Detailed information for compound 438146

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 555.173 | Formula: C27H43ClN4O4S
  • H donors: 0 H acceptors: 3 LogP: 4.65 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC[C@@H]1CCC[C@@H](N1S(=O)(=O)c1ccc(cc1)Cl)COC(=O)N1CCC(CC1)N(C1CCN(CC1)C)C
  • InChi: 1S/C27H43ClN4O4S/c1-4-22-6-5-7-25(32(22)37(34,35)26-10-8-21(28)9-11-26)20-36-27(33)31-18-14-24(15-19-31)30(3)23-12-16-29(2)17-13-23/h8-11,22-25H,4-7,12-20H2,1-3H3/t22-,25-/m1/s1
  • InChiKey: WNLCBJQKFPOUQX-RCZVLFRGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APH1B gamma secretase subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K06172 anterior pharynx defective 1, putative Get druggable targets OG5_130831 All targets in OG5_130831
Echinococcus multilocularis gamma secretase subunit aph 1 Get druggable targets OG5_130831 All targets in OG5_130831
Schistosoma mansoni gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Echinococcus granulosus gamma secretase subunit aph 1 Get druggable targets OG5_130831 All targets in OG5_130831
Loa Loa (eye worm) gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Brugia malayi gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii phospholipase 0.0018 0.0177 0.1284
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0338 0.4984 0.4956
Echinococcus granulosus presenilin enhancer 2 0.0233 0.3402 0.3402
Echinococcus multilocularis dnaJ subfamily B 0.0293 0.4301 0.4301
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0249 0.0249
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0757
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0986 0.2161
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0021 0.0225 0.0225
Mycobacterium ulcerans hypothetical protein 0.0018 0.0177 0.0321
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0057 0.0767 0.0757
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0222 0.0422
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0249 0.0249
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0222 0.0104
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0112 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0249 0.0249
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0067 0.0056
Toxoplasma gondii peptidase S15, putative 0.0018 0.0177 0.1284
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0713 0.5667
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0249 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Onchocerca volvulus 0.0021 0.0222 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0249 0.0238
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0248 0.3631 0.8017
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0045 0.0585 0.0585
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0014 0.0112 0.0177
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0081 0.1122 0.1122
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Trichomonas vaginalis Nicastrin precursor, putative 0.0121 0.1721 0.3771
Schistosoma mansoni hypothetical protein 0.0075 0.1024 0.0974
Brugia malayi hypothetical protein 0.0087 0.121 0.12
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0044 0.0559 0.0507
Onchocerca volvulus 0.0021 0.0222 0.0315
Echinococcus multilocularis presenilin enhancer 2 0.0233 0.3402 0.3402
Loa Loa (eye worm) glutaminase 2 0.0221 0.3219 0.3219
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0183
Loa Loa (eye worm) hypothetical protein 0.0121 0.1721 0.1721
Schistosoma mansoni amidase 0.0672 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0222 0.0422
Brugia malayi Amidase family protein 0.0081 0.1122 0.1113
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0021 0.0225 0.0428
Toxoplasma gondii protein c14orf29, putative 0.0018 0.0177 0.1284
Plasmodium vivax P-type ATPase4, putative 0.0021 0.0225 0.0111
Loa Loa (eye worm) hypothetical protein 0.0338 0.4984 0.4984
Onchocerca volvulus 0.0023 0.0249 0.037
Schistosoma mansoni nuclear receptor 0.0011 0.0067 0.0012
Echinococcus granulosus nicalin 0.0044 0.0572 0.0572
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0067 0.0012
Echinococcus granulosus tar DNA binding protein 0.0045 0.0585 0.0585
Toxoplasma gondii hypothetical protein 0.0018 0.0177 0.1284
Brugia malayi conserved hypotetical protein 0.0011 0.0067 0.0056
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0177 0.0338
Plasmodium falciparum amino acid transporter, putative 0.0057 0.0767 0.1358
Brugia malayi ImpB/MucB/SamB family protein 0.0032 0.0386 0.0375
Loa Loa (eye worm) amidase 0.0081 0.1122 0.1122
Onchocerca volvulus 0.0057 0.0767 0.1423
Entamoeba histolytica hypothetical protein 0.0018 0.0177 0.0368
Schistosoma mansoni hypothetical protein 0.0253 0.3703 0.3668
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0249 0.0249
Trypanosoma cruzi monoglyceride lipase, putative 0.0307 0.4523 1
Echinococcus multilocularis cpg binding protein 0.0022 0.0231 0.0231
Entamoeba histolytica presenilin 1 peptidase, putative 0.0248 0.3631 0.8023
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0307 0.4523 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0057 0.0767 0.0767
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.001 0.0055 0.0055
