Detailed information for compound 437835

Basic information

Technical information
  • TDR Targets ID: 437835
  • Name: methyl 4-[[[6-cyano-1-[(3-methylimidazol-4-yl )methyl]-3,4-dihydro-2H-quinolin-3-yl]-(1,2-d imethylimidazol-4-yl)sulfonylamino]methyl]pip eridine-1-carboxylate
  • MW: 580.702 | Formula: C28H36N8O4S
  • H donors: 0 H acceptors: 6 LogP: 1.8 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)N1CCC(CC1)CN(S(=O)(=O)c1cn(c(n1)C)C)C1CN(Cc2cncn2C)c2c(C1)cc(cc2)C#N
  • InChi: 1S/C28H36N8O4S/c1-20-31-27(18-32(20)2)41(38,39)36(15-21-7-9-34(10-8-21)28(37)40-4)24-12-23-11-22(13-29)5-6-26(23)35(16-24)17-25-14-30-19-33(25)3/h5-6,11,14,18-19,21,24H,7-10,12,15-17H2,1-4H3
  • InChiKey: MRTIOCFLJIEKLR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 4-[[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-(1,2-dimethylimidazol-4-yl)sulfonyl-amino]methyl]piperidine-1-carboxylate
  • 4-[[[6-cyano-1-[(3-methyl-4-imidazolyl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-[(1,2-dimethyl-4-imidazolyl)sulfonyl]amino]methyl]-1-piperidinecarboxylic acid methyl ester
  • 4-[[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-(1,2-dimethylimidazol-4-yl)sulfonyl-amino]methyl]piperidine-1-carboxylic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ribokinase 0.0136 0.1068 0.1068
Trypanosoma brucei adenosine transporter 2 0.0189 0.1508 0.1488
Toxoplasma gondii kinase, pfkB family protein 0.0136 0.1068 0.1068
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Trypanosoma brucei NEDD8 activating enzyme subunit, putative 0.0039 0.0249 0.0226
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0451 0.3718 0.4083
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0069 0.0069
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0376 0.3089 0.3089
Echinococcus multilocularis somatostatin receptor 0.0376 0.3089 0.3089
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0295 0.2406 0.2388
Trypanosoma brucei adenosine transporter 2 0.0189 0.1508 0.1488
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0543 0.052
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0069 0.0046
Echinococcus granulosus tachykinin peptides receptor 99D 0.0376 0.3089 0.3089
Trypanosoma brucei adenosine transporter 2, putative 0.0189 0.1508 0.1488
Schistosoma mansoni biogenic amine (5HT) receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0083 0.0616 0.0616
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0451 0.3718 0.3718
Schistosoma mansoni amine GPCR 0.0376 0.3089 0.3089
Onchocerca volvulus 0.0376 0.3089 0.3367
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0159 0.0293
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Echinococcus multilocularis adenosine kinase 0.1197 1 1
Onchocerca volvulus 0.1061 0.8851 0.9754
Echinococcus granulosus neuropeptide receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0451 0.3718 0.3718
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0921 0.2072
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0921 0.0991
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0069 0.0069
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0022 0.0105 0.0105
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.0543 0.0543
Echinococcus multilocularis neuropeptide Y receptor 0.0376 0.3089 0.3089
Echinococcus granulosus ribokinase 0.0136 0.1068 0.1068
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0376 0.3089 0.3089
Brugia malayi hypothetical protein 0.0376 0.3089 0.3089
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0296 0.2408 0.2408
Loa Loa (eye worm) RecQ helicase 0.0023 0.0115 0.0115
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0136 0.1068 0.2665
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0376 0.3089 0.3089
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0376 0.3089 0.3089
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0069 0.0069
Toxoplasma gondii endonuclease IV APN 0.0084 0.0625 0.0625
Loa Loa (eye worm) hypothetical protein 0.1087 0.9073 0.9073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Echinococcus multilocularis dro:myosuppressin receptor 0.0376 0.3089 0.3089
Schistosoma mansoni netrin receptor unc5 0.0016 0.0051 0.0051
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0921 0.7328
Trypanosoma brucei unspecified product 0.0189 0.1508 0.1488
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0262 0.0262
Onchocerca volvulus 0.0083 0.0616 0.0626
Echinococcus granulosus biogenic amine 5HT receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0189 0.1508 0.1641
Brugia malayi phosphofructokinase 0.0119 0.0921 0.0921
Trypanosoma cruzi ribokinase, putative 0.0136 0.1068 0.1046
Echinococcus granulosus serotonin receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0091 0.0689 0.0735
Echinococcus granulosus hypothetical protein 0.0376 0.3089 0.3089
Onchocerca volvulus 0.0376 0.3089 0.3367
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0921 0.0899
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Brugia malayi neuropeptide F receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis Ankyrin 0.0016 0.0052 0.0052
