TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 394.383 | Formula: C18H25F3O6
H donors: 1 H acceptors: 1 LogP: 2.14 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OCCOCC1=C(O[C@H]2C34C1CC[C@@H](C4CC[C@@](OO3)(O2)C)C)C(F)(F)F
InChi: 1S/C18H25F3O6/c1-10-3-4-13-11(9-23-8-7-22)14(18(19,20)21)24-15-17(13)12(10)5-6-16(2,25-15)26-27-17/h10,12-13,15,22H,3-9H2,1-2H3/t10-,12?,13?,15-,16-,17?/m1/s1
InChiKey: QHUDOEURFVUUGT-SECXBUAJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0016	0.0025	0.0025
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0719	1	1
Giardia lamblia	Aldose reductase	0.0719	1	0.5
Onchocerca volvulus		0.0719	1	1
Plasmodium falciparum	aldehyde reductase, putative	0.0208	0.2751	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0208	0.2751	0.2725
Echinococcus multilocularis	aldehyde reductase	0.0511	0.7044	0.7044
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0719	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0025	0.0025
Mycobacterium tuberculosis	Probable oxidoreductase	0.0719	1	1
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0719	1	1
Plasmodium falciparum	aldo-keto reductase, putative	0.0208	0.2751	0.5
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0719	1	1
Onchocerca volvulus		0.0719	1	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0025	0.0147	0.0147
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0031	0.0229	0.0229
Schistosoma mansoni	voltage-gated potassium channel	0.0025	0.0147	0.0147
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0208	0.2751	0.2751
Trichomonas vaginalis	aldo-keto reductase, putative	0.0719	1	1
Onchocerca volvulus	Bile acid receptor homolog	0.0031	0.0229	0.0229
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0031	0.0229	0.0229
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0031	0.0229	0.0229
Echinococcus granulosus	aldo keto reductase	0.0719	1	1
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0017	0.0036	0.0036
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0719	1	1
Brugia malayi	ecdysteroid receptor	0.0031	0.0229	0.0229
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0031	0.0229	0.0229
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0719	1	1
Schistosoma mansoni	potassium channel beta	0.0208	0.2751	0.2751
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0031	0.0229	0.0229
Schistosoma mansoni	coup transcription factor	0.0031	0.0229	0.0229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0031	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0025	0.0025
Schistosoma mansoni	voltage-gated potassium channel	0.0093	0.1121	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0229	0.0229
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0031	0.0229	0.0229
Leishmania major	prostaglandin f synthase, putative	0.0719	1	1
Brugia malayi	hypothetical protein	0.0016	0.0025	0.0025
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0208	0.2751	0.2751
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0031	0.0229	0.0229
Schistosoma mansoni	voltage-gated potassium channel	0.0093	0.1121	0.1121
Plasmodium vivax	aldehyde reductase, putative	0.0208	0.2751	0.5
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0017	0.0036	0.0036
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0719	1	1
Loa Loa (eye worm)	hypothetical protein	0.0719	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0031	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0229	0.0229
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0031	0.0229	0.0229
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0719	1	1
Leishmania major	aldo-keto reductase-like protein	0.0719	1	1
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0208	0.2751	0.2725
Echinococcus multilocularis	aldo keto reductase	0.0719	1	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0016	0.0025	0.0025
Entamoeba histolytica	aldose reductase, putative	0.0719	1	1
Loa Loa (eye worm)	oxidoreductase	0.0719	1	1
Brugia malayi	hypothetical protein	0.0016	0.0025	0.0025
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0017	0.0036	0.0036
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0719	1	1
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0208	0.2751	0.2751
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0017	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0229	0.0229
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.0229	0.0229
Loa Loa (eye worm)	oxidoreductase	0.0719	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0719	1	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0719	1	1
Entamoeba histolytica	aldose reductase, putative	0.0719	1	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0017	0.0036	0.0036
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0031	0.0229	0.0229
Echinococcus granulosus	voltage gated potassium channel subunit	0.0208	0.2751	0.2751
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0719	1	1
Onchocerca volvulus		0.0719	1	1
Schistosoma mansoni	aldo-keto reductase	0.0719	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0031	0.0229	0.0229
Echinococcus granulosus	voltage gated potassium channel	0.0025	0.0147	0.0147
Echinococcus multilocularis	FTZ F1 alpha	0.0031	0.0229	0.0229
