TDR Targets

Basic information

Technical information

TDR Targets ID: 438141
Name: [(2R,6R)-1-(4-chlorophenyl)sulfonyl-6-methylp iperidin-2-yl]methyl N-(3-imidazol-1-ylpropyl )carbamate
MW: 454.971 | Formula: C20H27ClN4O4S
H donors: 1 H acceptors: 4 LogP: 2.84 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: O=C(OC[C@H]1CCC[C@H](N1S(=O)(=O)c1ccc(cc1)Cl)C)NCCCn1cncc1
InChi: 1S/C20H27ClN4O4S/c1-16-4-2-5-18(25(16)30(27,28)19-8-6-17(21)7-9-19)14-29-20(26)23-10-3-12-24-13-11-22-15-24/h6-9,11,13,15-16,18H,2-5,10,12,14H2,1H3,(H,23,26)/t16-,18-/m1/s1
InChiKey: RCOHZBMIMMGVAW-SJLPKXTDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[(2R,6R)-1-(4-chlorophenyl)sulfonyl-6-methyl-2-piperidyl]methyl N-(3-imidazol-1-ylpropyl)carbamate
N-[3-(1-imidazolyl)propyl]carbamic acid [(2R,6R)-1-(4-chlorophenyl)sulfonyl-6-methyl-2-piperidinyl]methyl ester
[(2R,6R)-1-(4-chlorophenyl)sulfonyl-6-methyl-piperidin-2-yl]methyl N-(3-imidazol-1-ylpropyl)carbamate
N-(3-imidazol-1-ylpropyl)carbamic acid [(2R,6R)-1-(4-chlorophenyl)sulfonyl-6-methyl-2-piperidyl]methyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APH1B gamma secretase subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	gamma secretase subunit aph 1	Get druggable targets OG5_130831	All targets in OG5_130831
Schistosoma mansoni	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831
Loa Loa (eye worm)	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831
Schistosoma japonicum	ko:K06172 anterior pharynx defective 1, putative	Get druggable targets OG5_130831	All targets in OG5_130831
Echinococcus granulosus	gamma secretase subunit aph 1	Get druggable targets OG5_130831	All targets in OG5_130831
Brugia malayi	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.042	1	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0215	0.4554	0.3616
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Brugia malayi	gamma-secretase subunit aph-1	0.0296	0.671	0.671
Echinococcus granulosus	fibropellin Ia	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0098	0.147	0.147
Brugia malayi	EGF-like domain containing protein	0.0122	0.2094	0.2094
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Echinococcus multilocularis	peroxidasin	0.042	1	1
Schistosoma mansoni	notch	0.0122	0.2094	0.0731
Schistosoma mansoni	alpha-glucosidase	0.012	0.2058	0.069
Brugia malayi	hypothetical protein	0.0098	0.147	0.147
Onchocerca volvulus	Slit protein homolog	0.0122	0.2094	0.1205
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Brugia malayi	Calcium binding EGF domain containing protein	0.0122	0.2094	0.2094
Brugia malayi	hypothetical protein	0.0098	0.147	0.147
Brugia malayi	EGF-like domain containing protein	0.0122	0.2094	0.2094
Schistosoma mansoni	hypothetical protein	0.0122	0.2094	0.0731
Brugia malayi	Cadherin domain containing protein	0.0122	0.2094	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.014	0.2575	0.2575
Echinococcus granulosus	lysosomal alpha glucosidase	0.014	0.2575	0.1295
Brugia malayi	putative neuropeptide receptor NPR1	0.0098	0.147	0.147
Schistosoma mansoni	notch	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Loa Loa (eye worm)	hypothetical protein	0.042	1	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Echinococcus granulosus	neural cadherin	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Brugia malayi	RE15519p	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.042	1	1
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Brugia malayi	amidase	0.0215	0.4554	0.4554
Echinococcus granulosus	neurogenic locus notch protein	0.0122	0.2094	0.0731
Brugia malayi	follicle stimulating hormone receptor	0.0098	0.147	0.147
Echinococcus multilocularis	neurogenic locus protein delta	0.0122	0.2094	0.0731
Onchocerca volvulus		0.0098	0.147	0.0511
Brugia malayi	Serotonin receptor	0.0098	0.147	0.147
