Detailed information for compound 438145

Basic information

Technical information
  • TDR Targets ID: 438145
  • Name: [(2R,6R)-1-(4-chlorophenyl)sulfonyl-6-methylp iperidin-2-yl]methyl 4-piperidin-1-ylpiperidi ne-1-carboxylate
  • MW: 498.078 | Formula: C24H36ClN3O4S
  • H donors: 0 H acceptors: 3 LogP: 4.38 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)S(=O)(=O)N1[C@H](CCC[C@H]1C)COC(=O)N1CCC(CC1)N1CCCCC1
  • InChi: 1S/C24H36ClN3O4S/c1-19-6-5-7-22(28(19)33(30,31)23-10-8-20(25)9-11-23)18-32-24(29)27-16-12-21(13-17-27)26-14-3-2-4-15-26/h8-11,19,21-22H,2-7,12-18H2,1H3/t19-,22-/m1/s1
  • InChiKey: MFAXLGACINNOJC-DENIHFKCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2R,6R)-1-(4-chlorophenyl)sulfonyl-6-methyl-2-piperidyl]methyl 4-(1-piperidyl)piperidine-1-carboxylate
  • 4-(1-piperidyl)-1-piperidinecarboxylic acid [(2R,6R)-1-(4-chlorophenyl)sulfonyl-6-methyl-2-piperidinyl]methyl ester
  • [(2R,6R)-1-(4-chlorophenyl)sulfonyl-6-methyl-piperidin-2-yl]methyl 4-piperidin-1-ylpiperidine-1-carboxylate
  • 4-piperidinopiperidine-1-carboxylic acid [(2R,6R)-1-(4-chlorophenyl)sulfonyl-6-methyl-2-piperidyl]methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APH1B gamma secretase subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K06172 anterior pharynx defective 1, putative Get druggable targets OG5_130831 All targets in OG5_130831
Echinococcus multilocularis gamma secretase subunit aph 1 Get druggable targets OG5_130831 All targets in OG5_130831
Schistosoma mansoni gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Echinococcus granulosus gamma secretase subunit aph 1 Get druggable targets OG5_130831 All targets in OG5_130831
Brugia malayi gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Loa Loa (eye worm) gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0222 0.0422
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0249 0.0249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0986 0.2123
Loa Loa (eye worm) amidase 0.0081 0.1122 0.1122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0993 0.0943
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0081 0.1122 0.1073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0993 0.0943
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0557 0.1168
Echinococcus granulosus gamma secretase subunit aph 1 0.0592 0.8789 0.8789
Plasmodium vivax amine transporter, putative 0.0057 0.0767 0.1358
Leishmania major hypothetical protein, conserved 0.0018 0.0177 0.0338
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0067 0.0067
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0222 0.0439
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0015 0.0127 0.0127
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0249 0.0249
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0222 0.0422
Loa Loa (eye worm) hypothetical protein 0.0021 0.0225 0.0225
Trypanosoma brucei Aph-1 protein, putative 0.0231 0.3367 0.743
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Brugia malayi Cytochrome P450 family protein 0.0015 0.0128 0.0117
Schistosoma mansoni thyroid hormone receptor 0.0117 0.1658 0.1611
Trypanosoma brucei calcium motive p-type ATPase, putative 0.001 0.0055 0.0069
Plasmodium vivax calcium-transporting ATPase, putative 0.0021 0.0225 0.0111
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Leishmania major monoglyceride lipase, putative 0.0307 0.4523 1
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Leishmania major presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative 0.0248 0.3631 0.8017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0249 0.0238
Trypanosoma cruzi Aph-1 protein, putative 0.0231 0.3367 0.743
Brugia malayi hypothetical protein 0.0087 0.121 0.12
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0057 0.0767 0.6241
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0307 0.4523 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0986 0.2123
Echinococcus granulosus fatty acid amide hydrolase 1 0.0672 1 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0672 1 1
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0021 0.0225 0.0111
Brugia malayi E1-E2 ATPase family protein 0.0008 0.0025 0.0014
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0067 0.0012
Echinococcus multilocularis calcium transporting atpase 0.0019 0.0187 0.0187
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Leishmania major calcium motive p-type ATPase, putative 0.001 0.0055 0.0069
Schistosoma mansoni survival motor neuron protein 0.0075 0.1024 0.0974
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0243 0.1841
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0222 0.0422
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0222 0.1667
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0072 0.0993 0.0983
Plasmodium vivax PST-A protein 0.0307 0.4523 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Trypanosoma cruzi serine peptidase, putative 0.0018 0.0177 0.0338
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0067 0.0056
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0183
Brugia malayi hypothetical protein 0.0012 0.0086 0.0076