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0017	0.0036	0.0036
Trichomonas vaginalis	aldo-keto reductase, putative	0.0719	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0208	0.2751	0.2725
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0031	0.0229	0.0229
Brugia malayi	nuclear receptor NHR-88	0.0031	0.0229	0.0229
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0031	0.0229	0.0229
Trichomonas vaginalis	aldo-keto reductase, putative	0.0719	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0025	0.0025
Onchocerca volvulus		0.0719	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0031	0.0229	0.0229
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0017	0.0036	0.0036
Schistosoma mansoni	thyroid hormone receptor	0.0031	0.0229	0.0229
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0719	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0719	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0719	1	1
Mycobacterium ulcerans	oxidoreductase	0.0719	1	1
Trypanosoma brucei	aldo-keto reductase, putative	0.0719	1	1
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0017	0.0036	0.0036
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0025	0.0147	0.0147
Toxoplasma gondii	aldose reductase, putative	0.0719	1	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0719	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0719	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0031	0.0229	0.0229
Mycobacterium leprae	Conserved hypothetical protein	0.0511	0.7044	0.5922
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0085	0.1009	0.1009
Trichomonas vaginalis	aldo-keto reductase, putative	0.0719	1	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0017	0.0036	0.0036
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0031	0.0229	0.0229
Echinococcus granulosus	ecdysone induced protein 78C	0.0031	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0229	0.0229
Trichomonas vaginalis	aldo-keto reductase, putative	0.0719	1	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0031	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0025	0.0025
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0719	1	1
Onchocerca volvulus		0.0208	0.2751	0.2751
Trichomonas vaginalis	aldo-keto reductase, putative	0.0208	0.2751	0.2725
Schistosoma mansoni	thyroid hormone receptor	0.0031	0.0229	0.0229
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0719	1	1
Echinococcus multilocularis	voltage gated potassium channel	0.0025	0.0147	0.0147
Echinococcus multilocularis	ecdysone induced protein 78C	0.0031	0.0229	0.0229
Brugia malayi	nuclear hormone receptor	0.0031	0.0229	0.0229
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.0229	0.0229
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0017	0.0036	0.0036
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0719	1	1
Echinococcus multilocularis	aldo keto reductase	0.0719	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0719	1	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0849	0.0849
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.0036	0.0036
Onchocerca volvulus	Protein ultraspiracle homolog	0.0031	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0229	0.0229
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0031	0.0229	0.0229
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0016	0.0025	0.0025
Loa Loa (eye worm)	steroid hormone receptor	0.0031	0.0229	0.0229
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.008	0.0929	0.0897
Brugia malayi	Steroid receptor seven-up type 2	0.0031	0.0229	0.0229
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0031	0.0229	0.0229
Echinococcus granulosus	aldo keto reductase	0.0719	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0031	0.0229	0.0229
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0719	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0719	1	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0017	0.0036	0.0036
Schistosoma mansoni	aldo-keto reductase	0.0719	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0229	0.0229
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0017	0.0036	0.0036
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0031	0.0229	0.0229
Echinococcus granulosus	hypothetical protein	0.0719	1	1
Echinococcus multilocularis	aldo keto reductase	0.0719	1	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0085	0.1009	0.1009
Onchocerca volvulus		0.0719	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0025	0.0147	0.0147
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0031	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0229	0.0229
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0031	0.0229	0.0229
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0031	0.0229	0.0229
Brugia malayi	Nuclear hormone receptor-like 1	0.0031	0.0229	0.0229
Trichomonas vaginalis	aldo-keto reductase, putative	0.0719	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0025	0.0147	0.0147
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0016	0.0025	0.0025
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0719	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0719	1	1
