Detailed information for compound 438013

Basic information

Technical information
  • TDR Targets ID: 438013
  • Name: (3S,5S)-5-[(2S)-2-cyanopyrrolidine-1-carbonyl ]-N-ethyl-N-methylpyrrolidine-3-carboxamide
  • MW: 278.35 | Formula: C14H22N4O2
  • H donors: 1 H acceptors: 3 LogP: -0.37 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C[C@@H]1CCCN1C(=O)[C@H]1NC[C@H](C1)C(=O)N(CC)C
  • InChi: 1S/C14H22N4O2/c1-3-17(2)13(19)10-7-12(16-9-10)14(20)18-6-4-5-11(18)8-15/h10-12,16H,3-7,9H2,1-2H3/t10-,11-,12-/m0/s1
  • InChiKey: HUYOEFVNKFTLQH-SRVKXCTJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3S,5S)-5-[(2S)-2-cyanopyrrolidine-1-carbonyl]-N-ethyl-N-methyl-pyrrolidine-3-carboxamide
  • (3S,5S)-5-[[(2S)-2-cyano-1-pyrrolidinyl]-oxomethyl]-N-ethyl-N-methyl-3-pyrrolidinecarboxamide
  • (3S,5S)-5-[(2S)-2-cyanopyrrolidin-1-yl]carbonyl-N-ethyl-N-methyl-pyrrolidine-3-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum beta-ketoacyl-ACP synthase III Curated by TDR Targets References
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Chlamydia trachomatis oxoacyl-ACP synthase III Get druggable targets OG5_129509 All targets in OG5_129509
Plasmodium berghei apicoplast beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
Mycobacterium ulcerans beta-ketoacyl synthase-like protein Get druggable targets OG5_129509 All targets in OG5_129509
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Neospora caninum 3-oxoacyl-(acyl-carrier-protein) synthase III family protein, putative Get druggable targets OG5_129509 All targets in OG5_129509
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Mycobacterium ulcerans 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Plasmodium knowlesi beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Plasmodium falciparum beta-ketoacyl-ACP synthase III Get druggable targets OG5_129509 All targets in OG5_129509
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) Get druggable targets OG5_129509 All targets in OG5_129509
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0067 0.1365 0.1329
Toxoplasma gondii prolyl endopeptidase 0.0017 0.0058 0.0057
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0017 0.0058 0.0057
Brugia malayi hypothetical protein 0.0031 0.0429 0.0406
Brugia malayi glutathione reductase 0.0046 0.0826 0.0822
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0121 0.278 0.2749
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0429 0.0406
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0873 0.087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0399 0.0359
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0086 0.0046
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0121 0.278 0.2868
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.035 0.0618
Loa Loa (eye worm) hypothetical protein 0.0383 0.9584 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0086 0.0046
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0086 0.0046
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.008 0.008
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0086 0.0046
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0121 0.278 0.29
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0086 0.0046
Onchocerca volvulus 0.0232 0.565 0.587
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.0058 0.0057
Onchocerca volvulus 0.003 0.0401 0.036
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0572 0.0532
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0067 0.1365 0.1365
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0873 0.9452
Schistosoma mansoni neurotransmitter gated ion channel 0.0031 0.0429 0.0388
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0067 0.1365 0.1388
Trypanosoma brucei prolyl endopeptidase 0.0017 0.0058 0.0031
Echinococcus multilocularis glycine receptor subunit beta 0.0067 0.1365 0.1365
Echinococcus multilocularis cpg binding protein 0.003 0.0396 0.0396
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0086 0.0046
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.0058 0.0057
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0067 0.1365 0.1329
Echinococcus multilocularis nAChR subunit 0.0067 0.1365 0.1365
Loa Loa (eye worm) cytochrome P450 0.0018 0.0086 0.009
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0086 0.0046
Schistosoma mansoni acetylcholine receptor-related 0.0031 0.0429 0.0388
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0067 0.1365 0.1365
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0873 0.1668
Loa Loa (eye worm) hypothetical protein 0.0067 0.1359 0.1418
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0248 0.0216
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0086 0.0046
Loa Loa (eye worm) hypothetical protein 0.0194 0.4681 0.4884
Mycobacterium ulcerans hypothetical protein 0.0048 0.0873 0.087
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0067 0.1365 0.1365
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0031 0.0429 0.0406
Leishmania major hypothetical protein, conserved 0.0207 0.5022 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0386 0.0403
Schistosoma mansoni hypothetical protein 0.0018 0.0086 0.0045
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.1456 0.2839
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0558 0.054
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0873 0.087
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.035 0.0323