Schistosoma mansoni	hypothetical protein	0.0122	0.2094	0.0731
Brugia malayi	Serotonin receptor	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Brugia malayi	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0098	0.147	0.147
Onchocerca volvulus		0.042	1	1
Brugia malayi	Blistered cuticle protein 3	0.042	1	1
Echinococcus granulosus	protein jagged 1	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.042	1	1
Brugia malayi	GCC2 and GCC3 family protein	0.0122	0.2094	0.2094
Brugia malayi	EGF-like domain containing protein	0.0122	0.2094	0.2094
Onchocerca volvulus		0.0098	0.147	0.0511
Loa Loa (eye worm)	hypothetical protein	0.042	1	1
Schistosoma mansoni	notch	0.0122	0.2094	0.0731
Echinococcus granulosus	neurogenic locus protein delta	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Echinococcus multilocularis	fibropellin Ia	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Schistosoma mansoni	hypothetical protein	0.0122	0.2094	0.0731
Loa Loa (eye worm)	melatonin receptor type 1A	0.0098	0.147	0.147
Schistosoma mansoni	slit	0.0122	0.2094	0.0731
Brugia malayi	putative neuropeptide receptor	0.0098	0.147	0.147
Echinococcus granulosus	neurogenic locus notch protein	0.0122	0.2094	0.0731
Loa Loa (eye worm)	G-protein coupled receptor	0.0098	0.147	0.147
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0098	0.147	0.147
Onchocerca volvulus		0.0122	0.2094	0.1205
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Trypanosoma cruzi	Aph-1 protein, putative	0.0115	0.1922	0.5
Brugia malayi	Animal haem peroxidase family protein	0.042	1	1
Brugia malayi	GnHR receptor homolog	0.0098	0.147	0.147
Echinococcus multilocularis	neurogenic locus notch protein	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	blistered cuticle protein 3	0.042	1	1
Schistosoma mansoni	amidase	0.0215	0.4554	0.3616
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Onchocerca volvulus	Neurogenic locus notch homolog	0.0122	0.2094	0.1205
Onchocerca volvulus		0.0122	0.2094	0.1205
Schistosoma mansoni	hypothetical protein	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Echinococcus multilocularis	lysosomal alpha glucosidase	0.014	0.2575	0.1295
Onchocerca volvulus	Chorion peroxidase homolog	0.042	1	1
Brugia malayi	G-protein coupled receptor	0.0098	0.147	0.147
Brugia malayi	EGF-like domain containing protein	0.0122	0.2094	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Onchocerca volvulus		0.0098	0.147	0.0511
Brugia malayi	G-protein coupled receptor	0.0098	0.147	0.147
Brugia malayi	Peroxidasin	0.042	1	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Onchocerca volvulus		0.0098	0.147	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Echinococcus granulosus	slit 2 protein	0.0122	0.2094	0.0731
Echinococcus multilocularis	protein jagged 1	0.0122	0.2094	0.0731
Schistosoma mansoni	notch	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.042	1	1
Loa Loa (eye worm)	hypothetical protein	0.042	1	1
Loa Loa (eye worm)	hypothetical protein	0.042	1	1
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0296	0.671	0.6143
Brugia malayi	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	neuropeptide F receptor	0.0098	0.147	0.147
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0098	0.147	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Brugia malayi	Calcium binding EGF domain containing protein	0.0122	0.2094	0.2094
Brugia malayi	Glycosyl hydrolases family 31 protein	0.014	0.2575	0.2575
Trypanosoma cruzi	Aph-1 protein, putative	0.0115	0.1922	0.5
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Echinococcus granulosus	notch	0.0122	0.2094	0.0731
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0296	0.671	0.6143
Loa Loa (eye worm)	hypothetical protein	0.042	1	1
Onchocerca volvulus		0.0098	0.147	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Brugia malayi	Animal haem peroxidase family protein	0.042	1	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Echinococcus multilocularis	neurogenic locus protein delta	0.0122	0.2094	0.0731
