Detailed information for compound 437837

Basic information

Technical information
  • TDR Targets ID: 437837
  • Name: methyl 4-[[[6-cyano-1-[(3-methylimidazol-4-yl )methyl]-3,4-dihydro-2H-quinolin-3-yl]-(3-met hylthiophen-2-yl)sulfonylamino]methyl]piperid ine-1-carboxylate
  • MW: 582.737 | Formula: C28H34N6O4S2
  • H donors: 0 H acceptors: 5 LogP: 3.35 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)N1CCC(CC1)CN(S(=O)(=O)c1sccc1C)C1CN(Cc2cncn2C)c2c(C1)cc(cc2)C#N
  • InChi: 1S/C28H34N6O4S2/c1-20-8-11-39-27(20)40(36,37)34(16-21-6-9-32(10-7-21)28(35)38-3)24-13-23-12-22(14-29)4-5-26(23)33(17-24)18-25-15-30-19-31(25)2/h4-5,8,11-12,15,19,21,24H,6-7,9-10,13,16-18H2,1-3H3
  • InChiKey: AKGRLTZPQIQIAX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 4-[[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-[(3-methyl-2-thienyl)sulfonyl]amino]methyl]piperidine-1-carboxylate
  • 4-[[[6-cyano-1-[(3-methyl-4-imidazolyl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-[(3-methyl-2-thienyl)sulfonyl]amino]methyl]-1-piperidinecarboxylic acid methyl ester
  • methyl 4-[[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-(3-methylthiophen-2-yl)sulfonyl-amino]methyl]piperidine-1-carboxylate
  • 4-[[[6-cyano-1-[(3-methylimidazol-4-yl)methyl]-3,4-dihydro-2H-quinolin-3-yl]-[(3-methyl-2-thienyl)sulfonyl]amino]methyl]piperidine-1-carboxylic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0057 0.0057
Echinococcus multilocularis sex peptide receptor 0.0237 0.2263 0.2263
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0429 0.418 0.4164
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.1255 0.1255
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0213 0.033
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0086 0.0086
Onchocerca volvulus 0.0237 0.2263 0.2508
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0117 0.0237
Entamoeba histolytica hypothetical protein 0.0041 0.0314 0.051
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0237 0.2263 0.2263
Leishmania major hypothetical protein, conserved 0.0029 0.0193 0.0167
Echinococcus granulosus 7tm_1 domain containing protein 0.0237 0.2263 0.2263
Leishmania major ubiquitin activating enzyme, putative 0.002 0.0108 0.0081
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.0703 0.4753
Brugia malayi Melatonin receptor type 1A 0.0237 0.2263 0.2263
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0429 0.418 0.4164
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0116 0.1058 0.7492
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0237 0.2263 0.2263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0237 0.2263 0.2263
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0213 0.033
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0609 0.1034
Schistosoma mansoni adenosine kinase 0.1014 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0237 0.2263 0.2263
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.418 0.7366
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0086 0.0031
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0476 0.4648 0.4648
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0057 0.0057
Brugia malayi hypothetical protein 0.0237 0.2263 0.2263
Loa Loa (eye worm) melatonin receptor type 1A 0.0237 0.2263 0.2263
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.0908 0.0884
Echinococcus multilocularis G-protein coupled receptor, putative 0.0237 0.2263 0.2263
Echinococcus granulosus rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0213 0.0376
Entamoeba histolytica hypothetical protein 0.0041 0.0314 0.051
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0429 0.418 1
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0148 0.1381 0.1381
Schistosoma mansoni histamine h1 receptor 0.0237 0.2263 0.2263
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0148 0.1384 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0213 0.033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0579 0.5665 0.6377
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.1035 0.1035
Echinococcus multilocularis allatostatin A receptor 0.0237 0.2263 0.2263
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0237 0.2263 0.2263
Echinococcus granulosus biogenic amine 5HT receptor 0.0237 0.2263 0.2263
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1035 0.1789
Echinococcus multilocularis GPCR, family 2 0.0018 0.0086 0.0086
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.418 0.7366
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0237 0.2263 0.2263
Entamoeba histolytica hypothetical protein 0.0041 0.0314 0.051
Onchocerca volvulus 0.0237 0.2263 0.2508
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.002 0.0108 0.0144
Trypanosoma brucei NEDD8 activating enzyme subunit, putative 0.002 0.0108 0.0081
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Schistosoma mansoni hypothetical protein 0.0018 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0237 0.2263 0.2263
Echinococcus granulosus GPCR family 2 0.0018 0.0086 0.0086
Echinococcus granulosus 7TM GPCR rhodopsin 0.0237 0.2263 0.2263