Brugia malayi Membrane calcium atpase protein 3 0.001 0.0055 0.0045
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0222 0.0439
Loa Loa (eye worm) hypothetical protein 0.0338 0.4984 0.4984
Schistosoma mansoni sodium-dependent amino acid transporter 0.0057 0.0767 0.0715
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0249 0.0249
Schistosoma mansoni thyroid hormone receptor 0.0117 0.1658 0.1611
Echinococcus granulosus Na:K ATPase alpha subunit 0.001 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0072 0.0993 0.0993
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0057 0.0767 0.0767
Leishmania major DNA polymerase eta, putative 0.0032 0.0386 0.0803
Loa Loa (eye worm) oxidoreductase 0.0021 0.0222 0.0222
Leishmania major hypothetical protein, conserved 0.0018 0.0177 0.0338
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0128 0.0229
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0112 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0713 0.1514
Schistosoma mansoni hypothetical protein 0.0121 0.1721 0.1675
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0081 0.1122 0.1122
Echinococcus granulosus dna polymerase eta 0.0032 0.0386 0.0386
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0067 0.0056
Brugia malayi Cytochrome P450 family protein 0.0015 0.0128 0.0117
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Schistosoma mansoni microtubule-associated protein tau 0.0494 0.7322 0.7307
Brugia malayi MGC83647 protein 0.0018 0.0177 0.0166
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0222 0.0422
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0557 0.0505
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0057 0.0767 0.0767
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0672 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0249 0.0238
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0081 0.1122 0.2427
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0222 0.0422
Trypanosoma cruzi amidase, putative 0.0081 0.1122 0.244
Loa Loa (eye worm) solute carrier family 6 member 4 0.0338 0.4984 0.4984
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0249 0.0194
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0222 0.0422
Schistosoma mansoni coup transcription factor 0.0023 0.0249 0.0194
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0757
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0013 0.0093 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.4523 1
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0013 0.0093 0.0038
Onchocerca volvulus 0.0057 0.0767 0.1423
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0986 0.2161
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0986 0.2123
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.001 0.0055 0.0069
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0249 0.0194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0072 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0249 0.0194
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0248 0.3631 0.8017
Schistosoma mansoni ATPase 0.0021 0.0225 0.017
Brugia malayi hypothetical protein 0.0121 0.1721 0.1712
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0249 0.0249
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0249 0.0249
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0067 0.0012
Brugia malayi Presenilin-like protein At2g29900 0.0087 0.121 0.12
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0222 0.1667
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0249 0.0194
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0222 0.0422
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0081 0.1122 0.2427
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0112 0.0224
Echinococcus granulosus survival motor neuron protein 1 0.0366 0.5395 0.5395
Leishmania major DNA polymerase eta, putative 0.0023 0.0243 0.0485
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0086 0.0076
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0057 0.0767 0.0767
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0177 0.0338
Brugia malayi hypothetical protein 0.0057 0.0767 0.0757
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0222 0.0422
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0249 0.0249
Leishmania major hypothetical protein, conserved 0.007 0.0957 0.2073
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.001 0.0055 0.0069
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0013 0.0093 0.0152
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0057 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Loa Loa (eye worm) presenilin spe-4 0.0087 0.121 0.121
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Brugia malayi Presenilin spe-4 0.0087 0.121 0.12
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0075 0.1024 0.1015
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0986 0.2123
Onchocerca volvulus 0.0057 0.0767 0.1423
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0081 0.1122 0.2427
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0021 0.0225 0.0225
Echinococcus granulosus abhydrolase domain containing protein 13 0.0018 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0067 0.0056