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0086 0.0046
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0086 0.0046
Brugia malayi hypothetical protein 0.0383 0.9584 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Echinococcus granulosus prolyl endopeptidase 0.0017 0.0058 0.0058
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.5067 0.5287
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0401 0.0377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0787 0.0787
Brugia malayi glucose-6-phosphate dehydrogenase 0.0121 0.278 0.287
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0086 0.0089
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0017 0.0058 0.0016
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.5067 0.5067
Echinococcus multilocularis glycine receptor subunit beta 0.0067 0.1365 0.1365
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.5022 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0873 0.087
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.1456 0.2839
Echinococcus granulosus nAChR subunit 0.0036 0.0563 0.0563
Mycobacterium tuberculosis Probable reductase 0.0105 0.2362 0.243
Loa Loa (eye worm) acetylcholine receptor protein 0.0031 0.0429 0.0447
Brugia malayi Thioredoxin reductase 0.0046 0.0826 0.0822
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0826 0.0826
Loa Loa (eye worm) hypothetical protein 0.0036 0.0563 0.0588
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.5067 0.5046
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.008 0.008
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0067 0.1365 0.1425
Schistosoma mansoni nAChR subunit 0.0067 0.1365 0.1329
Brugia malayi excitatory GABA receptor EXP-1A 0.0067 0.1365 0.1388
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0067 0.1365 0.1329
Onchocerca volvulus Putative nachr subunit 0.0067 0.1365 0.1373
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0086 0.0046
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0309 0.0322
Onchocerca volvulus 0.0031 0.0429 0.0389
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.2667 0.275
Onchocerca volvulus 0.0067 0.1365 0.1373
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0067 0.1365 0.1365
Leishmania major hypothetical protein, conserved 0.0028 0.035 0.0618
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0908 0.0908
Loa Loa (eye worm) hypothetical protein 0.003 0.0399 0.0417
Brugia malayi Cation transporter family protein 0.0067 0.1365 0.1388
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.5067 0.5267
Entamoeba histolytica hypothetical protein 0.0036 0.0572 0.5966
Loa Loa (eye worm) hypothetical protein 0.0036 0.0558 0.0582
Echinococcus granulosus lamin dm0 0.003 0.0401 0.0401
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0067 0.1365 0.1329
Echinococcus multilocularis GPCR, family 2 0.0049 0.0908 0.0908
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Schistosoma mansoni tar DNA-binding protein 0.007 0.1445 0.1409
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.1456 0.2839
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0036 0.0563 0.0547
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0248 0.0248
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0787 0.0787
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0309 0.0279
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.085 0.0847
Echinococcus granulosus glycine receptor subunit alpha 1 0.0067 0.1365 0.1365
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0086 0.0046
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.008 0.0038
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.008 0.0076
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Onchocerca volvulus 0.003 0.0401 0.036
Echinococcus multilocularis lamin dm0 0.003 0.0401 0.0401
Mycobacterium ulcerans hypothetical protein 0.0024 0.0248 0.0216
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0086 0.0046
Trichomonas vaginalis set domain proteins, putative 0.0232 0.565 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0067 0.1365 0.1425
Loa Loa (eye worm) hypothetical protein 0.0054 0.1024 0.1069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0787 0.0748
Loa Loa (eye worm) TAR-binding protein 0.007 0.1445 0.1507
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0086 0.0046
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0086 0.0046
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0248 0.0248
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0873 0.087
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.008 0.008
Schistosoma mansoni nAChR subunit 0.0031 0.0429 0.0388
Loa Loa (eye worm) hypothetical protein 0.032 0.7936 0.8281
Brugia malayi cytochrome P450 0.0018 0.0086 0.0047
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0558 0.054
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0248 0.0413
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0248 0.0367
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0873 0.9452
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0248 0.0413
Onchocerca volvulus 0.0036 0.0563 0.0531
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0067 0.1365 0.1365
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.008 0.0139
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0017 0.0058 0.0028
Schistosoma mansoni cytochrome P450 0.0018 0.0086 0.0045
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0121 0.278 0.278
