Echinococcus granulosus hypothetical protein 0.038 0.3389 0.3389
Trichomonas vaginalis ribokinase, putative 0.0126 0.1068 0.1769
Brugia malayi STAT protein, DNA binding domain containing protein 0.014 0.1194 0.1194
Echinococcus granulosus ribokinase 0.0126 0.1068 0.1068
Echinococcus multilocularis rhodopsin orphan GPCR 0.038 0.3389 0.3389
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Trypanosoma brucei adenosine transporter, putative 0.0116 0.098 0.0956
Echinococcus multilocularis g protein coupled receptor 0.038 0.3389 0.3389
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0126 0.0205
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0437 0.3912 0.6493
Trypanosoma cruzi nucleobase transporter, putative 0.0116 0.098 0.0956
Echinococcus granulosus g protein coupled receptor 0.038 0.3389 0.3389
Schistosoma mansoni amine GPCR 0.038 0.3389 0.3389
Schistosoma mansoni hypothetical protein 0.0015 0.0059 0.0059
Entamoeba histolytica hypothetical protein 0.0039 0.028 0.0424
Echinococcus multilocularis NEDD8 activating enzyme E1 regulatory subunit 0.0012 0.0026 0.0026
Loa Loa (eye worm) neuropeptide F receptor 0.038 0.3389 0.3389
Leishmania major nucleoside transporter 1, putative 0.0116 0.098 0.0956
Brugia malayi 6-phosphofructokinase 0.0115 0.0973 0.0973
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0669 0.6024 1
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0126 0.1068 0.1068
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Echinococcus granulosus neuropeptide Y receptor 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0172 0.0172
Echinococcus granulosus NEDD8 activating enzyme E1 catalytic subunit 0.038 0.3392 0.3392
Brugia malayi MH1 domain containing protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Onchocerca volvulus 0.038 0.3389 0.3829
Brugia malayi hypothetical protein 0.0039 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Schistosoma mansoni adenosine kinase 0.1104 1 1
Onchocerca volvulus 0.038 0.3389 0.3829
Echinococcus multilocularis fmrfamide receptor 0.038 0.3389 0.3389
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0126 0.1068 0.1737
Schistosoma mansoni neuropeptide receptor 0.038 0.3389 0.3389
Echinococcus multilocularis g protein coupled receptor 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0012 0.0026 0.0039
Loa Loa (eye worm) neuropeptide F receptor 0.038 0.3389 0.3389
Schistosoma mansoni biogenic amine (5HT) receptor 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0026
Trichomonas vaginalis ubiquitin-activating enzyme E1c, putative 0.0012 0.0026 0.0039
Brugia malayi AKH receptor 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.0337 0.2994 0.2994
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0078 0.0052
Onchocerca volvulus 0.038 0.3389 0.3829
Brugia malayi G protein-coupled receptor 0.038 0.3389 0.3389
Brugia malayi Uncoordinated protein 44 0.0015 0.0059 0.0059
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.038 0.3389 0.3389
Schistosoma mansoni smad1 5 8 and 0.0009 0.0001 0.0001
Echinococcus multilocularis dro:myosuppressin receptor 0.038 0.3389 0.3389
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0078 0.0078
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0624 0.5618 0.5618
Trypanosoma cruzi nucleoside transporter 1, putative 0.0116 0.098 0.0956
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0116 0.098 0.1622
Mycobacterium leprae Probable adenosine kinase adk 0.0126 0.1068 0.819
Echinococcus granulosus dro:myosuppressin receptor 0.038 0.3389 0.3389
Trypanosoma brucei adenosine transporter, putative 0.0116 0.098 0.0956
Echinococcus granulosus rhodopsin orphan GPCR 0.038 0.3389 0.3389
Loa Loa (eye worm) G-protein coupled receptor 0.038 0.3389 0.3389
Echinococcus granulosus rhodopsin orphan GPCR 0.038 0.3389 0.3389
Giardia lamblia Hypothetical protein 0.0669 0.6024 1
Trypanosoma brucei adenosine transporter 2, putative 0.0116 0.098 0.0956
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0078 0.0078
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0078 0.0078
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.038 0.3389 0.3389
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.0973 0.0973
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0135 0.1157 0.1133
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0437 0.3912 0.3912
Schistosoma mansoni hypothetical protein 0.038 0.3389 0.3389