Loa Loa (eye worm)	TYRA-2 protein	0.0098	0.147	0.147
Echinococcus granulosus	gamma secretase subunit aph 1	0.0296	0.671	0.6143
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Echinococcus multilocularis	protein jagged 1	0.0122	0.2094	0.0731
Onchocerca volvulus	Peroxidasin homolog	0.042	1	1
Loa Loa (eye worm)	hypothetical protein	0.0215	0.4554	0.4554
Brugia malayi	sulfakinin receptor protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Brugia malayi	larval opioid receptor	0.0098	0.147	0.147
Brugia malayi	Melatonin receptor type 1A	0.0098	0.147	0.147
Echinococcus multilocularis	protein jagged 2	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Schistosoma mansoni	notch	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Echinococcus multilocularis	neural cadherin	0.0122	0.2094	0.0731
Onchocerca volvulus		0.0098	0.147	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0098	0.147	0.147
Brugia malayi	EGF-like domain containing protein	0.0122	0.2094	0.2094
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0296	0.671	0.671
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.042	1	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Onchocerca volvulus		0.0098	0.147	0.0511
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0215	0.4554	0.3616
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0122	0.2094	0.2094
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Echinococcus multilocularis	lysosomal alpha glucosidase	0.014	0.2575	0.1295
Loa Loa (eye worm)	animal heme peroxidase	0.042	1	1
Brugia malayi	Animal haem peroxidase family protein	0.042	1	1
Onchocerca volvulus		0.0098	0.147	0.0511
Brugia malayi	neuropeptide F receptor	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Echinococcus multilocularis	slit 2 protein	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Brugia malayi	Dopamine receptor	0.0098	0.147	0.147
Schistosoma mansoni	peroxidasin	0.042	1	1
Brugia malayi	notch-like transmembrane receptor	0.0122	0.2094	0.2094
Schistosoma mansoni	hypothetical protein	0.0122	0.2094	0.0731
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0215	0.4554	0.3616
Loa Loa (eye worm)	neuropeptide F receptor	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Schistosoma mansoni	fatty-acid amide hydrolase	0.0215	0.4554	0.3616
Onchocerca volvulus		0.0122	0.2094	0.1205
Onchocerca volvulus		0.0098	0.147	0.0511
Brugia malayi	G protein-coupled receptor F59B2.13	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.042	1	1
Echinococcus granulosus	protein jagged 1	0.0122	0.2094	0.0731
Onchocerca volvulus		0.0098	0.147	0.0511
Brugia malayi	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Loa Loa (eye worm)	hypothetical protein	0.042	1	1
Loa Loa (eye worm)	notch protein	0.0122	0.2094	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Schistosoma mansoni	alpha-glucosidase	0.012	0.2058	0.069
Brugia malayi	Muscle positioning protein 4	0.0122	0.2094	0.2094
Onchocerca volvulus		0.042	1	1
Brugia malayi	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Brugia malayi	Dopamine receptor protein 1	0.0098	0.147	0.147
Loa Loa (eye worm)	animal heme peroxidase	0.042	1	1
Brugia malayi	Dopamine receptor protein 2	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Schistosoma mansoni	hypothetical protein	0.0122	0.2094	0.0731
Echinococcus granulosus	protein jagged 2	0.0122	0.2094	0.0731
Echinococcus granulosus	delta-like protein 1	0.0122	0.2094	0.0731
Loa Loa (eye worm)	Notch2	0.0122	0.2094	0.2094
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0098	0.147	0.147
Onchocerca volvulus		0.0098	0.147	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0098	0.147	0.0511
Brugia malayi	EGF-like domain containing protein	0.0122	0.2094	0.2094