Echinococcus granulosus rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Leishmania major nucleobase transporter 0.01 0.0908 0.0884
Loa Loa (eye worm) STAT protein 0.0137 0.1272 0.1272
Trypanosoma cruzi adenosine kinase, putative 0.0116 0.1058 0.1034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Schistosoma mansoni alpha-1 adrenergic receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0117
Echinococcus multilocularis rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Brugia malayi G protein-coupled receptor F59B2.13 0.0237 0.2263 0.2263
Schistosoma mansoni netrin receptor unc5 0.0015 0.0057 0.0057
Schistosoma mansoni opsin-like receptor 0.0237 0.2263 0.2263
Echinococcus multilocularis fmrfamide receptor 0.0237 0.2263 0.2263
Schistosoma mansoni neuropeptide F-like receptor 0.0237 0.2263 0.2263
Plasmodium falciparum NEDD8-activating enzyme E1 catalytic subunit, putative 0.002 0.0108 0.0052
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0237 0.2263 0.2263
Onchocerca volvulus 0.0237 0.2263 0.2508
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0429 0.418 0.418
Trypanosoma brucei unspecified product 0.01 0.0908 0.0884
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0845 0.8316 0.8316
Echinococcus granulosus g protein coupled receptor 0.0237 0.2263 0.2263
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1035 0.1789
Schistosoma mansoni amine GPCR 0.0237 0.2263 0.2263
Entamoeba histolytica nucleoside transporter, putative 0.01 0.0908 0.1563
Trypanosoma brucei adenosine transporter, putative 0.01 0.0908 0.0884
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0193 0.0167
Loa Loa (eye worm) hypothetical protein 0.0018 0.0086 0.0086
Brugia malayi hypothetical protein 0.0237 0.2263 0.2263
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0237 0.2263 0.2263
Echinococcus multilocularis rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Brugia malayi hypothetical protein 0.0237 0.2263 0.2263
Onchocerca volvulus 0.0237 0.2263 0.2508
Onchocerca volvulus 0.0237 0.2263 0.2508
Loa Loa (eye worm) hypothetical protein 0.0579 0.5665 0.5665
Echinococcus granulosus adenylate cyclase 9 0.0079 0.0694 0.0694
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0237 0.2263 0.2263
Echinococcus multilocularis neuropeptides capa receptor 0.0237 0.2263 0.2263
Onchocerca volvulus 0.0116 0.1058 0.1138
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0213 0.0308
Loa Loa (eye worm) neuropeptide F receptor 0.0237 0.2263 0.2263
Schistosoma mansoni adenoreceptor 0.0237 0.2263 0.2263
Echinococcus granulosus alpha 1A adrenergic receptor 0.0237 0.2263 0.2263
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0703 0.1565
Schistosoma mansoni ribokinase 0.0116 0.1058 0.1058
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0129 0.0183
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0429 0.418 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0133 0.1232 0.1208
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.0908 0.0884
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0429 0.418 0.418
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1035 0.1789
Trypanosoma cruzi nucleoside transporter 1, putative 0.01 0.0908 0.0884
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0609 0.0609
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0314 0.0314
Brugia malayi 6-phosphofructokinase 0.0113 0.1035 0.1035
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.1255 0.1255
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0086 0.0086
Brugia malayi hypothetical protein 0.0237 0.2263 0.2263
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.1035 0.1035
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0237 0.2263 0.2263
Echinococcus granulosus tm gpcr rhodopsin 0.0237 0.2263 0.2263
Brugia malayi Protein kinase domain containing protein 0.0015 0.0057 0.0057
Echinococcus multilocularis neuropeptides capa receptor 0.0237 0.2263 0.2263
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0193 0.0167
Loa Loa (eye worm) hypothetical protein 0.0116 0.1058 0.1058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Loa Loa (eye worm) TYRA-2 protein 0.0237 0.2263 0.2263
Schistosoma mansoni neuropeptide receptor 0.0237 0.2263 0.2263
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.1035 0.2073
Schistosoma mansoni myosin xvIII 0.0237 0.2263 0.2263
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.0908 0.1563
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0609 0.0609
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0237 0.2263 0.2263
Echinococcus multilocularis g protein coupled receptor 0.0237 0.2263 0.2263
Onchocerca volvulus Neuropeptide F receptor homolog 0.0237 0.2263 0.2508
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0036 0.0036
Brugia malayi Pax transcription factor protein 2 0.0273 0.2623 0.2623
Trypanosoma brucei adenosine kinase, putative 0.1014 1 1
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0314 0.0314
Schistosoma mansoni neuropeptide F-like receptor 0.0237 0.2263 0.2263
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0429 0.418 0.4164