Trypanosoma brucei presenilin-like aspartic peptidase, putative 0.0248 0.3631 0.8017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0222 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0067 0.0056
Loa Loa (eye worm) hypothetical protein 0.0072 0.0986 0.0986
Brugia malayi putative amidase 0.0081 0.1122 0.1113
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0249 0.0238
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0014 0.0112 0.0194
Loa Loa (eye worm) RNA binding protein 0.0045 0.0585 0.0585
Toxoplasma gondii hypothetical protein 0.0018 0.0177 0.1284
Loa Loa (eye worm) TAR-binding protein 0.0045 0.0585 0.0585
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0094 0.1313 0.1313
Brugia malayi RNA recognition motif domain containing protein 0.0045 0.0585 0.0575
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0222 0.0422
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0986 0.2137
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0067 0.0067
Echinococcus multilocularis Phospholipase carboxylesterase 0.0018 0.0177 0.0177
Trypanosoma brucei unspecified product 0.001 0.0048 0.0051
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0249 0.0238
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0013 0.0093 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0249 0.0238
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0222 0.0211
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0081 0.1122 1
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0081 0.1122 0.2427
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0249 0.0249
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0043 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Mycobacterium ulcerans hydrolase 0.0018 0.0177 0.0321
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0222 0.0222
Mycobacterium ulcerans peptide amidase, GatA 0.0081 0.1122 0.2427
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0177 0.0321
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0222 0.0422
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0081 0.1122 0.1122
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0067 0.0067
Echinococcus multilocularis Nicastrin 0.0121 0.1721 0.1721
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0249 0.0238
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0713 0.1233
Trichomonas vaginalis Nicastrin precursor, putative 0.0121 0.1721 0.3771
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0081 0.1122 0.2427
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.0213 0.0213
Echinococcus multilocularis Nicastrin 0.0121 0.1721 0.1721
Echinococcus multilocularis thyroid hormone receptor alpha 0.0117 0.1658 0.1658
Toxoplasma gondii hypothetical protein 0.0057 0.0767 0.6264
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0986 0.2137
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.001 0.0055 0.0055
Brugia malayi glutaminase DH11.1 0.0221 0.3219 0.3212
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0112 0.0194
Entamoeba histolytica hypothetical protein 0.0044 0.0572 0.1244
Leishmania major calcium-transporting ATPase, putative 0.001 0.0055 0.0069
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0222 0.0222
Echinococcus multilocularis sodium and chloride dependent glycine 0.0057 0.0767 0.0767
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0013 0.0093 0.0579
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0249 0.037
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0018 0.0177 0.0177
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0018 0.0177 0.1284
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0043 0.0557 0.0557
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0014 0.0112 0.0194
Leishmania major DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Trichomonas vaginalis cation-transporting ATPase, putative 0.0021 0.0225 0.0445
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Echinococcus granulosus fatty acid amide hydrolase 1 0.0081 0.1122 0.1122
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Brugia malayi nuclear hormone receptor 0.0023 0.0249 0.0238
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0021 0.0225 0.0225
Mycobacterium tuberculosis Possible lysophospholipase 0.0307 0.4523 1
Echinococcus multilocularis presenilin 0.0248 0.3631 0.3631
Brugia malayi hypothetical protein 0.0366 0.5395 0.539
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0222 0.0211
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0057 0.0767 0.0715
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0067 0.0067
Echinococcus granulosus geminin 0.0253 0.3703 0.3703
Echinococcus granulosus sodium and chloride dependent glycine 0.0057 0.0767 0.0767
Brugia malayi CXXC zinc finger family protein 0.0021 0.0213 0.0203
Brugia malayi nuclear receptor RXR 0.0011 0.0067 0.0056
Echinococcus granulosus abhydrolase domain containing 3 0.0018 0.0177 0.0177
Brugia malayi hypothetical protein 0.0087 0.121 0.12
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0063
Schistosoma mansoni cpg binding protein 0.0021 0.0213 0.0159
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0081 0.1122 0.244
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0086 0.0086
Echinococcus multilocularis tar DNA binding protein 0.0045 0.0585 0.0585
