TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 470.56 | Formula: C20H26N2O7S2
H donors: 2 H acceptors: 6 LogP: 0.7 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: ONC(=O)C1(CCN(CC1)S(=O)(=O)C1CC1)CS(=O)(=O)c1ccc(cc1)OCC#CC
InChi: 1S/C20H26N2O7S2/c1-2-3-14-29-16-4-6-17(7-5-16)30(25,26)15-20(19(23)21-24)10-12-22(13-11-20)31(27,28)18-8-9-18/h4-7,18,24H,8-15H2,1H3,(H,21,23)
InChiKey: HQGORWGMKQFFGB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ADAM metallopeptidase domain 17	Starlite/ChEMBL	References
Homo sapiens	matrix metallopeptidase 13 (collagenase 3)	Starlite/ChEMBL	References
Homo sapiens	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	Blood coagulation inhibitor Disintegrin	Get druggable targets OG5_132656	All targets in OG5_132656
Echinococcus granulosus	adam 17 protease	Get druggable targets OG5_132656	All targets in OG5_132656
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132656	All targets in OG5_132656
Echinococcus multilocularis	Blood coagulation inhibitor, Disintegrin	Get druggable targets OG5_132656	All targets in OG5_132656
Schistosoma mansoni	ADAM17 peptidase (M12 family)	Get druggable targets OG5_132656	All targets in OG5_132656
Schistosoma japonicum	ko:K06059 a disintegrin and metalloproteinase domain 17, putative	Get druggable targets OG5_132656	All targets in OG5_132656
Echinococcus multilocularis	adam 17 protease	Get druggable targets OG5_132656	All targets in OG5_132656

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	matrix metallopeptidase 13 (collagenase 3)	471 aa	448 aa	34.1 %
Brugia malayi	Disintegrin family protein	ADAM metallopeptidase domain 17	824 aa	724 aa	27.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0146	0.1607	0.1607
Brugia malayi	beta-lactamase	0.0037	0.0167	0.0107
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0114	0.0114
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0321	0.0321
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0146	0.1607	0.1607
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0237	0.2816	1
Toxoplasma gondii	histone arginine methyltransferase PRMT4/CARM1	0.0128	0.1375	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0301	0.3665	1
Onchocerca volvulus		0.0117	0.1222	0.1276
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0045	0.0273	0.0273
Echinococcus multilocularis	adam	0.0039	0.0189	0.0189
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0065	0.053	0.053
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0146	0.1607	0.1555
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0146	0.1607	0.1607
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0301	0.3665	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0145	0.1597	0.1597
Echinococcus granulosus	histone arginine methyltransferase CARMER	0.0128	0.1375	0.1375
Echinococcus multilocularis	nAChR subunit	0.0065	0.053	0.053
Schistosoma mansoni	cpg binding protein	0.0029	0.0061	0.0061
Loa Loa (eye worm)	GABA receptor subunit	0.0065	0.053	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Loa Loa (eye worm)	ACC-1 protein	0.0146	0.1607	0.1555
Echinococcus multilocularis	nAChR subunit	0.0146	0.1607	0.1607
Loa Loa (eye worm)	hypothetical protein	0.0132	0.142	0.1368
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0194	1
Loa Loa (eye worm)	matrixin family protein	0.0115	0.1193	0.114
Trypanosoma brucei	glucosidase, putative	0.0038	0.018	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0065	0.053	0.0472
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0184	0.212	0.2071
Loa Loa (eye worm)	hypothetical protein	0.0132	0.142	0.1368
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0031	0.009	0.009
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0146	0.1607	0.1607
Loa Loa (eye worm)	hypothetical protein	0.0031	0.009	0.003
Echinococcus granulosus	a disintegrin and metalloproteinase with	0.0105	0.1071	0.1071
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0038	0.018	0.0036
Brugia malayi	Cation transporter family protein	0.0146	0.1607	0.1555
Brugia malayi	Bromodomain containing protein	0.0081	0.0751	0.0694
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.1062	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0065	0.053	0.0472
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0171	0.1948	0.1948
Schistosoma mansoni	nAChR subunit	0.0146	0.1607	0.1607
Brugia malayi	Matrixin family protein	0.0047	0.0303	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0303	0.0244
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0045	0.0273	0.0302
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0031	0.009	0.009
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0066	0.0546	0.0546
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0716	0.9158	0.9158
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0081	0.0752	0.0695
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0146	0.1607	0.1555
Schistosoma mansoni	nAChR subunit	0.0081	0.0752	0.0752
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0301	0.3665	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0167	0.0107
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0172	0.1958	0.1958
Onchocerca volvulus		0.0146	0.1607	0.1699
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0105	0.1068	0.1107
Onchocerca volvulus		0.0067	0.0566	0.0555
