Detailed information for compound 43849

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 424.576 | Formula: C26H36N2O3
  • H donors: 1 H acceptors: 2 LogP: 5.34 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H]1CCCN1C(=O)NC12C[C@@H]3C[C@H](C2)C[C@H](C1)C3)OCCCCc1ccccc1
  • InChi: 1S/C26H36N2O3/c29-24(31-12-5-4-9-19-7-2-1-3-8-19)23-10-6-11-28(23)25(30)27-26-16-20-13-21(17-26)15-22(14-20)18-26/h1-3,7-8,20-23H,4-6,9-18H2,(H,27,30)/t20-,21+,22-,23-,26?/m0/s1
  • InChiKey: YUECPDIXKSOAJX-WKMKYRINSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens FK506 binding protein 1A, 12kDa Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Peptidylprolyl isomerase D (Cyclophilin D), related Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania infantum fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium yoelii FK506-binding protein Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania braziliensis fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans hypothetical protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum ko:K09571 FK506-binding protein 4/5, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis fk506-binding protein, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium berghei peptidyl-prolyl cis-trans isomerase FKBP35, putative Get druggable targets OG5_126727 All targets in OG5_126727
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum FK506-binding protein 1A, putative Get druggable targets OG5_126727 All targets in OG5_126727
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) Get druggable targets OG5_126727 All targets in OG5_126727
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) FKBP5 protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania major peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis fk506 binding protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania major fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei gambiense peptidylprolyl isomerase-like protein, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania braziliensis peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma congolense FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania mexicana peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative Get druggable targets OG5_126727 All targets in OG5_126727
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum ko:K09568 FK506-binding protein 1, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium knowlesi peptidyl-prolyl cis-trans isomerase FKBP35, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania infantum peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis immunophilin, putative Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania mexicana fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 Get druggable targets OG5_126727 All targets in OG5_126727
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative FK506 binding protein 1A, 12kDa 108 aa 107 aa 48.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0056 0.2466 0.2466
Plasmodium falciparum apical sushi protein 0.0038 0.1371 0.096
Leishmania major peptidylprolyl isomerase-like protein 0.0065 0.3009 0.2675
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Plasmodium falciparum glutathione reductase 0.0066 0.3083 0.2753
Brugia malayi hypothetical protein 0.0038 0.1371 0.1297
Echinococcus granulosus delta-like protein 1 0.0021 0.0312 0.0312
Onchocerca volvulus 0.0038 0.1371 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.1631 0.1631
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Plasmodium falciparum thioredoxin reductase 0.0066 0.3083 0.2753
Brugia malayi Sushi domain 0.0038 0.1371 0.1297
Brugia malayi Delta serrate ligand family protein 0.0021 0.0312 0.0229
Onchocerca volvulus 0.0038 0.1371 1
Echinococcus multilocularis slit 2 protein 0.0021 0.0312 0.0312
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0065 0.3009 0.2675
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.3009 0.2675
Leishmania major N-myristoyl transferase, putative 0.0181 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.3009 0.2675
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0023 0.0455 0.5
Brugia malayi Cadherin domain containing protein 0.0021 0.0312 0.0229
Plasmodium vivax thioredoxin reductase, putative 0.0066 0.3083 0.2753
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0312 0.0229
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0065 0.3009 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.1371 0.1371
Loa Loa (eye worm) hypothetical protein 0.0038 0.1371 0.1371
Loa Loa (eye worm) FKBP5 protein 0.0065 0.3009 0.3009
Echinococcus granulosus protein jagged 1 0.0021 0.0312 0.0312
