Detailed information for compound 437954

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 566.716 | Formula: C32H34N6O2S
  • H donors: 0 H acceptors: 4 LogP: 4.52 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cn1cnc(c1)CN1CC(Cc2c1ccc(c2)c1ccccc1)N(S(=O)(=O)c1ncn(c1)C)Cc1ccccc1C
  • InChi: 1S/C32H34N6O2S/c1-24-9-7-8-12-27(24)17-38(41(39,40)32-21-36(3)23-34-32)30-16-28-15-26(25-10-5-4-6-11-25)13-14-31(28)37(20-30)19-29-18-35(2)22-33-29/h4-15,18,21-23,30H,16-17,19-20H2,1-3H3
  • InChiKey: MZCRLEHHMLPYIR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.001 0.0011 0.0065
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0028 0.0126 0.0119
Schistosoma mansoni cytochrome b 0.0271 0.1619 0.1857
Loa Loa (eye worm) hypothetical protein 0.0064 0.0345 0.213
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0013
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0013 0.0029 0.0776
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0011 0.0000029685
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0065
Echinococcus granulosus expressed conserved protein 0.0132 0.0766 0.0877
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0546 1
Plasmodium vivax pyruvate kinase, putative 0.0069 0.0374 0.1362
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0013
Schistosoma mansoni thyroid hormone receptor 0.001 0.0015 0.0014
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0015 0.0014
Brugia malayi DKFZp564C0469 protein 0.001 0.0011 0.0065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0584 0.3606
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.0546 0.4611
Plasmodium falciparum cytochrome b 0.0443 0.2682 1
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0012 0.0028 0.0065
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0027 0.0118 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0094
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0096 0.0546 0.0555
Echinococcus granulosus nervana 2 0.0064 0.0345 0.0393
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0065 0.1729
Loa Loa (eye worm) patched family protein 0.0012 0.0025 0.0155
Loa Loa (eye worm) hypothetical protein 0.0032 0.0151 0.0934
Schistosoma mansoni hypothetical protein 0.0032 0.0151 0.0171
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0013 0.0029 0.003
Schistosoma mansoni hypothetical protein 0.0032 0.0151 0.0171
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Loa Loa (eye worm) hypothetical protein 0.0022 0.0087 0.0535
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0012 0.0028 0.0029
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0228 0.1406
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0126 0.2479
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0096 0.0546 0.0502
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0065 0.1729
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0007 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0151 0.0934
Onchocerca volvulus Pyruvate kinase homolog 0.0069 0.0374 0.0377
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0028 0.0125 0.0775
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Plasmodium falciparum pyruvate kinase 2 0.0035 0.0168 0.0591
Brugia malayi MH2 domain containing protein 0.0008 0.0003 0.0016
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0096 0.0546 0.0555
Brugia malayi hypothetical protein 0.0012 0.0025 0.0155
Brugia malayi protein C24B5.3 0.0012 0.0025 0.0155
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Echinococcus granulosus pyruvate kinase 0.0035 0.0168 0.019
Echinococcus multilocularis Niemann Pick C1 protein 0.0283 0.1695 0.1692
Echinococcus multilocularis pyruvate kinase 0.0035 0.0168 0.0166
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0126 0.0119
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0065 0.0062
Brugia malayi Niemann-Pick C1 protein precursor 0.0198 0.1171 0.7233
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0546 1
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.145 0.1448
Schistosoma mansoni cytochrome b 0.0443 0.2682 0.3079
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0015 0.0014
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0228 0.1406
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0029 0.0398
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0014
Giardia lamblia Pyruvate kinase 0.0035 0.0168 0.4337
Plasmodium vivax sentrin-specific protease 2, putative 0.0013 0.0029 0.0069
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0126 0.1996
Toxoplasma gondii patched family protein 0.0012 0.0025 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0094
Schistosoma mansoni hypothetical protein 0.0082 0.0456 0.0521
Echinococcus granulosus pyruvate kinase 0.0069 0.0374 0.0427
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0012 0.0028 0.0065
Schistosoma mansoni ATPase 0.0011 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0094
Loa Loa (eye worm) patched family protein 0.0012 0.0025 0.0155
Loa Loa (eye worm) Ulp1 protease 0.0013 0.0029 0.0179
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0065 0.1168
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Onchocerca volvulus 0.0028 0.0126 0.0119
Schistosoma mansoni hypothetical protein 0.0082 0.0456 0.0521
Brugia malayi Patched protein homolog 1 0.0012 0.0025 0.0155
Schistosoma mansoni ap endonuclease 0.0018 0.0065 0.0071
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0012 0.0028 0.0065
Trichomonas vaginalis Sentrin-specific protease, putative 0.0013 0.0029 0.0398
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0065 1
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0011 0.0021 0.0021