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0146	0.1607	0.1607
Schistosoma mansoni	hypothetical protein	0.0033	0.0114	0.0114
Echinococcus granulosus	adam	0.0039	0.0189	0.0189
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.019	0.2195	0.2195
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0167	0.0107
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0132	0.142	0.142
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0031	0.009	0.009
Onchocerca volvulus		0.0065	0.053	0.0516
Brugia malayi	Matrixin family protein	0.0047	0.0303	0.0244
Brugia malayi	Carboxylesterase family protein	0.0132	0.142	0.1368
Loa Loa (eye worm)	acetylcholinesterase 1	0.0779	1	1
Loa Loa (eye worm)	hypothetical protein	0.0716	0.9158	0.9153
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0301	0.3665	1
Onchocerca volvulus		0.0146	0.1607	0.1699
Loa Loa (eye worm)	carboxylesterase	0.0779	1	1
Onchocerca volvulus		0.0132	0.142	0.1494
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0146	0.1607	0.1555
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0146	0.1607	0.1607
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0031	0.009	0.009
Onchocerca volvulus		0.0081	0.0752	0.0759
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0184	0.212	0.212
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0031	0.009	0.003
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0146	0.1607	0.1607
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0303	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Echinococcus multilocularis	geminin	0.035	0.4312	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0132	0.142	0.1368
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0132	0.142	0.4731
Schistosoma mansoni	adam (A disintegrin and metalloprotease	0.0039	0.0189	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0269	0.021
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0146	0.1607	0.1555
Loa Loa (eye worm)	matrixin family protein	0.0105	0.1068	0.1013
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0058	0.044	0.1031
Echinococcus granulosus	BC026374 protein S09 family	0.0132	0.142	0.142
Brugia malayi	hypothetical protein	0.0467	0.5861	0.5836
Loa Loa (eye worm)	hypothetical protein	0.0031	0.009	0.003
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0132	0.142	0.142
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.019	0.2195	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0167	0.0107
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0081	0.0752	0.0695
Brugia malayi	Bromodomain containing protein	0.0042	0.0237	0.0177
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0146	0.1607	0.1555
Schistosoma mansoni	neurotransmitter gated ion channel	0.0065	0.053	0.053
Echinococcus multilocularis	glycine receptor subunit beta	0.0146	0.1607	0.1607
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0045	0.0273	1
Schistosoma mansoni	acetylcholine receptor-related	0.0081	0.0752	0.0752
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0147	0.1625	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0031	0.009	0.009
Schistosoma mansoni	cpg binding protein	0.0033	0.0108	0.0108
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0146	0.1607	0.1607
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0184	0.212	0.2071
Onchocerca volvulus		0.0031	0.0093	0.0035
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0145	0.1597	0.1597
Echinococcus granulosus	sodium channel protein	0.019	0.2195	0.2195
Echinococcus granulosus	zinc finger protein	0.0025	0.0007	0.0007
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.0508	0.0508
Loa Loa (eye worm)	ACC-1 protein	0.0146	0.1607	0.1555
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0132	0.142	0.142
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0146	0.1607	0.1607
Mycobacterium ulcerans	carboxylesterase, LipT	0.0132	0.142	0.8597
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.018	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0146	0.1607	0.1607
Schistosoma mansoni	nAChR subunit	0.0146	0.1607	0.1607
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0194	0.0041
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0031	0.009	0.5
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0081	0.0752	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Brugia malayi	Pre-SET motif family protein	0.0031	0.0093	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Loa Loa (eye worm)	hypothetical protein	0.0065	0.053	0.0472
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0093	0.0093
Brugia malayi	hypothetical protein	0.0031	0.009	0.003
Brugia malayi	Carboxylesterase family protein	0.0132	0.142	0.1368
Brugia malayi	Cation transporter family protein	0.0146	0.1607	0.1555
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0146	0.1607	0.1607
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.005	0.0338	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0779	1	1
Onchocerca volvulus		0.0047	0.0303	0.0267
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0146	0.1607	0.1555
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0081	0.0752	0.0752
Brugia malayi	hypothetical protein	0.0132	0.142	0.1368
Schistosoma mansoni	hypothetical protein	0.0072	0.0624	0.0624
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0065	0.053	0.0472