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0557 0.0505
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0557 0.1168
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0018 0.0177 0.1284
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0128 0.0229
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0986 0.0976
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0021 0.0225 0.0445
Trypanosoma cruzi Nicastrin, putative 0.0044 0.0572 0.1217
Plasmodium falciparum lysophospholipase, putative 0.0307 0.4523 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0057 0.0767 0.0767
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.001 0.0055 0.0055
Brugia malayi Membrane calcium atpase protein 3 0.001 0.0055 0.0045
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0222 0.0439
Loa Loa (eye worm) hypothetical protein 0.0338 0.4984 0.4984
Schistosoma mansoni sodium-dependent amino acid transporter 0.0057 0.0767 0.0715
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0249 0.0249
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Echinococcus granulosus Na:K ATPase alpha subunit 0.001 0.0055 0.0055
Schistosoma mansoni thyroid hormone receptor 0.0117 0.1658 0.1611
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Leishmania major DNA polymerase eta, putative 0.0032 0.0386 0.0803
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0057 0.0767 0.0767
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0072 0.0993 0.0993
Loa Loa (eye worm) oxidoreductase 0.0021 0.0222 0.0222
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0128 0.0229
Leishmania major hypothetical protein, conserved 0.0018 0.0177 0.0338
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0112 0.0194
Brugia malayi Amidase family protein 0.0081 0.1122 0.1113
Toxoplasma gondii protein c14orf29, putative 0.0018 0.0177 0.1284
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0021 0.0225 0.0428
Loa Loa (eye worm) hypothetical protein 0.0338 0.4984 0.4984
Plasmodium vivax P-type ATPase4, putative 0.0021 0.0225 0.0111
Echinococcus granulosus nicalin 0.0044 0.0572 0.0572
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0067 0.0012
Echinococcus granulosus tar DNA binding protein 0.0045 0.0585 0.0585
Schistosoma mansoni nuclear receptor 0.0011 0.0067 0.0012
Onchocerca volvulus 0.0023 0.0249 0.037
Brugia malayi conserved hypotetical protein 0.0011 0.0067 0.0056
Toxoplasma gondii hypothetical protein 0.0018 0.0177 0.1284
Brugia malayi ImpB/MucB/SamB family protein 0.0032 0.0386 0.0375
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0177 0.0338
Plasmodium falciparum amino acid transporter, putative 0.0057 0.0767 0.1358
Loa Loa (eye worm) amidase 0.0081 0.1122 0.1122
Entamoeba histolytica hypothetical protein 0.0018 0.0177 0.0368
Onchocerca volvulus 0.0057 0.0767 0.1423
Trypanosoma cruzi monoglyceride lipase, putative 0.0307 0.4523 1
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0249 0.0249
Schistosoma mansoni hypothetical protein 0.0253 0.3703 0.3668
Entamoeba histolytica presenilin 1 peptidase, putative 0.0248 0.3631 0.8023
Echinococcus multilocularis cpg binding protein 0.0022 0.0231 0.0231
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0307 0.4523 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0248 0.3631 0.8017
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0045 0.0585 0.0585
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0014 0.0112 0.0177
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0081 0.1122 0.1122
Trichomonas vaginalis Nicastrin precursor, putative 0.0121 0.1721 0.3771
Schistosoma mansoni hypothetical protein 0.0075 0.1024 0.0974
Brugia malayi hypothetical protein 0.0087 0.121 0.12
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0044 0.0559 0.0507
Onchocerca volvulus 0.0021 0.0222 0.0315
Echinococcus multilocularis presenilin enhancer 2 0.0233 0.3402 0.3402
Loa Loa (eye worm) hypothetical protein 0.0121 0.1721 0.1721
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0183
Loa Loa (eye worm) glutaminase 2 0.0221 0.3219 0.3219
Schistosoma mansoni amidase 0.0672 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0222 0.0422
Toxoplasma gondii phospholipase 0.0018 0.0177 0.1284
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0757
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0338 0.4984 0.4956
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0249 0.0249
Echinococcus granulosus presenilin enhancer 2 0.0233 0.3402 0.3402
Echinococcus multilocularis dnaJ subfamily B 0.0293 0.4301 0.4301
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0986 0.2161
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0021 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Mycobacterium ulcerans hypothetical protein 0.0018 0.0177 0.0321
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0222 0.0422
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0057 0.0767 0.0757
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0222 0.0104
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0249 0.0249
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0249 0.0249
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0112 0.0112
