Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | progesterone receptor | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.6 nM | Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cells | ChEMBL. | 17317167 |
IC50 (functional) | = 1.6 nM | Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cells | ChEMBL. | 17317167 |
IC50 (functional) | = 56 nM | Antagonist activity at human glucocorticoid receptor assessed as inhibition of corticoid-induced transcription in human A549 cells by GRE-linked luciferase reporter gene assay | ChEMBL. | 17317167 |
IC50 (functional) | = 56 nM | Antagonist activity at human glucocorticoid receptor assessed as inhibition of corticoid-induced transcription in human A549 cells by GRE-linked luciferase reporter gene assay | ChEMBL. | 17317167 |
Ratio IC50 (binding) | = 35 | Selectivity of human progesterone receptor over human glucocorticoid receptor | ChEMBL. | 17317167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.