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0237 0.2263 0.2263
Onchocerca volvulus 0.0237 0.2263 0.2508
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Brugia malayi Tachykinin-like peptides receptor 99D 0.0237 0.2263 0.2263
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.418 0.7366
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0133 0.1232 0.1208
Echinococcus granulosus peptide allatostatin:somatostatin 0.0237 0.2263 0.2263
Echinococcus multilocularis tumor protein p63 0.0361 0.3497 0.3497
Echinococcus granulosus rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0237 0.2263 0.2263
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0429 0.418 0.7276
Brugia malayi hypothetical protein 0.0127 0.117 0.117
Trypanosoma brucei nucleoside transporter 1, putative 0.01 0.0908 0.0884
Trypanosoma cruzi nucleoside transporter 1, putative 0.01 0.0908 0.0884
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Echinococcus granulosus g protein coupled receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) RecQ helicase 0.0022 0.0129 0.0129
Echinococcus granulosus biogenic amine 5HT receptor 0.0237 0.2263 0.2263
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0237 0.2263 0.2263
Schistosoma mansoni hypothetical protein 0.0237 0.2263 0.2263
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0579 0.5665 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0237 0.2263 0.2263
Brugia malayi hypothetical protein 0.0237 0.2263 0.2263
Schistosoma mansoni opsin-like receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0296 0.2857 0.2857
Schistosoma mansoni amine GPCR 0.0237 0.2263 0.2263
Echinococcus multilocularis dro:myosuppressin receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0237 0.2263 0.2263
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.418 0.7366
Echinococcus granulosus neuropeptides capa receptor 0.0237 0.2263 0.2263
Brugia malayi follicle stimulating hormone receptor 0.0476 0.4648 0.4648
Echinococcus multilocularis g protein coupled receptor 0.0237 0.2263 0.2263
Echinococcus multilocularis rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1035 0.1789
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0237 0.2263 0.2263
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0086 0.0086
Leishmania major nucleoside transporter 1, putative 0.01 0.0908 0.0884
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0237 0.2263 0.2263
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0281 0.2707 0.4754
Echinococcus granulosus allatostatin A receptor 0.0237 0.2263 0.2263
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Schistosoma mansoni biogenic amine (5HT) receptor 0.0237 0.2263 0.2263
Entamoeba histolytica ribokinase, putative 0.0116 0.1058 0.183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0237 0.2263 0.2263
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0086 0.006
Echinococcus multilocularis g protein coupled receptor 0.0237 0.2263 0.2263
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0579 0.5665 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0086 0.0086
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Onchocerca volvulus Ribokinase homolog 0.0116 0.1058 0.1138
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0237 0.2263 0.2263
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.1035 0.226
Loa Loa (eye worm) hypothetical protein 0.0018 0.0085 0.0085
Brugia malayi Nucleoside transporter family protein 0.0579 0.5665 0.5665
Leishmania major adenosine kinase-like protein 0.0116 0.1058 0.1034
Onchocerca volvulus 0.0237 0.2263 0.2508
Brugia malayi hypothetical protein 0.0029 0.0193 0.0193
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.0908 0.0884
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0703 0.1506
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.0908 0.0884
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0237 0.2263 0.2263
Echinococcus granulosus tm gpcr rhodopsin 0.0237 0.2263 0.2263
Brugia malayi putative neuropeptide receptor 0.0237 0.2263 0.2263
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0237 0.2263 0.2263
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0086 0.0069
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0579 0.5665 0.6377
Brugia malayi hypothetical protein 0.0116 0.1058 0.1058
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.0908 0.1563
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0086 0.006
Leishmania major nucleobase transporter 0.01 0.0908 0.0884
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.1035 0.1035
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0213 0.0376
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0039 0.0293 0.0293
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.0703 0.0703
Brugia malayi RE15519p 0.0237 0.2263 0.2263
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0429 0.418 0.418
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0609 0.0609
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0065 0.0552 0.0933