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0067 0.0056
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0713 0.5667
Toxoplasma gondii peptidase S15, putative 0.0018 0.0177 0.1284
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Onchocerca volvulus 0.0021 0.0222 0.0315
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0249 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0249 0.0238
Leishmania major hypothetical protein, conserved 0.007 0.0957 0.2073
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0249 0.0249
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0222 0.0422
Brugia malayi hypothetical protein 0.0057 0.0767 0.0757
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.001 0.0055 0.0069
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0013 0.0093 0.0152
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0057 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Loa Loa (eye worm) presenilin spe-4 0.0087 0.121 0.121
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0075 0.1024 0.1015
Brugia malayi Presenilin spe-4 0.0087 0.121 0.12
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0986 0.2123
Onchocerca volvulus 0.0057 0.0767 0.1423
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0021 0.0225 0.0225
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0081 0.1122 0.2427
Echinococcus granulosus abhydrolase domain containing protein 13 0.0018 0.0177 0.0177
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Brugia malayi hypothetical protein 0.0121 0.1721 0.1712
Schistosoma mansoni ATPase 0.0021 0.0225 0.017
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0249 0.0249
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0067 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0249 0.0249
Brugia malayi Presenilin-like protein At2g29900 0.0087 0.121 0.12
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0222 0.1667
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0249 0.0194
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0222 0.0422
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0112 0.0224
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0081 0.1122 0.2427
Echinococcus granulosus survival motor neuron protein 1 0.0366 0.5395 0.5395
Leishmania major DNA polymerase eta, putative 0.0023 0.0243 0.0485
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0057 0.0767 0.0767
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0086 0.0076
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0177 0.0338
Loa Loa (eye worm) solute carrier family 6 member 4 0.0338 0.4984 0.4984
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0128 0.0128
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0249 0.0194
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0222 0.0422
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0757
Schistosoma mansoni coup transcription factor 0.0023 0.0249 0.0194
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0013 0.0093 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.4523 1
Onchocerca volvulus 0.0057 0.0767 0.1423
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0013 0.0093 0.0038
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0986 0.2161
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0986 0.2123
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0055 0.0069
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0249 0.0194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0072 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0249 0.0194
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0248 0.3631 0.8017
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0713 0.1514
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0081 0.1122 0.1122
Echinococcus granulosus dna polymerase eta 0.0032 0.0386 0.0386
Schistosoma mansoni hypothetical protein 0.0121 0.1721 0.1675
Brugia malayi Cytochrome P450 family protein 0.0015 0.0128 0.0117
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0067 0.0056
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Brugia malayi MGC83647 protein 0.0018 0.0177 0.0166
Schistosoma mansoni microtubule-associated protein tau 0.0494 0.7322 0.7307
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0557 0.0505
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0222 0.0422
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0672 1 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0057 0.0767 0.0767
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0249 0.0238
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0081 0.1122 0.2427
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0222 0.0422
Trypanosoma cruzi amidase, putative 0.0081 0.1122 0.244
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0086 0.0076
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0013 0.0093 0.0152
Loa Loa (eye worm) calcium ATPase 0.0007 0.0011 0.0011
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0013 0.0093 0.3106
Brugia malayi Protein C20orf22 0.0018 0.0177 0.0166
Toxoplasma gondii hypothetical protein 0.0018 0.0177 0.1284
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0668 0.1416
