Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cathepsin B | Starlite/ChEMBL | References |
Homo sapiens | beta-site APP-cleaving enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin VII | beta-site APP-cleaving enzyme 1 | 401 aa | 352 aa | 21.3 % |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | cathepsin B | 339 aa | 368 aa | 26.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0166 | 0.289 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.289 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 0.289 | 0.289 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.0665 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 0.289 | 0.289 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Echinococcus granulosus | cathepsin b | 0.0166 | 0.289 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 0.289 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.0665 | 0.5 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0055 | 0.0665 | 0.0665 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0055 | 0.0665 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0166 | 0.289 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 0.289 | 1 |
Echinococcus granulosus | cathepsin b | 0.0166 | 0.289 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.0665 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 0.289 | 0.289 |
Loa Loa (eye worm) | cathepsin B | 0.0055 | 0.0665 | 0.2302 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0166 | 0.289 | 0.289 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0055 | 0.0665 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0055 | 0.0665 | 0.5 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Toxoplasma gondii | cathepsin B | 0.0055 | 0.0665 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 4 nM | Inhibition of BACE expressed in HEK293 cells | ChEMBL. | 17049233 |
EC50 (binding) | = 4 nM | Inhibition of BACE expressed in HEK293 cells | ChEMBL. | 17049233 |
IC50 (binding) | = 4 nM | Inhibition of BACE | ChEMBL. | 17049233 |
IC50 (binding) | = 4 nM | Inhibition of BACE | ChEMBL. | 17049233 |
IC50 (binding) | = 341 nM | Inhibition of cathepsin D | ChEMBL. | 17049233 |
IC50 (binding) | = 341 nM | Inhibition of cathepsin D | ChEMBL. | 17049233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.