Detailed information for compound 439316

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 565.684 | Formula: C29H35N5O5S
  • H donors: 0 H acceptors: 2 LogP: 2.63 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N([C@H]1CCN(C1)C1CCOCC1)C)N1CC[C@@H](C1)n1cnc2c(c1=O)sc(c2)c1ccc2c(c1)OCCO2
  • InChi: 1S/C29H35N5O5S/c1-31(21-4-8-32(16-21)20-6-10-37-11-7-20)29(36)33-9-5-22(17-33)34-18-30-23-15-26(40-27(23)28(34)35)19-2-3-24-25(14-19)39-13-12-38-24/h2-3,14-15,18,20-22H,4-13,16-17H2,1H3/t21-,22-/m0/s1
  • InChiKey: BEAGBDCOCNSBFF-VXKWHMMOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanin-concentrating hormone receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.0025 0.0156 0.0151
Brugia malayi Nuclear hormone receptor-like 1 0.0121 0.1557 0.1553
Echinococcus granulosus importin subunit beta 1 0.0028 0.0206 0.0489
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0121 0.1557 0.1553
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0121 0.1557 0.1553
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0057 0.0625 0.1447
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0663 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0121 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0625
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0121 0.1557 0.1557
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0523 0.1243
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0663 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0057 0.0625 0.0625
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0156 0.0156
Brugia malayi nuclear receptor NHR-88 0.0057 0.0625 0.062
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0064 0.0725 0.1721
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0121 0.1557 0.37
Echinococcus granulosus nuclear receptor nhr 48 0.0057 0.0625 0.1484
Schistosoma mansoni coup transcription factor 0.0121 0.1557 0.3672
Trypanosoma brucei protein kinase, putative 0.005 0.0523 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0121 0.1557 0.1553
Schistosoma mansoni importin beta-1 0.0028 0.0206 0.0447
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0625 0.1447
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.1228 0.2917
Schistosoma mansoni hypothetical protein 0.0042 0.0411 0.0938
Schistosoma mansoni hypothetical protein 0.0042 0.0411 0.0938
Brugia malayi hypothetical protein 0.0064 0.0725 0.072
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0057 0.0625 0.1484
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0725 0.072
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.129 0.1285
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0359 0.3997
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0359 0.6141
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0156 0.0156
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0127 0.0726
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0206 0.256
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0018 0.0043
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0096 0.0092
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0523 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0625 0.1484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0121 0.1557 0.1557
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0121 0.1557 0.37
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0121 0.1557 0.3672
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.129 0.3064
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0663 0.1539
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0121 0.1557 0.37
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0663 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0064 0.0725 0.1685
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0121 0.1557 0.37
Brugia malayi nuclear receptor NHR-67 0.0057 0.0625 0.062
Brugia malayi nuclear hormone receptor 0.0121 0.1557 0.1553
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0127 0.0726
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0523 1
Loa Loa (eye worm) nuclear hormone receptor 0.0057 0.0625 0.0625
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0523 0.1243
Brugia malayi orphan nuclear receptor NR2E1 0.0057 0.0625 0.062
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1599 0.3798
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0121 0.1557 0.37
Brugia malayi nuclear receptor RXR 0.0057 0.0625 0.062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0121 0.1557 0.1557
Schistosoma mansoni RAR-like nuclear receptor 0.0121 0.1557 0.3672
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0663 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0018 0.0018
Echinococcus granulosus snurportin 1 0.0302 0.421 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0057 0.0625 0.062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0121 0.1557 0.1553
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0523 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0523 0.7528
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0359 0.6141
Brugia malayi conserved hypotetical protein 0.0057 0.0625 0.062
Schistosoma mansoni patched 1 0.0044 0.0435 0.0993
Echinococcus granulosus Nuclear hormone receptor HR96 0.0057 0.0625 0.1484
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0359 0.2196
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0625
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0435 0.1033
Echinococcus multilocularis expressed conserved protein 0.0096 0.1199 0.2848
Brugia malayi hypothetical protein 0.0064 0.0725 0.072
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.1228 0.2917
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.421 0.421
Schistosoma mansoni nuclear receptor 0.0057 0.0625 0.1447
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0121 0.1557 0.3672
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0161 0.1503
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0523 1
Schistosoma mansoni hypothetical protein 0.0123 0.1599 0.3771
Brugia malayi nuclear receptor NHR-88 0.0121 0.1557 0.1553
Brugia malayi Nuclear hormone receptor E75 0.0057 0.0625 0.062
Loa Loa (eye worm) hypothetical protein 0.0044 0.0435 0.0435
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0507 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0435 0.7925
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0121 0.1557 0.37
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0725 0.072