Schistosoma mansoni biogenic amine receptor 0.0237 0.2263 0.2263
Trypanosoma brucei purine nucleoside transporter 0.01 0.0908 0.0884
Trypanosoma brucei purine nucleoside transporter 0.01 0.0908 0.0884
Echinococcus multilocularis neuropeptide receptor A26 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.01 0.0908 0.0908
Schistosoma mansoni biogenic amine receptor 0.0237 0.2263 0.2263
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0672 0.0672
Loa Loa (eye worm) hypothetical protein 0.1014 1 1
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.1035 0.1012
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0429 0.418 0.4147
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.0703 0.4626
Echinococcus granulosus ribokinase 0.0116 0.1058 0.1058
Brugia malayi Dopamine receptor protein 2 0.0237 0.2263 0.2263
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0117 0.0068
Echinococcus multilocularis serotonin receptor 0.0237 0.2263 0.2263
Brugia malayi STAT protein, DNA binding domain containing protein 0.0137 0.1272 0.1272
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0086 0.006
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0429 0.418 0.418
Onchocerca volvulus 0.0237 0.2263 0.2508
Loa Loa (eye worm) hypothetical protein 0.0215 0.2052 0.2052
Loa Loa (eye worm) ectopic membrane ruffles in embryo protein 1 0.0065 0.0552 0.0552
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Brugia malayi hypothetical protein 0.0041 0.0314 0.0314
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0609 0.0585
Toxoplasma gondii kinase, pfkB family protein 0.0116 0.1058 0.1008
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0129 0.0129
Schistosoma mansoni hypothetical protein 0.0018 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0086 0.0086
Trichomonas vaginalis ribokinase, putative 0.0116 0.1058 0.183
Echinococcus multilocularis neuropeptide receptor 0.0237 0.2263 0.2263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0237 0.2263 0.2263
Echinococcus multilocularis rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0314 0.0314
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0116 0.1058 0.2316
Giardia lamblia Hypothetical protein 0.0579 0.5665 1
Trypanosoma cruzi nucleobase transporter, putative 0.01 0.0908 0.0884
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0429 0.418 0.418
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0213 0.0158
Mycobacterium ulcerans endonuclease IV 0.008 0.0703 0.1442
Entamoeba histolytica nucleoside transporter, putative 0.01 0.0908 0.1563
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.008 0.0703 0.0703
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.1035 0.1035
Brugia malayi hypothetical protein 0.0237 0.2263 0.2263
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0237 0.2263 0.2263
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0079 0.0694 0.0724
Echinococcus multilocularis neuropeptide s receptor 0.0237 0.2263 0.2263
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.1035 0.1012
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.418 0.4164
Leishmania major tagatose-6-phosphate kinase-like protein 0.0116 0.1058 0.1034
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0429 0.418 1
Brugia malayi neuropeptide F receptor 0.0237 0.2263 0.2263
Echinococcus multilocularis G protein coupled receptor 139 0.0237 0.2263 0.2263
Toxoplasma gondii nucleoside transporter protein 0.01 0.0908 0.0857
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.0908 0.0884
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Echinococcus multilocularis orexin receptor type 2 0.0237 0.2263 0.2263
Trypanosoma cruzi nucleoside transporter 1, putative 0.01 0.0908 0.0884
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Trypanosoma cruzi adenosine kinase, putative 0.0116 0.1058 0.1034
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0036 0.0036
Brugia malayi Adenylyl cyclase protein 0.0079 0.0694 0.0694
Echinococcus granulosus fmrfamide receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) G-protein coupled receptor 0.0237 0.2263 0.2263
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0057
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.0908 0.0884
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0429 0.418 0.4147
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0237 0.2263 0.2508
Entamoeba histolytica fructokinase, putative 0.0116 0.1058 0.183
Brugia malayi hypothetical protein 0.0579 0.5665 0.5665
Onchocerca volvulus 0.0053 0.0434 0.0428
Trypanosoma brucei ribokinase, putative 0.0116 0.1058 0.1034
Echinococcus granulosus adenosine kinase 0.1014 1 1
Schistosoma mansoni hypothetical protein 0.0018 0.0086 0.0086
Brugia malayi hypothetical protein 0.0018 0.0092 0.0092
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0609 0.0585
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0429 0.418 0.7366
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0086 0.0086
Brugia malayi GnHR receptor homolog 0.0237 0.2263 0.2263
Echinococcus granulosus tachykinin peptides receptor 99D 0.0237 0.2263 0.2263