Brugia malayi putative amidase 0.0081 0.1122 0.1113
Loa Loa (eye worm) hypothetical protein 0.0072 0.0986 0.0986
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0249 0.0238
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0014 0.0112 0.0194
Toxoplasma gondii hypothetical protein 0.0018 0.0177 0.1284
Loa Loa (eye worm) RNA binding protein 0.0045 0.0585 0.0585
Loa Loa (eye worm) TAR-binding protein 0.0045 0.0585 0.0585
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0094 0.1313 0.1313
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Brugia malayi RNA recognition motif domain containing protein 0.0045 0.0585 0.0575
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0222 0.0422
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0986 0.2137
Echinococcus multilocularis Phospholipase carboxylesterase 0.0018 0.0177 0.0177
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0067 0.0067
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0307 0.4523 1
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0057 0.0767 0.6241
Brugia malayi hypothetical protein 0.0087 0.121 0.12
Echinococcus granulosus fatty acid amide hydrolase 1 0.0672 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0986 0.2123
Schistosoma mansoni fatty-acid amide hydrolase 0.0672 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0067 0.0012
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0021 0.0225 0.0111
Brugia malayi E1-E2 ATPase family protein 0.0008 0.0025 0.0014
Echinococcus multilocularis calcium transporting atpase 0.0019 0.0187 0.0187
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Leishmania major calcium motive p-type ATPase, putative 0.001 0.0055 0.0069
Schistosoma mansoni survival motor neuron protein 0.0075 0.1024 0.0974
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0243 0.1841
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0222 0.0422
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0222 0.1667
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0072 0.0993 0.0983
Trypanosoma cruzi serine peptidase, putative 0.0018 0.0177 0.0338
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Plasmodium vivax PST-A protein 0.0307 0.4523 1
Brugia malayi hypothetical protein 0.0012 0.0086 0.0076
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0067 0.0056
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0183
Loa Loa (eye worm) hypothetical protein 0.0021 0.0222 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Trypanosoma brucei presenilin-like aspartic peptidase, putative 0.0248 0.3631 0.8017
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0222 0.0439
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0067 0.0067
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0249 0.0249
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0015 0.0127 0.0127
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0222 0.0422
Loa Loa (eye worm) hypothetical protein 0.0021 0.0225 0.0225
Trypanosoma brucei Aph-1 protein, putative 0.0231 0.3367 0.743
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Brugia malayi Cytochrome P450 family protein 0.0015 0.0128 0.0117
Schistosoma mansoni thyroid hormone receptor 0.0117 0.1658 0.1611
Trypanosoma brucei calcium motive p-type ATPase, putative 0.001 0.0055 0.0069
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0249 0.0249
Plasmodium vivax calcium-transporting ATPase, putative 0.0021 0.0225 0.0111
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Leishmania major monoglyceride lipase, putative 0.0307 0.4523 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0249 0.0238
Leishmania major presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative 0.0248 0.3631 0.8017
Trypanosoma cruzi Aph-1 protein, putative 0.0231 0.3367 0.743
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0222 0.0422
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0249 0.0249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0986 0.2123
Loa Loa (eye worm) amidase 0.0081 0.1122 0.1122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0993 0.0943
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0993 0.0943
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0081 0.1122 0.1073
Echinococcus granulosus gamma secretase subunit aph 1 0.0592 0.8789 0.8789
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0557 0.1168
Leishmania major hypothetical protein, conserved 0.0018 0.0177 0.0338
Plasmodium vivax amine transporter, putative 0.0057 0.0767 0.1358
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0063
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0067 0.0067
Brugia malayi hypothetical protein 0.0087 0.121 0.12
Schistosoma mansoni cpg binding protein 0.0021 0.0213 0.0159
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0086 0.0086
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0081 0.1122 0.244
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0557 0.0505
Echinococcus multilocularis tar DNA binding protein 0.0045 0.0585 0.0585
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0018 0.0177 0.1284
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0557 0.1168
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0128 0.0229