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0161 0.1131
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0121 0.1557 0.1557
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.1932 0.459
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1228 0.2886
Onchocerca volvulus 0.0121 0.1557 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0625
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1228 0.2886
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0523 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0663 1
Echinococcus multilocularis snurportin 1 0.0302 0.421 1
Echinococcus granulosus expressed conserved protein 0.0096 0.1199 0.2848
Schistosoma mansoni zinc finger protein 0.0057 0.0625 0.1447
Schistosoma mansoni nuclear hormone receptor 0.0121 0.1557 0.3672
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.1228 0.1228
Brugia malayi nuclear hormone receptor family member odr-7 0.0057 0.0625 0.062
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0018 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0523 0.1205
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0206
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0057 0.0625 0.1484
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0523 0.0523
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0033 0.0281 0.0281
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0359 1
Toxoplasma gondii exonuclease III APE 0.0039 0.0359 0.4622
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.129 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0121 0.1557 0.37
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0127 0.0726
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0625
Schistosoma mansoni hypothetical protein 0.0302 0.421 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0057 0.0625 0.1484
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0064 0.0725 0.0725
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0507 0.0507
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.1932 0.459
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0359 0.0852
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0435 0.1033
Brugia malayi Cytochrome P450 family protein 0.0025 0.0156 0.0151
Brugia malayi MAP kinase sur-1 0.005 0.0523 0.0519
Echinococcus multilocularis protein patched 0.0044 0.0435 0.1033
Loa Loa (eye worm) hypothetical protein 0.0121 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0121 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0064 0.0725 0.0725
Brugia malayi nuclear hormone receptor 0.0057 0.0625 0.062
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0663 0.1539
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0523 0.7528
Loa Loa (eye worm) hypothetical protein 0.0064 0.0725 0.0725
Loa Loa (eye worm) hypothetical protein 0.0064 0.0725 0.0725
Brugia malayi Nuclear hormone receptor E75 0.0057 0.0625 0.062
Onchocerca volvulus Protein ultraspiracle homolog 0.0121 0.1557 1
Brugia malayi hypothetical protein 0.0057 0.0625 0.062
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0096 0.0229
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0359 0.5
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0064 0.0725 0.1721
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0121 0.1557 0.37
Schistosoma mansoni steroid hormone receptor ad4bp 0.0121 0.1557 0.3672
Brugia malayi CHE-14 protein 0.0044 0.0435 0.043
Echinococcus multilocularis thyroid hormone receptor alpha 0.0244 0.3364 0.7992
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.1228 0.2917
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0359 0.6141
Loa Loa (eye worm) hypothetical protein 0.0121 0.1557 0.1557
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0121 0.1557 0.37
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0359 0.6141
Loa Loa (eye worm) DR-78 0.0057 0.0625 0.0625
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.1313 0.3089
Schistosoma mansoni ran 0.0021 0.0096 0.0187
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0206 0.0489
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0057 0.0625 0.1484
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0127 0.0726
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0121 0.1557 0.1557
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0663 0.1576
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0121 0.1557 0.3672
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0435 0.1033
Echinococcus granulosus thyroid hormone receptor alpha 0.0057 0.0625 0.1484
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.1228 0.2917
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0018 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0121 0.1557 0.1553
Echinococcus granulosus GPCR family 2 0.0015 0.0018 0.0043
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0161 0.2448
Brugia malayi Importin beta-1 subunit 0.0028 0.0206 0.0201
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0206 0.1927
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0625 0.1484
Schistosoma mansoni thyroid hormone receptor 0.0244 0.3364 0.7983
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0156 0.1385
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0625
Leishmania major hypothetical protein, conserved 0.0025 0.0161 0.1131
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0435 0.0435
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0121 0.1557 0.1553
Onchocerca volvulus Bile acid receptor homolog 0.0121 0.1557 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0064 0.0725 0.1685
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0156 0.1385
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0625
Schistosoma mansoni hypothetical protein 0.0042 0.0411 0.0938
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0161 0.1503
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0161 0.2448
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0849 0.2016
Leishmania major importin beta-1 subunit, putative 0.0023 0.0127 0.0547
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0523 1
Brugia malayi RNA, U transporter 1 0.008 0.0969 0.0964
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0625
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0121 0.1557 0.37
Schistosoma mansoni ap endonuclease 0.0039 0.0359 0.0812
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1228 0.2886
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0051