Brugia malayi	EGF-like domain containing protein	0.0122	0.2094	0.2094
Schistosoma mansoni	laminin gamma-3 chain	0.0122	0.2094	0.0731
Onchocerca volvulus	Peroxidasin homolog	0.042	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.042	1	1
Onchocerca volvulus		0.0098	0.147	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Onchocerca volvulus		0.0122	0.2094	0.1205
Schistosoma mansoni	peroxidasin	0.042	1	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Onchocerca volvulus		0.0098	0.147	0.0511
Loa Loa (eye worm)	hypothetical protein	0.042	1	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Brugia malayi	Cadherin domain containing protein	0.0122	0.2094	0.2094
Onchocerca volvulus		0.0098	0.147	0.0511
Schistosoma mansoni	notch	0.0122	0.2094	0.0731
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0122	0.2094	0.0731
Loa Loa (eye worm)	G-protein coupled receptor	0.0098	0.147	0.147
Echinococcus granulosus	peroxidasin	0.042	1	1
Brugia malayi	hypothetical protein	0.0098	0.147	0.147
Giardia lamblia	High cysteine protein	0.0122	0.2094	0.5
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Brugia malayi	Animal haem peroxidase family protein	0.042	1	1
Schistosoma mansoni	septate junction protein	0.0122	0.2094	0.0731
Onchocerca volvulus		0.0098	0.147	0.0511
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0215	0.4554	0.3616
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0098	0.147	0.147
Trypanosoma brucei	Aph-1 protein, putative	0.0115	0.1922	0.5
Onchocerca volvulus	Dual oxidase homolog	0.042	1	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Brugia malayi	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Brugia malayi	ORL1-like opioid receptor	0.0098	0.147	0.147
Onchocerca volvulus		0.042	1	1
Loa Loa (eye worm)	hypothetical protein	0.042	1	1
Toxoplasma gondii	EGF family domain-containing protein	0.0122	0.2094	0.5
Brugia malayi	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Echinococcus multilocularis	neurogenic locus notch protein	0.0122	0.2094	0.0731
Onchocerca volvulus		0.0122	0.2094	0.1205
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Brugia malayi	Calcium binding EGF domain containing protein	0.0122	0.2094	0.2094
Echinococcus granulosus	protein jagged 2	0.0122	0.2094	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Onchocerca volvulus	Peroxidase homolog	0.042	1	1
Schistosoma mansoni	hypothetical protein	0.0122	0.2094	0.0731
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0122	0.2094	0.1205
Onchocerca volvulus	Peroxidase homolog	0.042	1	1
Brugia malayi	Animal haem peroxidase family protein	0.042	1	1
Echinococcus multilocularis	notch	0.0122	0.2094	0.0731
Brugia malayi	Delta serrate ligand family protein	0.0122	0.2094	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0098	0.147	0.147
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2094	0.2094
Onchocerca volvulus	Putative cubilin	0.0122	0.2094	0.1205
Brugia malayi	AKH receptor	0.0098	0.147	0.147
Echinococcus granulosus	neurogenic locus notch protein 4	0.0122	0.2094	0.0731
Onchocerca volvulus		0.0098	0.147	0.0511
Loa Loa (eye worm)	animal heme peroxidase	0.042	1	1
Brugia malayi	neuropeptide F receptor	0.0098	0.147	0.147
Schistosoma mansoni	cell polarity protein	0.0122	0.2094	0.0731
Onchocerca volvulus		0.0098	0.147	0.0511
Brugia malayi	G protein-coupled receptor	0.0098	0.147	0.147
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0098	0.147	0.147
Brugia malayi	hypothetical protein	0.0098	0.147	0.147

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.57 uM	Inhibition of gamma secretase-mediated amyloid-beta peptid aggregation	ChEMBL.	17055268
IC50 (binding)	= 0.57 uM	Inhibition of gamma secretase-mediated amyloid-beta peptid aggregation	ChEMBL.	17055268

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10127574

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 438141