Loa Loa (eye worm) hypothetical protein 0.0036 0.0563 0.0588
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0031 0.0429 0.0429
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0507 0.0487
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0908 0.0908
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0086 0.0046
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.5624 0.5624
Brugia malayi hypothetical protein 0.0036 0.0572 0.0556
Loa Loa (eye worm) hypothetical protein 0.0048 0.0873 0.0911
Leishmania major trypanothione reductase 0.0046 0.0826 0.1574
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0067 0.1365 0.1365
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.1365 0.1388
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0017 0.0058 0.0031
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0039 0.0641 0.1203
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0248 0.0216
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0086 0.0046
Schistosoma mansoni tar DNA-binding protein 0.007 0.1445 0.1409
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0067 0.1365 0.1425
Brugia malayi CXXC zinc finger family protein 0.0028 0.0355 0.0329
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0383 0.9588 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.4921 0.5134
Leishmania major cytochrome p450-like protein 0.0018 0.0086 0.0089
Brugia malayi Cytochrome P450 family protein 0.0036 0.057 0.0554
Echinococcus multilocularis nAChR subunit 0.0036 0.0563 0.0563
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0086 0.0046
Onchocerca volvulus 0.0031 0.0429 0.0389
Entamoeba histolytica fatty acid elongase, putative 0.005 0.092 1
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0121 0.278 1
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0058 0.0017
Echinococcus multilocularis lamin 0.003 0.0401 0.0401
Schistosoma mansoni nAChR subunit 0.0067 0.1365 0.1329
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0067 0.1365 0.1388
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0086 0.0046
Trypanosoma cruzi oligopeptidase b 0.0017 0.0058 0.0031
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0873 0.087
Loa Loa (eye worm) hypothetical protein 0.0036 0.0563 0.0588
Schistosoma mansoni acetylcholine receptor subunit beta 0.0031 0.0429 0.0388
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0058 0.0017
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0067 0.1365 0.1365
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.1456 0.142
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0036 0.0563 0.0523
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.035 0.1125
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0873 0.1668
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Brugia malayi hypothetical protein 0.0028 0.035 0.0324
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0058 0.0016
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0086 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0086 0.0046
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0356 0.0356
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0121 0.278 0.4882
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.2362 0.243
Schistosoma mansoni tar DNA-binding protein 0.007 0.1445 0.1409
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0031 0.0429 0.0447
Schistosoma mansoni hypothetical protein 0.0187 0.4491 0.4467
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0908 0.0909
Loa Loa (eye worm) hypothetical protein 0.0048 0.0873 0.0911
Schistosoma mansoni hypothetical protein 0.0049 0.0908 0.087
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0826 0.0826
Loa Loa (eye worm) glutathione reductase 0.0046 0.0826 0.0861
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.3678 0.3811
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.006
Onchocerca volvulus Huntingtin homolog 0.0383 0.9584 1
Brugia malayi prolyl oligopeptidase family protein 0.007 0.1456 0.1482
Loa Loa (eye worm) hypothetical protein 0.0036 0.0563 0.0588
Echinococcus granulosus nAChR subunit 0.0067 0.1365 0.1365
Onchocerca volvulus 0.0067 0.1365 0.1373
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0086 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0086 0.0046
Loa Loa (eye worm) GABA receptor subunit 0.0036 0.0563 0.0588
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0355 0.037
Loa Loa (eye worm) hypothetical protein 0.0036 0.0563 0.0588
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0067 0.1365 0.1388
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Echinococcus multilocularis geminin 0.0187 0.4491 0.4491
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0067 0.1365 0.1388
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0067 0.1365 0.1365
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0383 0.9588 1
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0086 0.0086
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0017 0.0058 0.0031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0572 0.0572
Entamoeba histolytica fatty acid elongase, putative 0.005 0.092 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0399 0.0399
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0121 0.278 0.4882
Schistosoma mansoni survival motor neuron protein 0.0047 0.085 0.0811
Brugia malayi Cytochrome P450 family protein 0.0018 0.0086 0.0047
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0067 0.1365 0.1365