Echinococcus multilocularis	Blood coagulation inhibitor, Disintegrin	0.014	0.1529	0.1529
Onchocerca volvulus		0.0031	0.009	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0114	0.0054
Schistosoma mansoni	protein arginine n-methyltransferase	0.0128	0.1375	0.1375
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0167	0.4201
Onchocerca volvulus		0.0099	0.099	0.1021
Brugia malayi	Carm1-pending protein	0.0128	0.1375	0.1322
Loa Loa (eye worm)	hypothetical protein	0.0184	0.212	0.2071
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0301	0.3665	1
Brugia malayi	hypothetical protein	0.0039	0.0189	0.0129
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0038	0.018	0.018
Loa Loa (eye worm)	LGC-31 protein	0.0146	0.1607	0.1555
Schistosoma mansoni	alpha-glucosidase	0.0148	0.1631	0.1631
Echinococcus granulosus	acetylcholinesterase	0.0779	1	1
Echinococcus granulosus	adam 17 protease	0.0245	0.2924	0.2924
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0081	0.0752	0.0695
Echinococcus granulosus	cpg binding protein	0.0033	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Brugia malayi	Carboxylesterase family protein	0.0132	0.142	0.1368
Loa Loa (eye worm)	hypothetical protein	0.0716	0.9158	0.9153
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0114	0.0114
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0146	0.1607	0.1555
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0146	0.1607	0.1607
Schistosoma mansoni	sodium/chloride dependent transporter	0.0031	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0468	0.5883	0.5858
Echinococcus multilocularis	zinc finger protein	0.0025	0.0007	0.0007
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0146	0.1607	0.1607
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0624	0.0566
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0066	0.0546	0.0546
Brugia malayi	Hemopexin family protein	0.0067	0.0566	0.0508
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0114	0.0054
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0172	0.1958	0.1958
Mycobacterium ulcerans	hydrolase	0.0058	0.044	0.1874
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0301	0.3665	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0031	0.009	0.009
Toxoplasma gondii	ABC1 family protein	0.0037	0.0167	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0467	0.5861	0.5836
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0045	0.0273	0.0302
Brugia malayi	Matrixin family protein	0.0115	0.1193	0.114
Onchocerca volvulus	Matrilysin homolog	0.0047	0.0303	0.0267
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.018	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0065	0.053	0.0472
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0132	0.142	0.142
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0167	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Echinococcus multilocularis	cpg binding protein	0.0033	0.0108	0.0108
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0146	0.1607	0.1607
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0081	0.0752	0.0752
Loa Loa (eye worm)	Carm1-pending protein	0.0128	0.1375	0.1322
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0321	0.0262
Loa Loa (eye worm)	carboxylesterase	0.0132	0.142	0.1368
Echinococcus granulosus	neuroligin	0.0132	0.142	0.142
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0146	0.1607	0.1555
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0114	0.0114
Onchocerca volvulus		0.0245	0.2926	0.3149
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0038	0.018	0.012
Loa Loa (eye worm)	hypothetical protein	0.0184	0.212	0.2071
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0045	0.0273	0.142
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0147	0.1625	1
Onchocerca volvulus		0.0065	0.053	0.0516
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0038	0.018	0.0036
Brugia malayi	Cation transporter family protein	0.0716	0.9158	0.9153
Echinococcus multilocularis	a disintegrin and metalloproteinase with	0.0105	0.1071	0.1071
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0031	0.009	0.009
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0031	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0167	0.0107
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0038	0.018	0.0696
Plasmodium vivax	SET domain protein, putative	0.0031	0.0093	0.0113
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.018	0.0036
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0093	0.0093
Schistosoma mansoni	acetylcholinesterase	0.0132	0.142	0.142
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Echinococcus multilocularis	acetylcholinesterase	0.0779	1	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0184	0.212	0.212
Brugia malayi	Carboxylesterase family protein	0.0132	0.142	0.1368
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0624	0.0567
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0031	0.009	0.009
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0081	0.0752	0.0752
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0146	0.1607	0.1607
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0146	0.1607	0.1607
Brugia malayi	hypothetical protein	0.0081	0.0752	0.0695
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0093	0.0093