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0083 0.0083
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.1035 0.1789
Onchocerca volvulus 0.0076 0.066 0.0686
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0579 0.5665 0.5665
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0059 0.0059
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0429 0.418 0.5
Mycobacterium tuberculosis Adenosine kinase 0.0116 0.1058 0.7492
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0193 0.0137
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0057 0.0057
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0237 0.2263 0.2263
Schistosoma mansoni equilibrative nucleoside transporter 0.01 0.0908 0.0908
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.01 0.0908 0.0884
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0237 0.2263 0.2263
Echinococcus multilocularis fmrfamide receptor 0.0237 0.2263 0.2263
Entamoeba histolytica hypothetical protein 0.0041 0.0314 0.051
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0579 0.5665 1
Onchocerca volvulus 0.0899 0.885 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0471 0.0471
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0193 0.0259
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0148 0.1384 1
Brugia malayi hypothetical protein 0.0237 0.2263 0.2263
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0213 0.033
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0237 0.2263 0.2263
Brugia malayi larval opioid receptor 0.0237 0.2263 0.2263
Mycobacterium tuberculosis Ribokinase RbsK 0.0116 0.1058 0.7492
Schistosoma mansoni hypothetical protein 0.0013 0.0036 0.0036
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0281 0.2707 0.2707
Echinococcus granulosus death domain containing protein 0.0015 0.0057 0.0057
Schistosoma mansoni biogenic amine receptor 0.0237 0.2263 0.2263
Schistosoma mansoni amine GPCR 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0237 0.2263 0.2263
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.418 0.4164
Loa Loa (eye worm) hypothetical protein 0.0079 0.0694 0.0694
Brugia malayi MH2 domain containing protein 0.0135 0.1255 0.1255
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0237 0.2263 0.2263
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0116 0.1058 0.1058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0237 0.2263 0.2263
Echinococcus granulosus dro:myosuppressin receptor 0.0237 0.2263 0.2263
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0213 0.033
Trypanosoma cruzi nucleobase transporter, putative 0.01 0.0908 0.0884
Loa Loa (eye worm) adenylyl cyclase 3 0.0079 0.0694 0.0694
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0086 0.0086
Schistosoma mansoni neuropeptide f receptor 76f 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0429 0.418 0.418
Brugia malayi sulfakinin receptor protein 0.0237 0.2263 0.2263
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.002 0.0108 0.0081
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0429 0.418 1
Schistosoma mansoni hypothetical protein 0.0039 0.0293 0.0293
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0129 0.0129
Echinococcus granulosus neuropeptide receptor 0.0237 0.2263 0.2263
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.0908 0.1563
Brugia malayi Dopamine receptor protein 1 0.0237 0.2263 0.2263
Onchocerca volvulus Putative pyridoxal kinase 0.0116 0.1058 0.1138
Schistosoma mansoni hypothetical protein 0.0237 0.2263 0.2263
Schistosoma mansoni opsin-like receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Echinococcus granulosus NEDD8 activating enzyme E1 catalytic subunit 0.0065 0.0552 0.0552
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0148 0.1381 0.2403
Trypanosoma brucei unspecified product 0.01 0.0908 0.0884
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0237 0.2263 0.2263
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0609 0.0585
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0429 0.418 0.4164
Brugia malayi Ectopic membrane ruffles in embryo protein 1 0.0065 0.0552 0.0552
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0281 0.2707 0.4754
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0237 0.2263 0.2263
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0237 0.2263 0.2263
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1035 0.1789
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0429 0.418 0.7366
Echinococcus granulosus neuropeptide Y receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0057 0.0471 0.0471
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0579 0.5665 1
Echinococcus granulosus orexin receptor type 2 0.0237 0.2263 0.2263
Schistosoma mansoni neuropeptide receptor 0.0237 0.2263 0.2263
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0086 0.006
Loa Loa (eye worm) hypothetical protein 0.0053 0.0434 0.0434
Mycobacterium leprae Probable adenosine kinase adk 0.0116 0.1058 0.7431
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0116 0.1058 0.1058
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Echinococcus multilocularis ribokinase 0.0116 0.1058 0.1058