Schistosoma mansoni biogenic amine receptor 0.038 0.3389 0.3389
Brugia malayi hypothetical protein 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Echinococcus granulosus Ankyrin 0.0015 0.006 0.006
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0116 0.098 0.0956
Loa Loa (eye worm) hypothetical protein 0.1104 1 1
Brugia malayi hypothetical protein 0.038 0.3389 0.3389
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0005 0.0005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0078 0.0078
Echinococcus granulosus GPCR family 2 0.0017 0.0078 0.0078
Echinococcus granulosus 7TM GPCR rhodopsin 0.038 0.3389 0.3389
Schistosoma mansoni hypothetical protein 0.0039 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0575 0.055
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0126 0.1068 0.8222
Mycobacterium ulcerans epimerase 0.0021 0.0115 0.0287
Echinococcus granulosus alpha 1A adrenergic receptor 0.038 0.3389 0.3389
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0204 0.0297
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Echinococcus multilocularis allatostatin A receptor 0.038 0.3389 0.3389
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0078 0.0052
Echinococcus granulosus geminin 0.0366 0.326 0.326
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.038 0.3389 0.3389
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0437 0.3912 0.3896
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Trypanosoma brucei adenosine transporter 2, putative 0.0116 0.098 0.0956
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0172 0.0146
Echinococcus granulosus g protein coupled receptor 0.038 0.3389 0.3389
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0669 0.6024 0.6806
Trichomonas vaginalis autophagy protein, putative 0.0012 0.0026 0.0039
Brugia malayi MoeZ/MoeB domain containing protein 0.0012 0.0026 0.0026
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0302 0.2675 0.2675
Mycobacterium tuberculosis Possible molybdopterin biosynthesis protein MoeW 0.0012 0.0026 0.018
Loa Loa (eye worm) hypothetical protein 0.008 0.0653 0.0653
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0116 0.098 0.1622
Brugia malayi hypothetical protein 0.0028 0.0172 0.0172
Loa Loa (eye worm) melatonin receptor type 1A 0.038 0.3389 0.3389
Trypanosoma cruzi adenosine kinase, putative 0.0126 0.1068 0.1045
Brugia malayi gonadotropin-releasing hormone receptor 2 0.038 0.3389 0.3389
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.1552 0.1754
Brugia malayi hypothetical protein 0.038 0.3389 0.3389
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0078 0.0187
Schistosoma mansoni amine GPCR 0.038 0.3389 0.3389
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0078 0.0078
Brugia malayi G-protein coupled receptor 0.038 0.3389 0.3389
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0001 0.0001
Onchocerca volvulus 0.038 0.3389 0.3829
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0078 0.0078
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.038 0.3389 0.3389
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.038 0.3389 0.3389
Onchocerca volvulus 0.0126 0.1068 0.1207
Leishmania major putative PfkB family sugar kinase 0.0126 0.1068 0.1045
Schistosoma mansoni neuropeptide F-like receptor 0.038 0.3389 0.3389
Brugia malayi Serotonin receptor 0.038 0.3389 0.3389
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0135 0.1157 0.1133
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0437 0.3912 0.3912
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0437 0.3912 0.3912
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.038 0.3389 0.3389
Schistosoma mansoni app binding protein 0.0012 0.0026 0.0026
Echinococcus multilocularis ubiquitin modifier activating enzyme 5 0.0012 0.0026 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.038 0.3389 0.3389
Echinococcus granulosus sex peptide receptor 0.038 0.3389 0.3389
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.038 0.3389 0.3389
Brugia malayi Dopamine receptor protein 1 0.038 0.3389 0.3389
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.038 0.3389 0.3389
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0973 0.1578
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0662 0.1637
Schistosoma mansoni ubiquitin-activating enzyme E1 0.0012 0.0026 0.0026
Leishmania major ribokinase, putative 0.0126 0.1068 0.1045
Echinococcus granulosus neuropeptide receptor A26 0.038 0.3389 0.3389
