Detailed information for compound 439822

Basic information

Technical information
  • TDR Targets ID: 439822
  • Name: 3-(4-fluorophenyl)-6-hydroxy-4-oxo-7H-thieno[ 2,3-b]pyridine-5-carbonitrile
  • MW: 286.281 | Formula: C14H7FN2O2S
  • H donors: 2 H acceptors: 3 LogP: 2.92 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(=O)[nH]c2c(c1O)c(cs2)c1ccc(cc1)F
  • InChi: 1S/C14H7FN2O2S/c15-8-3-1-7(2-4-8)10-6-20-14-11(10)12(18)9(5-16)13(19)17-14/h1-4,6H,(H2,17,18,19)
  • InChiKey: FXZKXWHZVPQTSB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(4-fluorophenyl)-6-hydroxy-4-keto-7H-thieno[2,3-b]pyridine-5-carbonitrile
  • 3-(4-fluorophenyl)-6-hydroxy-4-oxo-7H-thieno[3,2-e]pyridine-5-carbonitrile
  • 3-(4-fluorophenyl)-6-hydroxy-4-keto-7H-thieno[3,2-e]pyridine-5-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 0.0373 0.0445
Schistosoma mansoni neuropeptide receptor 0.0786 0.3816 0.4549
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0034 0.0072 0.0086
Loa Loa (eye worm) hypothetical protein 0.0907 0.4419 0.4399
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 0.0373 0.0445
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0786 0.3816 0.4549
Brugia malayi Matrixin family protein 0.0043 0.0117 0.0083
Echinococcus granulosus dnaJ subfamily B 0.1705 0.8389 1
Loa Loa (eye worm) TYRA-2 protein 0.0786 0.3816 0.3795
Plasmodium falciparum plasmepsin VI 0.0049 0.0145 0.0195
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0043 0.0117 0.0139
Onchocerca volvulus Neuropeptide F receptor homolog 0.0786 0.3816 1
Schistosoma mansoni amine GPCR 0.0786 0.3816 0.4549
Loa Loa (eye worm) proprotein convertase 2 0.0071 0.0255 0.0221
Schistosoma mansoni nck2/grb4 0.003 0.0051 0.0061
Echinococcus granulosus tubulin subunit beta 0.116 0.5677 0.6767
Leishmania major beta tubulin 0.116 0.5677 1
Brugia malayi G protein-coupled receptor 0.0786 0.3816 0.3795
Leishmania major beta tubulin 0.116 0.5677 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0786 0.3816 0.4549
Echinococcus granulosus neuropeptides capa receptor 0.0786 0.3816 0.4549
Entamoeba histolytica protein kinase, putative 0.0065 0.0224 0.0336
Giardia lamblia Furin precursor putative serine protease 0.0058 0.0191 0.0328
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0049 0.0145 0.0111
Loa Loa (eye worm) hypothetical protein 0.0043 0.0117 0.0083
Leishmania major beta tubulin 0.116 0.5677 1
Echinococcus multilocularis fmrfamide receptor 0.0786 0.3816 0.4549
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0058 0.0191 0.0278
Loa Loa (eye worm) hypothetical protein 0.1256 0.6154 0.614
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0786 0.3816 0.3795
Echinococcus granulosus beta tubulin 0.116 0.5677 0.6767
Echinococcus granulosus alpha 1A adrenergic receptor 0.0786 0.3816 0.4549
Schistosoma mansoni tubulin subunit beta 0.116 0.5677 0.6767
Trichomonas vaginalis tubulin beta chain, putative 0.116 0.5677 1
Echinococcus granulosus tm gpcr rhodopsin 0.1609 0.7914 0.9433
Echinococcus multilocularis beta tubulin 0.116 0.5677 0.6767
Echinococcus multilocularis dro:myosuppressin receptor 0.0786 0.3816 0.4549
Schistosoma mansoni neuropeptide receptor 0.0786 0.3816 0.4549
Onchocerca volvulus 0.0786 0.3816 1
Echinococcus multilocularis neuropeptide Y receptor 0.0786 0.3816 0.4549
Schistosoma mansoni neuropeptide receptor 0.0786 0.3816 0.4549
Echinococcus multilocularis rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Echinococcus granulosus 7TM GPCR rhodopsin 0.0786 0.3816 0.4549
Echinococcus granulosus tyrosine protein kinase Blk 0.008 0.03 0.0357
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0786 0.3816 0.4549
Echinococcus multilocularis growth factor receptor bound protein 2 0.003 0.0051 0.0061
Schistosoma mansoni neuropeptide F-like receptor 0.0786 0.3816 0.4549
Echinococcus granulosus rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Brugia malayi sulfakinin receptor protein 0.2028 1 1
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Schistosoma mansoni myosin xvIII 0.0786 0.3816 0.4549
Brugia malayi ORL1-like opioid receptor 0.0786 0.3816 0.3795
Leishmania major cathepsin L-like protease 0.0027 0.0034 0.0051
Schistosoma mansoni tubulin subunit beta 0.116 0.5677 0.6767
Schistosoma mansoni hypothetical protein 0.0058 0.0191 0.0228
Plasmodium vivax aspartyl proteinase, putative 0.0049 0.0145 0.0195
Echinococcus granulosus tm gpcr rhodopsin 0.0786 0.3816 0.4549
Schistosoma mansoni histamine h1 receptor 0.0786 0.3816 0.4549
Onchocerca volvulus 0.0786 0.3816 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0786 0.3816 0.4549
