Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | aldose reductase, putative | 0.0615 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0615 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0437 | 0.6954 | 0.5922 |
Onchocerca volvulus | 0.0615 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase | 0.0615 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0615 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0178 | 0.2529 | 0.5 |
Schistosoma mansoni | potassium channel beta | 0.0178 | 0.2529 | 0.2529 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0615 | 1 | 1 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0178 | 0.2529 | 0.2529 |
Trypanosoma cruzi | aldo-keto reductase | 0.0615 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0615 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0615 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0615 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0615 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0615 | 1 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0178 | 0.2529 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.0615 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0615 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0615 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0615 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0615 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0615 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0615 | 1 | 1 |
Onchocerca volvulus | 0.0615 | 1 | 1 | |
Entamoeba histolytica | aldose reductase, putative | 0.0615 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0615 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0615 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0615 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0178 | 0.2529 | 0.2529 |
Echinococcus multilocularis | aldo keto reductase | 0.0615 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0615 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0615 | 1 | 1 |
Onchocerca volvulus | 0.0615 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0615 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0615 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0615 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0615 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0615 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0615 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0615 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0615 | 1 | 0.5 |
Echinococcus multilocularis | aldehyde reductase | 0.0437 | 0.6954 | 0.6954 |
Loa Loa (eye worm) | oxidoreductase | 0.0615 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0615 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0615 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0615 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0615 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0615 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0615 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0437 | 0.6954 | 0.6954 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0615 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0615 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0615 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0615 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0615 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0615 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0615 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0615 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0615 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0615 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0615 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0615 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0615 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0615 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0615 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0615 | 1 | 1 |
Onchocerca volvulus | 0.0615 | 1 | 1 | |
Entamoeba histolytica | aldose reductase, putative | 0.0615 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0615 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0615 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0615 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0178 | 0.2529 | 0.2529 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0178 | 0.2529 | 0.2529 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0615 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0615 | 1 | 1 |
Onchocerca volvulus | 0.0178 | 0.2529 | 0.2529 | |
Plasmodium falciparum | aldehyde reductase, putative | 0.0178 | 0.2529 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0615 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0178 | 0.2529 | 0.2529 |
Loa Loa (eye worm) | oxidoreductase | 0.0615 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0615 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0615 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0615 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0615 | 1 | 1 |
Brugia malayi | NADH-dependent xylose reductase | 0.0178 | 0.2529 | 0.2529 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0615 | 1 | 1 |
Onchocerca volvulus | 0.0615 | 1 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0615 | 1 | 1 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0178 | 0.2529 | 0.5 |
Onchocerca volvulus | 0.0615 | 1 | 1 | |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0615 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0615 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0615 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0615 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 28 ug ml-1 | Binding affinity towards Penicillin-binding protein 2a from homogeneous MRSA COL strain using [3H]-radioligand | ChEMBL. | No reference |
IC50 (binding) | = 28 ug ml-1 | Binding affinity towards Penicillin-binding protein 2a from homogeneous MRSA COL strain using [3H]-radioligand | ChEMBL. | No reference |
MIC (functional) | = 0.05 ug ml-1 | Inhibitory activity against methicillin-sensitive staphylococcus aureus(MSSA) | ChEMBL. | No reference |
MIC (functional) | = 4.9 ug ml-1 | Inhibitory activity against enterococcus evaluated by computational method | ChEMBL. | No reference |
MIC (functional) | = 6.3 ug ml-1 | Inhibitory activity against methicillin-resistant staphylococcus aureus(MRSA) | ChEMBL. | No reference |
MIC (functional) | = 10.1 ug ml-1 | The gram-negative activity is derived from eleven strains selected from seven enteric genera | ChEMBL. | No reference |
MIC (functional) | = 14.6 ug ml-1 | Inhibitory activity against methicillin-resistant coagulase negative staphylococci (MRCNS) | ChEMBL. | No reference |
Susceptibility (binding) | Susceptibility of the compound to DHP-I (swine kidney enzyme); NT means not tested | ChEMBL. | No reference | |
Susceptibility (binding) | 0 | Susceptibility of the compound to DHP-I (swine kidney enzyme); NT means not tested | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.