Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 3 (endothelial cell) | Starlite/ChEMBL | References |
Homo sapiens | nitric oxide synthase 1 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.6798 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0059 | 0.0033 | 0.0033 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0059 | 0.0033 | 0.0033 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6599 | 0.9706 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0059 | 0.0033 | 0.001 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0059 | 0.0033 | 0.001 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0059 | 0.0033 | 0.0033 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0059 | 0.0033 | 0.0033 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3259 | 0.4766 | 0.4766 |
Schistosoma mansoni | dihydrofolate reductase | 0.6798 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.6798 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0059 | 0.0033 | 0.0033 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6599 | 0.9706 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.3259 | 0.4766 | 0.3256 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.6599 | 0.9706 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.3259 | 0.4766 | 0.4766 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0059 | 0.0033 | 0.0033 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1551 | 0.2239 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.3259 | 0.4766 | 0.4766 |
Mycobacterium ulcerans | thymidylate synthase | 0.3259 | 0.4766 | 0.4749 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0059 | 0.0033 | 0.0045 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.6599 | 0.9706 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.6798 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.6798 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1551 | 0.2239 | 0.228 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0052 | 0.0024 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.6798 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0059 | 0.0033 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0033 | 0.0033 |
Brugia malayi | thymidylate synthase | 0.3259 | 0.4766 | 0.4766 |
Chlamydia trachomatis | dihydrofolate reductase | 0.6798 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0059 | 0.0033 | 0.0033 |
Brugia malayi | hypothetical protein | 0.1551 | 0.2239 | 0.2239 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.6599 | 0.9706 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.3259 | 0.4766 | 0.4766 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.6599 | 0.9706 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.6798 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0059 | 0.0033 | 0.0033 |
Onchocerca volvulus | 0.3259 | 0.4766 | 0.5 | |
Giardia lamblia | Hypothetical protein | 0.0052 | 0.0024 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.6798 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.6 uM | Inhibition of human neuronal NOS activity | ChEMBL. | 17317165 |
IC50 (binding) | = 4.6 uM | Inhibition of human neuronal NOS activity | ChEMBL. | 17317165 |
IC50 (binding) | = 12 uM | Inhibition of human endothelial NOS activity | ChEMBL. | 17317165 |
IC50 (binding) | = 12 uM | Inhibition of human endothelial NOS activity | ChEMBL. | 17317165 |
IC50 (binding) | = 97 uM | Inhibition of human inducible NOS activity | ChEMBL. | 17317165 |
IC50 (binding) | = 97 uM | Inhibition of human inducible NOS activity | ChEMBL. | 17317165 |
Ratio IC50 (binding) | = 3 | Selectivity for human nNOS over human eNOS | ChEMBL. | 17317165 |
Ratio IC50 (binding) | = 21 | Selectivity for human nNOS over human iNOS | ChEMBL. | 17317165 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.