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.028 0.1297 0.1267
Leishmania major cathepsin L-like protease 0.0027 0.0034 0.0051
Schistosoma mansoni hypothetical protein 0.0786 0.3816 0.4549
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0191 0.0278
Echinococcus multilocularis g protein coupled receptor 0.0786 0.3816 0.4549
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 0.0373 0.0445
Loa Loa (eye worm) tubulin beta-1 chain 0.116 0.5677 0.5662
Echinococcus granulosus cathepsin b 0.0142 0.0609 0.0726
Echinococcus multilocularis neuropeptides capa receptor 0.0786 0.3816 0.4549
Brugia malayi Melatonin receptor type 1A 0.0786 0.3816 0.3795
Loa Loa (eye worm) SH2 domain-containing protein 0.0049 0.0148 0.0114
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0049 0.0145 0.0195
Echinococcus granulosus tyrosine protein kinase Lyn 0.0095 0.0373 0.0445
Brugia malayi Dopamine receptor protein 2 0.0786 0.3816 0.3795
Echinococcus multilocularis Tubulin beta 2C chain 0.116 0.5677 0.6767
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0786 0.3816 0.4549
Echinococcus granulosus orexin receptor type 2 0.0786 0.3816 0.4549
Echinococcus granulosus growth factor receptor bound protein 2 0.003 0.0051 0.0061
Giardia lamblia Beta tubulin 0.116 0.5677 1
Giardia lamblia Cathepsin B precursor 0.005 0.0149 0.0254
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Brugia malayi endoprotease bli-4 precursor 0.03 0.1396 0.1366
Leishmania major beta tubulin 0.116 0.5677 1
Leishmania major cathepsin L-like protease 0.0027 0.0034 0.0051
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Echinococcus granulosus tyrosine protein kinase Src64B 0.0095 0.0373 0.0445
Leishmania major beta tubulin 0.116 0.5677 1
Echinococcus granulosus fatty acid binding protein FABP2 0.0035 0.0076 0.009
Schistosoma mansoni adapter molecule crk 0.003 0.0051 0.0061
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0786 0.3816 0.4549
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0243 0.1111 0.1325
Echinococcus granulosus Tubulin beta 2C chain 0.116 0.5677 0.6767
Leishmania major cathepsin L-like protease 0.0027 0.0034 0.0051
Echinococcus multilocularis sex peptide receptor 0.0786 0.3816 0.4549
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.005 0.0149 0.0254
Brugia malayi Dopamine receptor 0.0786 0.3816 0.3795
Echinococcus granulosus allatostatin A receptor 0.0786 0.3816 0.4549
Echinococcus granulosus biogenic amine 5HT receptor 0.116 0.5678 0.6769
Echinococcus multilocularis tyrosine protein kinase Abl 0.012 0.0498 0.0593
Plasmodium vivax plasmepsin IV, putative 0.0049 0.0145 0.0195
Echinococcus granulosus g protein coupled receptor 0.0786 0.3816 0.4549
Giardia lamblia Cathepsin B precursor 0.005 0.0149 0.0254
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0786 0.3816 0.4549
Brugia malayi beta-tubulin, identical 0.116 0.5677 0.5662
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0786 0.3816 0.3795
Loa Loa (eye worm) hypothetical protein 0.0907 0.4419 0.4399
Echinococcus granulosus tyrosine kinase 0.008 0.03 0.0357
Trichomonas vaginalis hypothetical protein 0.0058 0.0191 0.0278
Brugia malayi neuropeptide F receptor 0.0786 0.3816 0.3795
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0786 0.3816 0.3795
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1609 0.7914 0.9433
Onchocerca volvulus 0.0061 0.0206 0.0455
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0786 0.3816 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.116 0.5677 1
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0103 0.0172
Echinococcus multilocularis tyrosine protein kinase Srms 0.008 0.03 0.0357
Echinococcus multilocularis rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Echinococcus multilocularis serotonin receptor 0.0907 0.4419 0.5267
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0786 0.3816 0.4549
Onchocerca volvulus 0.0043 0.0117 0.0218
Leishmania major beta tubulin 0.116 0.5677 1
Loa Loa (eye worm) G-protein coupled receptor 0.0786 0.3816 0.3795
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Echinococcus granulosus tubulin beta 4A class IVa 0.116 0.5677 0.6767
Onchocerca volvulus Matrix metalloproteinase homolog 0.0096 0.0378 0.0909
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.003 0.0051 0.0061
Schistosoma mansoni amine GPCR 0.0786 0.3816 0.4549
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0103 0.0122
Schistosoma mansoni hypothetical protein 0.0786 0.3816 0.4549
Leishmania major beta tubulin 0.116 0.5677 1
