Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1663 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0787 | 0.4345 | 0.6911 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0787 | 0.4345 | 0.6677 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1663 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.1088 | 0.6288 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0787 | 0.4345 | 0.6677 |
Onchocerca volvulus | 0.1088 | 0.6288 | 0.5 | |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.0183 | 0.0443 | 0.0704 |
Schistosoma mansoni | dihydrofolate reductase | 0.0787 | 0.4345 | 0.6677 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1088 | 0.6288 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0787 | 0.4345 | 0.4726 |
Brugia malayi | thymidylate synthase | 0.1088 | 0.6288 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1663 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.1088 | 0.6288 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1088 | 0.6288 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1663 | 1 | 1 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.0183 | 0.0443 | 0.0704 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1663 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0787 | 0.4345 | 0.6677 |
Brugia malayi | hypothetical protein | 0.0518 | 0.2605 | 0.3699 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1088 | 0.6288 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0183 | 0.0443 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.0183 | 0.0443 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0787 | 0.4345 | 0.6911 |
Loa Loa (eye worm) | thymidylate synthase | 0.1088 | 0.6288 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0518 | 0.2605 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0183 | 0.0443 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0787 | 0.4345 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.1088 | 0.6288 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.0183 | 0.0443 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 650 nM | Antimalarial activity against Plasmodium falciparum 3D7 | ChEMBL. | 17722901 |
ED50 (functional) | = 650 nM | Antimalarial activity against Plasmodium falciparum 3D7 | ChEMBL. | 17722901 |
ED50 (functional) | = 730 nM | Antimalarial activity against Plasmodium falciparum K1 | ChEMBL. | 17722901 |
ED50 (functional) | = 730 nM | Antimalarial activity against Plasmodium falciparum K1 | ChEMBL. | 17722901 |
Inhibition (binding) | = 0 % | Inhibition of plasmodium falciparum protein farnesyltransferase at 0.5 nM by scintillation proximity assay | ChEMBL. | 17722901 |
Inhibition (binding) | = 1 % | Inhibition of plasmodium falciparum protein farnesyltransferase at 5 nM by scintillation proximity assay | ChEMBL. | 17722901 |
Inhibition (binding) | = 43 % | Inhibition of plasmodium falciparum protein farnesyltransferase at 50 nM by scintillation proximity assay | ChEMBL. | 17722901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.