Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 1 | 1 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0298 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 1 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0229 | 0.6414 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0229 | 0.6414 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 41 % | Inhibition of LPS-induced NO production in RAW 264.7 cells at 5 uM after 20 hrs | ChEMBL. | 17467989 |
Inhibition (functional) | = 41 % | Inhibition of LPS-induced NO production in RAW 264.7 cells at 5 uM after 20 hrs | ChEMBL. | 17467989 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.