TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 366.497 | Formula: C23H30N2O2
H donors: 0 H acceptors: 0 LogP: 3.35 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)CC1COC(OC1C)(c1ccccc1)c1ccccc1
InChi: 1S/C23H30N2O2/c1-19-20(17-25-15-13-24(2)14-16-25)18-26-23(27-19,21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-12,19-20H,13-18H2,1-2H3
InChiKey: SJMBEOUPGLPONN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	neuropeptide receptor	0.0017	0.0038	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0106	0.6808	0.8705
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0017	0.0038	0.0063
Echinococcus granulosus	g protein coupled receptor	0.0017	0.0038	0.0063
Onchocerca volvulus		0.0017	0.0038	0.5
Onchocerca volvulus		0.0017	0.0038	0.5
Echinococcus granulosus	sex peptide receptor	0.0017	0.0038	0.0063
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0017	0.0038	0.0063
Echinococcus multilocularis	neuropeptide receptor	0.0017	0.0038	0.0063
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0038	0.0029
Brugia malayi	RE15519p	0.0017	0.0038	0.0082
Onchocerca volvulus		0.0017	0.0038	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0038	0.0029
Brugia malayi	hypothetical protein	0.0017	0.0038	0.0082
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0017	0.0038	0.0082
Echinococcus granulosus	g protein coupled receptor	0.0017	0.0038	0.0063
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0118	0.7703	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0017	0.0038	0.0063
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0027	0.0793	0.1708
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0664	0.1427
Schistosoma mansoni	hypothetical protein	0.0017	0.0038	0.0029
Echinococcus multilocularis	serotonin receptor	0.0017	0.0038	0.0063
Echinococcus granulosus	neuropeptide Y receptor	0.0017	0.0038	0.0063
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.4604	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.2601	0.3369
Schistosoma mansoni	hypothetical protein	0.0017	0.0038	0.0029
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0017	0.0038	0.0063
Brugia malayi	neuropeptide F receptor	0.0017	0.0038	0.0082
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0664	0.1427
Echinococcus granulosus	neuropeptide receptor	0.0017	0.0038	0.0063
Echinococcus granulosus	fmrfamide receptor	0.0017	0.0038	0.0063
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0793	0.1708
Brugia malayi	hypothetical protein	0.0017	0.0038	0.0082
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0017	0.0038	0.0063
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.4604	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.4604	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0038	0.0029
Echinococcus multilocularis	neuropeptide receptor A26	0.0017	0.0038	0.0063
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0017	0.0038	0.5
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Echinococcus multilocularis	fmrfamide receptor	0.0017	0.0038	0.0063
Echinococcus multilocularis	neuropeptide Y receptor	0.0017	0.0038	0.0063
Toxoplasma gondii	hypothetical protein	0.0027	0.0793	0.1708
Brugia malayi	hypothetical protein	0.0017	0.0038	0.0082
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0118	0.7703	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Toxoplasma gondii	thioredoxin reductase	0.0047	0.2305	0.4999
Brugia malayi	G-protein coupled receptor	0.0017	0.0038	0.0082
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Mycobacterium tuberculosis	Probable oxidoreductase	0.0118	0.7703	1
Onchocerca volvulus		0.0017	0.0038	0.5
Onchocerca volvulus		0.0017	0.0038	0.5
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0017	0.0038	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0077	0.4604	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0077	0.4604	0.5514
Echinococcus granulosus	serotonin receptor	0.0017	0.0038	0.0063
Echinococcus granulosus	tm gpcr rhodopsin	0.0017	0.0038	0.0063
Echinococcus granulosus	neuropeptide s receptor	0.0017	0.0038	0.0063
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0017	0.0038	0.0029
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0017	0.0038	0.0063
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0017	0.0038	0.0029
Echinococcus multilocularis	neuropeptide Y receptor	0.0017	0.0038	0.0063
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0017	0.0038	0.0029
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0017	0.0038	0.0063
Brugia malayi	larval opioid receptor	0.0017	0.0038	0.0082
Brugia malayi	Dopamine receptor protein 2	0.0017	0.0038	0.0082
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0017	0.0038	0.0063
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Echinococcus granulosus	neuropeptide receptor A26	0.0017	0.0038	0.0063