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0065	0.053	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0132	0.142	0.4731
Echinococcus granulosus	nAChR subunit	0.0065	0.053	0.053
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0105	0.1062	0.1008
Onchocerca volvulus		0.0716	0.9158	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.018	0.0036
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0158	0.0158
Schistosoma mansoni	ADAMTS5 peptidase (M12 family)	0.0105	0.1071	0.1071
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0058	0.044	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Brugia malayi	Carboxylesterase family protein	0.0779	1	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.0132	0.142	0.3582
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Onchocerca volvulus		0.0132	0.142	0.1494
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0716	0.9158	0.9158
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0031	0.009	0.009
Schistosoma mansoni	sodium/chloride dependent transporter	0.0031	0.009	0.009
Schistosoma mansoni	hypothetical protein	0.0033	0.0114	0.0114
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0167	0.0167
Schistosoma mansoni	bromodomain containing protein	0.0069	0.0594	0.0594
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0146	0.1607	0.1555
Echinococcus granulosus	geminin	0.035	0.4312	0.4312
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0031	0.009	0.003
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0031	0.009	0.003
Echinococcus granulosus	glycine receptor subunit beta	0.0146	0.1607	0.1607
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0081	0.0752	0.0695
Brugia malayi	Matrixin family protein	0.0047	0.0303	0.0244
Onchocerca volvulus	Matrilysin homolog	0.0105	0.1068	0.1107
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0132	0.142	0.142
Brugia malayi	excitatory GABA receptor EXP-1A	0.0146	0.1607	0.1555
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0065	0.053	0.053
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0031	0.009	0.003
Loa Loa (eye worm)	hypothetical protein	0.0031	0.009	0.003
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0031	0.009	0.003
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0146	0.1607	0.1607
Onchocerca volvulus		0.0037	0.0167	0.0117
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0171	0.1948	0.1898
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.0624	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0184	0.212	0.2071
Schistosoma mansoni	alpha glucosidase	0.0038	0.018	0.018
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0146	0.1607	0.1607
Schistosoma mansoni	zinc finger protein	0.0025	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Onchocerca volvulus		0.0037	0.0167	0.0117
Echinococcus multilocularis	dnaJ subfamily B	0.0414	0.5163	0.5163
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0132	0.142	0.3582
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0031	0.009	0.009
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0145	0.1597	0.1597
Echinococcus multilocularis	neuroligin	0.0132	0.142	0.142
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0065	0.053	0.0472
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0301	0.3665	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0031	0.009	0.009
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0145	0.1597	0.1597
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0167	0.0107
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0145	0.1597	0.1597
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0146	0.1607	0.1555
Brugia malayi	hypothetical protein	0.0081	0.0752	0.0695
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0145	0.1597	0.1545
Onchocerca volvulus		0.0132	0.142	0.1494
Loa Loa (eye worm)	hypothetical protein	0.0058	0.044	0.0382
Echinococcus granulosus	carboxylesterase 5A	0.0779	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0145	0.1597	0.1597
Echinococcus multilocularis	glycine receptor subunit beta	0.0146	0.1607	0.1607
Onchocerca volvulus		0.0184	0.212	0.2263
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0145	0.1597	0.1545
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0146	0.1607	0.1607
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.018	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.009	0.003
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0031	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0167	0.0107
Brugia malayi	hypothetical protein	0.0081	0.0752	0.0695
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0047	0.0303	0.0303
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0049	0.0321	0.0321
Loa Loa (eye worm)	acetyltransferase	0.0147	0.163	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0132	0.142	0.1368
Echinococcus granulosus	glycine receptor subunit beta	0.0146	0.1607	0.1607
Schistosoma mansoni	cpg binding protein	0.0033	0.0108	0.0108
Brugia malayi	metalloprotease disintegrin 16 with thrombospondin type I motif	0.0105	0.1071	0.1016
Giardia lamblia	Fructose-bisphosphate aldolase	0.0301	0.3665	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0301	0.3665	1
Echinococcus granulosus	nAChR subunit	0.0146	0.1607	0.1607
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0146	0.1607	0.1607