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0986 0.0976
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0021 0.0225 0.0445
Trypanosoma cruzi Nicastrin, putative 0.0044 0.0572 0.1217
Plasmodium falciparum lysophospholipase, putative 0.0307 0.4523 1
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Leishmania major DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0014 0.0112 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Trichomonas vaginalis cation-transporting ATPase, putative 0.0021 0.0225 0.0445
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Echinococcus granulosus fatty acid amide hydrolase 1 0.0081 0.1122 0.1122
Brugia malayi nuclear hormone receptor 0.0023 0.0249 0.0238
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0021 0.0225 0.0225
Mycobacterium tuberculosis Possible lysophospholipase 0.0307 0.4523 1
Echinococcus multilocularis presenilin 0.0248 0.3631 0.3631
Brugia malayi hypothetical protein 0.0366 0.5395 0.539
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0057 0.0767 0.0715
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0222 0.0211
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0067 0.0067
Echinococcus granulosus geminin 0.0253 0.3703 0.3703
Echinococcus granulosus sodium and chloride dependent glycine 0.0057 0.0767 0.0767
Brugia malayi CXXC zinc finger family protein 0.0021 0.0213 0.0203
Brugia malayi nuclear receptor RXR 0.0011 0.0067 0.0056
Echinococcus granulosus abhydrolase domain containing 3 0.0018 0.0177 0.0177
Trichomonas vaginalis Nicastrin precursor, putative 0.0121 0.1721 0.3771
Echinococcus multilocularis Nicastrin 0.0121 0.1721 0.1721
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.0213 0.0213
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0081 0.1122 0.2427
Echinococcus multilocularis thyroid hormone receptor alpha 0.0117 0.1658 0.1658
Toxoplasma gondii hypothetical protein 0.0057 0.0767 0.6264
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.001 0.0055 0.0055
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0986 0.2137
Brugia malayi glutaminase DH11.1 0.0221 0.3219 0.3212
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0112 0.0194
Entamoeba histolytica hypothetical protein 0.0044 0.0572 0.1244
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0222 0.0222
Leishmania major calcium-transporting ATPase, putative 0.001 0.0055 0.0069
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Echinococcus multilocularis sodium and chloride dependent glycine 0.0057 0.0767 0.0767
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0249 0.037
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0013 0.0093 0.0579
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0043 0.0557 0.0557
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0018 0.0177 0.0177
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0018 0.0177 0.1284
Trypanosoma brucei unspecified product 0.001 0.0048 0.0051
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0249 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0249 0.0238
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0013 0.0093 0.0152
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0081 0.1122 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0222 0.0211
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0081 0.1122 0.2427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0249 0.0249
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0043 0.0557 0.0557
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Mycobacterium ulcerans hydrolase 0.0018 0.0177 0.0321
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0177 0.0321
Mycobacterium ulcerans peptide amidase, GatA 0.0081 0.1122 0.2427
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0222 0.0222
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0222 0.0422
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0081 0.1122 0.1122
Echinococcus multilocularis Nicastrin 0.0121 0.1721 0.1721
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0067 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0249 0.0238
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0713 0.1233
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Echinococcus granulosus microtubule associated protein 2 0.0494 0.7322 0.7322
Trypanosoma brucei unspecified product 0.0014 0.0112 0.0194
Onchocerca volvulus 0.0338 0.4984 1
Schistosoma mansoni glutaminase 0.0221 0.3219 0.3181
Schistosoma mansoni sodium/chloride dependent transporter 0.0338 0.4984 0.4956
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0249 0.0249
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0072 0.0993 0.0993
Toxoplasma gondii phospholipase/carboxylesterase 0.0018 0.0177 0.1284
Loa Loa (eye worm) hypothetical protein 0.0672 1 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0014 0.0112 0.0194
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0013 0.0093 0.0152
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.001 0.0055 0.0055
Toxoplasma gondii histone lysine methyltransferase SET1 0.0039 0.0489 0.3923
Toxoplasma gondii hypothetical protein 0.0018 0.0177 0.1284
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0019 0.0187 0.0177
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0249 0.0249