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.008 0.004
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0826 0.0861
Echinococcus granulosus acylamino acid releasing enzyme 0.0017 0.0058 0.0058
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.008 0.008
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0826 0.0821
Leishmania major oligopeptidase b 0.0017 0.0058 0.0031
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0121 0.278 0.278
Brugia malayi hypothetical protein 0.0031 0.0429 0.0406
Entamoeba histolytica hypothetical protein 0.0036 0.0563 0.5863
Onchocerca volvulus 0.0028 0.0355 0.0312
Loa Loa (eye worm) hypothetical protein 0.0231 0.5624 0.5868
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.1365 0.1388
Schistosoma mansoni tar DNA-binding protein 0.007 0.1445 0.1409
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.008 0.0076
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0031 0.0429 0.0429
Echinococcus granulosus glycine receptor subunit alpha 1 0.0067 0.1365 0.1365
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0121 0.278 0.2868
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0058 0.0016
Brugia malayi hypothetical protein 0.0054 0.1024 0.103
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.008 0.0076
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0031 0.0429 0.0406
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0086 0.0046
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.1359 0.1322
Plasmodium falciparum glutathione reductase 0.0046 0.0826 0.0821
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.1365 0.1388
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0067 0.1365 0.1388
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.5067 0.5258
Schistosoma mansoni hypothetical protein 0.0036 0.0572 0.0532
Onchocerca volvulus 0.0067 0.1365 0.1373
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0042 0.0001
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0042
Plasmodium vivax glutathione reductase, putative 0.0046 0.0826 0.0821
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0908 0.0908
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.3678 0.3811
Loa Loa (eye worm) intermediate filament protein 0.003 0.0401 0.0418
Echinococcus multilocularis tar DNA binding protein 0.007 0.1445 0.1445
Loa Loa (eye worm) ACC-1 protein 0.0067 0.1365 0.1425
Schistosoma mansoni hypothetical protein 0.0049 0.0908 0.087
Entamoeba histolytica hypothetical protein 0.0036 0.0572 0.5966
Loa Loa (eye worm) hypothetical protein 0.0049 0.0908 0.0948
Echinococcus granulosus tar DNA binding protein 0.007 0.1445 0.1445
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0042 0.072 0.0711
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0507 0.0487
Trypanosoma cruzi oligopeptidase b 0.0017 0.0058 0.0031
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0558 0.054
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0908 0.0909
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0031 0.0429 0.0429
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0031 0.0429 0.0447
Leishmania major cytochrome p450-like protein 0.0026 0.0309 0.0535
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0067 0.1365 0.1425
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Loa Loa (eye worm) hypothetical protein 0.0225 0.5483 0.5721
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.008 0.0076
Entamoeba histolytica fatty acid elongase, putative 0.005 0.092 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.3678 0.3838
Schistosoma mansoni nAChR subunit 0.0067 0.1365 0.1329
Loa Loa (eye worm) hypothetical protein 0.0048 0.0873 0.0911
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0086 0.0089
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.1365 0.1388
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.2224 0.2191
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0507 0.0487
Onchocerca volvulus 0.0067 0.1365 0.1373
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0058 0.0031
Echinococcus granulosus cpg binding protein 0.003 0.0396 0.0396
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0067 0.1365 0.1365
Brugia malayi Cation transporter family protein 0.0067 0.1365 0.1388
Loa Loa (eye worm) prolyl oligopeptidase 0.0017 0.0058 0.006
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.2362 0.243
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0017 0.0058 0.0016
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0826 0.0821
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0309 0.0322
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0383 0.9588 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0067 0.1365 0.1388
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.1359 0.2348
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0121 0.278 0.5498
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0787 0.0787
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0067 0.1365 0.1425
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0086 0.0046
Onchocerca volvulus 0.0031 0.0429 0.0389
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0086 0.0046
Loa Loa (eye worm) RNA binding protein 0.007 0.1445 0.1507
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0383 0.9588 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0067 0.1365 0.1365
Brugia malayi Cytochrome P450 family protein 0.0026 0.0309 0.028