Echinococcus granulosus fmrfamide receptor 0.0786 0.3816 0.4549
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0142 0.0609 0.1018
Onchocerca volvulus 0.0786 0.3816 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0786 0.3816 0.4549
Echinococcus multilocularis tyrosine protein kinase Fyn 0.008 0.03 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0191 0.0278
Brugia malayi larval opioid receptor 0.0786 0.3816 0.3795
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0034 0.0051
Echinococcus granulosus tyrosine protein kinase csk 0.0039 0.0094 0.0112
Brugia malayi neuropeptide F receptor 0.0786 0.3816 0.3795
Loa Loa (eye worm) BEN-1 protein 0.116 0.5677 0.5662
Loa Loa (eye worm) hypothetical protein 0.0118 0.0488 0.0455
Giardia lamblia Beta tubulin 0.116 0.5677 1
Leishmania major beta tubulin 0.116 0.5677 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0907 0.4419 0.5267
Echinococcus multilocularis rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0071 0.0255 0.0391
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0071 0.0255 0.0391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0786 0.3816 0.4549
Leishmania major beta tubulin 0.116 0.5677 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0786 0.3816 0.4549
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0786 0.3816 0.4549
Toxoplasma gondii beta tubulin 0.116 0.5677 1
Schistosoma mansoni tyrosine kinase 0.0095 0.0373 0.0445
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.0034 0.0041
Schistosoma mansoni tubulin subunit beta 0.116 0.5677 0.6767
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Echinococcus granulosus g protein coupled receptor 0.0786 0.3816 0.4549
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0071 0.0255 0.0391
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0103 0.0172
Schistosoma mansoni tubulin subunit beta 0.116 0.5677 0.6767
Echinococcus multilocularis fmrfamide receptor 0.0786 0.3816 0.4549
Schistosoma mansoni neuropeptide F-like receptor 0.0786 0.3816 0.4549
Loa Loa (eye worm) melatonin receptor type 1A 0.0786 0.3816 0.3795
Echinococcus granulosus Tubulin beta 2C chain 0.116 0.5677 0.6767
Echinococcus multilocularis NCK adaptor protein 0.003 0.0051 0.0061
Brugia malayi Serotonin receptor 0.1243 0.6092 0.6079
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0058 0.0191 0.0278
Echinococcus multilocularis neuroendocrine convertase 2 0.0189 0.0841 0.1002
Loa Loa (eye worm) neuropeptide F receptor 0.0786 0.3816 0.3795
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0058 0.0191 0.0278
Brugia malayi hypothetical protein 0.0786 0.3816 0.3795
Brugia malayi hypothetical protein 0.0786 0.3816 0.3795
Loa Loa (eye worm) sex muscle abnormal protein 5 0.003 0.0051 0.0017
Echinococcus multilocularis fatty acid binding protein FABP2 0.0035 0.0076 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0034 0.0051
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0157 0.0682 0.0813
Echinococcus multilocularis orexin receptor type 2 0.0786 0.3816 0.4549
Schistosoma mansoni biogenic amine receptor 0.0786 0.3816 0.4549
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0786 0.3816 0.4549
Brugia malayi neuroendocrine convertase 1 precursor 0.0189 0.0841 0.0809
Leishmania major beta tubulin 0.116 0.5677 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0349 0.0315
Brugia malayi hypothetical protein 0.0786 0.3816 0.3795
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0786 0.3816 0.4549
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0034 0.0041
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 0.0373 0.0445
Echinococcus multilocularis neuropeptide receptor A26 0.0786 0.3816 0.4549
Onchocerca volvulus 0.0786 0.3816 1
Entamoeba histolytica tubulin family protein 0.116 0.5677 1
Brugia malayi proprotein convertase 2 0.0189 0.0841 0.0809
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0609 0.0726
Echinococcus multilocularis dna polymerase kappa 0.004 0.0103 0.0123
Plasmodium vivax tubulin beta chain, putative 0.116 0.5677 1
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0786 0.3816 0.3795
Echinococcus granulosus cathepsin l1 0.0027 0.0034 0.0041
Schistosoma mansoni amine GPCR 0.0786 0.3816 0.4549
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0049 0.0145 0.0195
Echinococcus granulosus dna polymerase kappa 0.004 0.0103 0.0123
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0103 0.0122
Echinococcus granulosus rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Loa Loa (eye worm) cathepsin B 0.005 0.0149 0.0115
Schistosoma mansoni growth hormone secretagogue receptor 0.0786 0.3816 0.4549