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0177 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0048 0.0051
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0018 0.0177 0.0177
Entamoeba histolytica ;Alias 0.0018 0.0177 0.0368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0249 0.0249
Schistosoma mansoni nuclear receptor 0.0011 0.0067 0.0012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0249 0.0194
Plasmodium falciparum calcium-transporting ATPase 0.0019 0.0187 0.0024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0222 0.0222
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0177 0.0338
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0015 0.0127 0.0116
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0222 0.0439
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.001 0.0055 0.0261
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0222 0.0211
Brugia malayi RNA binding protein 0.0045 0.0585 0.0575
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0592 0.8789 0.8789
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Brugia malayi Presenilin spe-4 0.0087 0.121 0.12
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0986 0.2123
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Onchocerca volvulus 0.0021 0.0222 0.0315
Echinococcus multilocularis microtubule associated protein 2 0.0494 0.7322 0.7322
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0081 0.1122 0.2427
Toxoplasma gondii P-type ATPase4, putative 0.0013 0.0093 0.0579
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0128 0.0128
Schistosoma mansoni DNA polymerase eta 0.0032 0.0386 0.0332
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0986 0.2137
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0249 0.0249
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Brugia malayi tailless protein 0.0011 0.0067 0.0056
Giardia lamblia DINP protein human, muc B family 0.0014 0.0112 0.4658
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0248 0.3631 0.8017
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0222 0.0422
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0249 0.0194
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0067 0.0067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0249 0.0238
Trypanosoma brucei unspecified product 0.001 0.0048 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0249 0.0238
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Brugia malayi hypothetical protein 0.0011 0.0067 0.0056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0668 0.1416
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Onchocerca volvulus 0.0021 0.0222 0.0315
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0018 0.0177 0.0338
Trichomonas vaginalis glutaminase, putative 0.0221 0.3219 0.7102
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0013 0.0093 0.0152
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0338 0.4984 0.4979
Mycobacterium ulcerans lysophospholipase 0.0307 0.4523 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0767
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.6264
Brugia malayi Na,K-ATPase alpha subunit 0.0013 0.0093 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0067 0.0067
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0672 1 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0222 0.0104
Loa Loa (eye worm) hypothetical protein 0.0013 0.0097 0.0097
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0986 0.2123
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.6264
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0128 0.0229
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0081 0.1122 0.2427
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.6264
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.001 0.0055 0.0055
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0986 0.2123
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0018 0.0177 0.0338
Brugia malayi Presenilin spe-4 0.0087 0.121 0.12
Loa Loa (eye worm) norepinephrine transporter 0.0338 0.4984 0.4984
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0013 0.0093 0.0135
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0067 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0112 0.0057
Brugia malayi gamma-secretase subunit aph-1 0.0592 0.8789 0.8788
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0067 0.0056
Leishmania major P-type ATPase, putative 0.001 0.0055 0.0069
Echinococcus multilocularis abhydrolase domain containing 3 0.0018 0.0177 0.0177
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0043 0.0557 0.1168
Echinococcus multilocularis serotonin transporter 0.0338 0.4984 0.4984
Trypanosoma cruzi Aph-1 protein, putative 0.0231 0.3367 0.743
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0993 0.0943
Schistosoma mansoni cpg binding protein 0.0022 0.0231 0.0176
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0067 0.0056
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0067 0.0067
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0249 0.0249
Trypanosoma cruzi serine peptidase, putative 0.0018 0.0177 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.4523 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0249 0.0249
