Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | aldo-keto reductase | 0.2626 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2626 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.2626 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2626 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2626 | 1 | 1 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0227 | 0.0698 | 0.0698 |
Echinococcus multilocularis | aldehyde reductase | 0.1865 | 0.7051 | 0.7051 |
Loa Loa (eye worm) | oxidoreductase | 0.2626 | 1 | 1 |
Onchocerca volvulus | 0.2626 | 1 | 1 | |
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0227 | 0.0698 | 0.0698 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0227 | 0.0698 | 0.0698 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2626 | 1 | 1 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0227 | 0.0698 | 0.0698 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.076 | 0.2768 | 0.2768 |
Brugia malayi | Muscleblind-like protein | 0.0156 | 0.0424 | 0.0424 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.076 | 0.2768 | 0.2768 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.076 | 0.2768 | 0.2768 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.076 | 0.2768 | 0.2768 |
Onchocerca volvulus | 0.1085 | 0.4027 | 0.3578 | |
Mycobacterium tuberculosis | Conserved protein | 0.076 | 0.2768 | 0.2225 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0858 | 0.3147 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0858 | 0.3147 | 0.3147 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2626 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0424 | 0.0424 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0576 | 0.205 | 0.205 |
Echinococcus granulosus | hypothetical protein | 0.2626 | 1 | 1 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0227 | 0.0698 | 0.0698 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.2626 | 1 | 1 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.076 | 0.2768 | 0.2225 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0698 | 0.0698 |
Trypanosoma brucei | aldo/keto reductase, putative | 0.076 | 0.2768 | 0.2768 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0227 | 0.0698 | 0.0698 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1085 | 0.4027 | 0.4027 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2626 | 1 | 1 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0833 | 0.305 | 0.305 |
Leishmania major | fatty-acid desaturase, putative | 0.1085 | 0.4027 | 0.4027 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2626 | 1 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0227 | 0.0698 | 0.0698 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2626 | 1 | 1 |
Onchocerca volvulus | 0.2626 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase | 0.2626 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.2626 | 1 | 1 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0227 | 0.0698 | 0.0698 |
Brugia malayi | acyl-CoA desaturase | 0.0858 | 0.3147 | 0.3147 |
Echinococcus granulosus | aldo keto reductase | 0.2626 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.2626 | 1 | 1 |
Leishmania major | fatty acid desaturase, putative | 0.0227 | 0.0698 | 0.0698 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1085 | 0.4027 | 0.4027 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0424 | 0.0424 |
Schistosoma mansoni | fatty acid desaturase | 0.0227 | 0.0698 | 0.0698 |
Trypanosoma cruzi | cytochrome b5-dependent oleate desaturase | 0.0227 | 0.0698 | 0.0698 |
Onchocerca volvulus | 0.2626 | 1 | 1 | |
Loa Loa (eye worm) | fatty acid desaturase | 0.0227 | 0.0698 | 0.0698 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2626 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.2626 | 1 | 0.5 |
Loa Loa (eye worm) | FAT-3 protein | 0.0227 | 0.0698 | 0.0698 |
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0227 | 0.0698 | 0.0698 |
Echinococcus granulosus | aldo keto reductase | 0.2626 | 1 | 1 |
Leishmania major | fatty acid desaturase, putative | 0.0227 | 0.0698 | 0.0698 |
Trypanosoma cruzi | sphingolipid delta 4 desaturase, putative | 0.0227 | 0.0698 | 0.0698 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2626 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.1865 | 0.7051 | 0.5922 |
Loa Loa (eye worm) | oxidoreductase | 0.2626 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.076 | 0.2768 | 0.2768 |
Schistosoma mansoni | pol-related | 0.2626 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.085 | 0.3113 | 0.3113 |
Mycobacterium ulcerans | hypothetical protein | 0.076 | 0.2768 | 0.2225 |
Leishmania major | delta-12 fatty acid desaturase | 0.0227 | 0.0698 | 0.0698 |
Leishmania major | prostaglandin f synthase, putative | 0.2626 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2626 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2626 | 1 | 1 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0227 | 0.0698 | 0.0698 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2626 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2626 | 1 | 1 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.076 | 0.2768 | 0.2768 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2626 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2626 | 1 | 1 |
Leishmania major | aldo/keto reductase, putative,aldo/keto reductase family-like protein | 0.076 | 0.2768 | 0.2768 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2626 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0156 | 0.0424 | 0.0424 |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0227 | 0.0698 | 0.0698 |
Onchocerca volvulus | 0.076 | 0.2768 | 0.2225 | |
Onchocerca volvulus | 0.2626 | 1 | 1 | |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2626 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2626 | 1 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0227 | 0.0698 | 0.0698 |