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0296 0.2408 0.2408
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0451 0.3718 0.3703
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Entamoeba histolytica nucleoside transporter, putative 0.0189 0.1508 0.1641
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0451 0.3718 1
Echinococcus granulosus tm gpcr rhodopsin 0.0376 0.3089 0.3089
Echinococcus multilocularis fmrfamide receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis geminin 0.0377 0.3096 0.3096
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0598 0.0598
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0069 0.0069
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0451 0.3718 0.4083
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0189 0.1508 0.1488
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0376 0.3089 0.3089
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0376 0.3089 0.3367
Schistosoma mansoni neuropeptide F-like receptor 0.0376 0.3089 0.3089
Echinococcus granulosus bloom syndrome protein 0.0023 0.0115 0.0115
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0376 0.3089 0.3089
Trypanosoma cruzi nucleobase transporter, putative 0.0189 0.1508 0.1488
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0115 0.0101
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0921 0.0991
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0189 0.1508 0.1641
Schistosoma mansoni hypothetical protein 0.0039 0.0244 0.0244
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0898 0.7483 0.7483
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.014 0.1096 0.1075
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0451 0.3718 0.3703
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0376 0.3089 0.3089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Brugia malayi hypothetical protein 0.1087 0.9073 0.9073
Loa Loa (eye worm) hypothetical protein 0.1087 0.9073 0.9073
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0311 0.2541 0.2541
Loa Loa (eye worm) TYRA-2 protein 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Giardia lamblia Hypothetical protein 0.1087 0.9073 1
Giardia lamblia Ribokinase 0.0136 0.1068 0.1177
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0069 0.0069
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0376 0.3089 0.3089
Echinococcus granulosus somatostatin receptor 0.0376 0.3089 0.3089
Schistosoma mansoni opsin-like receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0027 0.0027
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0189 0.051
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0451 0.3718 0.3718
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0084 0.0625 0.0625
Trypanosoma brucei adenosine transporter, putative 0.0189 0.1508 0.1488
Schistosoma mansoni hypothetical protein 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0189 0.1508 0.1488
Onchocerca volvulus 0.0376 0.3089 0.3367
Leishmania major putative PfkB family sugar kinase 0.0136 0.1068 0.1046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.005 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0376 0.3089 0.3089
Loa Loa (eye worm) pax transcription factor protein 2 0.0272 0.2214 0.2214
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0394 0.0394
Brugia malayi 6-phosphofructokinase 0.0119 0.0921 0.0921
Loa Loa (eye worm) adenylyl cyclase 3 0.0083 0.0616 0.0616
Schistosoma mansoni biogenic amine receptor 0.0376 0.3089 0.3089
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0451 0.3718 0.4083
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0451 0.3718 0.3718
Trichomonas vaginalis ribokinase, putative 0.0136 0.1068 0.1153
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0296 0.2408 0.2408
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0039 0.0249 0.0249
Schistosoma mansoni hypothetical protein 0.0018 0.0069 0.0069
Loa Loa (eye worm) neuropeptide F receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) G-protein coupled receptor 0.0376 0.3089 0.3089
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0027 0.0027
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0069 0.0046
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0069 0.0069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.014 0.1096 0.1075
Onchocerca volvulus 0.0376 0.3089 0.3367
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0451 0.3718 0.3703
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0376 0.3089 0.3089
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0451 0.3718 0.4098
Echinococcus granulosus g protein coupled receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis neuropeptide s receptor 0.0376 0.3089 0.3089
Trypanosoma brucei unspecified product 0.0189 0.1508 0.1488
Schistosoma mansoni neuropeptide receptor 0.0376 0.3089 0.3089
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0262 0.0262
Entamoeba histolytica hypothetical protein 0.0041 0.0262 0.0263
Schistosoma mansoni histamine h1 receptor 0.0376 0.3089 0.3089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0376 0.3089 0.3089
