Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin D (A01 family) | 0.0141 | 0.2319 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0105 | 0.1415 | 0.1175 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0111 | 0.1552 | 0.1403 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0111 | 0.1552 | 0.1509 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0105 | 0.1415 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0105 | 0.1415 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0106 | 0.1429 | 0.1067 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.2516 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0105 | 0.1415 | 0.1052 |
Mycobacterium ulcerans | thymidylate synthase | 0.0105 | 0.1415 | 0.5 |
Echinococcus granulosus | calpain A | 0.0111 | 0.1552 | 0.0259 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1121 | 0.0746 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0106 | 0.1429 | 0.015 |
Onchocerca volvulus | 0.0105 | 0.1415 | 1 | |
Brugia malayi | thymidylate synthase | 0.0105 | 0.1415 | 0.1415 |
Brugia malayi | sulfakinin receptor protein | 0.044 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.2516 | 0.5 |
Brugia malayi | calpain family protein 1 | 0.0106 | 0.1429 | 0.1429 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0713 | 0.0321 |
Brugia malayi | calpain family protein 1 | 0.0106 | 0.1429 | 0.1429 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0311 | 0.6689 | 1 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0111 | 0.1552 | 0.0259 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0311 | 0.6689 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0148 | 0.2516 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.2516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.2516 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1429 | 0.1067 |
Echinococcus multilocularis | calpain A | 0.0111 | 0.1552 | 0.1403 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0078 | 0.0713 | 0.0321 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0111 | 0.1552 | 0.1509 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0148 | 0.2516 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0141 | 0.2319 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimicrobial activity against Escherichia coli MC4100 assessed as inhibition zone at >2 mg/mL | ChEMBL. | 17150357 | |
Activity (functional) | 0 | Antimicrobial activity against Escherichia coli MC4100 assessed as inhibition zone at >2 mg/mL | ChEMBL. | 17150357 |
MIC (functional) | = 0.5 mg/ml | Antimicrobial activity against Bacillus subtilis | ChEMBL. | 17150357 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.