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Echinococcus multilocularis sodium and chloride dependent glycine 0.0057 0.0767 0.0767
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0081 0.1122 0.2427
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0249 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0249 0.0238
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0081 0.1122 0.2176
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0009 0.0033 0.0022
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0043 0.0557 0.1184
Echinococcus multilocularis dna polymerase kappa 0.0014 0.0112 0.0112
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0112 0.0177
Trypanosoma cruzi Nicastrin, putative 0.0044 0.0572 0.1217
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0222 0.0422
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0249 0.0249
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0986 0.0976
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0713 0.1514
Loa Loa (eye worm) hypothetical protein 0.0013 0.0093 0.0093
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0112 0.0112
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0222 0.0439
Echinococcus multilocularis dna polymerase eta 0.0032 0.0386 0.0386
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0986 0.2123
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0222 0.0422
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0222 0.0222
Echinococcus granulosus dna polymerase kappa 0.0014 0.0112 0.0112
Echinococcus granulosus fatty acid amide hydrolase 1 0.0672 1 1
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0019 0.0187 0.0132
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Toxoplasma gondii aldehyde dehydrogenase 0.0043 0.0557 0.4495
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Brugia malayi nuclear receptor RXR 0.0012 0.0086 0.0076
Leishmania major calcium-translocating P-type ATPase 0.0021 0.0225 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0249 0.0238
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Echinococcus granulosus calcium transporting atpase 0.0019 0.0187 0.0187
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0249 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Trichomonas vaginalis cation-transporting ATPase, putative 0.0013 0.0093 0.0152
Mycobacterium ulcerans DNA polymerase IV 0.0014 0.0112 0.0177
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0019 0.0187 0.0132
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0222 0.0211
Schistosoma mansoni subfamily A22A unassigned peptidase (A22 family) 0.0248 0.3631 0.3595
Schistosoma mansoni hypothetical protein 0.0094 0.1313 0.1265
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0067 0.0067
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0986 0.2161
Brugia malayi nuclear receptor NHR-88 0.0011 0.0067 0.0056
Entamoeba histolytica hypothetical protein 0.0018 0.0177 0.0368
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0072 0.0993 0.0993
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0222 0.0211
Plasmodium falciparum lysophospholipase, putative 0.0307 0.4523 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0986 0.0986
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0057 0.0767 0.0767
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0249 0.0194
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0986 0.2123
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0178 0.0324
Schistosoma mansoni sodium/chloride dependent transporter 0.0057 0.0767 0.0715
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0222 0.0422
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0067 0.0067
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0112 0.0112
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0019 0.0187 0.0132
Loa Loa (eye worm) hypothetical protein 0.0032 0.0386 0.0386
Trypanosoma brucei monoglyceride lipase, putative 0.0307 0.4523 1
Brugia malayi MGC79044 protein 0.0018 0.0177 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0249 0.0238
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0293 0.4301 0.4269
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0057 0.0767 0.0767
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0986 0.2123
Mycobacterium ulcerans glutaminase 0.0221 0.3219 0.7097
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0018 0.0177 0.0122
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0307 0.4523 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Loa Loa (eye worm) E1-E2 ATPase 0.0008 0.0025 0.0025
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0128 0.0212
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0094 0.1313 0.1313
Toxoplasma gondii hypothetical protein 0.0057 0.0767 0.6264
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0222 0.0468
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0021 0.0225 0.0225
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0668 0.1416
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0222 0.0222
Mycobacterium ulcerans DNA polymerase IV 0.0014 0.0112 0.0177
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0013 0.0093 0.0152
Schistosoma mansoni ATPase 0.0021 0.0225 0.017
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0249 0.037