Loa Loa (eye worm) matrixin family protein 0.0104 0.0421 0.0388
Brugia malayi Variant SH3 domain containing protein 0.003 0.0051 0.0017
Trypanosoma brucei beta tubulin 0.116 0.5677 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0034 0.0041
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Echinococcus granulosus tyrosine protein kinase csk 0.0039 0.0094 0.0112
Loa Loa (eye worm) beta-tubulin 0.116 0.5677 0.5662
Echinococcus multilocularis tubulin beta 1 chain 0.116 0.5677 0.6767
Loa Loa (eye worm) endoprotease bli-4 0.03 0.1396 0.1366
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0103 0.0172
Giardia lamblia Cathepsin B precursor 0.005 0.0149 0.0254
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0182 0.081 0.0966
Onchocerca volvulus 0.0786 0.3816 1
Echinococcus multilocularis fatty acid binding protein FABP2 0.0035 0.0076 0.009
Echinococcus multilocularis tubulin, beta 4A class IVa 0.116 0.5677 0.6767
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0786 0.3816 0.4549
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Schistosoma mansoni biogenic amine (5HT) receptor 0.116 0.5678 0.6769
Echinococcus granulosus tyrosine protein kinase Src42A 0.0076 0.0278 0.0332
Onchocerca volvulus 0.0786 0.3816 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0051 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0034 0.0051
Schistosoma mansoni tyrosine kinase 0.0095 0.0373 0.0445
Echinococcus multilocularis tyrosine protein kinase csk 0.0039 0.0094 0.0112
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182 0.081 0.1375
Schistosoma mansoni fatty acid binding protein 0.0035 0.0076 0.009
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0095 0.0373 0.0445
Echinococcus multilocularis tyrosine protein kinase Blk 0.008 0.03 0.0357
Brugia malayi putative neuropeptide receptor NPR1 0.0786 0.3816 0.3795
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0786 0.3816 0.4549
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.003 0.0036
Schistosoma mansoni tubulin subunit beta 0.116 0.5677 0.6767
Leishmania major beta tubulin 0.116 0.5677 1
Giardia lamblia High cysteine membrane protein Group 2 0.0111 0.0457 0.0797
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0034 0.0041
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0609 0.0726
Loa Loa (eye worm) BEN-1 protein 0.116 0.5677 0.5662
Echinococcus granulosus neuroendocrine convertase 2 0.0189 0.0841 0.1002
Leishmania major beta tubulin 0.116 0.5677 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 0.0373 0.0445
Trypanosoma brucei unspecified product 0.0034 0.0071 0.0115
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0052 0.0164 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0609 0.0726
Schistosoma mansoni fatty acid binding protein 0.0035 0.0076 0.009
Schistosoma mansoni tyrosine kinase 0.0068 0.0243 0.029
Loa Loa (eye worm) TK protein kinase 0.0065 0.0224 0.019
Loa Loa (eye worm) hypothetical protein 0.2028 1 1
Loa Loa (eye worm) hypothetical protein 0.1043 0.5096 0.508
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0049 0.0145 0.0172
Schistosoma mansoni biogenic amine receptor 0.0786 0.3816 0.4549
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0103 0.0172
Loa Loa (eye worm) tubulin beta-4 chain 0.116 0.5677 0.5662
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0191 0.0278
Echinococcus granulosus neuropeptide s receptor 0.0786 0.3816 0.4549
Loa Loa (eye worm) TK/CSK protein kinase 0.0039 0.0094 0.006
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Trichomonas vaginalis tubulin, putative 0.116 0.5677 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0786 0.3816 0.3795
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0034 0.0051
Echinococcus granulosus g-protein coupled receptor 0.0786 0.3816 0.4549
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0786 0.3816 0.4549
Echinococcus multilocularis g protein coupled receptor 0.0786 0.3816 0.4549
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.0034 0.0041
Echinococcus granulosus neuropeptide receptor 0.0786 0.3816 0.4549
Leishmania major beta tubulin 0.116 0.5677 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0065 0.0224 0.0267
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0786 0.3816 0.4549
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0191 0.0278
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Schistosoma mansoni amine GPCR 0.0786 0.3816 0.4549
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0191 0.0278