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0161 0.2448
Echinococcus multilocularis FTZ F1 alpha 0.0121 0.1557 0.37
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0121 0.1557 0.3672
Echinococcus multilocularis nuclear receptor nhr 48 0.0057 0.0625 0.1484
Loa Loa (eye worm) hypothetical protein 0.0121 0.1557 0.1557
Schistosoma mansoni hypothetical protein 0.0033 0.0281 0.0627
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0096 0.0229
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0121 0.1557 0.37
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0057 0.0625 0.1484
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0849 0.2016
Schistosoma mansoni ran 0.0021 0.0096 0.0187
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0121 0.1557 0.37
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0359 0.5
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0523 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.1557 0.1557
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0057 0.0625 0.1447
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0121 0.1557 0.3672
Loa Loa (eye worm) hypothetical protein 0.0121 0.1557 0.1557
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0121 0.1557 0.1553
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0121 0.1557 0.1553
Schistosoma mansoni thyroid hormone receptor 0.0244 0.3364 0.7983
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0523 0.1243
Brugia malayi hypothetical protein 0.0057 0.0625 0.062
Loa Loa (eye worm) hypothetical protein 0.0064 0.0725 0.0725
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0121 0.1557 0.1553
Brugia malayi ecdysone receptor 0.0057 0.0625 0.062
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0359 0.4622
Schistosoma mansoni nuclear receptor 0.0057 0.0625 0.1447
Plasmodium vivax importin-beta 2, putative 0.0028 0.0206 0.417
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0523 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.1557 0.1557
Entamoeba histolytica hypothetical protein 0.0023 0.0127 0.026
Loa Loa (eye worm) hypothetical protein 0.0102 0.129 0.129
Echinococcus granulosus Nuclear hormone receptor HR96 0.0057 0.0625 0.1484
Brugia malayi nuclear receptor RXR 0.0064 0.0725 0.072
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0507 0.0503
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0523 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0121 0.1557 0.1553
Brugia malayi tailless protein 0.0057 0.0625 0.062
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0018 0.0043
Brugia malayi steroid hormone receptor 0.0121 0.1557 0.1553
Loa Loa (eye worm) steroid hormone receptor 0.0121 0.1557 0.1557
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0625 0.1447
Schistosoma mansoni hypothetical protein 0.0042 0.0411 0.0938
Schistosoma mansoni ap endonuclease 0.0039 0.0359 0.0812
Plasmodium falciparum importin beta, putative 0.0028 0.0206 0.417
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0057 0.0625 0.0625
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.0049 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0625
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0523 0.7528
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0121 0.1557 0.1553
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0096 0.0096
Brugia malayi hypothetical protein 0.0016 0.003 0.0025
Brugia malayi Steroid receptor seven-up type 2 0.0121 0.1557 0.1553
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.129 0.3064
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0057 0.0625 0.062
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0523 0.1243
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0359 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0625
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0359 0.6141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0121 0.1557 0.1557
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0359 0.0354
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0663 0.1576
Brugia malayi hypothetical protein 0.0025 0.0161 0.0156
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0697 1 1
Leishmania major cytochrome p450-like protein 0.0025 0.0156 0.1042
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.0054 0.0579 0.0579
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0359 0.0852
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0121 0.1557 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0121 0.1557 0.37
Echinococcus multilocularis GPCR, family 2 0.0015 0.0018 0.0043
Schistosoma mansoni nuclear receptor nhr-48 0.0057 0.0625 0.1447
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0121 0.1557 0.1553
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0625
Echinococcus granulosus FTZ F1 alpha 0.0121 0.1557 0.37
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1599 0.3798
Loa Loa (eye worm) hypothetical protein 0.0064 0.0725 0.0725
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0359 0.6141
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0663 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0281 0.0276
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0359 0.0359
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0161 0.1503
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0156 0.1385
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0206 0.256
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0121 0.1557 0.3672
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0121 0.1557 0.37
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.1228 0.1224
Loa Loa (eye worm) hypothetical protein 0.0121 0.1557 0.1557
Echinococcus granulosus ecdysone induced protein 78C 0.0121 0.1557 0.37
Brugia malayi photoreceptor-specific nuclear receptor 0.0121 0.1557 0.1553
Loa Loa (eye worm) hypothetical protein 0.0025 0.0161 0.0161
Brugia malayi ecdysteroid receptor 0.0121 0.1557 0.1553
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0121 0.1557 0.1553
Echinococcus multilocularis protein dispatched 1 0.005 0.0525 0.1248
Schistosoma mansoni retinoic acid receptor RXR 0.0121 0.1557 0.3672
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0625
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0523 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 45 nM Binding affinity to human MCHR1 ChEMBL. 17329101
Ki (binding) = 45 nM Binding affinity to human MCHR1 ChEMBL. 17329101

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.