Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | Curated by TDR Targets | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0268 | 0.2777 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0028 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 0.4219 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0128 | 0.1009 | 0.1009 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0383 | 0.4219 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0105 | 0.0722 | 0.2598 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0169 | 0.1531 | 0.5514 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0128 | 0.1009 | 0.4964 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.007 | 0.0287 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.007 | 0.0287 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.2033 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0209 | 0.2033 | 0.732 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0209 | 0.2033 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0304 | 0.1496 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.1736 | 0.1027 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0028 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.007 | 0.0287 | 0.141 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0128 | 0.1009 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.0304 | 0.1095 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.007 | 0.0287 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.2777 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0722 | 0.2598 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.007 | 0.0287 | 0.0287 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.2777 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0146 | 0.1235 | 0.6075 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.007 | 0.0287 | 0.141 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0383 | 0.4219 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0105 | 0.0722 | 0.2598 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0028 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.2777 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0209 | 0.2033 | 0.732 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.2777 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0383 | 0.4219 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0186 | 0.1736 | 0.1027 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0383 | 0.4219 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0169 | 0.1531 | 0.5514 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0176 | 0.1617 | 0.7025 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0128 | 0.1009 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0128 | 0.1009 | 0.4964 |
Brugia malayi | prolyl oligopeptidase family protein | 0.007 | 0.0287 | 0.1032 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0169 | 0.1531 | 0.1531 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0383 | 0.4219 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0105 | 0.0722 | 0.2598 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0304 | 0.1095 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0169 | 0.1531 | 0.1531 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.2777 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.2777 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0028 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.005 | 0.0028 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0146 | 0.1235 | 0.6075 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0268 | 0.2777 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.2033 | 0.2033 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.007 | 0.0287 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0209 | 0.2033 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0169 | 0.1531 | 0.7533 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0078 | 0.0281 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0128 | 0.1009 | 0.4964 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 0.4219 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0078 | 0.0281 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0383 | 0.4219 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16 nM | Inhibition of human DPP4 | ChEMBL. | 17293118 |
IC50 (binding) | = 16 nM | Inhibition of human DPP4 | ChEMBL. | 17293118 |
Inhibition (binding) | = 58 % | Ex vivo inhibition of DPP4 in Sprague-Dawley rat plasma at 1 mg/kg, po after 6 hrs | ChEMBL. | 17293118 |
Inhibition (binding) | = 58 % | Ex vivo inhibition of DPP4 in Sprague-Dawley rat plasma at 1 mg/kg, po after 6 hrs | ChEMBL. | 17293118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.