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0921 0.0991
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0039 0.0249 0.0226
Leishmania major adenosine kinase, putative 0.1197 1 1
Onchocerca volvulus 0.0376 0.3089 0.3367
Echinococcus multilocularis rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0451 0.3718 0.3703
Echinococcus granulosus neuropeptides capa receptor 0.0376 0.3089 0.3089
Schistosoma mansoni neuropeptide receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis serotonin receptor 0.0376 0.3089 0.3089
Schistosoma mansoni hypothetical protein 0.0376 0.3089 0.3089
Echinococcus granulosus 7TM GPCR rhodopsin 0.0376 0.3089 0.3089
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0092 0.0246
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0136 0.1068 0.1068
Schistosoma mansoni growth hormone secretagogue receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0189 0.1508 0.1488
Echinococcus multilocularis g protein coupled receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.1057 0.1057
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0451 0.3718 0.4083
Trypanosoma cruzi nucleoside transporter-like, putative 0.0189 0.1508 0.1488
Brugia malayi Uncoordinated protein 44 0.0016 0.0051 0.0051
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0376 0.3089 0.3089
Trypanosoma cruzi nucleoside transporter 1, putative 0.0189 0.1508 0.1488
Brugia malayi neuropeptide F receptor 0.0376 0.3089 0.3089
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0189 0.1508 0.1488
Trypanosoma brucei adenosine transporter 2, putative 0.0189 0.1508 0.1488
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Trichomonas vaginalis ribokinase, putative 0.0136 0.1068 0.1153
Brugia malayi Dopamine receptor protein 1 0.0376 0.3089 0.3089
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0376 0.3089 0.3089
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0376 0.3089 0.3089
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Schistosoma mansoni neuropeptide f receptor 76f 0.0376 0.3089 0.3089
Schistosoma mansoni adenosine kinase 0.1197 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0376 0.3089 0.3089
Echinococcus granulosus neuropeptides capa receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0019 0.0076 0.0076
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0156 0.1231 1
Schistosoma mansoni adenosine kinase 0.1197 1 1
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0189 0.1508 0.1488
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0159 0.0428
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0376 0.3089 0.3089
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0159 0.0428
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0069 0.0046
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.1087 0.9073 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0386 0.0386
Onchocerca volvulus 0.0056 0.0386 0.0371
Schistosoma mansoni hypothetical protein 0.0376 0.3089 0.3089
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0039 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0376 0.3089 0.3089
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0376 0.3089 0.3089
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0189 0.1508 0.1641
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0052
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0311 0.2541 0.2541
Echinococcus granulosus G protein coupled receptor 139 0.0376 0.3089 0.3089
Echinococcus granulosus fmrfamide receptor 0.0376 0.3089 0.3089
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0295 0.2406 0.2388
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0069 0.0069
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0451 0.3718 0.3718
Brugia malayi GnHR receptor homolog 0.0376 0.3089 0.3089
Echinococcus multilocularis neuropeptides capa receptor 0.0376 0.3089 0.3089
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0451 0.3718 0.3703
Schistosoma mansoni biogenic amine receptor 0.0376 0.3089 0.3089
Schistosoma mansoni hypothetical protein 0.0018 0.0069 0.0069
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0451 0.3718 0.3718
Leishmania major nucleobase transporter 0.0189 0.1508 0.1488
Echinococcus granulosus g protein coupled receptor 0.0376 0.3089 0.3089
Echinococcus granulosus rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Echinococcus granulosus adenosine kinase 0.1197 1 1
Trypanosoma brucei nucleoside transporter 1, putative 0.0189 0.1508 0.1488
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.1057 0.1057
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Schistosoma mansoni hypothetical protein 0.0041 0.0262 0.0262
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0189 0.0376
Trypanosoma brucei adenosine transporter, putative 0.0189 0.1508 0.1488
Loa Loa (eye worm) hypothetical protein 0.0136 0.1068 0.1068
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.014 0.1096 0.1096
Chlamydia trachomatis endonuclease IV 0.0084 0.0625 0.1235
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0296 0.2408 0.2635