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0038	0.0029
Brugia malayi	hypothetical protein	0.0017	0.0038	0.0082
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.2601	0.3369
Brugia malayi	putative neuropeptide receptor NPR1	0.0017	0.0038	0.0082
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Schistosoma mansoni	growth hormone secretagogue receptor	0.0017	0.0038	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Echinococcus multilocularis	neuropeptides capa receptor	0.0017	0.0038	0.0063
Onchocerca volvulus		0.0017	0.0038	0.5
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Brugia malayi	Probable ClpP-like protease	0.0077	0.4604	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0038	0.0029
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0017	0.0038	0.0082
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.2305	0.4967
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Echinococcus multilocularis	g protein coupled receptor	0.0017	0.0038	0.0063
Echinococcus granulosus	neuropeptides capa receptor	0.0017	0.0038	0.0063
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.2305	0.4999
Schistosoma mansoni	opsin-like receptor	0.0017	0.0038	0.0029
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.2601	0.5642
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0077	0.4604	1
Brugia malayi	hypothetical protein	0.0025	0.0664	0.1443
Brugia malayi	putative neuropeptide receptor	0.0017	0.0038	0.0082
Brugia malayi	hypothetical protein	0.0017	0.0038	0.0082
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.5427	1
Schistosoma mansoni	histamine h1 receptor	0.0017	0.0038	0.0029
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.4604	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0017	0.0038	0.0063
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0017	0.0038	0.0029
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0017	0.0038	0.0029
Echinococcus multilocularis	neuropeptide receptor	0.0017	0.0038	0.0063
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0017	0.0038	0.5
Echinococcus multilocularis	sex peptide receptor	0.0017	0.0038	0.0063
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0022	0.0448	0.0812
Plasmodium falciparum	glutathione reductase	0.0047	0.2305	0.4999
Brugia malayi	hypothetical protein	0.0017	0.0038	0.0082
Trypanosoma brucei	trypanothione reductase	0.0047	0.2305	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0017	0.0038	0.0082
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0017	0.0038	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.5427	1
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0088	0.5427	1
Leishmania major	trypanothione reductase	0.0047	0.2305	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0017	0.0038	0.0063
Onchocerca volvulus		0.0017	0.0038	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0038	0.0029
Echinococcus multilocularis	dro:myosuppressin receptor	0.0017	0.0038	0.0063
Onchocerca volvulus		0.0017	0.0038	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0017	0.0038	0.0063
Onchocerca volvulus		0.0017	0.0038	0.5
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.4604	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0017	0.0038	0.0063
Schistosoma mansoni	opsin-like receptor	0.0017	0.0038	0.0029
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0017	0.0038	0.0029
Echinococcus granulosus	allatostatin A receptor	0.0017	0.0038	0.0063
Brugia malayi	GnHR receptor homolog	0.0017	0.0038	0.0082
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0038	0.0029
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0077	0.4604	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0664	0.2855
Echinococcus multilocularis	somatostatin receptor	0.0017	0.0038	0.0063
Echinococcus multilocularis	g-protein coupled receptor	0.0017	0.0038	0.0063
Echinococcus granulosus	hypothetical protein	0.0017	0.0038	0.0063
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0017	0.0038	0.0063
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0017	0.0038	0.0063
Echinococcus granulosus	orexin receptor type 2	0.0017	0.0038	0.0063
Echinococcus multilocularis	orexin receptor type 2	0.0017	0.0038	0.0063
Schistosoma mansoni	biogenic amine receptor	0.0017	0.0038	0.0029
Brugia malayi	hypothetical protein	0.0017	0.0038	0.0082
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0038	0.0029
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.2601	0.5642
Loa Loa (eye worm)	glutathione reductase	0.0047	0.2305	0.4967
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0664	0.2855
Onchocerca volvulus		0.0017	0.0038	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0017	0.0038	0.0082
Schistosoma mansoni	adenoreceptor	0.0017	0.0038	0.0029
Echinococcus multilocularis	fmrfamide receptor	0.0017	0.0038	0.0063