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0012 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Echinococcus multilocularis expressed conserved protein 0.0132 0.0766 0.0764
Toxoplasma gondii hypothetical protein 0.0012 0.0025 0.0054
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0011 0.0282
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0065
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0126 0.0119
Echinococcus multilocularis expressed conserved protein 0.0186 0.1097 0.1095
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0065 0.0836
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0353 0.0403
Brugia malayi Patched related family protein 4 0.0012 0.0025 0.0155
Echinococcus granulosus microtubule associated protein 2 0.142 0.8706 1
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0475 0.0542
Toxoplasma gondii cytochrome b 0.0443 0.2682 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.145 0.8958
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0014
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0013 0.0029 0.003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0065 0.0203
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0179
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0015 0.0013
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0011 0.0021 0.0283
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0015 0.0005
Entamoeba histolytica acyl-coA synthetase, putative 0.0096 0.0546 0.4611
Plasmodium vivax patched family protein, putative 0.0012 0.0025 0.0054
Loa Loa (eye worm) hypothetical protein 0.0028 0.0126 0.0776
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0015 0.0014
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0126 0.0119
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0064 0.0345 0.0342
Brugia malayi nuclear hormone receptor 0.001 0.0015 0.0094
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0094
Wolbachia endosymbiont of Brugia malayi cytochrome b subunit of the bc complex 0.0443 0.2682 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0069 0.0374 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Schistosoma mansoni survival motor neuron protein 0.005 0.0257 0.0292
Brugia malayi Patched related family protein 10 0.0012 0.0025 0.0155
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.2442
Schistosoma mansoni transmemberane protein 0.0064 0.0345 0.0393
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0015 0.0014
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0126 0.3355
Leishmania major calcium motive p-type ATPase, putative 0.0012 0.0028 0.0136
Brugia malayi protein C24B5.3 0.0012 0.0025 0.0155
Echinococcus granulosus cytochrome B 0.0443 0.2682 0.3079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0371 0.0319
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0126 0.0776
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0011 0.0021 0.0557
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0011 0.0021 0.0557
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0029 0.0179
Trypanosoma brucei pyruvate kinase 1, putative 0.0069 0.0374 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0228 0.0225
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0353 0.0351
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0228 0.0225
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0094
Echinococcus multilocularis microtubule associated protein 2 0.142 0.8706 0.8706
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0094
Loa Loa (eye worm) pyruvate kinase-PB 0.0048 0.0246 0.1521
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0126 0.3355
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0228 0.0258
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0094
Entamoeba histolytica hypothetical protein 0.0109 0.0625 0.5294
Echinococcus granulosus Niemann Pick C1 protein 0.0198 0.1171 0.1343
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0133 0.0823
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0012 0.0028 0.0029
Schistosoma mansoni patched 1 0.0085 0.0475 0.0542
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.0029 0.0069
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.0029 0.0069
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0012 0.0028 0.0375
Trichomonas vaginalis cation-transporting ATPase, putative 0.0011 0.0021 0.0222
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0011 0.0000074239
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0065 0.0056
Brugia malayi Patched related family protein 12 0.0012 0.0025 0.0155
Entamoeba histolytica hypothetical protein 0.0109 0.0625 0.5294
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0546 0.0555
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0065 0.1489
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0029 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0094
Brugia malayi pyruvate kinase, muscle isozyme 0.0014 0.004 0.0249
Mycobacterium ulcerans hypothetical protein 0.0096 0.0546 0.0555
Loa Loa (eye worm) RNA binding protein 0.0065 0.0353 0.2181
Toxoplasma gondii patched family protein 0.0012 0.0025 0.0054
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0028 0.0126 0.0119
Brugia malayi hypothetical protein 0.0243 0.145 0.8958
Toxoplasma gondii apocytochrome b, putative 0.0443 0.2682 1
Brugia malayi hypothetical protein 0.0012 0.0025 0.0155
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0011 0.0282
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0011 0.0021 0.0557
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0094
Brugia malayi cytochrome b 0.0271 0.1619 1
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0029 0.0159
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0094