Echinococcus granulosus rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Onchocerca volvulus 0.0786 0.3816 1
Trypanosoma brucei beta tubulin 0.116 0.5677 1
Echinococcus multilocularis cathepsin b 0.0142 0.0609 0.0726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0034 0.0051
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0095 0.0373 0.0445
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.008 0.03 0.0357
Brugia malayi Variant SH3 domain containing protein 0.003 0.0051 0.0017
Echinococcus multilocularis neuropeptide FF receptor 2 0.1256 0.6154 0.7335
Echinococcus granulosus G protein coupled receptor 139 0.0786 0.3816 0.4549
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0786 0.3816 0.3795
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0191 0.0278
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0052 0.0164 0.013
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0786 0.3816 0.4549
Echinococcus multilocularis beta tubulin 0.116 0.5677 0.6767
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Echinococcus multilocularis cathepsin b 0.0142 0.0609 0.0726
Echinococcus multilocularis G protein coupled receptor 139 0.0786 0.3816 0.4549
Schistosoma mansoni neuropeptide receptor 0.0786 0.3816 0.4549
Entamoeba histolytica tubulin family protein 0.116 0.5677 1
Echinococcus granulosus serotonin receptor 0.0786 0.3816 0.4549
Echinococcus granulosus Tubulin beta 2C chain 0.116 0.5677 0.6767
Echinococcus multilocularis g-protein coupled receptor 0.0786 0.3816 0.4549
Schistosoma mansoni tyrosine kinase 0.0228 0.1036 0.1235
Echinococcus granulosus furin 0.03 0.1396 0.1664
Leishmania major beta tubulin 0.116 0.5677 1
Schistosoma mansoni opsin-like receptor 0.0786 0.3816 0.4549
Echinococcus multilocularis g protein coupled receptor 0.0786 0.3816 0.4549
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0034 0.0041
Echinococcus granulosus peptide allatostatin:somatostatin 0.0786 0.3816 0.4549
Loa Loa (eye worm) TK/ABL protein kinase 0.0243 0.1111 0.108
Echinococcus multilocularis biogenic amine (5HT) receptor 0.116 0.5678 0.6769
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0786 0.3816 0.4549
Onchocerca volvulus 0.0786 0.3816 1
Echinococcus multilocularis neuropeptides capa receptor 0.0786 0.3816 0.4549
Echinococcus multilocularis serotonin receptor 0.0907 0.4419 0.5267
Schistosoma mansoni adenoreceptor 0.0786 0.3816 0.4549
Brugia malayi Hemopexin family protein 0.0061 0.0206 0.0173
Loa Loa (eye worm) hypothetical protein 0.0052 0.0164 0.013
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Brugia malayi GnHR receptor homolog 0.0786 0.3816 0.3795
Loa Loa (eye worm) SRC-1 0.0095 0.0373 0.034
Brugia malayi Serotonin receptor 0.0786 0.3816 0.3795
Echinococcus granulosus Furin 1 0.0071 0.0255 0.0304
Echinococcus granulosus tubulin beta 1 chain 0.116 0.5677 0.6767
Echinococcus granulosus hypothetical protein 0.0786 0.3816 0.4549
Onchocerca volvulus 0.0786 0.3816 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0095 0.0373 0.0445
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.003 0.0036
Onchocerca volvulus 0.0786 0.3816 1
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0786 0.3816 0.4549
Echinococcus granulosus tachykinin peptides receptor 99D 0.0786 0.3816 0.4549
Mycobacterium leprae PROBABLE HYDROLASE 0.0052 0.0164 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0786 0.3816 0.4549
Echinococcus multilocularis rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Onchocerca volvulus 0.0054 0.017 0.0358
Brugia malayi Matrixin family protein 0.0043 0.0117 0.0083
Schistosoma mansoni furin-1 (S08 family) 0.0131 0.0552 0.0658
Brugia malayi G protein-coupled receptor F59B2.13 0.0786 0.3816 0.3795
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0034 0.0041
Loa Loa (eye worm) tubulin beta-2A chain 0.116 0.5677 0.5662
Echinococcus granulosus sex peptide receptor 0.0786 0.3816 0.4549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0034 0.0051
Echinococcus granulosus NCK adaptor protein 0.003 0.0051 0.0061
Loa Loa (eye worm) hypothetical protein 0.0043 0.0117 0.0083
Echinococcus granulosus Tubulin beta 2C chain 0.116 0.5677 0.6767
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0786 0.3816 0.4549
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0191 0.0278
Echinococcus granulosus tyrosine protein kinase Src42A 0.0095 0.0373 0.0445
Loa Loa (eye worm) hypothetical protein 0.0049 0.0145 0.0111
Loa Loa (eye worm) TK protein kinase 0.008 0.03 0.0266
Echinococcus multilocularis neuropeptide receptor 0.0786 0.3816 0.4549
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0786 0.3816 0.4549