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0208	0.2751	0.2751
Onchocerca volvulus		0.0031	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0036	0.0036
Brugia malayi	nuclear receptor RXR	0.0016	0.0025	0.0025
Trichomonas vaginalis	aldo/keto reductase, putative	0.0719	1	1
Loa Loa (eye worm)	oxidoreductase	0.0719	1	1
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0017	0.0036	0.0036
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0016	0.0025	0.0025
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0031	0.0229	0.0229
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0719	1	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0017	0.0036	0.0036
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0719	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0031	0.0229	0.0229
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0085	0.1009	0.1009
Schistosoma mansoni	pol-related	0.0719	1	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0017	0.0036	0.0036
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0719	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0719	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0031	0.0229	0.0229
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0031	0.0229	0.0229
Echinococcus granulosus	hyperpolarization activated cyclic	0.0017	0.0036	0.0036
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0017	0.0036	0.0036
Trichomonas vaginalis	aldo/keto reductase, putative	0.0719	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0208	0.2751	0.2725
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0031	0.0229	0.0229
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0208	0.2751	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0031	0.0229	0.0229
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0031	0.0229	0.0229
Loa Loa (eye worm)	oxidoreductase	0.0719	1	1
Onchocerca volvulus		0.0719	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0719	1	1
Echinococcus granulosus	aldehyde reductase	0.0511	0.7044	0.7044
Echinococcus granulosus	aldo keto reductase	0.0719	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0031	0.0229	0.0229
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0031	0.0229	0.0229
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0031	0.0229	0.0229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0031	0.0229	0.0229
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0719	1	1
Echinococcus multilocularis	aldo keto reductase	0.0719	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0719	1	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0017	0.0036	0.0036
Schistosoma mansoni	nuclear hormone receptor	0.0031	0.0229	0.0229
Brugia malayi	photoreceptor-specific nuclear receptor	0.0031	0.0229	0.0229
Trichomonas vaginalis	aldo-keto reductase, putative	0.0719	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0719	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0719	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0025	0.0025
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.008	0.0929	0.0897
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0017	0.0036	0.0036
Trypanosoma brucei	prostaglandin f synthase	0.0719	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0025	0.0025
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0085	0.1009	0.1009
Brugia malayi	NADH-dependent xylose reductase	0.0208	0.2751	0.2751
Loa Loa (eye worm)	oxidoreductase	0.0719	1	1
Trypanosoma cruzi	aldo-keto reductase	0.0719	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0031	0.0229	0.0229
Brugia malayi	steroid hormone receptor	0.0031	0.0229	0.0229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0031	0.0229	0.0229
Trypanosoma cruzi	aldo/keto reductase, putative	0.0719	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.0229	0.0229
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.0229	0.0229
Giardia lamblia	Aldose reductase	0.0719	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0147	0.0147
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0719	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0031	0.0229	0.0229
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0031	0.0229	0.0229
Entamoeba histolytica	aldose reductase, putative	0.0719	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0229	0.0229
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0031	0.0229	0.0229

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 2.4 nM	In vitro inhibitory concentration on chloroquine resistant Plasmodium falciparum FcB1 strain	ChEMBL.	14998331
Parasitemia (functional)	0 %	In vivo antimalarial activity against Plasmodium bergi NK 173 in mice by intraperitoneal route at a concentration of 35.5 microM/kg at day 11; nd = not determined	ChEMBL.	14998331
Parasitemia (functional)	= 2 %	In vivo antimalarial activity against Plasmodium bergi NK 173 in mice by intraperitoneal route at a concentration of 35.5 microM/kg at day 4	ChEMBL.	14998331
Survival (functional)	= 5 %	Percent survival of mice after 20 days post infection of malarial parasite in out of 5 mice	ChEMBL.	14998331

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 145453

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 43845