Onchocerca volvulus 0.0064 0.0345 0.0347
Brugia malayi Myosin head containing protein 0.0012 0.0025 0.0155
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0072 0.0395 1
Schistosoma mansoni hypothetical protein 0.0032 0.0151 0.0171
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0051 0.0265 0.1634
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0003 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.0546 0.4611
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0345 0.0342
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Loa Loa (eye worm) hypothetical protein 0.0025 0.0108 0.0669
Plasmodium vivax sentrin-specific protease 1, putative 0.0013 0.0029 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0353 0.0403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0094
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0338 0.0385
Plasmodium vivax pyruvate kinase 2, putative 0.0035 0.0168 0.0591
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0013 0.0029 0.003
Echinococcus multilocularis pyruvate kinase 0.0054 0.0285 0.0283
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0094
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0011 0.0021 0.0222
Leishmania major pyruvate kinase 0.0069 0.0374 0.6738
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0584 0.3606
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0013 0.0029 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0094
Echinococcus granulosus sentrin specific protease 8 0.0013 0.0029 0.003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Brugia malayi CXXC zinc finger family protein 0.003 0.0133 0.0823
Brugia malayi RNA binding protein 0.0065 0.0353 0.2181
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0028 0.0126 0.0119
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0201 0.119 0.1364
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0011 0.0009
Loa Loa (eye worm) Ulp1 protease 0.0013 0.0029 0.0179
Onchocerca volvulus Pyruvate kinase homolog 0.0069 0.0374 0.0377
Trypanosoma cruzi pyruvate kinase 2, putative 0.0069 0.0374 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0029 0.0398
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0065
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0064 0.0345 0.0393
Onchocerca volvulus Pyruvate kinase homolog 0.0069 0.0374 0.0377
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0126 0.0063
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0345 0.0393
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0015 0.0094
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0029 0.0159
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0065 0.04
Plasmodium vivax P-type ATPase4, putative 0.0012 0.0028 0.0065
Echinococcus granulosus pyruvate kinase 0.0035 0.0168 0.019
Schistosoma mansoni DNA ligase IV 0.001 0.0011 0.0009
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0029 0.0398
Mycobacterium ulcerans acetyl-CoA synthetase 0.0028 0.0126 0.0119
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0011 0.0021 0.0283
Chlamydia trachomatis pyruvate kinase 0.0069 0.0374 0.9458
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0126 0.0063
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0584 0.3606
Schistosoma mansoni hypothetical protein 0.0109 0.0625 0.0715
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0013 0.0029 0.048
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.0546 0.0555
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0708 0.4373
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0151 0.0171
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0065 0.0071
Echinococcus granulosus tumor protein p63 0.0347 0.2094 0.2402
Onchocerca volvulus 0.0028 0.0126 0.0119
Toxoplasma gondii apocytochrome b, putative 0.0172 0.1014 0.3756
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0126 0.1996
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0126 0.0063
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0011 0.0000074239
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0011 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0011 0.0282
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0371 0.0319
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0473
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0015 0.0094
Onchocerca volvulus Protein patched homolog 0.0012 0.0025 0.0015
Schistosoma mansoni topbp1 0.001 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0126 0.3355
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0011 0.0065
Entamoeba histolytica hypothetical protein 0.0109 0.0625 0.5294
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0228 0.0258
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.2442
Schistosoma mansoni hypothetical protein 0.005 0.0257 0.0292
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0475 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0353 0.0403
Echinococcus granulosus expressed conserved protein 0.0186 0.1097 0.1258
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0151 0.0171
Echinococcus multilocularis protein dispatched 1 0.0097 0.0549 0.0546
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0065 0.04
Loa Loa (eye worm) patched family protein 0.0012 0.0025 0.0155
Echinococcus granulosus sentrin specific protease 7 0.0145 0.0844 0.0967
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0012 0.0028 0.0375
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0126 0.0776
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Echinococcus granulosus pyruvate kinase 0.0035 0.0168 0.019
Onchocerca volvulus 0.0064 0.0345 0.0347
Echinococcus granulosus calcium transporting atpase 0.0012 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0179