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0451 0.3718 0.3718
Brugia malayi G protein-coupled receptor F59B2.13 0.0376 0.3089 0.3089
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0921 0.0921
Echinococcus multilocularis orexin receptor type 2 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Echinococcus multilocularis neuropeptide Y receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0376 0.3089 0.3089
Brugia malayi ORL1-like opioid receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Brugia malayi Dopamine receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Mycobacterium tuberculosis Ribokinase RbsK 0.0136 0.1068 0.8592
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0921 0.0921
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0051 0.0051
Brugia malayi hypothetical protein 0.0376 0.3089 0.3089
Trypanosoma cruzi nucleobase transporter, putative 0.0189 0.1508 0.1488
Leishmania major nucleobase transporter 0.0189 0.1508 0.1488
Brugia malayi Adenylyl cyclase protein 0.0083 0.0616 0.0616
Echinococcus granulosus death domain containing protein 0.0016 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0084 0.0625 0.0625
Echinococcus multilocularis neuropeptide receptor 0.0376 0.3089 0.3089
Schistosoma mansoni equilibrative nucleoside transporter 0.0189 0.1508 0.1508
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0189 0.0183
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0189 0.0183
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.0543 0.0543
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0451 0.3718 0.3718
Schistosoma mansoni amine GPCR 0.0376 0.3089 0.3089
Entamoeba histolytica hypothetical protein 0.0041 0.0262 0.0263
Brugia malayi G protein-coupled receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0069 0.0069
Brugia malayi hypothetical protein 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Entamoeba histolytica fructokinase, putative 0.0136 0.1068 0.1153
Loa Loa (eye worm) melatonin receptor type 1A 0.0376 0.3089 0.3089
Brugia malayi sulfakinin receptor protein 0.0376 0.3089 0.3089
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Brugia malayi Protein kinase domain containing protein 0.0016 0.0051 0.0051
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0921 0.0921
Echinococcus multilocularis neuropeptide receptor A26 0.0376 0.3089 0.3089
Brugia malayi hypothetical protein 0.0029 0.0159 0.0159
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0921 0.0899
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0136 0.1068 0.1068
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0105 0.0105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0376 0.3089 0.3089
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0451 0.3718 0.3703
Entamoeba histolytica kinase, PfkB family 0.0136 0.1068 0.1153
Schistosoma mansoni biogenic amine (5HT) receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0136 0.1068 0.8592
Schistosoma mansoni biogenic amine receptor 0.0376 0.3089 0.3089
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.014 0.1096 0.1075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0376 0.3089 0.3089
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0451 0.3718 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0376 0.3089 0.3089
Entamoeba histolytica hypothetical protein 0.0041 0.0262 0.0263
Schistosoma mansoni myosin xvIII 0.0376 0.3089 0.3089
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.1087 0.9073 1
Onchocerca volvulus 0.0376 0.3089 0.3367
Echinococcus granulosus peptide allatostatin:somatostatin 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Echinococcus multilocularis allatostatin A receptor 0.0376 0.3089 0.3089
Echinococcus granulosus allatostatin A receptor 0.0376 0.3089 0.3089
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0295 0.2406 0.2652
Onchocerca volvulus 0.0376 0.3089 0.3367
Brugia malayi Death domain containing protein 0.0016 0.0051 0.0051
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0189 0.0209
Brugia malayi AKH receptor 0.0376 0.3089 0.3089
Mycobacterium tuberculosis Adenosine kinase 0.0136 0.1068 0.8592
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0052 0.0052
Echinococcus multilocularis G protein coupled receptor 139 0.0376 0.3089 0.3089
Echinococcus granulosus transcription factor Dp 1 0.0043 0.028 0.028
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0921 0.0991
Schistosoma mansoni amine GPCR 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Echinococcus granulosus tm gpcr rhodopsin 0.0376 0.3089 0.3089
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0543 0.052
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0069 0.0046
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0451 0.3718 0.4083
Leishmania major nucleoside transporter 1, putative 0.0189 0.1508 0.1488
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.0543 0.0574
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0376 0.3089 0.3089
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0189 0.0183
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.1197 1 1