Brugia malayi ecdysone receptor 0.0011 0.0067 0.0056
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase A CtpF 0.0009 0.0036 0.0008
Trypanosoma cruzi amidase, putative 0.0081 0.1122 0.244
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0086 0.0031
Brugia malayi nuclear receptor NHR-88 0.0023 0.0249 0.0238
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0086 0.0031
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0249 0.0249
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.001 0.0055 0.0055
Echinococcus multilocularis survival motor neuron protein 1 0.0366 0.5395 0.5395
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Plasmodium falciparum lysophospholipase, putative 0.0307 0.4523 1
Loa Loa (eye worm) gamma-secretase subunit pen-2 0.0233 0.3402 0.3402
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Plasmodium falciparum esterase, putative 0.0307 0.4523 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0222 0.0211
Trypanosoma brucei monoglyceride lipase, putative 0.0307 0.4523 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0249 0.0238
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0249 0.0249
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0018 0.0177 0.0338
Echinococcus multilocularis nicalin 0.0044 0.0572 0.0572
Echinococcus granulosus Phospholipase carboxylesterase 0.0018 0.0177 0.0177
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Schistosoma mansoni cpg binding protein 0.0022 0.0231 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0048 0.0051
Echinococcus granulosus sodium and chloride dependent glycine 0.0057 0.0767 0.0767
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0249 0.0194
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Mycobacterium ulcerans hypothetical protein 0.0018 0.0177 0.0321
Mycobacterium ulcerans hypothetical protein 0.0072 0.0986 0.2123
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.001 0.0055 0.0069
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Onchocerca volvulus 0.0072 0.0986 0.1869
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0249 0.037
Leishmania major hypothetical protein, conserved 0.0081 0.1122 0.244
Schistosoma mansoni fatty-acid amide hydrolase 0.0081 0.1122 0.1073
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0081 0.1122 0.5
Echinococcus granulosus cpg binding protein 0.0022 0.0231 0.0231
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0013 0.0093 0.0183
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0249 0.0249
Treponema pallidum sodium- and chloride- dependent transporter 0.0338 0.4984 1
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0112 0.0101
Trypanosoma brucei DNA polymerase eta, putative 0.0032 0.0386 0.0803
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0668 0.1416
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0986 0.0976
Trichomonas vaginalis cation-transporting ATPase, putative 0.0021 0.0225 0.0445
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0222 0.0439
Brugia malayi nuclear receptor NHR-67 0.0011 0.0067 0.0056
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0222 0.0422
Echinococcus granulosus dnaJ subfamily B 0.0293 0.4301 0.4301
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0081 0.1122 0.2176
Trypanosoma brucei Presenilin enhancer-2 subunit of gamma secretase, putative 0.007 0.0957 0.2073
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0013 0.0093 0.0152
Toxoplasma gondii hypothetical protein 0.007 0.0957 0.7868
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0757
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0013 0.0093 0.0093
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0222 0.1667
Onchocerca volvulus 0.0075 0.1024 0.1947
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0048 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0072 0.0993 0.0993
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Brugia malayi gamma-secretase subunit pen-2 0.0233 0.3402 0.3395
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0767 0.1358
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0112 0.0057
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Loa Loa (eye worm) DR-78 0.0011 0.0067 0.0067
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0986 0.2123
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.001 0.0055 0.0055
Brugia malayi Presenilin spe-4 0.0087 0.121 0.12
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0018 0.0177 0.0338
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0067 0.0012
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0013 0.0093 0.0135
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Loa Loa (eye worm) norepinephrine transporter 0.0338 0.4984 0.4984
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0112 0.0057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Brugia malayi gamma-secretase subunit aph-1 0.0592 0.8789 0.8788
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0067 0.0056
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0043 0.0557 0.1168
Leishmania major P-type ATPase, putative 0.001 0.0055 0.0069
Echinococcus multilocularis abhydrolase domain containing 3 0.0018 0.0177 0.0177