Leishmania major | delta-5 fatty acid desaturase | 0.0227 | 0.0698 | 0.0698 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2626 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.2626 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2626 | 1 | 1 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0227 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | oxidoreductase | 0.2626 | 1 | 1 |
Toxoplasma gondii | aldo-keto reductase | 0.076 | 0.2768 | 0.2225 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0156 | 0.0424 | 0.0424 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0858 | 0.3147 | 0.3147 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2626 | 1 | 1 |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.076 | 0.2768 | 0.2225 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2626 | 1 | 1 |
Schistosoma mansoni | potassium channel beta | 0.076 | 0.2768 | 0.2768 |
Leishmania major | delta-6 fatty acid desaturase | 0.0227 | 0.0698 | 0.0698 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0227 | 0.0698 | 0.0698 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2626 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2626 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2626 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2626 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0858 | 0.3147 | 0.3147 |
Echinococcus multilocularis | aldo keto reductase | 0.2626 | 1 | 1 |
Brugia malayi | NADH-dependent xylose reductase | 0.076 | 0.2768 | 0.2768 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2626 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.2626 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.2626 | 1 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0227 | 0.0698 | 0.0698 |
Trypanosoma brucei | prostaglandin f synthase | 0.2626 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.2626 | 1 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0576 | 0.205 | 0.205 |
Toxoplasma gondii | aldose reductase, putative | 0.2626 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.2626 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.2626 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2626 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2626 | 1 | 1 |
Onchocerca volvulus | 0.2626 | 1 | 1 | |
Echinococcus granulosus | aldehyde reductase | 0.1865 | 0.7051 | 0.7051 |
Echinococcus multilocularis | muscleblind protein | 0.0156 | 0.0424 | 0.0424 |
Echinococcus multilocularis | aldo keto reductase | 0.2626 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.2626 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2626 | 1 | 1 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0227 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | hypothetical protein | 0.2626 | 1 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0858 | 0.3147 | 1 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0227 | 0.0698 | 0.0698 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2626 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2626 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.2626 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2626 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2626 | 1 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0227 | 0.0698 | 0.0698 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2626 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2626 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.2626 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2626 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.2626 | 1 | 1 |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0227 | 0.0698 | 0.0698 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0227 | 0.0698 | 0.0698 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.2626 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2626 | 1 | 1 |
Brugia malayi | Serotonin receptor | 0.0572 | 0.2036 | 0.2036 |
Leishmania major | delta-4 fatty acid desaturase | 0.0227 | 0.0698 | 0.0698 |
Loa Loa (eye worm) | oxidoreductase | 0.2626 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2626 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.2626 | 1 | 1 |
Leishmania major | stearic acid desaturase, putative | 0.1085 | 0.4027 | 0.4027 |
Schistosoma mansoni | aldo-keto reductase | 0.2626 | 1 | 1 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0227 | 0.0698 | 0.0698 |
Onchocerca volvulus | 0.1085 | 0.4027 | 0.3578 | |
Onchocerca volvulus | 0.2626 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2626 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Agonist activity at human 5HT2A receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 | |
Activity (functional) | Agonist activity at human 5HT2B receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 | |
Activity (functional) | Agonist activity at human 5HT2C receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 | |
Activity (functional) | 0 | Agonist activity at human 5HT2A receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 |
Activity (functional) | 0 | Agonist activity at human 5HT2B receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 |
Activity (functional) | 0 | Agonist activity at human 5HT2C receptor expressed in HEK293 cells by measuring intracellular calcium mobilization upto 10 uM | ChEMBL. | 17079142 |
Log Ki (binding) | Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 cells | ChEMBL. | 17079142 | |
Log Ki (binding) | Displacement of [3H]mesulergine from human 5HT2C receptor expressed in HEK293 cells | ChEMBL. | 17079142 | |
Log Ki (binding) | Displacement of [3H]5HT from human 5HT2B receptor expressed in HEK293 cells | ChEMBL. | 17079142 | |
Log Ki (binding) | 0 | Displacement of [3H]mesulergine from human 5HT2C receptor expressed in HEK293 cells | ChEMBL. | 17079142 |
Log Ki (binding) | 0 | Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 cells | ChEMBL. | 17079142 |
Log Ki (binding) | 0 | Displacement of [3H]5HT from human 5HT2B receptor expressed in HEK293 cells | ChEMBL. | 17079142 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.