Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase domain 17 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K06059 a disintegrin and metalloproteinase domain 17, putative | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Disintegrin family protein | ADAM metallopeptidase domain 17 | 824 aa | 724 aa | 27.4 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0172 | 0.1848 | 0.2673 |
Loa Loa (eye worm) | carboxylesterase | 0.0356 | 0.69 | 0.69 |
Onchocerca volvulus | Matrilysin homolog | 0.0105 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0356 | 0.69 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0105 | 0 | 0.5 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.014 | 0.0958 | 0.1381 |
Brugia malayi | Carboxylesterase family protein | 0.0356 | 0.69 | 1 |
Brugia malayi | Matrixin family protein | 0.0115 | 0.0261 | 0.037 |
Echinococcus granulosus | acetylcholinesterase | 0.0356 | 0.69 | 1 |
Echinococcus granulosus | adam 17 protease | 0.0245 | 0.3855 | 0.5583 |
Echinococcus multilocularis | acetylcholinesterase | 0.0356 | 0.69 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0356 | 0.69 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0356 | 0.69 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0356 | 0.69 | 0.69 |
Loa Loa (eye worm) | matrixin family protein | 0.0115 | 0.0261 | 0.0261 |
Echinococcus granulosus | carboxylesterase 5A | 0.0356 | 0.69 | 1 |
Echinococcus multilocularis | adam 17 protease | 0.0223 | 0.3243 | 0.4696 |
Echinococcus granulosus | acetylcholinesterase | 0.0356 | 0.69 | 1 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0223 | 0.3243 | 0.4696 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0172 | 0.1848 | 0.2673 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 0.69 | 0.69 |
Loa Loa (eye worm) | hypothetical protein | 0.0356 | 0.69 | 0.69 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0356 | 0.69 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.014 | 0.0958 | 0.1381 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 nM | Inhibition of TACE | ChEMBL. | 17064892 |
IC50 (binding) | = 1.1 nM | Inhibition of TACE | ChEMBL. | 17064892 |
IC50 (binding) | = 40 nM | Inhibition of MMP2 | ChEMBL. | 17064892 |
IC50 (binding) | = 40 nM | Inhibition of MMP2 | ChEMBL. | 17064892 |
IC50 (binding) | = 56 nM | Inhibition of MMP13 | ChEMBL. | 17064892 |
IC50 (binding) | = 56 nM | Inhibition of MMP13 | ChEMBL. | 17064892 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.