Trypanosoma cruzi nucleobase transporter, putative 0.0189 0.1508 0.1488
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.014 0.1096 0.1075
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0921 0.0899
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0451 0.3718 0.3703
Schistosoma mansoni neuropeptide receptor 0.0376 0.3089 0.3089
Echinococcus granulosus equilibrative nucleoside transporter 0.1087 0.9073 0.9073
Onchocerca volvulus Ribokinase homolog 0.0136 0.1068 0.1126
Echinococcus granulosus neuropeptide Y receptor 0.0376 0.3089 0.3089
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0625 0.1682
Schistosoma mansoni adenoreceptor 0.0376 0.3089 0.3089
Brugia malayi hypothetical protein 0.0133 0.1041 0.1041
Onchocerca volvulus 0.0136 0.1068 0.1126
Brugia malayi G-protein coupled receptor 0.0376 0.3089 0.3089
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0376 0.3089 0.3089
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0376 0.3089 0.3089
Trypanosoma brucei adenosine kinase, putative 0.1197 1 1
Brugia malayi hypothetical protein 0.0189 0.1508 0.1508
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0394 0.0394
Brugia malayi RE15519p 0.0376 0.3089 0.3089
Entamoeba histolytica hypothetical protein 0.0041 0.0262 0.0263
Loa Loa (eye worm) hypothetical protein 0.0189 0.1508 0.1508
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis g protein coupled receptor 0.0376 0.3089 0.3089
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0376 0.3089 0.3089
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0451 0.3718 1
Brugia malayi hypothetical protein 0.0018 0.0074 0.0074
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0376 0.3089 0.3089
Leishmania major tagatose-6-phosphate kinase-like protein 0.0136 0.1068 0.1046
Trypanosoma cruzi adenosine kinase, putative 0.1197 1 1
Brugia malayi larval opioid receptor 0.0376 0.3089 0.3089
Onchocerca volvulus Neuropeptide F receptor homolog 0.0376 0.3089 0.3367
Echinococcus multilocularis ribokinase 0.0136 0.1068 0.1068
Loa Loa (eye worm) neuropeptide F receptor 0.0376 0.3089 0.3089
Trypanosoma cruzi adenosine kinase, putative 0.0136 0.1068 0.1046
Leishmania major ubiquitin activating enzyme, putative 0.0039 0.0249 0.0226
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0921 0.7245
Schistosoma mansoni hypothetical protein 0.0016 0.0051 0.0051
Brugia malayi hypothetical protein 0.0041 0.0262 0.0262
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0084 0.0625 0.4622
Schistosoma mansoni protein kinase 0.0189 0.1508 0.1508
Trypanosoma cruzi nucleoside transporter 1, putative 0.0189 0.1508 0.1488
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0189 0.051
Echinococcus granulosus Ankyrin 0.0016 0.0052 0.0052
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0625 0.1564
Brugia malayi Pax transcription factor protein 2 0.0272 0.2214 0.2214
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0105 0.0303
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Brugia malayi MH2 domain containing protein 0.0135 0.1057 0.1057
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0069 0.0069
Brugia malayi G-protein coupled receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0921 0.0921
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0189 0.0376
Brugia malayi hypothetical protein 0.0376 0.3089 0.3089
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0451 0.3718 0.3703
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0069 0.0069
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0376 0.3089 0.3089
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0921 0.0991
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0136 0.1068 0.1153
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0039 0.0249 0.0226
Schistosoma mansoni amine GPCR 0.0376 0.3089 0.3089
Brugia malayi 6-phosphofructokinase 0.0119 0.0921 0.0921
Onchocerca volvulus 0.0376 0.3089 0.3367
Toxoplasma gondii nucleoside transporter protein 0.0189 0.1508 0.1508
Echinococcus granulosus tm gpcr rhodopsin 0.0376 0.3089 0.3089
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0921 0.0991
Toxoplasma gondii NEDD8-activating enzyme E1 catalytic subunit 0.0127 0.0986 0.0986
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0189 0.0183
Trypanosoma brucei adenosine transporter 2, putative 0.0189 0.1508 0.1488
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0296 0.2408 0.2635
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0127 0.0986 0.1064
Brugia malayi Nucleoside transporter family protein 0.1087 0.9073 0.9073
Toxoplasma gondii nucleoside transporter protein 0.0189 0.1508 0.1508
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0051 0.0051
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0159 0.0136
Echinococcus granulosus rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Schistosoma mansoni hypothetical protein 0.0013 0.0027 0.0027
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.1087 0.9073 0.9073
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0115 0.0101
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0244 0.0244