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0193 0.0327
Echinococcus multilocularis NEDD8 activating enzyme E1 catalytic subunit 0.0065 0.0552 0.0552
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0219 0.2085 0.2306
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0213 0.033
Schistosoma mansoni growth hormone secretagogue receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0296 0.2857 0.2857
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0133 0.1232 0.1208
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0579 0.5665 0.5665
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0129 0.0183
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.418 0.4164
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0429 0.418 0.4164
Leishmania major ribokinase, putative 0.0116 0.1058 0.1034
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0281 0.2705 0.2685
Echinococcus granulosus G protein coupled receptor 139 0.0237 0.2263 0.2263
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.0908 0.1563
Toxoplasma gondii kinase, pfkB family protein 0.1014 1 1
Brugia malayi phosphofructokinase 0.0113 0.1035 0.1035
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.1035 0.1035
Entamoeba histolytica kinase, PfkB family 0.0116 0.1058 0.183
Schistosoma mansoni hypothetical protein 0.0041 0.0314 0.0314
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0086 0.0086
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0133 0.1232 0.1208
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.0908 0.0884
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0429 0.418 0.418
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0331 0.3198 0.3198
Onchocerca volvulus 0.0237 0.2263 0.2508
Toxoplasma gondii nucleoside transporter protein 0.01 0.0908 0.0857
Toxoplasma gondii NEDD8-activating enzyme E1 catalytic subunit 0.0065 0.0552 0.0499
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0237 0.2263 0.2263
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0281 0.2705 0.2685
Brugia malayi 6-phosphofructokinase 0.0113 0.1035 0.1035
Onchocerca volvulus 0.0237 0.2263 0.2508
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0237 0.2263 0.2263
Echinococcus multilocularis serotonin receptor 0.0237 0.2263 0.2263
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.002 0.0108 0.0081
Echinococcus multilocularis somatostatin receptor 0.0237 0.2263 0.2263
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0193
Echinococcus granulosus somatostatin receptor 0.0237 0.2263 0.2263
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Brugia malayi neuropeptide F receptor 0.0237 0.2263 0.2263
Echinococcus granulosus neuropeptides capa receptor 0.0237 0.2263 0.2263
Trypanosoma brucei adenosine transporter, putative 0.01 0.0908 0.0884
Leishmania major nucleoside transporter 1, putative 0.01 0.0908 0.0884
Echinococcus granulosus rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Schistosoma mansoni hypothetical protein 0.0015 0.0057 0.0057
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0213 0.0158
Trypanosoma cruzi adenosine kinase, putative 0.1014 1 1
Trichomonas vaginalis ribokinase, putative 0.0116 0.1058 0.183
Trichomonas vaginalis ribokinase, putative 0.0116 0.1058 0.183
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0429 0.418 0.4164
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0133 0.1232 0.1208
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0193 0.0167
Toxoplasma gondii endonuclease IV APN 0.008 0.0703 0.0651
Schistosoma mansoni biogenic amine (5HT) receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Echinococcus multilocularis adenosine kinase 0.1014 1 1
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.0908 0.0884
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Chlamydia trachomatis endonuclease IV 0.008 0.0703 0.1236
Onchocerca volvulus 0.0273 0.2623 0.2918
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0086 0.0086
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0116 0.1058 0.1058
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0116 0.1058 0.183
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Brugia malayi hypothetical protein 0.0237 0.2263 0.2263
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0314 0.0314
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0281 0.2705 0.2685
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0429 0.418 0.418
Brugia malayi hypothetical protein 0.0237 0.2263 0.2263
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0281 0.2707 0.2707
Echinococcus granulosus sex peptide receptor 0.0237 0.2263 0.2263
Brugia malayi isocitrate dehydrogenase 0.0018 0.0086 0.0086
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0237 0.2263 0.2263
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.1035 0.1789
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0213 0.033
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0057 0.0057
Trypanosoma brucei nucleoside transporter 1, putative 0.01 0.0908 0.0884