Trypanosoma brucei trypanothione reductase 0.0046 0.0826 0.1574
Schistosoma mansoni cpg binding protein 0.003 0.0396 0.0356
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0079 0.1686 0.6005
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.008 0.004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.2362 0.243
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0787 0.0748
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0121 0.278 0.5498
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0558 0.054
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0086 0.0162
Brugia malayi RNA recognition motif domain containing protein 0.007 0.1445 0.1471
Loa Loa (eye worm) hypothetical protein 0.0036 0.0563 0.0588
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0086 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0399 0.0359
Echinococcus granulosus GPCR family 2 0.0049 0.0908 0.0908
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0086 0.011
Onchocerca volvulus 0.0067 0.1365 0.1373
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.01 0.2224 0.2224
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0067 0.1365 0.1388
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.2224 0.2191
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0873 0.0872
Schistosoma mansoni hypothetical protein 0.0047 0.085 0.0811
Schistosoma mansoni tar DNA-binding protein 0.007 0.1445 0.1409
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0121 0.278 0.4882
Schistosoma mansoni hypothetical protein 0.0187 0.4491 0.4467
Brugia malayi hypothetical protein 0.0031 0.0429 0.0406
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.035 0.0618
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0401 0.0418
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1034 0.3624
Toxoplasma gondii melibiase subfamily protein 0.01 0.2224 0.7971
Loa Loa (eye worm) hypothetical protein 0.0036 0.0558 0.0582
Schistosoma mansoni hypothetical protein 0.0049 0.0908 0.087
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0036 0.0563 0.0547
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Schistosoma mansoni nAChR subunit 0.0067 0.1365 0.1329
Schistosoma mansoni cpg binding protein 0.003 0.0396 0.0356
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0036 0.0563 0.0547
Plasmodium falciparum peptidase, putative 0.0017 0.0058 0.0016
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0873 0.3124
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0041 0.0043
Brugia malayi Cytochrome P450 family protein 0.0026 0.0309 0.028
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0017 0.0058 0.0031
Loa Loa (eye worm) hypothetical protein 0.003 0.0401 0.0418
Entamoeba histolytica fatty acid elongase, putative 0.005 0.092 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.01 0.2224 0.2224
Schistosoma mansoni hypothetical protein 0.0102 0.2272 0.2239
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0121 0.278 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0826 0.1574
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0058 0.0028
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0067 0.1365 0.1365
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0787 0.0748
Echinococcus granulosus lamin 0.003 0.0401 0.0401
Schistosoma mansoni lamin 0.003 0.0401 0.036
Brugia malayi RNA binding protein 0.007 0.1445 0.1471
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Mycobacterium leprae putative cytochrome p450 0.0018 0.0086 0.011
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0086 0.0046
Schistosoma mansoni nAChR subunit 0.0067 0.1365 0.1329
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0383 0.9588 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0558 0.054
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0086 0.0089
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.5624 0.5624
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0067 0.1365 0.1365
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0086 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0086 0.0046
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.2362 0.243
Echinococcus granulosus glycine receptor subunit beta 0.0067 0.1365 0.1365
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0248 0.0216
Loa Loa (eye worm) hypothetical protein 0.0383 0.9584 1
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0383 0.9588 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0067 0.1365 0.1388
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.2396 0.2468
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0383 0.9588 1
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0121 0.278 0.5498
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.1456 0.1456
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.035 0.0323
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0067 0.1365 0.1365
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0248 0.0216
Brugia malayi TAR-binding protein 0.007 0.1445 0.1471
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0067 0.1365 0.1329
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0309 0.0535
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0086 0.0046
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.5067 0.5067
Entamoeba histolytica hypothetical protein 0.0036 0.0572 0.5966
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0873 0.087
Schistosoma mansoni nAChR subunit 0.0031 0.0429 0.0388