Echinococcus multilocularis serotonin transporter 0.0338 0.4984 0.4984
Trypanosoma cruzi Aph-1 protein, putative 0.0231 0.3367 0.743
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0993 0.0943
Schistosoma mansoni cpg binding protein 0.0022 0.0231 0.0176
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0249 0.0249
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0067 0.0067
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0067 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.4523 1
Trypanosoma cruzi serine peptidase, putative 0.0018 0.0177 0.0338
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0249 0.0249
Echinococcus multilocularis geminin 0.0253 0.3703 0.3703
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0249 0.0238
Trypanosoma brucei unspecified product 0.001 0.0048 0.0051
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Brugia malayi hypothetical protein 0.0011 0.0067 0.0056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0668 0.1416
Onchocerca volvulus 0.0021 0.0222 0.0315
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Trichomonas vaginalis glutaminase, putative 0.0221 0.3219 0.7102
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0018 0.0177 0.0338
Mycobacterium ulcerans lysophospholipase 0.0307 0.4523 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0013 0.0093 0.0152
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0338 0.4984 0.4979
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0767
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.6264
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0222 0.0104
Brugia malayi Na,K-ATPase alpha subunit 0.0013 0.0093 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0067 0.0067
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0672 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0097 0.0097
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.6264
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0986 0.2123
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.6264
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0128 0.0229
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0081 0.1122 0.2427
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0021 0.0222 0.0222
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0222 0.0439
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0015 0.0127 0.0116
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0177 0.0338
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.001 0.0055 0.0261
Brugia malayi RNA binding protein 0.0045 0.0585 0.0575
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0222 0.0211
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0592 0.8789 0.8789
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0986 0.2123
Brugia malayi Presenilin spe-4 0.0087 0.121 0.12
Echinococcus multilocularis microtubule associated protein 2 0.0494 0.7322 0.7322
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0081 0.1122 0.2427
Toxoplasma gondii P-type ATPase4, putative 0.0013 0.0093 0.0579
Onchocerca volvulus 0.0021 0.0222 0.0315
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0986 0.2137
Schistosoma mansoni DNA polymerase eta 0.0032 0.0386 0.0332
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0128 0.0128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Brugia malayi tailless protein 0.0011 0.0067 0.0056
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0249 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Giardia lamblia DINP protein human, muc B family 0.0014 0.0112 0.4658
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0248 0.3631 0.8017
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0249 0.0194
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0222 0.0422
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0249 0.0238
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0067 0.0067
Onchocerca volvulus 0.0338 0.4984 1
Trypanosoma brucei unspecified product 0.0014 0.0112 0.0194
Echinococcus granulosus microtubule associated protein 2 0.0494 0.7322 0.7322
Schistosoma mansoni glutaminase 0.0221 0.3219 0.3181
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0072 0.0993 0.0993
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0249 0.0249
Schistosoma mansoni sodium/chloride dependent transporter 0.0338 0.4984 0.4956
Loa Loa (eye worm) hypothetical protein 0.0672 1 1
Toxoplasma gondii phospholipase/carboxylesterase 0.0018 0.0177 0.1284
Toxoplasma gondii histone lysine methyltransferase SET1 0.0039 0.0489 0.3923
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.001 0.0055 0.0055
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0013 0.0093 0.0152
Trichomonas vaginalis DNA polymerase eta, putative 0.0014 0.0112 0.0194
Toxoplasma gondii hypothetical protein 0.0018 0.0177 0.1284
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0019 0.0187 0.0177
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0249 0.0249
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0018 0.0177 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0048 0.0051
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0177 0.0338
Entamoeba histolytica ;Alias 0.0018 0.0177 0.0368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0249 0.0249