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.1035 0.1012
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0057 0.0057
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0237 0.2263 0.2263
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0429 0.418 0.7366
Echinococcus granulosus geminin 0.0369 0.3577 0.3577
Trypanosoma cruzi adenosine kinase, putative 0.1014 1 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Loa Loa (eye worm) G-protein coupled receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0579 0.5665 0.5665
Schistosoma mansoni adenosine kinase 0.1014 1 1
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.01 0.0908 0.0884
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Schistosoma mansoni hypothetical protein 0.0369 0.3577 0.3577
Trypanosoma cruzi nucleobase transporter, putative 0.01 0.0908 0.0884
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Entamoeba histolytica nucleoside transporter, putative 0.0579 0.5665 1
Echinococcus multilocularis adenylate cyclase 9 0.0079 0.0694 0.0694
Brugia malayi Dopamine receptor 0.0237 0.2263 0.2263
Schistosoma mansoni amine GPCR 0.0237 0.2263 0.2263
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0117 0.0117
Giardia lamblia Ribokinase 0.0116 0.1058 0.1551
Onchocerca volvulus 0.0237 0.2263 0.2508
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0213 0.0158
Brugia malayi G protein-coupled receptor 0.0237 0.2263 0.2263
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0237 0.2263 0.2263
Leishmania major adenosine kinase, putative 0.1014 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0237 0.2263 0.2263
Onchocerca volvulus 0.0237 0.2263 0.2508
Brugia malayi hypothetical protein 0.0237 0.2263 0.2263
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0237 0.2263 0.2263
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0237 0.2263 0.2263
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Echinococcus multilocularis rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0237 0.2263 0.2263
Echinococcus granulosus Ankyrin 0.0015 0.0059 0.0059
Brugia malayi Uncoordinated protein 44 0.0015 0.0057 0.0057
Onchocerca volvulus 0.0237 0.2263 0.2508
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0478 0.4665 0.4665
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.01 0.0908 0.0884
Trypanosoma brucei adenosine transporter 2 0.01 0.0908 0.0884
Echinococcus granulosus rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0015 0.0059 0.0059
Echinococcus multilocularis neuropeptide receptor 0.0237 0.2263 0.2263
Leishmania major putative PfkB family sugar kinase 0.0116 0.1058 0.1034
Echinococcus multilocularis geminin 0.0369 0.3577 0.3577
Leishmania major tagatose-6-phosphate kinase-like protein 0.0116 0.1058 0.1034
Echinococcus granulosus neuropeptide receptor 0.0237 0.2263 0.2263
Trypanosoma cruzi nucleoside transporter-like, putative 0.01 0.0908 0.0884
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0103 0.0039
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0237 0.2263 0.2263
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.0908 0.0884
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.418 0.7366
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Schistosoma mansoni neuropeptide receptor 0.0237 0.2263 0.2263
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0293 0.0293
Trypanosoma cruzi nucleoside transporter-like, putative 0.01 0.0908 0.0884
Brugia malayi hypothetical protein 0.01 0.0908 0.0908
Brugia malayi Serotonin receptor 0.0237 0.2263 0.2263
Echinococcus granulosus equilibrative nucleoside transporter 0.0579 0.5665 0.5665
Trypanosoma cruzi ribokinase, putative 0.0116 0.1058 0.1034
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Brugia malayi AKH receptor 0.0237 0.2263 0.2263
Schistosoma mansoni hypothetical protein 0.0369 0.3577 0.3577
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0047 0.0373 0.0614
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0213 0.033
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Echinococcus granulosus tm gpcr rhodopsin 0.0237 0.2263 0.2263
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0086 0.006
Mycobacterium ulcerans fructokinase, PfkB 0.0116 0.1058 0.2316
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0193 0.0259
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0237 0.2263 0.2263
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0281 0.2705 0.2685
Brugia malayi Death domain containing protein 0.0015 0.0057 0.0057
Echinococcus granulosus hypothetical protein 0.0237 0.2263 0.2263
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.0908 0.0884
Brugia malayi putative neuropeptide receptor NPR1 0.0237 0.2263 0.2263
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.418 0.4164
Echinococcus granulosus neuropeptide Y receptor 0.0237 0.2263 0.2263
Echinococcus granulosus bloom syndrome protein 0.0022 0.0129 0.0129
Echinococcus granulosus rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0579 0.5665 0.5665
Onchocerca volvulus 0.0237 0.2263 0.2508
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0281 0.2707 0.2707