Onchocerca volvulus 0.0272 0.2214 0.2397
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0921 0.0921
Echinococcus granulosus geminin 0.0377 0.3096 0.3096
Trypanosoma brucei nucleoside transporter 1, putative 0.0189 0.1508 0.1488
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0394 0.0394
Echinococcus granulosus adenylate cyclase 9 0.0083 0.0616 0.0616
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0159 0.0136
Loa Loa (eye worm) hypothetical protein 0.0226 0.1821 0.1821
Loa Loa (eye worm) STAT protein 0.0144 0.1131 0.1131
Brugia malayi isocitrate dehydrogenase 0.0018 0.0069 0.0069
Brugia malayi Serotonin receptor 0.0376 0.3089 0.3089
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0189 0.1508 0.1488
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0159 0.0159
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.1087 0.9073 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.2408 0.2408
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0115 0.0115
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0543 0.052
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0451 0.3718 0.4083
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.014 0.1096 0.1075
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0069 0.0048
Echinococcus granulosus neuropeptide receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Echinococcus granulosus orexin receptor type 2 0.0376 0.3089 0.3089
Schistosoma mansoni neuropeptide receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0029 0.0159 0.0159
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0189 0.0183
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0376 0.3089 0.3089
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0189 0.1508 0.1641
Brugia malayi Melatonin receptor type 1A 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0451 0.3718 0.3703
Brugia malayi hypothetical protein 0.0376 0.3089 0.3089
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0069 0.0187
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0051
Onchocerca volvulus Putative pyridoxal kinase 0.0136 0.1068 0.1126
Echinococcus multilocularis NEDD8 activating enzyme E1 catalytic subunit 0.0127 0.0986 0.0986
Schistosoma mansoni alpha-1 adrenergic receptor 0.0376 0.3089 0.3089
Echinococcus granulosus dro:myosuppressin receptor 0.0376 0.3089 0.3089
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0386 0.0386
Brugia malayi Ectopic membrane ruffles in embryo protein 1 0.0127 0.0986 0.0986
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0376 0.3089 0.3089
Echinococcus granulosus rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0069 0.0069
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0084 0.0625 0.4785
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0376 0.3089 0.3089
Schistosoma mansoni opsin-like receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0051 0.0051
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0136 0.1068 0.1153
Leishmania major adenosine kinase-like protein 0.0136 0.1068 0.1046
Onchocerca volvulus 0.0376 0.3089 0.3367
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0189 0.0183
Echinococcus multilocularis fmrfamide receptor 0.0376 0.3089 0.3089
Trypanosoma brucei adenosine kinase, putative 0.1197 1 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0451 0.3718 0.3718
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.1068 0.1153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Schistosoma mansoni hypothetical protein 0.0018 0.0069 0.0069
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0376 0.3089 0.3089
Echinococcus granulosus sex peptide receptor 0.0376 0.3089 0.3089
Toxoplasma gondii kinase, pfkB family protein 0.1197 1 1
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0051 0.0051
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0376 0.3089 0.3089
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0069 0.0069
Onchocerca volvulus 0.0376 0.3089 0.3367
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis adenylate cyclase 9 0.0083 0.0616 0.0616
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0083 0.0616 0.0626
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0189 0.1508 0.1488
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Echinococcus multilocularis sex peptide receptor 0.0376 0.3089 0.3089
Echinococcus granulosus biogenic amine 5HT receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0069 0.0069
Brugia malayi Dopamine receptor protein 2 0.0376 0.3089 0.3089
Schistosoma mansoni neuropeptide F-like receptor 0.0376 0.3089 0.3089
Trypanosoma brucei ribokinase, putative 0.0136 0.1068 0.1046
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0376 0.3089 0.3089
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0376 0.3089 0.3089
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0451 0.3718 0.4083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0376 0.3089 0.3089
Onchocerca volvulus 0.0376 0.3089 0.3367
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0156 0.1229 0.1332
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0921 0.0921