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0191 0.0278
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0786 0.3816 0.3795
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Echinococcus multilocularis tyrosine protein kinase csk 0.0039 0.0094 0.0112
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0786 0.3816 0.4549
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0191 0.0278
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0103 0.0122
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0034 0.0072 0.0086
Schistosoma mansoni hypothetical protein 0.0786 0.3816 0.4549
Leishmania major beta tubulin 0.116 0.5677 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0786 0.3816 0.4549
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0103 0.0172
Echinococcus multilocularis somatostatin receptor 0.0786 0.3816 0.4549
Mycobacterium ulcerans hydrolase 0.0052 0.0164 1
Brugia malayi putative neuropeptide receptor 0.0786 0.3816 0.3795
Loa Loa (eye worm) matrix metalloproteinase 0.0043 0.0117 0.0083
Brugia malayi SRC-1 0.0095 0.0373 0.034
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0071 0.0255 0.0304
Leishmania major beta tubulin 0.116 0.5677 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.1256 0.6154 0.614
Echinococcus multilocularis tyrosine protein kinase csk 0.0039 0.0094 0.0112
Echinococcus granulosus tyrosine protein kinase csk 0.0039 0.0094 0.0112
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Brugia malayi Dopamine receptor protein 1 0.0786 0.3816 0.3795
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0182 0.081 0.0966
Schistosoma mansoni cathepsin D (A01 family) 0.0144 0.0617 0.0735
Trichomonas vaginalis tubulin epsilon chain, putative 0.116 0.5677 1
Echinococcus multilocularis 0.0242 0.1107 0.132
Leishmania major cathepsin L-like protease 0.0027 0.0034 0.0051
Brugia malayi Tyrosine-protein kinase abl-1 0.012 0.0498 0.0465
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0786 0.3816 0.4549
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0786 0.3816 0.4549
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0095 0.0373 0.0445
Loa Loa (eye worm) neuropeptide F receptor 0.0786 0.3816 0.3795
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0034 0.0041
Brugia malayi polk-prov protein 0.0031 0.0054 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0103 0.0172
Toxoplasma gondii beta-tubulin, putative 0.116 0.5677 1
Brugia malayi Matrixin family protein 0.0043 0.0117 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0034 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0103 0.0172
Toxoplasma gondii aspartyl protease ASP1 0.0049 0.0145 0.0195
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0095 0.0373 0.0445
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0034 0.0072 0.0086
Loa Loa (eye worm) tubulin beta chain 0.116 0.5677 0.5662
Plasmodium falciparum plasmepsin I 0.0049 0.0145 0.0195
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.03 0.1396 0.1664
Brugia malayi Tyrosine-protein kinase abl-1 0.0138 0.0589 0.0557
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Toxoplasma gondii beta-1 tubulin, putative 0.116 0.5677 1
Brugia malayi RE15519p 0.0786 0.3816 0.3795
Giardia lamblia Beta tubulin 0.116 0.5677 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0786 0.3816 0.4549
Echinococcus granulosus neuropeptides capa receptor 0.0786 0.3816 0.4549
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0103 0.0122
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0071 0.0255 0.0391
Loa Loa (eye worm) hypothetical protein 0.0043 0.0117 0.0083
Echinococcus granulosus tyrosine protein kinase HCK 0.0065 0.0224 0.0267
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0786 0.3816 0.3795
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0103 0.0122
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Brugia malayi hypothetical protein 0.0786 0.3816 0.3795
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0095 0.0373 0.0445
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Plasmodium falciparum plasmepsin IV 0.0049 0.0145 0.0195
Brugia malayi SH2 domain containing protein 0.0054 0.017 0.0136
Plasmodium falciparum plasmepsin II 0.0049 0.0145 0.0195
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 0.0373 0.0445
Echinococcus multilocularis Tubulin beta 2C chain 0.116 0.5677 0.6767
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.005 0.0149 0.0204
Echinococcus multilocularis Tubulin beta 2C chain 0.116 0.5677 0.6767