Brugia malayi Ribokinase 0.0116 0.1058 0.1058
Brugia malayi G-protein coupled receptor 0.0237 0.2263 0.2263
Schistosoma mansoni protein kinase 0.01 0.0908 0.0908
Echinococcus multilocularis neuropeptide Y receptor 0.0237 0.2263 0.2263
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0057 0.0057
Echinococcus multilocularis Ankyrin 0.0015 0.0059 0.0059
Echinococcus granulosus neuropeptide s receptor 0.0237 0.2263 0.2263
Trypanosoma brucei adenosine transporter 2 0.01 0.0908 0.0884
Loa Loa (eye worm) hypothetical protein 0.0579 0.5665 0.5665
Echinococcus granulosus serotonin receptor 0.0237 0.2263 0.2263
Leishmania major adenosine kinase-like protein 0.0116 0.1058 0.1034
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.0908 0.1563
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Onchocerca volvulus 0.0237 0.2263 0.2508
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0429 0.418 0.418
Schistosoma mansoni amine GPCR 0.0237 0.2263 0.2263
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0237 0.2263 0.2263
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0057 0.0057
Trypanosoma brucei adenosine kinase, putative 0.1014 1 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.1035 0.7315
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0018 0.0086 0.0086
Onchocerca volvulus 0.0237 0.2263 0.2508
Echinococcus granulosus neuropeptide receptor A26 0.0237 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.0281 0.2707 0.2707
Schistosoma mansoni hypothetical protein 0.0237 0.2263 0.2263
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0609 0.0585
Loa Loa (eye worm) phosphofructokinase 0.0113 0.1035 0.1035
Loa Loa (eye worm) hypothetical protein 0.0237 0.2263 0.2263
Brugia malayi G-protein coupled receptor 0.0237 0.2263 0.2263
Onchocerca volvulus 0.0079 0.0694 0.0724
Loa Loa (eye worm) pax transcription factor protein 2 0.0273 0.2623 0.2623
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0086 0.0031
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0672 0.0672
Onchocerca volvulus 0.0237 0.2263 0.2508
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0429 0.418 0.4164
Brugia malayi ORL1-like opioid receptor 0.0237 0.2263 0.2263
Echinococcus granulosus tumor protein p63 0.0361 0.3497 0.3497
Trypanosoma brucei ribokinase, putative 0.0116 0.1058 0.1034
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0213 0.0308
Toxoplasma gondii nucleoside transporter protein 0.01 0.0908 0.0857
Plasmodium vivax ubiquitin-activating enzyme E1C, putative 0.002 0.0108 0.0121
Brugia malayi Serotonin receptor 0.0237 0.2263 0.2263
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.0065 0.0552 0.0552
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0237 0.2263 0.2263
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0116 0.1058 0.183
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0086 0.0086
Echinococcus granulosus g-protein coupled receptor 0.0237 0.2263 0.2263
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0086 0.0086
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0133 0.1232 0.1232
Echinococcus multilocularis g-protein coupled receptor 0.0237 0.2263 0.2263
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0086 0.0086
Loa Loa (eye worm) neuropeptide F receptor 0.0237 0.2263 0.2263
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0281 0.2705 0.457
Schistosoma mansoni neuropeptide receptor 0.0237 0.2263 0.2263
Echinococcus granulosus g protein coupled receptor 0.0237 0.2263 0.2263
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.1035 0.1035
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.1035 0.725
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0429 0.418 0.4164
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.1058 0.183
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0429 0.418 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0237 0.2263 0.2263
Echinococcus multilocularis neuropeptide FF receptor 2 0.0237 0.2263 0.2263
Echinococcus multilocularis neuropeptide Y receptor 0.0237 0.2263 0.2263
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0281 0.2707 0.2707

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 55 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 17722901
ED50 (functional) = 55 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 17722901
ED50 (functional) = 75 nM Antimalarial activity against Plasmodium falciparum K1 ChEMBL. 17722901
ED50 (functional) = 75 nM Antimalarial activity against Plasmodium falciparum K1 ChEMBL. 17722901
Inhibition (binding) = 18 % Inhibition of plasmodium falciparum protein farnesyltransferase at 0.5 nM by scintillation proximity assay ChEMBL. 17722901
Inhibition (binding) = 66 % Inhibition of plasmodium falciparum protein farnesyltransferase at 5 nM by scintillation proximity assay ChEMBL. 17722901
Inhibition (binding) = 95 % Inhibition of plasmodium falciparum protein farnesyltransferase at 50 nM by scintillation proximity assay ChEMBL. 17722901

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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