Echinococcus granulosus neurogenic locus notch protein 0.0021 0.0312 0.0312
Trypanosoma cruzi N-myristoyl transferase, putative 0.0181 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Onchocerca volvulus 0.0038 0.1371 1
Echinococcus multilocularis C type lectin domian containing protein 0.0038 0.1371 0.1371
Loa Loa (eye worm) N-myristoyltransferase 2 0.0181 1 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0065 0.3009 0.2675
Loa Loa (eye worm) hypothetical protein 0.0038 0.1371 0.1371
Brugia malayi Cadherin domain containing protein 0.0021 0.0312 0.0229
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.3009 0.2675
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.2466 0.2466
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0065 0.3009 0.3009
Echinococcus granulosus protein jagged 2 0.0021 0.0312 0.0312
Trypanosoma brucei N-myristoyltransferase 0.0181 1 1
Echinococcus granulosus protein jagged 1 0.0021 0.0312 0.0312
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0065 0.3009 0.2783
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Brugia malayi hypothetical protein 0.0038 0.1371 0.1297
Echinococcus multilocularis neurogenic locus notch protein 4 0.0021 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0065 0.3009 0.3009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Loa Loa (eye worm) glutathione reductase 0.0066 0.3083 0.3083
Echinococcus multilocularis neurogenic locus protein delta 0.0021 0.0312 0.0312
Onchocerca volvulus 0.0038 0.1371 1
Leishmania major fk506-binding protein 1-like protein 0.0065 0.3009 0.2675
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Loa Loa (eye worm) notch protein 0.0021 0.0312 0.0312
Echinococcus multilocularis neural cadherin 0.0021 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0038 0.1371 0.1371
Brugia malayi pregnancy-associated plasma protein-A 0.0038 0.1371 0.1297
Echinococcus multilocularis thioredoxin glutathione reductase 0.0066 0.3083 0.3083
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0455 0.0455
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.2466 0.2466
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0066 0.3083 1
Echinococcus multilocularis neurogenic locus notch protein 0.0021 0.0312 0.0312
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0065 0.3009 0.3009
Schistosoma mansoni N-myristoyltransferase 0.0181 1 1
Schistosoma mansoni c4b-binding protein beta chain 0.0038 0.1371 0.1093
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.3009 0.2675
Trypanosoma brucei trypanothione reductase 0.0066 0.3083 0.2753
Brugia malayi EGF-like domain containing protein 0.0021 0.0312 0.0229
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0312 0.0229
Loa Loa (eye worm) hypothetical protein 0.0038 0.1371 0.1371
Leishmania major trypanothione reductase 0.0066 0.3083 0.2753
Onchocerca volvulus 0.0038 0.1371 1
Echinococcus granulosus protein jagged 2 0.0021 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Trypanosoma brucei N-myristoyl transferase, putative 0.0181 1 1
Brugia malayi hypothetical protein 0.0038 0.1371 0.1297
Trichomonas vaginalis fk506-binding protein, putative 0.0065 0.3009 0.2675
Trichomonas vaginalis immunophilin, putative 0.0065 0.3009 0.2675
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0455 0.5
Echinococcus multilocularis neurogenic locus protein delta 0.0021 0.0312 0.0312
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0065 0.3009 0.2675
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0455 0.0147
Plasmodium vivax apical sushi protein, putative 0.0038 0.1371 0.096
Brugia malayi Muscle positioning protein 4 0.0021 0.0312 0.0229
Brugia malayi EGF-like domain containing protein 0.0021 0.0312 0.0229
Brugia malayi EGF-like domain containing protein 0.0021 0.0312 0.0229
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0065 0.3009 0.2949
Onchocerca volvulus 0.0038 0.1371 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.3009 0.2675
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0181 1 1
Brugia malayi EGF-like domain containing protein 0.0021 0.0312 0.0229
Echinococcus multilocularis protein jagged 1 0.0021 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Trypanosoma cruzi N-myristoyl transferase, putative 0.0181 1 1
Echinococcus granulosus neurogenic locus notch protein 4 0.0021 0.0312 0.0312
Brugia malayi hypothetical protein 0.0038 0.1371 0.1297
Schistosoma mansoni immunophilin 0.0065 0.3009 0.2783
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0038 0.1371 0.1371
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Brugia malayi EGF-like domain containing protein 0.0021 0.0312 0.0229