Echinococcus granulosus	neuropeptide Y receptor	0.0017	0.0038	0.0063
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.5427	1
Giardia lamblia	NADPH oxidoreductase, putative	0.0088	0.5427	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.6808	0.8837
Brugia malayi	sulfakinin receptor protein	0.0017	0.0038	0.0082
Echinococcus granulosus	7tm_1 domain containing protein	0.0017	0.0038	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.5427	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0017	0.0038	0.0063
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0017	0.0038	0.0029
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0022	0.0448	0.0812
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0664	0.1427
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.2601	0.2616
Onchocerca volvulus		0.0017	0.0038	0.5
Brugia malayi	Serotonin receptor	0.0017	0.0038	0.0082
Brugia malayi	glutathione reductase	0.0047	0.2305	0.5008
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.3769	0.694
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0017	0.0038	0.0029
Echinococcus multilocularis	g protein coupled receptor	0.0017	0.0038	0.0063
Mycobacterium tuberculosis	Probable reductase	0.0106	0.6808	0.8837
Echinococcus multilocularis	G protein coupled receptor 139	0.0017	0.0038	0.0063
Brugia malayi	Serotonin receptor	0.0017	0.0038	0.0082
Brugia malayi	G protein-coupled receptor F59B2.13	0.0017	0.0038	0.0082
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0017	0.0038	0.0063
Schistosoma mansoni	amine GPCR	0.0017	0.0038	0.0029
Schistosoma mansoni	amine GPCR	0.0017	0.0038	0.0029
Schistosoma mansoni	amine GPCR	0.0017	0.0038	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.5427	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.4604	1
Brugia malayi	hypothetical protein	0.0017	0.0038	0.0082
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Giardia lamblia	NADPH oxidoreductase, putative	0.0088	0.5427	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0017	0.0038	0.0063
Echinococcus granulosus	G protein coupled receptor 139	0.0017	0.0038	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0118	0.7703	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0664	0.1427
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0664	0.2855
Echinococcus granulosus	somatostatin receptor	0.0017	0.0038	0.0063
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0017	0.0038	0.0029
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0017	0.0038	0.0029
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.5427	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0017	0.0038	0.0029
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Trichomonas vaginalis	FMN-dependent NADH-azoreductase, putative	0.0022	0.0448	0.0812
Echinococcus granulosus	dro:myosuppressin receptor	0.0017	0.0038	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Onchocerca volvulus		0.0017	0.0038	0.5
Brugia malayi	Thioredoxin reductase	0.0047	0.2305	0.5008
Echinococcus granulosus	biogenic amine 5HT receptor	0.0017	0.0038	0.0063
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.6808	0.8837
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0017	0.0038	0.0063
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0008	0.0018
Echinococcus granulosus	7TM GPCR rhodopsin	0.0017	0.0038	0.0063
Brugia malayi	hypothetical protein	0.0017	0.0038	0.0082
Schistosoma mansoni	amine GPCR	0.0017	0.0038	0.0029
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.4604	1
Brugia malayi	Melatonin receptor type 1A	0.0017	0.0038	0.0082
Echinococcus granulosus	biogenic amine 5HT receptor	0.0017	0.0038	0.0063
Echinococcus granulosus	neuropeptide receptor	0.0017	0.0038	0.0063
Schistosoma mansoni	peptidase Clp (S14 family)	0.0077	0.4604	0.4599
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0017	0.0038	0.0063
Schistosoma mansoni	biogenic amine receptor	0.0017	0.0038	0.0029
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.6808	0.8837
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Onchocerca volvulus		0.0017	0.0038	0.5
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.2305	0.4999
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.4604	1
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.5427	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0664	0.1372
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0017	0.0038	0.0029
Brugia malayi	AKH receptor	0.0017	0.0038	0.0082
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.5427	1
Entamoeba histolytica	hypothetical protein	0.0022	0.0448	0.5
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0088	0.5427	1
Schistosoma mansoni	neuropeptide receptor	0.0017	0.0038	0.0029
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0017	0.0038	0.0063
Schistosoma mansoni	neuropeptide f receptor 76f	0.0017	0.0038	0.0029