Onchocerca volvulus 0.0786 0.3816 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0039 0.0094 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0103 0.0172
Echinococcus granulosus fatty acid binding protein FABP2 0.0035 0.0076 0.009
Brugia malayi Matrixin family protein 0.0104 0.0421 0.0388
Echinococcus multilocularis dnaJ subfamily B 0.1705 0.8389 1
Echinococcus multilocularis cysteine protease 0.0027 0.0034 0.0041
Schistosoma mansoni growth factor receptor-bound protein 0.003 0.0051 0.0061
Onchocerca volvulus 0.0786 0.3816 1
Leishmania major cathepsin L-like protease 0.0027 0.0034 0.0051
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.002
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0786 0.3816 0.4549
Leishmania major beta tubulin 0.116 0.5677 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0142 0.0609 0.0576
Onchocerca volvulus 0.0786 0.3816 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0103 0.0172
Schistosoma mansoni hypothetical protein 0.1705 0.8389 1
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Echinococcus multilocularis Tubulin beta 2C chain 0.116 0.5677 0.6767
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0095 0.0373 0.0445
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0786 0.3816 0.4549
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0786 0.3816 0.4549
Schistosoma mansoni growth factor receptor-bound protein 0.003 0.0051 0.0061
Trypanosoma brucei beta tubulin 0.116 0.5677 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0786 0.3816 0.3795
Echinococcus granulosus g protein coupled receptor 0.0786 0.3816 0.4549
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.003 0.0036
Onchocerca volvulus Matrilysin homolog 0.0043 0.0117 0.0218
Echinococcus granulosus tyrosine protein kinase ABL1 0.0243 0.1111 0.1325
Brugia malayi AKH receptor 0.0786 0.3816 0.3795
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.0149 0.0204
Loa Loa (eye worm) G-protein coupled receptor 0.0786 0.3816 0.3795
Echinococcus granulosus neuropeptide Y receptor 0.0786 0.3816 0.4549
Echinococcus granulosus neuropeptide receptor A26 0.0786 0.3816 0.4549
Echinococcus granulosus beta tubulin 0.116 0.5677 0.6767
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0786 0.3816 0.4549
Trypanosoma cruzi beta tubulin, putative 0.116 0.5677 1
Schistosoma mansoni hypothetical protein 0.0061 0.0206 0.0246
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0182 0.081 0.1375
Brugia malayi Sex muscle abnormal protein 5 0.003 0.0051 0.0017
Echinococcus granulosus tm gpcr rhodopsin 0.0786 0.3816 0.4549
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0054 0.0086
Echinococcus multilocularis cysteine protease 0.0027 0.0034 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0786 0.3816 0.4549
Trichomonas vaginalis tubulin gamma chain, putative 0.116 0.5677 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0157 0.0682 0.0813
Echinococcus multilocularis Tubulin beta 2C chain 0.116 0.5677 0.6767
Schistosoma mansoni opsin-like receptor 0.0786 0.3816 0.4549
Schistosoma mansoni amine GPCR 0.0786 0.3816 0.4549
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0076 0.0278 0.0332
Echinococcus multilocularis rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Echinococcus multilocularis rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0786 0.3816 0.4549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0034 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0034 0.0051
Brugia malayi hypothetical protein 0.0786 0.3816 0.3795
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0054 0.0086
Schistosoma mansoni cathepsin D (A01 family) 0.0144 0.0617 0.0735
Loa Loa (eye worm) matrixin family protein 0.0096 0.0378 0.0345
Echinococcus multilocularis neuropeptide Y receptor 0.0786 0.3816 0.4549
Leishmania major cysteine peptidase A (CPA) 0.0027 0.0034 0.0051
Schistosoma mansoni opsin-like receptor 0.0786 0.3816 0.4549
Echinococcus granulosus rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0191 0.0278
Echinococcus granulosus rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Schistosoma mansoni hypothetical protein 0.0786 0.3816 0.4549
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0786 0.3816 0.4549
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0786 0.3816 0.4549
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0786 0.3816 0.4549
Loa Loa (eye worm) hypothetical protein 0.03 0.1396 0.1366
Echinococcus granulosus neuropeptide receptor 0.0786 0.3816 0.4549
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0049 0.0145 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0191 0.0278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0034 0.0051