Echinococcus multilocularis tumor protein p63 0.0379 0.3113 0.3113
Trypanosoma brucei purine nucleoside transporter 0.0189 0.1508 0.1488
Echinococcus multilocularis g protein coupled receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0598 0.0598
Trypanosoma brucei adenosine transporter 2, putative 0.0189 0.1508 0.1488
Echinococcus granulosus equilibrative nucleoside transporter 3 0.1087 0.9073 0.9073
Mycobacterium ulcerans endonuclease IV 0.0084 0.0625 0.1441
Mycobacterium leprae Probable adenosine kinase adk 0.0136 0.1068 0.8548
Echinococcus granulosus g protein coupled receptor 0.0376 0.3089 0.3089
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0159 0.0136
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0376 0.3089 0.3089
Echinococcus multilocularis neuropeptides capa receptor 0.0376 0.3089 0.3089
Entamoeba histolytica nucleoside transporter, putative 0.1087 0.9073 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0376 0.3089 0.3089
Onchocerca volvulus 0.0376 0.3089 0.3367
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0451 0.3718 0.4083
Brugia malayi hypothetical protein 0.0376 0.3089 0.3089
Echinococcus granulosus g-protein coupled receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0376 0.3089 0.3089
Trichomonas vaginalis ribokinase, putative 0.0136 0.1068 0.1153
Loa Loa (eye worm) hypothetical protein 0.1087 0.9073 0.9073
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0451 0.3718 0.5
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0295 0.2406 0.2388
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0451 0.3718 1
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Onchocerca volvulus 0.0376 0.3089 0.3367
Echinococcus multilocularis neuropeptide FF receptor 2 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Trypanosoma brucei purine nucleoside transporter 0.0189 0.1508 0.1488
Echinococcus multilocularis G-protein coupled receptor, putative 0.0376 0.3089 0.3089
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0156 0.1229 0.1229
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.1087 0.9073 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0376 0.3089 0.3089
Echinococcus multilocularis GPCR, family 2 0.0018 0.0069 0.0069
Echinococcus granulosus rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Onchocerca volvulus 0.0376 0.3089 0.3367
Echinococcus granulosus tumor protein p63 0.0379 0.3113 0.3113
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0376 0.3089 0.3089
Echinococcus multilocularis rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Entamoeba histolytica nucleoside transporter, putative 0.0189 0.1508 0.1641
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.0543 0.052
Brugia malayi putative neuropeptide receptor NPR1 0.0376 0.3089 0.3089
Leishmania major nucleoside transporter 1, putative 0.0189 0.1508 0.1488
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0189 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Brugia malayi STAT protein, DNA binding domain containing protein 0.0144 0.1131 0.1131
Brugia malayi hypothetical protein 0.0376 0.3089 0.3089
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0921 0.0991
Plasmodium vivax ubiquitin-activating enzyme E1C, putative 0.0039 0.0249 0.0538
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) G-protein coupled receptor 0.0376 0.3089 0.3089
Entamoeba histolytica ribokinase, putative 0.0136 0.1068 0.1153
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0229 0.185 0.1994
Schistosoma mansoni hypothetical protein 0.0377 0.3096 0.3096
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0189 0.0183
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.0127 0.0986 0.0986
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0296 0.2408 0.2408
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0136 0.1068 0.1068
Trypanosoma cruzi nucleoside transporter-like, putative 0.0189 0.1508 0.1488
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0376 0.3089 0.3089
Leishmania major tagatose-6-phosphate kinase-like protein 0.0136 0.1068 0.1046
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.1087 0.9073 1
Schistosoma mansoni amine GPCR 0.0376 0.3089 0.3089
Loa Loa (eye worm) ectopic membrane ruffles in embryo protein 1 0.0127 0.0986 0.0986
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.1087 0.9073 1
Onchocerca volvulus 0.0079 0.0586 0.0593
Trypanosoma cruzi adenosine kinase, putative 0.1197 1 1
Schistosoma mansoni hypothetical protein 0.0018 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0069
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0051 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0376 0.3089 0.3089
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0051 0.0051
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0628 0.5209 0.5209
Brugia malayi hypothetical protein 0.0376 0.3089 0.3089
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0921 0.2258
Trypanosoma brucei ribokinase, putative 0.0136 0.1068 0.1046
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0189 0.1508 0.1641