Schistosoma mansoni hypothetical protein 0.0017 0.0078 0.0078
Echinococcus multilocularis sex peptide receptor 0.038 0.3389 0.3389
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0437 0.3912 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0973 0.0949
Brugia malayi Dopamine receptor 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.0126 0.1068 0.1068
Entamoeba histolytica hypothetical protein 0.0039 0.028 0.0424
Brugia malayi ThiF family protein 0.0012 0.0026 0.0026
Schistosoma mansoni growth hormone secretagogue receptor 0.038 0.3389 0.3389
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0204 0.0334
Onchocerca volvulus 0.0264 0.2332 0.2635
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0575 0.0575
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.038 0.3389 0.3829
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0204 0.051
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0033 0.0033
Onchocerca volvulus 0.038 0.3389 0.3829
Schistosoma mansoni rhodopsin-like orphan GPCR 0.038 0.3389 0.3389
Brugia malayi Protein kinase domain containing protein 0.0015 0.0059 0.0059
Trichomonas vaginalis ribokinase, putative 0.0126 0.1068 0.1769
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0078 0.0078
Giardia lamblia Ubiquitin-conjugating enzyme E1 0.0012 0.0026 0.0039
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0286 0.2533 0.2514
Schistosoma mansoni hypothetical protein 0.0012 0.0026 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.038 0.3389 0.3389
Schistosoma mansoni clathrin coat associated protein ap-50 0.0012 0.0026 0.0026
Onchocerca volvulus 0.038 0.3389 0.3829
Brugia malayi G protein-coupled receptor F59B2.13 0.038 0.3389 0.3389
Brugia malayi ThiF family protein 0.0012 0.0026 0.0026
Schistosoma mansoni opsin-like receptor 0.038 0.3389 0.3389
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0078 0.0133
Onchocerca volvulus Neuropeptide F receptor homolog 0.038 0.3389 0.3829
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0437 0.3912 0.3896
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0081 0.0662 0.4999
Plasmodium falciparum ubiquitin-activating enzyme 0.0012 0.0026 0.0054
Echinococcus multilocularis neuropeptide Y receptor 0.038 0.3389 0.3389
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0083 0.0083
Plasmodium falciparum NEDD8-activating enzyme E1 catalytic subunit, putative 0.0118 0.0994 0.2532
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0059 0.0059
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0669 0.6024 0.6024
Loa Loa (eye worm) ThiF family protein 0.0012 0.0026 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.038 0.3389 0.3389
Entamoeba histolytica ribokinase, putative 0.0126 0.1068 0.1737
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0204 0.0334
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0437 0.3912 0.3912
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0116 0.098 0.0956
Loa Loa (eye worm) hypothetical protein 0.0015 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0012 0.0026 0.0039
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0286 0.2536 0.4206
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0116 0.098 0.0956
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0299 0.0299
Entamoeba histolytica nucleoside transporter, putative 0.0669 0.6024 1
Onchocerca volvulus 0.0978 0.8851 1
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Leishmania major hypothetical protein, conserved 0.0028 0.0172 0.0146
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0012 0.0026 0.0026
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.028 0.028
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0437 0.3912 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.038 0.3389 0.3389
Brugia malayi MH2 domain containing protein 0.0131 0.1116 0.1116
Trypanosoma brucei adenosine transporter 2 0.0116 0.098 0.0956
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0001 0.0001
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.038 0.3389 0.3389
Toxoplasma gondii NEDD8-activating enzyme E1 catalytic subunit 0.038 0.3392 0.3392
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Toxoplasma gondii ThiF family protein 0.0012 0.0026 0.0026
Loa Loa (eye worm) adenylyl cyclase 3 0.008 0.0653 0.0653
Brugia malayi hypothetical protein 0.038 0.3389 0.3389