Echinococcus multilocularis neuropeptide s receptor 0.0786 0.3816 0.4549
Schistosoma mansoni tubulin subunit beta 0.116 0.5677 0.6767
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0071 0.0255 0.0391
Echinococcus granulosus neuropeptide Y receptor 0.0786 0.3816 0.4549
Onchocerca volvulus 0.0786 0.3816 1
Echinococcus granulosus Tubulin beta 2C chain 0.116 0.5677 0.6767
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.0149 0.0178
Leishmania major cathepsin L-like protease 0.0027 0.0034 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.028 0.1297 0.1267
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0095 0.0373 0.0445
Leishmania major beta tubulin 0.116 0.5677 1
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0103 0.0172
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0786 0.3816 0.4549
Echinococcus multilocularis allatostatin A receptor 0.0786 0.3816 0.4549
Brugia malayi hypothetical protein 0.0786 0.3816 0.3795
Brugia malayi hypothetical protein 0.0786 0.3816 0.3795
Onchocerca volvulus 0.0786 0.3816 1
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Echinococcus granulosus rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Loa Loa (eye worm) variant SH3 domain-containing protein 0.003 0.0051 0.0017
Brugia malayi Matrixin family protein 0.0043 0.0117 0.0083
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Echinococcus multilocularis rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Brugia malayi protein-tyrosine kinase 0.008 0.03 0.0266
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0786 0.3816 0.4549
Echinococcus multilocularis neuropeptide receptor 0.0786 0.3816 0.4549
Loa Loa (eye worm) hypothetical protein 0.0142 0.0609 0.0576
Trypanosoma brucei cysteine peptidase C (CPC) 0.005 0.0149 0.0254
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0786 0.3816 0.4549
Echinococcus multilocularis tubulin subunit beta 0.116 0.5677 0.6767
Leishmania major cathepsin L-like protease 0.0027 0.0034 0.0051
Echinococcus multilocularis Furin 1 0.0071 0.0255 0.0304
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0103 0.0122
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0049 0.0145 0.0172
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0071 0.0115
Plasmodium falciparum tubulin beta chain 0.116 0.5677 1
Echinococcus multilocularis c src tyrosine kinase 0.0068 0.0243 0.029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0034 0.0051
Onchocerca volvulus Matrilysin homolog 0.0096 0.0378 0.0909
Onchocerca volvulus 0.0786 0.3816 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0786 0.3816 0.4549
Echinococcus granulosus dro:myosuppressin receptor 0.0786 0.3816 0.4549
Brugia malayi follicle stimulating hormone receptor 0.0786 0.3816 0.3795
Echinococcus granulosus c src tyrosine kinase 0.0068 0.0243 0.029
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0142 0.0609 0.0726
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0786 0.3816 0.3795
Schistosoma mansoni biogenic amine receptor 0.0786 0.3816 0.4549
Echinococcus granulosus biogenic amine 5HT receptor 0.0907 0.4419 0.5267
Echinococcus granulosus neuropeptide FF receptor 2 0.1256 0.6154 0.7335
Brugia malayi celfurPC protein 0.0242 0.1107 0.1076
Schistosoma mansoni tyrosine kinase 0.0034 0.0072 0.0086
Onchocerca volvulus 0.0786 0.3816 1
Toxoplasma gondii cathepsin B 0.005 0.0149 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0103 0.0172
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0786 0.3816 0.4549
Echinococcus multilocularis G-protein coupled receptor, putative 0.0786 0.3816 0.4549
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0071 0.0255 0.0391
Loa Loa (eye worm) hypothetical protein 0.0786 0.3816 0.3795
Trichomonas vaginalis tubulin alpha chain, putative 0.116 0.5677 1
Brugia malayi G-protein coupled receptor 0.0786 0.3816 0.3795
Echinococcus granulosus cathepsin b 0.0142 0.0609 0.0726
Echinococcus granulosus somatostatin receptor 0.0786 0.3816 0.4549
Trypanosoma brucei beta tubulin 0.116 0.5677 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0786 0.3816 0.4549
Brugia malayi G-protein coupled receptor 0.0786 0.3816 0.3795
Brugia malayi hypothetical protein 0.0786 0.3816 0.3795
Brugia malayi hypothetical protein 0.0786 0.3816 0.3795
Brugia malayi Tubulin beta-1 chain 0.116 0.5677 0.5662

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 84 uM Activation of AMPK in rat liver assessed as SAMS peptide phosphorylation ChEMBL. 17451949

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.