Echinococcus multilocularis geminin 0.0253 0.3703 0.3703
Echinococcus granulosus presenilin 0.0248 0.3631 0.3631
Schistosoma mansoni zinc finger protein 0.0011 0.0067 0.0012
Schistosoma mansoni gamma-secretase subunit aph-1 0.0592 0.8789 0.8783
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0307 0.4523 1
Brugia malayi hypothetical protein 0.0011 0.0067 0.0056
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0183
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0086 0.0086
Brugia malayi Amidase family protein 0.0081 0.1122 0.1113
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0009 0.0033 0.0033
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0112 0.0194
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0222 0.0167
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0013 0.0093 0.0093
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0248 0.3631 0.8017
Mycobacterium ulcerans hypothetical protein 0.0307 0.4523 1
Loa Loa (eye worm) hypothetical protein 0.0338 0.4984 0.4984
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0557 0.1168
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0067 0.0067
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0986 0.2123
Brugia malayi hypothetical protein 0.0012 0.0086 0.0076
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0386 0.0803
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Loa Loa (eye worm) glutaminase 0.0221 0.3219 0.3219
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Schistosoma mansoni peptidase 0.0018 0.0177 0.0122
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0018 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0057 0.0767 0.0715
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0067 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0249 0.0249
Schistosoma mansoni sodium/chloride dependent transporter 0.0057 0.0767 0.0715
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Schistosoma mansoni hypothetical protein 0.0253 0.3703 0.3668
Loa Loa (eye worm) hypothetical protein 0.0072 0.0986 0.0986
Onchocerca volvulus 0.0013 0.0093 0.0053
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0018 0.0177 0.0368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0249 0.0249
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0067 0.0067
Brugia malayi Presenilin family protein 0.0248 0.3631 0.3624
Echinococcus granulosus serotonin transporter 0.0338 0.4984 0.4984
Trypanosoma brucei Nicastrin, putative 0.0044 0.0572 0.1217
Brugia malayi ecdysteroid receptor 0.0023 0.0249 0.0238
Loa Loa (eye worm) serotonin transporter b 0.0338 0.4984 0.4984
Loa Loa (eye worm) hypothetical protein 0.0366 0.5395 0.5395
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0067 0.0067
Plasmodium falciparum transporter, putative 0.0057 0.0767 0.1358
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0021 0.0225 0.169
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Trypanosoma brucei calcium-translocating P-type ATPase 0.0019 0.0187 0.0362
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0018 0.0177 0.0338
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0067 0.0067
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0248 0.3631 0.8017
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Loa Loa (eye worm) hypothetical protein 0.0018 0.0177 0.0177
Brugia malayi TAR-binding protein 0.0045 0.0585 0.0575
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0243 0.0485
Brugia malayi nuclear hormone receptor 0.0011 0.0067 0.0056
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0713 0.1233
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0249 0.0249
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0177 0.0338
Echinococcus granulosus Nicastrin 0.0121 0.1721 0.1721
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0013 0.0105 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0249 0.0238
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0067 0.0067
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0222 0.0422
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0249 0.0194
Toxoplasma gondii hypothetical protein 0.0087 0.121 1
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0018 0.0177 0.1284
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0018 0.0177 0.0122
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0013 0.0093 0.0093
Brugia malayi hypothetical protein 0.0121 0.1721 0.1712
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0222 0.0439
Brugia malayi steroid hormone receptor 0.0023 0.0249 0.0238
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0086 0.0086
Onchocerca volvulus 0.0021 0.0213 0.0298
Echinococcus multilocularis gamma secretase subunit aph 1 0.0592 0.8789 0.8789
Leishmania major cytochrome p450-like protein 0.0015 0.0128 0.0229
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0767
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0249 0.0194
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0986 0.2123
Schistosoma mansoni sodium/chloride dependent transporter 0.0057 0.0767 0.0715
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0222 0.0422
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0178 0.0324