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0067 0.1365 0.1388
Loa Loa (eye worm) hypothetical protein 0.0036 0.0558 0.0582
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0787 0.0821
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0067 0.1365 0.1365
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0873 0.1668
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.057 0.0595
Schistosoma mansoni nAChR subunit 0.0067 0.1365 0.1329
Brugia malayi Melibiase family protein 0.0067 0.1359 0.1381
Echinococcus multilocularis dnaJ subfamily B 0.0399 1 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0036 0.0563 0.0523
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0873 0.087
Echinococcus multilocularis acylamino acid releasing enzyme 0.0017 0.0058 0.0058
Echinococcus multilocularis musashi 0.003 0.0401 0.0401
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.008 0.0076
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0036 0.0563 0.0523
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0873 0.0872
Plasmodium falciparum thioredoxin reductase 0.0046 0.0826 0.0821
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0908 0.0948
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0067 0.1365 0.1365
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0873 0.9452
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0225 0.5483 0.5703
Schistosoma mansoni intermediate filament proteins 0.003 0.0401 0.036
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0086 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0086 0.0046
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.1456 0.2839
Toxoplasma gondii hypothetical protein 0.0017 0.0058 0.0057
Echinococcus granulosus glycine receptor subunit beta 0.0067 0.1365 0.1365
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.5022 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0086 0.0089
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.1456 0.2839
Mycobacterium ulcerans hypothetical protein 0.0024 0.0248 0.0216
Loa Loa (eye worm) ACC-1 protein 0.0067 0.1365 0.1425
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0031 0.0429 0.0429
Schistosoma mansoni hypothetical protein 0.0107 0.2396 0.2364
Echinococcus granulosus intermediate filament protein 0.003 0.0401 0.0401
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0017 0.0058 0.0031
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0429 0.0406
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.008 0.0139
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0017 0.0058 0.0031
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0399 0.0399
Schistosoma mansoni hypothetical protein 0.0049 0.0908 0.087
Onchocerca volvulus 0.003 0.0399 0.0359
Schistosoma mansoni lamin 0.003 0.0401 0.036
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.008 0.004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0563 0.0588
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Brugia malayi hypothetical protein 0.0231 0.5624 0.585
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.1365 0.1388
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.2667 0.275
Onchocerca volvulus 0.0036 0.0563 0.0531
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0399 0.1306
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0058 0.0017
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0086 0.0046
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0031 0.0429 0.0406
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.0058 0.0028
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0399 0.0399
Schistosoma mansoni cpg binding protein 0.0028 0.0355 0.0314
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.035 0.0323
Schistosoma mansoni hypothetical protein 0.0399 1 1
Leishmania major cytochrome p450-like protein 0.0018 0.0086 0.0089
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0079 0.1686 0.1722
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0121 0.278 1
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0031 0.0429 0.0429
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.3678 0.3838
Trypanosoma brucei oligopeptidase b 0.0017 0.0058 0.0031
Brugia malayi hypothetical protein 0.0031 0.0429 0.0406
Brugia malayi hypothetical protein 0.032 0.7936 0.8273
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.2362 0.243
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.008 0.0083
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.1445 0.1507
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1199 0.1162
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0042
Entamoeba histolytica fatty acid elongase, putative 0.005 0.092 1
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.1456 0.1456
Toxoplasma gondii thioredoxin reductase 0.0046 0.0826 0.2862
Loa Loa (eye worm) hypothetical protein 0.0028 0.035 0.0365
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.2224 0.2191
Echinococcus multilocularis prolyl endopeptidase 0.0017 0.0058 0.0058
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.1359 0.1322
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0309 0.0322
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0787 0.0787
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0086 0.0046
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.2362 0.883
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0121 0.278 0.2868
Schistosoma mansoni nAChR subunit 0.0067 0.1365 0.1329