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0017	0.0038	0.0029
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0017	0.0038	0.0029
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Entamoeba histolytica	iron-sulfur flavoprotein, putative	0.0022	0.0448	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0017	0.0038	0.0063
Onchocerca volvulus		0.0017	0.0038	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Brugia malayi	neuropeptide F receptor	0.0017	0.0038	0.0082
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Echinococcus granulosus	g-protein coupled receptor	0.0017	0.0038	0.0063
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0017	0.0038	0.0029
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0017	0.0038	0.0029
Schistosoma mansoni	neuropeptide receptor	0.0017	0.0038	0.0029
Schistosoma mansoni	myosin xvIII	0.0017	0.0038	0.0029
Brugia malayi	Dopamine receptor	0.0017	0.0038	0.0082
Echinococcus multilocularis	serotonin receptor	0.0017	0.0038	0.0063
Echinococcus multilocularis	neuropeptide s receptor	0.0017	0.0038	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.5427	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0038	0.0029
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0017	0.0038	0.0063
Schistosoma mansoni	biogenic amine receptor	0.0017	0.0038	0.0029
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.2305	1
Entamoeba histolytica	modulator of drug activity B homolog, putative	0.0022	0.0448	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0017	0.0038	0.0029
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0088	0.5427	1
Schistosoma mansoni	amine GPCR	0.0017	0.0038	0.0029
Schistosoma mansoni	hypothetical protein	0.0017	0.0038	0.0029
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0017	0.0038	0.0063
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0017	0.0038	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.5427	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0793	0.1708
Giardia lamblia	NADPH oxidoreductase, putative	0.0088	0.5427	1
Brugia malayi	hypothetical protein	0.0017	0.0038	0.0082
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0017	0.0038	0.0063
Brugia malayi	ORL1-like opioid receptor	0.0017	0.0038	0.0082
Plasmodium falciparum	thioredoxin reductase	0.0047	0.2305	0.4999
Onchocerca volvulus		0.0017	0.0038	0.5
Schistosoma mansoni	opsin-like receptor	0.0017	0.0038	0.0029
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0017	0.0038	0.0063
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.2305	0.4999
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0017	0.0038	0.0063
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0017	0.0038	0.0082
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0077	0.4604	1
Brugia malayi	G-protein coupled receptor	0.0017	0.0038	0.0082
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0017	0.0038	0.0082
Brugia malayi	G protein-coupled receptor	0.0017	0.0038	0.0082
Schistosoma mansoni	neuropeptide receptor	0.0017	0.0038	0.0029
Echinococcus granulosus	g protein coupled receptor	0.0017	0.0038	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.5427	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.5427	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0017	0.0038	0.0063
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0017	0.0038	0.0063
Onchocerca volvulus		0.0017	0.0038	0.5
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.2305	0.2985
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0077	0.4604	1
Onchocerca volvulus		0.0017	0.0038	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0017	0.0038	0.0063
Echinococcus granulosus	tm gpcr rhodopsin	0.0017	0.0038	0.0063
Brugia malayi	follicle stimulating hormone receptor	0.0017	0.0038	0.0082
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.6808	0.8837
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.5427	1
Plasmodium vivax	glutathione reductase, putative	0.0047	0.2305	0.4999
Leishmania major	hypothetical protein, conserved	0.0025	0.0664	0.2855
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Echinococcus multilocularis	g protein coupled receptor	0.0017	0.0038	0.0063
Echinococcus granulosus	neuropeptide FF receptor 2	0.0017	0.0038	0.0063
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.6808	0.8837
Brugia malayi	Dopamine receptor protein 1	0.0017	0.0038	0.0082

Activities

Activity type	Activity value	Assay description	Source	Reference
IC10 (functional)	= 9.7 uM	Antiproliferative activity against human Caco2 cells assessed as cell viability by MTT assay after 48 hrs	ChEMBL.	17276076
IC10 (functional)	= 9.7 uM	Antiproliferative activity against human Caco2 cells assessed as cell viability by MTT assay after 48 hrs	ChEMBL.	17276076

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 438051