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Loa Loa (eye worm)	matrix metalloproteinase	0.0047	0.0303	0.0244
Entamoeba histolytica	hypothetical protein	0.0065	0.053	0.1006
Schistosoma mansoni	hypothetical protein	0.035	0.4312	0.4312
Echinococcus multilocularis	serotonin transporter	0.0184	0.212	0.212
Schistosoma mansoni	nAChR subunit	0.0081	0.0752	0.0752
Brugia malayi	acetyltransferase, GNAT family protein	0.0147	0.163	0.1579
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0147	0.163	0.163
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0081	0.0752	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Schistosoma mansoni	neurotransmitter gated ion channel	0.0081	0.0752	0.0752
Echinococcus granulosus	sodium and chloride dependent glycine	0.0031	0.009	0.009
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0093	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0031	0.009	0.003
Loa Loa (eye worm)	hypothetical protein	0.0065	0.053	0.0472
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0146	0.1607	0.1555
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0146	0.1607	0.1555
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0146	0.1607	0.1555
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0146	0.1607	0.1555
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0031	0.009	0.003
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0081	0.0752	0.0752
Schistosoma mansoni	hypothetical protein	0.0414	0.5163	0.5163
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0031	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0779	1	1
Schistosoma mansoni	nAChR subunit	0.0146	0.1607	0.1607
Onchocerca volvulus		0.0132	0.142	0.1494
Echinococcus granulosus	lysosomal alpha glucosidase	0.0171	0.1948	0.1948
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0167	0.0107
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0146	0.1607	0.1555
Onchocerca volvulus		0.0467	0.5861	0.6376
Echinococcus multilocularis	histone arginine methyltransferase CARMER	0.0128	0.1375	0.1375
Schistosoma mansoni	hypothetical protein	0.0033	0.0114	0.0114
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0216	0.2532	0.2486
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0132	0.142	0.4731
Schistosoma mansoni	BC026374 protein (S09 family)	0.0132	0.142	0.142
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0171	0.1948	0.1948
Echinococcus multilocularis	acetylcholinesterase	0.0779	1	1
Loa Loa (eye worm)	hypothetical protein	0.0132	0.142	0.1368
Onchocerca volvulus		0.0146	0.1607	0.1699
Onchocerca volvulus		0.0132	0.142	0.1494
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0167	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0065	0.053	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0065	0.053	0.0472
Onchocerca volvulus		0.0716	0.9158	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0301	0.3665	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0114	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0132	0.142	0.1368
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Schistosoma mansoni	hypothetical protein	0.0067	0.0566	0.0566
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.018	0.0036
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0146	0.1607	0.1555
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0301	0.3665	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Echinococcus granulosus	para nitrobenzyl esterase	0.0132	0.142	0.142
Onchocerca volvulus		0.0031	0.009	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0321	0.0321
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0146	0.1607	0.1555
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0146	0.1607	0.1555
Echinococcus granulosus	GPCR family 2	0.0033	0.0114	0.0114
Schistosoma mansoni	alpha-glucosidase	0.0148	0.1631	0.1631
Leishmania major	alpha glucosidase II subunit, putative	0.0038	0.018	0.0063
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0146	0.1607	0.1607
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0145	0.1597	0.1597
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0031	0.009	0.009
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0031	0.009	0.009
Schistosoma mansoni	nAChR subunit	0.0146	0.1607	0.1607
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0062	0.0499	0.3184
Loa Loa (eye worm)	norepinephrine transporter	0.0184	0.212	0.2071
Loa Loa (eye worm)	acetylcholine receptor protein	0.0081	0.0752	0.0695
Onchocerca volvulus		0.0037	0.0167	0.0117
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0081	0.0752	0.0695
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0069	0.0069
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0146	0.1607	0.1555
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0031	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0065	0.053	0.0472
Echinococcus multilocularis	adam 17 protease	0.0223	0.263	0.263
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0158	0.0158
Brugia malayi	hypothetical protein	0.0081	0.0752	0.0695
Schistosoma mansoni	nAChR subunit	0.0146	0.1607	0.1607
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0167	0.0167
Schistosoma mansoni	hypothetical protein	0.035	0.4312	0.4312
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0038	0.018	0.012
Mycobacterium leprae	PROBABLE HYDROLASE	0.0058	0.044	0.1874