Trypanosoma cruzi nucleobase transporter, putative 0.0116 0.098 0.0956
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0286 0.2536 0.2536
Echinococcus granulosus ubiquitin modifier activating enzyme 5 0.0012 0.0026 0.0026
Chlamydia trachomatis endonuclease IV 0.0081 0.0662 0.1236
Schistosoma mansoni hypothetical protein 0.0366 0.326 0.326
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0437 0.3912 1
Echinococcus granulosus adenylate cyclase 9 0.008 0.0653 0.0653
Schistosoma mansoni neuropeptide receptor 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.0179 0.1552 0.1552
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0973 0.1611
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0286 0.2533 0.2514
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0437 0.3912 0.6479
Echinococcus multilocularis neuropeptide FF receptor 2 0.038 0.3389 0.3389
Brugia malayi putative neuropeptide receptor 0.038 0.3389 0.3389
Echinococcus multilocularis smad 0.0009 0.0001 0.0001
Entamoeba histolytica kinase, PfkB family 0.0126 0.1068 0.1737
Echinococcus granulosus adenylyltransferase and sulfurtransferase 0.0012 0.0026 0.0026
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0204 0.0204
Echinococcus granulosus peptide allatostatin:somatostatin 0.038 0.3389 0.3389
Brugia malayi hypothetical protein 0.0116 0.098 0.098
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0973 0.1611
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0078 0.0078
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0005 0.0005
Schistosoma mansoni smad1 5 8 and 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Echinococcus granulosus rhodopsin orphan GPCR 0.038 0.3389 0.3389
Echinococcus granulosus bloom syndrome protein 0.0023 0.0126 0.0126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.038 0.3389 0.3389
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0437 0.3912 0.3896
Loa Loa (eye worm) hypothetical protein 0.0286 0.2536 0.2536
Schistosoma mansoni netrin receptor unc5 0.0015 0.0059 0.0059
Echinococcus multilocularis rhodopsin orphan GPCR 0.038 0.3389 0.3389
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0151 0.1296 0.2148
Loa Loa (eye worm) hypothetical protein 0.0669 0.6024 0.6024
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0172 0.0146
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0059 0.0059
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0437 0.3912 0.3896
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0437 0.3912 0.3896
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0135 0.1157 0.1133
Brugia malayi Serotonin receptor 0.038 0.3389 0.3389
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.038 0.3392 0.5611
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0973 0.1611
Trypanosoma brucei adenosine kinase, putative 0.1104 1 1
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0118 0.0994 0.1647
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0116 0.098 0.0956
Trichomonas vaginalis sumo-1-activating enzyme E1a, putative 0.0012 0.0026 0.0039
Toxoplasma gondii nucleoside transporter protein 0.0116 0.098 0.098
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0151 0.1299 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0575 0.0915
Brugia malayi hypothetical protein 0.0018 0.0083 0.0083
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0126 0.1068 0.1737
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0575 0.0575
Echinococcus multilocularis rhodopsin orphan GPCR 0.038 0.3389 0.3389
Mycobacterium tuberculosis Ribokinase RbsK 0.0126 0.1068 0.8222
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0437 0.3912 0.3896
Onchocerca volvulus 0.038 0.3389 0.3829
Brugia malayi ThiF family protein 0.0012 0.0026 0.0026
Brugia malayi hypothetical protein 0.0669 0.6024 0.6024
Mycobacterium tuberculosis Probable molybdenum cofactor biosynthesis protein MoeB2 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase) 0.0012 0.0026 0.018
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.038 0.3389 0.3389
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi hypothetical protein 0.038 0.3389 0.3389
Toxoplasma gondii kinase, pfkB family protein 0.0126 0.1068 0.1068
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0575 0.055
Echinococcus granulosus ubiquitin modifier activating enzyme ATG7 0.0012 0.0026 0.0026
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0012 0.0026 0.0026
