Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sterol regulatory element binding protein | 0.1555 | 0.4035 | 0.3525 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1555 | 0.4035 | 0.3525 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.3777 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.1555 | 0.4035 | 0.4035 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1555 | 0.4035 | 0.3525 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1555 | 0.4035 | 0.4035 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.3777 | 1 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1555 | 0.4035 | 0.3525 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3777 | 1 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.3777 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.3777 | 1 | 0.5 |
Echinococcus multilocularis | protein patched | 0.1555 | 0.4035 | 0.3525 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.3777 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3777 | 1 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.3777 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1772 | 0.4617 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1772 | 0.4617 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1555 | 0.4035 | 0.3525 |
Schistosoma mansoni | hypothetical protein | 0.0346 | 0.0788 | 0.0788 |
Echinococcus multilocularis | protein dispatched 1 | 0.1555 | 0.4035 | 0.3525 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1772 | 0.4617 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0346 | 0.0788 | 0.0788 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1772 | 0.4617 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3777 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED30 (functional) | = 5 uM kg-1 | Hypotensive activity in anesthetized rats, dose that produced a 30% fall in mean blood pressure | ChEMBL. | 6620302 |
ED30 (functional) | = 30 uM kg-1 | Hypotensive activity in anesthetized rats, dose that produced a 30% fall in mean blood pressure after 30 minutes | ChEMBL. | 6620302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.