Brugia malayi hypothetical protein 0.0376 0.3089 0.3089
Brugia malayi hypothetical protein 0.0376 0.3089 0.3089
Schistosoma mansoni hypothetical protein 0.0377 0.3096 0.3096
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0451 0.3718 0.3703
Schistosoma mansoni hypothetical protein 0.0376 0.3089 0.3089
Brugia malayi hypothetical protein 0.0136 0.1068 0.1068
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0069 0.0069
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0156 0.1231 1
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Echinococcus granulosus alpha 1A adrenergic receptor 0.0376 0.3089 0.3089
Brugia malayi follicle stimulating hormone receptor 0.0628 0.5209 0.5209
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0069 0.0046
Mycobacterium ulcerans fructokinase, PfkB 0.0136 0.1068 0.2665
Onchocerca volvulus 0.0376 0.3089 0.3367
Leishmania major hypothetical protein, conserved 0.0029 0.0159 0.0136
Loa Loa (eye worm) hypothetical protein 0.0347 0.2843 0.2843
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0451 0.3718 0.3703
Echinococcus granulosus neuropeptide FF receptor 2 0.0376 0.3089 0.3089
Echinococcus granulosus rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Trypanosoma cruzi nucleoside transporter 1, putative 0.0189 0.1508 0.1488
Toxoplasma gondii nucleoside transporter protein 0.0189 0.1508 0.1508
Trypanosoma brucei adenosine transporter 2, putative 0.0189 0.1508 0.1488
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0451 0.3718 0.3718
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0069 0.0069
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.1087 0.9073 0.9073
Onchocerca volvulus 0.0376 0.3089 0.3367
Echinococcus granulosus neuropeptide s receptor 0.0376 0.3089 0.3089
Schistosoma mansoni opsin-like receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis neuropeptide receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0376 0.3089 0.3089
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0295 0.2406 0.2388
Echinococcus granulosus rhodopsin orphan GPCR 0.0376 0.3089 0.3089
Echinococcus granulosus neuropeptide receptor A26 0.0376 0.3089 0.3089
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0115 0.0115
Plasmodium falciparum NEDD8-activating enzyme E1 catalytic subunit, putative 0.0039 0.0249 0.067
Echinococcus multilocularis serotonin receptor 0.0376 0.3089 0.3089
Echinococcus granulosus GPCR family 2 0.0018 0.0069 0.0069
Brugia malayi Serotonin receptor 0.0376 0.3089 0.3089
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0451 0.3718 0.3718
Onchocerca volvulus 0.0376 0.3089 0.3367
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Loa Loa (eye worm) hypothetical protein 0.0056 0.0394 0.0394
Echinococcus granulosus neuropeptide Y receptor 0.0376 0.3089 0.3089
Trypanosoma cruzi adenosine kinase, putative 0.0136 0.1068 0.1046
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0105 0.0059
Leishmania major ribokinase, putative 0.0136 0.1068 0.1046
Brugia malayi putative neuropeptide receptor 0.0376 0.3089 0.3089
Echinococcus multilocularis g-protein coupled receptor 0.0376 0.3089 0.3089
Echinococcus granulosus NEDD8 activating enzyme E1 catalytic subunit 0.0127 0.0986 0.0986
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0376 0.3089 0.3089
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0921 0.0921
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0451 0.3718 0.3703
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0887 0.7393 0.7393
Brugia malayi Ribokinase 0.0136 0.1068 0.1068
Leishmania major adenosine kinase-like protein 0.0136 0.1068 0.1046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0376 0.3089 0.3089
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.0543 0.0543
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0189 0.1508 0.1488
Loa Loa (eye worm) hypothetical protein 0.0376 0.3089 0.3089
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0376 0.3089 0.3089
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0189 0.0183
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0451 0.3718 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0189 0.0189

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 60 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 17722901
ED50 (functional) = 60 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 17722901
ED50 (functional) = 75 nM Antimalarial activity against Plasmodium falciparum K1 ChEMBL. 17722901
ED50 (functional) = 75 nM Antimalarial activity against Plasmodium falciparum K1 ChEMBL. 17722901
Inhibition (binding) = 39 % Inhibition of plasmodium falciparum protein farnesyltransferase at 0.5 nM by scintillation proximity assay ChEMBL. 17722901
Inhibition (binding) = 96 % Inhibition of plasmodium falciparum protein farnesyltransferase at 5 nM by scintillation proximity assay ChEMBL. 17722901
Inhibition (binding) = 100 % Inhibition of plasmodium falciparum protein farnesyltransferase at 50 nM by scintillation proximity assay ChEMBL. 17722901

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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