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0031	0.009	0.003
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0081	0.0752	0.0695
Treponema pallidum	fructose-bisphosphate aldolase	0.0301	0.3665	1
Echinococcus granulosus	neutral alpha glucosidase AB	0.0038	0.018	0.018
Echinococcus granulosus	serotonin transporter	0.0184	0.212	0.212
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Onchocerca volvulus		0.0081	0.0752	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0147	0.1625	0.5503
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1062	0.1008
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0146	0.1607	0.1607
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.018	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0065	0.053	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0132	0.142	0.1368
Echinococcus multilocularis	carboxylesterase 5A	0.0779	1	1
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0114	0.0054
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0114	0.0114
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0146	0.1607	0.1555
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0167	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0317	0.0257
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0081	0.0752	0.0752
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0147	0.163	0.163
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0171	0.1948	0.1898
Echinococcus granulosus	acetylcholinesterase	0.0779	1	1
Echinococcus granulosus	Blood coagulation inhibitor Disintegrin	0.014	0.1529	0.1529
Schistosoma mansoni	gliotactin	0.0132	0.142	0.142
Schistosoma mansoni	hypothetical protein	0.0033	0.0114	0.0114
Brugia malayi	beta-lactamase family protein	0.0037	0.0167	0.0107
Loa Loa (eye worm)	serotonin transporter b	0.0184	0.212	0.2071
Echinococcus granulosus	dnaJ subfamily B	0.0414	0.5163	0.5163
Brugia malayi	hypothetical protein	0.0081	0.0752	0.0695
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0045	0.0273	0.142
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0146	0.1607	0.1555
Brugia malayi	Matrixin family protein	0.0047	0.0303	0.0244
Echinococcus multilocularis	para nitrobenzyl esterase	0.0132	0.142	0.142
Loa Loa (eye worm)	hypothetical protein	0.0031	0.009	0.003
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0303	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0752	0.0695
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0146	0.1607	0.1607
Trichomonas vaginalis	set domain proteins, putative	0.0245	0.2926	0.7885
Loa Loa (eye worm)	hypothetical protein	0.0039	0.019	0.013
Brugia malayi	Pre-SET motif family protein	0.0216	0.2532	0.2486
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0132	0.142	0.142
Onchocerca volvulus	Putative nachr subunit	0.0146	0.1607	0.1699
Onchocerca volvulus		0.0716	0.9158	1
Schistosoma mansoni	nAChR subunit	0.0146	0.1607	0.1607
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0141	0.1545	0.1545
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0031	0.009	0.009
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.018	0.0036
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.1062	0.1008
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0146	0.1607	0.1607
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.018	0.0036
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0146	0.1607	0.1607
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0114	0.0114
Echinococcus granulosus	sodium and chloride dependent glycine	0.0031	0.009	0.009
Onchocerca volvulus		0.0081	0.0752	0.0759
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0167	0.0167
Schistosoma mansoni	nAChR subunit	0.0146	0.1607	0.1607
Loa Loa (eye worm)	carboxylesterase	0.0132	0.142	0.1368
Brugia malayi	beta-lactamase family protein	0.0037	0.0167	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0634	0.8082	0.807
Onchocerca volvulus		0.0031	0.009	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0779	1	1
Echinococcus multilocularis	sodium channel protein	0.019	0.2195	0.2195
Brugia malayi	PHD-finger family protein	0.003	0.0079	0.0018
Schistosoma mansoni	neurotransmitter gated ion channel	0.0081	0.0752	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1607	0.1555
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0081	0.0752	0.0695
Schistosoma mansoni	ADAM17 peptidase (M12 family)	0.0223	0.263	0.263
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0146	0.1607	0.1555
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0132	0.142	0.142
Echinococcus granulosus	histone lysine methyltransferase setb	0.0049	0.0321	0.0321

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.6 nM	Inhibition of TACE	ChEMBL.	17064892
IC50 (binding)	= 1.6 nM	Inhibition of TACE	ChEMBL.	17064892
IC50 (binding)	= 161 nM	Inhibition of MMP2	ChEMBL.	17064892
IC50 (binding)	= 161 nM	Inhibition of MMP2	ChEMBL.	17064892
IC50 (binding)	= 1159 nM	Inhibition of MMP13	ChEMBL.	17064892
IC50 (binding)	= 1159 nM	Inhibition of MMP13	ChEMBL.	17064892
Ratio IC50 (functional)	> 100	Selectivity for TACE over MMP2	ChEMBL.	17064892
Ratio IC50 (functional)	> 100	Selectivity for TACE over MMP13	ChEMBL.	17064892

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL392505

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 438373