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0033 0.0153 0.0173
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0345 0.0342
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0012 0.0028 0.0747
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0145 0.0844 0.7182
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0257 0.1586
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0064 0.0345 0.0393
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0126 0.0063
Plasmodium falciparum acyl-CoA synthetase 0.0072 0.0395 0.144
Plasmodium falciparum calcium-transporting ATPase 0.0012 0.0028 0.0065
Loa Loa (eye worm) Smad1 0.0008 0.0003 0.0016
Brugia malayi ecdysteroid receptor 0.001 0.0015 0.0094
Echinococcus granulosus nervana 2 0.0064 0.0345 0.0393
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0096 0.0546 0.0502
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0015 0.0014
Toxoplasma gondii P-type ATPase4, putative 0.0012 0.0028 0.0065
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0014
Brugia malayi topoisomerase 0.001 0.0011 0.0065
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0179
Loa Loa (eye worm) pyruvate kinase 0.0014 0.004 0.0249
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0126 0.0141
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0011 0.0021 0.0089
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0094
Echinococcus granulosus sentrin specific protease 1 0.0013 0.0029 0.003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0013
Mycobacterium ulcerans ubiquinol-cytochrome C reductase QcrB 0.1573 0.9653 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0028 0.0126 0.0119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Echinococcus multilocularis nervana 2 0.0064 0.0345 0.0342
Leishmania major P-type ATPase, putative 0.0012 0.0028 0.0136
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0012 0.0028 0.0025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0625 0.0715
Toxoplasma gondii pyruvate kinase PyKII 0.0035 0.0168 0.0591
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0126 0.2479
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0353 0.2181
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0065 0.1729
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0014
Echinococcus multilocularis cpg binding protein 0.0031 0.0144 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0065
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0021 0.0222
Brugia malayi Membrane calcium atpase protein 3 0.0012 0.0028 0.0173
Onchocerca volvulus Protein patched homolog 0.0012 0.0025 0.0015
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0028 0.0126 0.0119
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0015 0.0013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0015 0.0005
Echinococcus granulosus nibrin 0.001 0.0011 0.0009
Brugia malayi Pyruvate kinase, M2 isozyme 0.0069 0.0374 0.2313
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0126 0.3355
Brugia malayi pyruvate kinase 0.0014 0.004 0.0249
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0028 0.0126 0.0119
Loa Loa (eye worm) pyruvate kinase 0.0069 0.0374 0.2313
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0015 0.0094
Plasmodium vivax calcium-transporting ATPase, putative 0.0012 0.0028 0.0065
Brugia malayi MH2 domain containing protein 0.0008 0.0003 0.0016
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0033 0.0153 0.0151
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0126 0.0431
Onchocerca volvulus 0.003 0.0133 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0094
Brugia malayi nuclear receptor NHR-88 0.001 0.0015 0.0094
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0011 0.0008
Mycobacterium leprae Probable pyruvate kinase PykA 0.0069 0.0374 0.0377
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Echinococcus multilocularis pyruvate kinase 0.0069 0.0374 0.0372
Schistosoma mansoni ap endonuclease 0.0018 0.0065 0.0071
Trypanosoma brucei SUMO1/Ulp2, putative 0.0013 0.0029 0.0776
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0126 0.0776
Schistosoma mansoni microtubule-associated protein tau 0.142 0.8706 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0948
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Echinococcus multilocularis tumor protein p63 0.0347 0.2094 0.2091
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0012 0.0028 0.0029
Mycobacterium ulcerans pyruvate kinase 0.0069 0.0374 0.0377
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0475 0.0542
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0126 0.0991
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0015 0.0014
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0007 0.0005
Echinococcus granulosus replication factor c subunit 1 0.001 0.0011 0.0009
Schistosoma mansoni hypothetical protein 0.0032 0.0151 0.0171
Echinococcus multilocularis GPCR, family 2 0.0032 0.0151 0.0149
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0013 0.0029 0.048
Echinococcus granulosus nervana 2 0.0064 0.0345 0.0393
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0029 0.0398
Loa Loa (eye worm) hypothetical protein 0.0096 0.0546 0.337
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0032 0.0146 0.0141
Echinococcus multilocularis nervana 2 0.0064 0.0345 0.0342
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0015 0.0094
Onchocerca volvulus 0.005 0.0257 0.0255
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0345 0.0393
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0094
Echinococcus multilocularis sentrin specific protease 7 0.0145 0.0844 0.0842