Loa Loa (eye worm) hypothetical protein 0.0059 0.2622 0.2622
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0065 0.3009 0.2783
Echinococcus granulosus neurogenic locus protein delta 0.0021 0.0312 0.0312
Onchocerca volvulus 0.0038 0.1371 1
Echinococcus multilocularis notch 0.0021 0.0312 0.0312
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0023 0.0455 0.5
Echinococcus multilocularis c4b binding protein beta chain 0.0038 0.1371 0.1371
Echinococcus multilocularis neurogenic locus notch protein 0.0021 0.0312 0.0312
Echinococcus granulosus notch 0.0021 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Toxoplasma gondii thioredoxin reductase 0.0066 0.3083 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0065 0.3009 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.1371 0.1371
Brugia malayi glutathione reductase 0.0066 0.3083 0.3024
Onchocerca volvulus 0.0038 0.1371 1
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0181 1 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0021 0.0312 0.0229
Brugia malayi EGF-like domain containing protein 0.0021 0.0312 0.0229
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0065 0.3009 0.2949
Loa Loa (eye worm) hypothetical protein 0.0038 0.1371 0.1371
Toxoplasma gondii rhoptry neck protein RON9 0.0038 0.1371 0.3822
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0455 0.0147
Toxoplasma gondii rhoptry neck protein RON1 0.0038 0.1371 0.3822
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0065 0.3009 0.2675
Brugia malayi Thioredoxin reductase 0.0066 0.3083 0.3024
Trypanosoma cruzi trypanothione reductase, putative 0.0066 0.3083 0.2753
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0065 0.3009 0.2783
Echinococcus granulosus neurogenic locus notch protein 0.0021 0.0312 0.0312
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0455 0.0515
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0181 1 1
Echinococcus granulosus slit 2 protein 0.0021 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Echinococcus multilocularis fk506 binding protein 0.0065 0.3009 0.3009
Echinococcus granulosus fibropellin Ia 0.0021 0.0312 0.0312
Echinococcus granulosus C type lectin domian containing protein 0.0038 0.1371 0.1371
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Echinococcus multilocularis fat cadherin tumor suppressor 0.0021 0.0312 0.0312
Echinococcus granulosus thioredoxin glutathione reductase 0.0066 0.3083 0.3083
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0455 0.0515
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Onchocerca volvulus 0.0038 0.1371 1
Loa Loa (eye worm) Notch2 0.0021 0.0312 0.0312
Plasmodium vivax glutathione reductase, putative 0.0066 0.3083 0.2753
Brugia malayi hypothetical protein 0.0038 0.1371 0.1297
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0455 0.5
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0181 1 1
Brugia malayi GCC2 and GCC3 family protein 0.0059 0.2622 0.2559
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.3009 0.2675
Echinococcus multilocularis protein jagged 1 0.0021 0.0312 0.0312
Giardia lamblia CDC72 0.0181 1 1
Brugia malayi hypothetical protein 0.0038 0.1371 0.1297
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0312 0.0229
Echinococcus multilocularis fibropellin Ia 0.0021 0.0312 0.0312
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0181 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Brugia malayi hypothetical protein 0.0038 0.1371 0.1297
Echinococcus multilocularis protein jagged 2 0.0021 0.0312 0.0312
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0455 0.0373
Loa Loa (eye worm) thioredoxin reductase 0.0066 0.3083 0.3083
Loa Loa (eye worm) hypothetical protein 0.0021 0.0312 0.0312
Echinococcus granulosus neural cadherin 0.0021 0.0312 0.0312
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0065 0.3009 0.3009
Brugia malayi notch-like transmembrane receptor 0.0021 0.0312 0.0229
Onchocerca volvulus 0.0038 0.1371 1
Schistosoma mansoni immunophilin 0.0056 0.2466 0.2223
Brugia malayi EGF-like domain containing protein 0.0021 0.0312 0.0229
Echinococcus granulosus c4b binding protein beta chain 0.0038 0.1371 0.1371
Schistosoma mansoni immunophilin 0.0065 0.3009 0.2783
Trichomonas vaginalis N-myristoyl transferase, putative 0.0181 1 1
Trichomonas vaginalis N-myristoyl transferase, putative 0.0119 0.6248 0.607

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 470 nM Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12 ChEMBL. 11992790
Ki (binding) = 470 nM Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12 ChEMBL. 11992790

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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