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0067 0.0067
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0112 0.0112
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0019 0.0187 0.0132
Loa Loa (eye worm) hypothetical protein 0.0032 0.0386 0.0386
Trypanosoma brucei monoglyceride lipase, putative 0.0307 0.4523 1
Brugia malayi MGC79044 protein 0.0018 0.0177 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0249 0.0238
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Leishmania major calcium-translocating P-type ATPase 0.0021 0.0225 0.0445
Brugia malayi nuclear receptor RXR 0.0012 0.0086 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0249 0.0238
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0249 0.0238
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Echinococcus granulosus calcium transporting atpase 0.0019 0.0187 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Trichomonas vaginalis cation-transporting ATPase, putative 0.0013 0.0093 0.0152
Schistosoma mansoni subfamily A22A unassigned peptidase (A22 family) 0.0248 0.3631 0.3595
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0019 0.0187 0.0132
Mycobacterium ulcerans DNA polymerase IV 0.0014 0.0112 0.0177
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0222 0.0211
Schistosoma mansoni hypothetical protein 0.0094 0.1313 0.1265
Entamoeba histolytica hypothetical protein 0.0018 0.0177 0.0368
Brugia malayi nuclear receptor NHR-88 0.0011 0.0067 0.0056
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0986 0.2161
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0067 0.0067
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0072 0.0993 0.0993
Loa Loa (eye worm) hypothetical protein 0.0072 0.0986 0.0986
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0222 0.0211
Plasmodium falciparum lysophospholipase, putative 0.0307 0.4523 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0057 0.0767 0.0767
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0112 0.0177
Trypanosoma cruzi Nicastrin, putative 0.0044 0.0572 0.1217
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0222 0.0422
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0018 0.0177 0.0338
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0986 0.0976
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0249 0.0249
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0013 0.0093 0.0093
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0713 0.1514
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0057 0.0767 0.0715
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0222 0.0439
Echinococcus multilocularis dna polymerase eta 0.0032 0.0386 0.0386
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0222 0.0422
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0986 0.2123
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0222 0.0222
Echinococcus granulosus dna polymerase kappa 0.0014 0.0112 0.0112
Echinococcus granulosus fatty acid amide hydrolase 1 0.0672 1 1
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0019 0.0187 0.0132
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0222 0.0422
Toxoplasma gondii aldehyde dehydrogenase 0.0043 0.0557 0.4495
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0013 0.0093 0.0152
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0086 0.0076
Loa Loa (eye worm) calcium ATPase 0.0007 0.0011 0.0011
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0013 0.0093 0.3106
Toxoplasma gondii hypothetical protein 0.0018 0.0177 0.1284
Brugia malayi Protein C20orf22 0.0018 0.0177 0.0166
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0668 0.1416
Echinococcus multilocularis sodium and chloride dependent glycine 0.0057 0.0767 0.0767
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0081 0.1122 0.2427
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Loa Loa (eye worm) hypothetical protein 0.0012 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0249 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0249 0.0238
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0009 0.0033 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0081 0.1122 0.2176
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0043 0.0557 0.1184
Echinococcus multilocularis dna polymerase kappa 0.0014 0.0112 0.0112
Trypanosoma brucei Presenilin enhancer-2 subunit of gamma secretase, putative 0.007 0.0957 0.2073
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0013 0.0093 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0177 0.0338
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0057 0.0767 0.0757
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0013 0.0093 0.0093
Toxoplasma gondii hypothetical protein 0.007 0.0957 0.7868
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0222 0.1667
Onchocerca volvulus 0.0075 0.1024 0.1947
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0048 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0072 0.0993 0.0993
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0222 0.0422
Brugia malayi gamma-secretase subunit pen-2 0.0233 0.3402 0.3395
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0767 0.1358
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0112 0.0057