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0029 0.0179
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0151 0.0149
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0025 0.0054
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0011 0.0021 0.0038
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0029 0.0398
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.145 0.1663
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0094
Echinococcus multilocularis pyruvate kinase 0.0035 0.0168 0.0166
Schistosoma mansoni ATPase 0.0011 0.0021 0.0021
Toxoplasma gondii pyruvate kinase PyK1 0.0069 0.0374 0.1362
Echinococcus granulosus FTZ F1 alpha 0.001 0.0015 0.0014
Loa Loa (eye worm) cytochrome b 0.0271 0.1619 1
Onchocerca volvulus 0.0028 0.0126 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0094
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0065 0.0467
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0029 0.0179
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0012 0.0028 0.0747
Onchocerca volvulus 0.0013 0.0029 0.0019
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0012 0.0028 0.0025
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0384 0.2369
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0126 0.0776
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0126 0.0063
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0012 0.0028 0.0173
Schistosoma mansoni hypothetical protein 0.0082 0.0456 0.0521
Onchocerca volvulus 0.0012 0.0025 0.0015
Giardia lamblia Pyruvate kinase 0.0069 0.0374 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0065
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0013 0.0029 0.0398
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0012 0.0028 0.0029
Echinococcus granulosus nervana 2 0.0064 0.0345 0.0393
Echinococcus multilocularis nibrin 0.001 0.0011 0.0008
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0265 0.0301
Schistosoma mansoni hypothetical protein 0.007 0.0384 0.0438
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Trichomonas vaginalis pyruvate kinase, putative 0.0069 0.0374 0.7842
Onchocerca volvulus 0.0012 0.0025 0.0015
Echinococcus granulosus tar DNA binding protein 0.0065 0.0353 0.0403
Echinococcus multilocularis pyruvate kinase 0.0069 0.0374 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0094
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0033 0.0153 0.0173
Schistosoma mansoni pyruvate kinase 0.0035 0.0168 0.019
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0013 0.0029 0.0776
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0296 0.107
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0126 0.0063
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0126 0.0431
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Schistosoma mansoni cpg binding protein 0.0031 0.0144 0.0162
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0029 0.0398
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0011 0.0021 0.0089
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0065
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0126 0.0063
Schistosoma mansoni coup transcription factor 0.001 0.0015 0.0014
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0065 0.0203
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0028 0.0126 0.0119
Brugia malayi Na,K-ATPase alpha subunit 0.0033 0.0153 0.0948
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0029 0.0398
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0129
Echinococcus multilocularis pyruvate kinase 0.0035 0.0168 0.0166
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0012 0.0028 0.0025
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0064 0.0345 0.0393
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0012 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.0198 0.1171 0.7233
Loa Loa (eye worm) hypothetical protein 0.0103 0.0584 0.3606
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0096 0.0546 0.0555
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0126 0.0431
Onchocerca volvulus 0.0032 0.0146 0.0141
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0475 0.0472
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0094
Brugia malayi CHE-14 protein 0.0085 0.0475 0.2931
Mycobacterium leprae Probable Ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) 0.1573 0.9653 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.0546 0.0555
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0126 0.0119
Echinococcus multilocularis sentrin specific protease 8 0.0013 0.0029 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0353 0.0403
Loa Loa (eye worm) hypothetical protein 0.007 0.0384 0.2369
Trichomonas vaginalis pyruvate kinase, putative 0.0069 0.0374 0.7842
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0101 0.0038
Loa Loa (eye worm) hypothetical protein 0.0085 0.0475 0.2931
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0126 0.0123
Brugia malayi hypothetical protein 0.001 0.0011 0.0065
Loa Loa (eye worm) hypothetical protein 0.0096 0.0546 0.337
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0015 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0546 0.337
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0029 0.0179
Brugia malayi hypothetical protein 0.0109 0.0625 0.386
Onchocerca volvulus 0.0096 0.0546 0.0555
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0065 0.0203
Entamoeba histolytica hypothetical protein 0.0109 0.0625 0.5294
Trypanosoma brucei pyruvate kinase 1 0.0069 0.0374 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0151 0.0149
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0012 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.0048 0.0246 0.1521