Schistosoma mansoni nuclear receptor 0.0011 0.0067 0.0012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0249 0.0194
Plasmodium falciparum calcium-transporting ATPase 0.0019 0.0187 0.0024
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Echinococcus granulosus Nicastrin 0.0121 0.1721 0.1721
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0249 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0013 0.0105 0.0179
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0222 0.0422
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0067 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0249 0.0238
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0249 0.0194
Toxoplasma gondii hypothetical protein 0.0087 0.121 1
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0018 0.0177 0.0122
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0018 0.0177 0.1284
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0013 0.0093 0.0093
Brugia malayi hypothetical protein 0.0121 0.1721 0.1712
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0222 0.0439
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0086 0.0086
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Brugia malayi steroid hormone receptor 0.0023 0.0249 0.0238
Onchocerca volvulus 0.0021 0.0213 0.0298
Echinococcus multilocularis gamma secretase subunit aph 1 0.0592 0.8789 0.8789
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0767
Leishmania major cytochrome p450-like protein 0.0015 0.0128 0.0229
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0067 0.0067
Brugia malayi Presenilin family protein 0.0248 0.3631 0.3624
Echinococcus granulosus serotonin transporter 0.0338 0.4984 0.4984
Trypanosoma brucei Nicastrin, putative 0.0044 0.0572 0.1217
Loa Loa (eye worm) serotonin transporter b 0.0338 0.4984 0.4984
Brugia malayi ecdysteroid receptor 0.0023 0.0249 0.0238
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0366 0.5395 0.5395
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0021 0.0225 0.169
Plasmodium falciparum transporter, putative 0.0057 0.0767 0.1358
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Trypanosoma brucei calcium-translocating P-type ATPase 0.0019 0.0187 0.0362
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0018 0.0177 0.0338
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0248 0.3631 0.8017
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Brugia malayi TAR-binding protein 0.0045 0.0585 0.0575
Brugia malayi nuclear hormone receptor 0.0011 0.0067 0.0056
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0243 0.0485
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0713 0.1233
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0386 0.0803
Loa Loa (eye worm) glutaminase 0.0221 0.3219 0.3219
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Schistosoma mansoni peptidase 0.0018 0.0177 0.0122
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0018 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0057 0.0767 0.0715
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0067 0.0012
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Schistosoma mansoni sodium/chloride dependent transporter 0.0057 0.0767 0.0715
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0249 0.0249
Schistosoma mansoni hypothetical protein 0.0253 0.3703 0.3668
Loa Loa (eye worm) hypothetical protein 0.0072 0.0986 0.0986
Onchocerca volvulus 0.0013 0.0093 0.0053
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0018 0.0177 0.0368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0249 0.0249
Echinococcus granulosus presenilin 0.0248 0.3631 0.3631
Schistosoma mansoni zinc finger protein 0.0011 0.0067 0.0012
Schistosoma mansoni gamma-secretase subunit aph-1 0.0592 0.8789 0.8783
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0307 0.4523 1
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0183
Brugia malayi hypothetical protein 0.0011 0.0067 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0086 0.0086
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0009 0.0033 0.0033
Brugia malayi Amidase family protein 0.0081 0.1122 0.1113
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0112 0.0194
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0222 0.0167
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0248 0.3631 0.8017
Mycobacterium ulcerans hypothetical protein 0.0307 0.4523 1
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0013 0.0093 0.0093
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0557 0.1168
Loa Loa (eye worm) hypothetical protein 0.0338 0.4984 0.4984
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0067 0.0067
Brugia malayi hypothetical protein 0.0012 0.0086 0.0076
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0986 0.2123

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.076 uM Inhibition of gamma secretase-mediated amyloid-beta peptid aggregation ChEMBL. 17055268
IC50 (binding) = 0.076 uM Inhibition of gamma secretase-mediated amyloid-beta peptid aggregation ChEMBL. 17055268

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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