Loa Loa (eye worm) DR-78 0.0011 0.0067 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0112 0.0194
Schistosoma mansoni cpg binding protein 0.0022 0.0231 0.0176
Loa Loa (eye worm) hypothetical protein 0.0011 0.0067 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0048 0.0051
Echinococcus granulosus sodium and chloride dependent glycine 0.0057 0.0767 0.0767
Mycobacterium ulcerans hypothetical protein 0.0018 0.0177 0.0321
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0222 0.0439
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0249 0.0194
Mycobacterium ulcerans hypothetical protein 0.0072 0.0986 0.2123
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.001 0.0055 0.0069
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0249 0.037
Leishmania major hypothetical protein, conserved 0.0081 0.1122 0.244
Onchocerca volvulus 0.0072 0.0986 0.1869
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0093 0.0152
Echinococcus granulosus cpg binding protein 0.0022 0.0231 0.0231
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0081 0.1122 0.5
Schistosoma mansoni fatty-acid amide hydrolase 0.0081 0.1122 0.1073
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0249 0.0249
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0013 0.0093 0.0183
Trypanosoma brucei DNA polymerase eta, putative 0.0032 0.0386 0.0803
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0112 0.0101
Treponema pallidum sodium- and chloride- dependent transporter 0.0338 0.4984 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0222 0.0439
Brugia malayi nuclear receptor NHR-67 0.0011 0.0067 0.0056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0668 0.1416
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0986 0.0976
Trichomonas vaginalis cation-transporting ATPase, putative 0.0021 0.0225 0.0445
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0081 0.1122 0.2176
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0222 0.0422
Echinococcus granulosus dnaJ subfamily B 0.0293 0.4301 0.4301
Schistosoma mansoni ATPase 0.0021 0.0225 0.017
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0249 0.037
Brugia malayi ecdysone receptor 0.0011 0.0067 0.0056
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase A CtpF 0.0009 0.0036 0.0008
Trypanosoma cruzi amidase, putative 0.0081 0.1122 0.244
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0086 0.0031
Brugia malayi nuclear receptor NHR-88 0.0023 0.0249 0.0238
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0086 0.0031
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0249 0.0249
Echinococcus multilocularis survival motor neuron protein 1 0.0366 0.5395 0.5395
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.001 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0249
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Schistosoma mansoni tar DNA-binding protein 0.0045 0.0585 0.0533
Plasmodium falciparum lysophospholipase, putative 0.0307 0.4523 1
Loa Loa (eye worm) gamma-secretase subunit pen-2 0.0233 0.3402 0.3402
Loa Loa (eye worm) hypothetical protein 0.0054 0.0713 0.0713
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0249 0.0238
Trypanosoma brucei monoglyceride lipase, putative 0.0307 0.4523 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0222 0.0211
Plasmodium falciparum esterase, putative 0.0307 0.4523 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0249 0.0249
Echinococcus multilocularis nicalin 0.0044 0.0572 0.0572
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0018 0.0177 0.0338
Mycobacterium ulcerans amidase 0.0081 0.1122 0.2427
Echinococcus granulosus Phospholipase carboxylesterase 0.0018 0.0177 0.0177
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0057 0.0767 0.0767
Schistosoma mansoni hypothetical protein 0.0293 0.4301 0.4269
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0018 0.0177 0.0122
Mycobacterium ulcerans glutaminase 0.0221 0.3219 0.7097
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0986 0.2123
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0307 0.4523 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0128 0.0212
Loa Loa (eye worm) E1-E2 ATPase 0.0008 0.0025 0.0025
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0307 0.4523 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0222 0.0468
Toxoplasma gondii hypothetical protein 0.0057 0.0767 0.6264
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0094 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0057 0.0767 0.0767
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0021 0.0225 0.0225
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0668 0.1416
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0222 0.0222
Mycobacterium ulcerans DNA polymerase IV 0.0014 0.0112 0.0177
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0013 0.0093 0.0152

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.159 uM Inhibition of gamma secretase-mediated amyloid-beta peptid aggregation ChEMBL. 17055268
IC50 (binding) = 0.159 uM Inhibition of gamma secretase-mediated amyloid-beta peptid aggregation ChEMBL. 17055268

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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