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0011 0.0021 0.0557
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0126 0.0119
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0007 0.0046
Brugia malayi hypothetical protein 0.0012 0.0025 0.0155
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0198 0.1171 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0065 0.1168
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0126 0.0776
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0126 0.0119
Brugia malayi Pyruvate kinase, muscle isozyme 0.0069 0.0374 0.2313
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0013
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0011 0.0021 0.0557
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0011 0.0000012895
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0029 0.0159
Echinococcus granulosus GPCR family 2 0.0032 0.0151 0.0171
Echinococcus multilocularis nervana 2 0.0064 0.0345 0.0342
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0126 0.0119
Trichomonas vaginalis cation-transporting ATPase, putative 0.0011 0.0021 0.0222
Brugia malayi MH1 domain containing protein 0.0008 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.2442
Echinococcus multilocularis Niemann Pick C1 protein 0.0198 0.1171 0.1169
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0012 0.0028 0.0025
Onchocerca volvulus 0.0028 0.0126 0.0119
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0151 0.0934
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0228 0.0258
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0028 0.0126 0.0119
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0708 0.4373
Trypanosoma brucei calcium-translocating P-type ATPase 0.0012 0.0028 0.0747
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0353 0.2181
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0012 0.0028 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0126 0.0119
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0021 0.0222
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0013
Brugia malayi MH1 domain containing protein 0.0008 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0069 0.0374 0.2313
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0126 0.0119
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0126 0.1996
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0072 0.0395 0.0345
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0007 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Echinococcus granulosus Na:K ATPase alpha subunit 0.0033 0.0153 0.0173
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0096 0.0546 0.0555
Leishmania major calcium-transporting ATPase, putative 0.0012 0.0028 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0546 0.337
Echinococcus granulosus Niemann Pick C1 protein 0.0283 0.1695 0.1944
Entamoeba histolytica pyruvate kinase, putative 0.0048 0.0246 0.2032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Onchocerca volvulus 0.0012 0.0025 0.0015
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0625 0.0623
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0015 0.0014
Echinococcus granulosus pyruvate kinase 0.0069 0.0374 0.0427
Loa Loa (eye worm) hypothetical protein 0.0028 0.0126 0.0776
Loa Loa (eye worm) patched family protein 0.0012 0.0025 0.0155
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0029 0.0398
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0021 0.0222
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0015 0.0005
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0015 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0126 0.0776
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0012 0.0028 0.0029
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0012 0.0028 0.015
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0021 0.0079 0.0489
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0094
Onchocerca volvulus 0.0012 0.0025 0.0015
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0011 0.0021 0.0018
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0033 0.0153 0.0948
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0126 0.0776
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0546 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0015 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0228 0.0258
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0345 0.0393
Onchocerca volvulus 0.0012 0.0025 0.0015
Echinococcus multilocularis protein patched 0.0085 0.0475 0.0472
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0069 0.0374 0.0323
Plasmodium vivax acyl-CoA synthetase, putative 0.0072 0.0395 0.144
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0475 0.2931
Schistosoma mansoni hypothetical protein 0.0082 0.0456 0.0521
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0015 0.0013
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0126 0.0063
Schistosoma mansoni cpg binding protein 0.003 0.0133 0.015
Echinococcus granulosus cpg binding protein 0.0031 0.0144 0.0162
Toxoplasma gondii patched family protein 0.0012 0.0025 0.0054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0371 0.0319
Echinococcus multilocularis calcium transporting atpase 0.0012 0.0028 0.0025
Giardia lamblia Sentrin specific protease, putative 0.0013 0.0029 0.0508
Loa Loa (eye worm) pyruvate kinase 0.0069 0.0374 0.2313
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0011 0.0021 0.0089
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0003 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0094
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0126 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0126 0.0776