Trypanosoma cruzi ribokinase, putative 0.0126 0.1068 0.1045
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0012 0.0026 0.0039
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0286 0.2533 0.2514
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0204 0.0458
Echinococcus multilocularis ribokinase 0.0126 0.1068 0.1068
Toxoplasma gondii ThiF family protein 0.0012 0.0026 0.0026
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0633 0.0633
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0001 0.0001
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.028 0.028
Trichomonas vaginalis ubiquitin-activating enzyme E1c, putative 0.0012 0.0026 0.0039
Schistosoma mansoni neuropeptide receptor 0.038 0.3389 0.3389
Brugia malayi Ectopic membrane ruffles in embryo protein 1 0.038 0.3392 0.3392
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0012 0.0026 0.0039
Plasmodium falciparum ubiquitin-activating enzyme E1, putative 0.0012 0.0026 0.0054
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0116 0.098 0.0956
Echinococcus multilocularis G-protein coupled receptor, putative 0.038 0.3389 0.3389
Onchocerca volvulus 0.038 0.3389 0.3829
Schistosoma mansoni protein kinase 0.0116 0.098 0.098
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0059 0.0067
Toxoplasma gondii kinase, pfkB family protein 0.1104 1 1
Entamoeba histolytica hypothetical protein 0.0039 0.028 0.0424
Brugia malayi Ribokinase 0.0126 0.1068 0.1068
Brugia malayi MH2 domain containing protein 0.0009 0.0001 0.0001
Echinococcus granulosus Smad4 0.0009 0.0001 0.0001
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0005 0.0005
Trypanosoma cruzi adenosine kinase, putative 0.0126 0.1068 0.1045
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0204 0.051
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0437 0.3912 0.3912
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0151 0.1299 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0059 0.0059
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0437 0.3912 0.6479
Echinococcus granulosus neuropeptides capa receptor 0.038 0.3389 0.3389
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Brugia malayi Adenylyl cyclase protein 0.008 0.0653 0.0653
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.038 0.3389 0.3389
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.038 0.3389 0.3389
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0662 0.1682
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0116 0.098 0.0956
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.003 0.0004
Trypanosoma brucei NEDD8 activating enzyme subunit, putative 0.0118 0.0994 0.0971
Brugia malayi larval opioid receptor 0.038 0.3389 0.3389
Loa Loa (eye worm) hypothetical protein 0.038 0.3389 0.3389
Schistosoma mansoni hypothetical protein 0.0012 0.0033 0.0033
Echinococcus granulosus ubiquitin modifier activating enzyme 1 0.0012 0.0026 0.0026
Echinococcus granulosus tm gpcr rhodopsin 0.038 0.3389 0.3389
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0126 0.0205
Echinococcus granulosus rhodopsin orphan GPCR 0.038 0.3389 0.3389
Echinococcus multilocularis NEDD8 activating enzyme E1 catalytic subunit 0.038 0.3392 0.3392
Echinococcus multilocularis GPCR, family 2 0.0017 0.0078 0.0078
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.038 0.3389 0.3389
Echinococcus multilocularis biogenic amine (5HT) receptor 0.038 0.3389 0.3389
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0204 0.0334

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 1.6 nM Antimalarial activity against Plasmodium falciparum K1 ChEMBL. 17722901
ED50 (functional) = 1.6 nM Antimalarial activity against Plasmodium falciparum K1 ChEMBL. 17722901
ED50 (functional) = 3 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 17722901
ED50 (functional) = 3 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 17722901
Inhibition (binding) = 72 % Inhibition of plasmodium falciparum protein farnesyltransferase at 0.5 nM by scintillation proximity assay ChEMBL. 17722901
Inhibition (binding) = 99 % Inhibition of plasmodium falciparum protein farnesyltransferase at 50 nM by scintillation proximity assay ChEMBL. 17722901
Inhibition (binding) = 99 % Inhibition of plasmodium falciparum protein farnesyltransferase at 5 nM by scintillation proximity assay ChEMBL. 17722901

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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