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0017 0.0058 0.0031
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.2667 1
Brugia malayi intermediate filament protein 0.003 0.0401 0.0377
Plasmodium vivax SET domain protein, putative 0.003 0.0399 0.0374
Mycobacterium tuberculosis Probable peptidase 0.0017 0.0058 0.0016
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0383 0.9588 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0248 0.0413
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0309 0.0535
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.004 0.0671 0.1264
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0787 0.0781
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Onchocerca volvulus Huntingtin homolog 0.0383 0.9584 1
Onchocerca volvulus 0.032 0.7936 0.827
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0058 0.0016
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0067 0.1365 0.1388
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0309 0.0535
Mycobacterium tuberculosis Conserved protein 0.0024 0.0248 0.0216
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0067 0.1365 0.1329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0399 0.0359
Trypanosoma brucei prolyl oligopeptidase, putative 0.0017 0.0058 0.0031
Echinococcus granulosus geminin 0.0187 0.4491 0.4491
Loa Loa (eye worm) LGC-31 protein 0.0067 0.1365 0.1425
Loa Loa (eye worm) hypothetical protein 0.0366 0.9144 0.9541
Brugia malayi hypothetical protein 0.0018 0.0094 0.0055
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.035 0.0618
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.1456 0.5164
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0873 0.087
Echinococcus granulosus glycine receptor subunit alpha 1 0.0067 0.1365 0.1365
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.2667 0.275
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0572 0.0572
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0873 0.0872
Schistosoma mansoni neurotransmitter gated ion channel 0.0031 0.0429 0.0388
Loa Loa (eye worm) hypothetical protein 0.0036 0.0563 0.0588
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0873 0.087
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.2224 0.2191
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0399 0.0359
Onchocerca volvulus 0.0048 0.0873 0.0856
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0058 0.0031
Onchocerca volvulus 0.0047 0.085 0.0831
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0429 0.0406
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0017 0.0058 0.0016
Brugia malayi Isocitrate dehydrogenase 0.0017 0.008 0.0041
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0908 0.0908
Loa Loa (eye worm) hypothetical protein 0.0067 0.1365 0.1425
Brugia malayi Pre-SET motif family protein 0.0204 0.4921 0.5113
Loa Loa (eye worm) hypothetical protein 0.0036 0.0558 0.0582
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0086 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0086 0.0046
Trypanosoma cruzi prolyl endopeptidase 0.0017 0.0058 0.0031
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0067 0.1365 0.1365
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0036 0.0563 0.0547
Brugia malayi Pre-SET motif family protein 0.003 0.0399 0.0375
Loa Loa (eye worm) hypothetical protein 0.0036 0.0558 0.0582
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0086 0.0046
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.5022 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0507 0.0487
Echinococcus multilocularis Glycoside hydrolase, family 27 0.01 0.2224 0.2224
Loa Loa (eye worm) hypothetical protein 0.0107 0.2396 0.25
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0058 0.0016
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0086 0.0046
Entamoeba histolytica hypothetical protein 0.0036 0.0572 0.5966
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0086 0.0089
Brugia malayi hypothetical protein 0.0031 0.0429 0.0406
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0086 0.0046
Brugia malayi Cation transporter family protein 0.0067 0.1365 0.1388
Onchocerca volvulus 0.0067 0.1365 0.1373
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0067 0.1365 0.1365
Loa Loa (eye worm) hypothetical protein 0.0031 0.0429 0.0447
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0873 0.3124
Echinococcus multilocularis 0.0018 0.0086 0.0086
Brugia malayi isocitrate dehydrogenase 0.0017 0.008 0.0041
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0067 0.1365 0.1425
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.008 0.008
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0121 0.278 0.2868

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.9 nM Inhibition of human DPP4 ChEMBL. 17293118
IC50 (binding) = 4.9 nM Inhibition of human DPP4 ChEMBL. 17293118
Inhibition (binding) = 34 % Ex vivo inhibition of DPP4 in Sprague-Dawley rats plasma at 1 mg/kg, po after 10 hrs ChEMBL. 17293118
Inhibition (binding) = 34 % Ex vivo inhibition of DPP4 in Sprague-Dawley rats plasma at 1 mg/kg, po after 10 hrs ChEMBL. 17293118
Inhibition (binding) = 71 % Ex vivo inhibition of DPP4 in Sprague-Dawley rat plasma at 1 mg/kg, po after 6 hrs ChEMBL. 17293118
Inhibition (binding) = 71 % Ex vivo inhibition of DPP4 in Sprague-Dawley rat plasma at 1 mg/kg, po after 6 hrs ChEMBL. 17293118

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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