Plasmodium falciparum pyruvate kinase 0.0069 0.0374 0.1362
Schistosoma mansoni pyruvate kinase 0.0069 0.0374 0.0427
Onchocerca volvulus 0.0012 0.0025 0.0015
Toxoplasma gondii exonuclease III APE 0.0018 0.0065 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0094
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0126 0.0063
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0064 0.0345 0.0393
Brugia malayi hypothetical protein 0.0012 0.0025 0.0155
Onchocerca volvulus 0.001 0.0015 0.0005
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0012 0.0028 0.0018
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.2442
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0126 0.0431
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0625 0.0715
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0028 0.0125 0.0775
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0028 0.0126 0.0119
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0126 0.0063
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0011 0.0282
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0371 0.0319
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0064 0.0345 0.0393
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0011 0.0282
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0228 0.0258
Brugia malayi steroid hormone receptor 0.001 0.0015 0.0094
Brugia malayi Smad1 0.0008 0.0003 0.0016
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0015 0.0094
Schistosoma mansoni thyroid hormone receptor 0.001 0.0015 0.0014
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0029 0.0159
Loa Loa (eye worm) hypothetical protein 0.0096 0.0546 0.337
Loa Loa (eye worm) pyruvate kinase 0.0069 0.0374 0.2313
Brugia malayi Patched family protein 0.0012 0.0025 0.0155
Schistosoma mansoni topbp1 0.001 0.0011 0.0009
Brugia malayi MH2 domain containing protein 0.0123 0.0708 0.4373
Onchocerca volvulus 0.0012 0.0025 0.0015
Brugia malayi TAR-binding protein 0.0065 0.0353 0.2181
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0013 0.0029 0.0398
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0013 0.0029 0.0156
Schistosoma mansoni nuclear hormone receptor 0.001 0.0015 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0353 0.0403
Toxoplasma gondii patched family protein 0.0012 0.0025 0.0054
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0033 0.0153 0.3926
Onchocerca volvulus 0.1573 0.9653 1
Trypanosoma cruzi hypothetical protein 0.0013 0.0029 0.0776
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0151 0.0934
Loa Loa (eye worm) hypothetical protein 0.0104 0.0592 0.3659
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.2442
Mycobacterium tuberculosis Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) 0.1573 0.9653 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0345 0.0342
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0126 0.3355
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0546 0.337
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0546 0.0555
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0126 0.3355
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0012 0.0028 0.0747
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0126 0.0431
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0011 0.0000074239
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0145 0.0844 0.0967
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0395 0.0399
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0546 0.0555
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0021 0.0222
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Echinococcus multilocularis sentrin specific protease 1 0.0013 0.0029 0.0026
Trichomonas vaginalis cation-transporting ATPase, putative 0.0011 0.0021 0.0222
Loa Loa (eye worm) oxidoreductase 0.0028 0.0126 0.0776
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0155
Plasmodium falciparum sentrin-specific protease 1 0.0013 0.0029 0.0069
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0011 0.0021 0.0557
Onchocerca volvulus 0.0051 0.0265 0.0264
Plasmodium vivax cytochrome b 0.0443 0.2682 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0126 0.0119
Loa Loa (eye worm) hypothetical protein 0.0064 0.0345 0.213
Leishmania major pyruvate kinase 0.0069 0.0374 0.6738
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0353 0.2181
Schistosoma mansoni pyruvate kinase 0.0069 0.0374 0.0427
Echinococcus multilocularis nervana 2 0.0064 0.0345 0.0342
Schistosoma mansoni cpg binding protein 0.0031 0.0144 0.0162
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0126 0.0141
Loa Loa (eye worm) patched family protein 0.0012 0.0025 0.0155
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0029 0.0159

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 1800 nM Antimalarial activity against Plasmodium falciparum K1 ChEMBL. 17722901
ED50 (functional) = 1800 nM Antimalarial activity against Plasmodium falciparum K1 ChEMBL. 17722901
ED50 (functional) = 2900 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 17722901
ED50 (functional) = 2900 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 17722901
Inhibition (binding) = 0 % Inhibition of plasmodium falciparum protein farnesyltransferase at 5 nM by scintillation proximity assay ChEMBL. 17722901
Inhibition (binding) = 0 % Inhibition of plasmodium falciparum protein farnesyltransferase at 0.5 nM by scintillation proximity assay ChEMBL. 17722901
Inhibition (binding) = 46 % Inhibition of plasmodium falciparum protein farnesyltransferase at 50 nM by scintillation proximity assay ChEMBL. 17722901

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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